Transplanted induced Pluripotent stem cells mitigate oxidative stress and improve cardiac function through the akt cell survival pathway in diabetic cardiomyopathy

Molecular Pharmaceutics

Volumn 10, Issue 9, 2013, Pages 3425-3432

  Yan, Binbin ^a   Singla, Dinender K ^a  

^a UNIVERSITY OF CENTRAL FLORIDA COLLEGE OF MEDICINE   (United States)

Author keywords

Akt; Apoptosis; Cardiomyopathy; Diabetes; Fibrosis; Heart; iPS cells

Indexed keywords

CASPASE 3; CATALASE; GELATINASE B; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PROTEIN KINASE B;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; AUTOCRINE EFFECT; CELL SURVIVAL; CELLULAR SECRETION; CONDITIONED MEDIUM; CONTROLLED STUDY; CULTURE MEDIUM; DIABETIC CARDIOMYOPATHY; FEMALE; GLYCEMIC CONTROL; HEART FUNCTION; HEART MUSCLE FIBROSIS; HEART VENTRICLE REMODELING; MALE; MOUSE; NONHUMAN; OXIDATIVE STRESS; PARACRINE SIGNALING; PLURIPOTENT STEM CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; STEM CELL TRANSPLANTATION; STREPTOZOCIN DIABETES; TREATMENT OUTCOME;

ANIMALS; APOPTOSIS; CELL LINE; CELL SURVIVAL; DIABETIC CARDIOMYOPATHIES; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; INDUCED PLURIPOTENT STEM CELLS; LIPID PEROXIDES; MALE; MICE; MICE, INBRED C57BL; OXIDATIVE STRESS; RATS;

EID: 84883575528     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/mp400258d     Document Type: Article

References (36)

1. Glass, C. E.; Singal, P. K.; Singla, D. K. Stem cells in the diabetic infarcted heart Heart Failure Rev. 2010, 15, 581-588
2. Rahman, S.; Rahman, T.; Ismail, A. A.; Rashid, A. R. Diabetes-associated macrovasculopathy: Pathophysiology and pathogenesis Diabetes, Obes. Metab. 2007, 9, 767-780
3. Neel, S.; Singla, D. K. Induced pluripotent stem (ips) cells inhibit apoptosis and fibrosis in streptozotocin-induced diabetic rats Mol. Pharmaceutics 2011, 8, 2350-2357
4. Diao, X.; Shen, E.; Wang, X.; Hu, B. Differentially expressed micrornas and their target genes in the hearts of streptozotocin-induced diabetic mice Mol. Med. Rep. 2011, 4, 633-640
5. Giacco, F.; Brownlee, M. Oxidative stress and diabetic complications Circ. Res. 2010, 107, 1058-1070
6. Mellor, K. M.; Ritchie, R. H.; Delbridge, L. M. Reactive oxygen species and insulin-resistant cardiomyopathy Clin. Exp. Pharmacol. Physiol. 2010, 37, 222-228
7. Selvaraju, V.; Joshi, M.; Suresh, S.; Sanchez, J. A.; Maulik, N.; Maulik, G. Diabetes, oxidative stress, molecular mechanism, and cardiovascular disease - an overview Toxicol. Mech. Methods 2012, 22, 330-335
8. Singla, D. K.; Ahmed, A.; Singla, R.; Yan, B. Embryonic stem cells improve cardiac function in doxorubicin-induced cardiomyopathy mediated through multiple mechanisms Cell Transplant. 2012, 21, 1919-1930
9. Ting, A. E.; Sherman, W. Allogeneic stem cell transplantation for ischemic myocardial dysfunction Curr. Opin. Organ Transplant. 2012, 17, 675-680
10. Zwi-Dantsis, L.; Gepstein, L. Induced pluripotent stem cells for cardiac repair Cell. Mol. Life Sci. 2012, 69, 3285-3299
11. Gnecchi, M.; Danieli, P.; Cervio, E. Mesenchymal stem cell therapy for heart disease Vasc. Pharmacol. 2012, 57, 48-55
12. Singla, D. K. Stem cells in the infarcted heart J. Cardiovasc. Transl. Res. 2010, 3, 73-78
13. Singla, D. K.; Long, X.; Glass, C.; Singla, R. D.; Yan, B. Induced pluripotent stem (ips) cells repair and regenerate infarcted myocardium Mol. Pharmaceutics 2011, 8, 1573-1581
14. Singla, D. K.; McDonald, D. E. Factors released from embryonic stem cells inhibit apoptosis of h9c2 cells Am. J. Physiol.: Heart Circ. Physiol. 2007, 293, H1590-1595
15. Singla, D. K.; Lyons, G. E.; Kamp, T. J. Transplanted embryonic stem cells following mouse myocardial infarction inhibit apoptosis and cardiac remodeling Am. J. Physiol.: Heart Circ. Physiol. 2007, 293, H1308-1314
16. Zhang, N.; Li, J.; Luo, R.; Jiang, J.; Wang, J. A. Bone marrow mesenchymal stem cells induce angiogenesis and attenuate the remodeling of diabetic cardiomyopathy Exp. Clin. Endocrinol. Diabetes 2008, 116, 104-111
17. Buccini, S.; Haider, K. H.; Ahmed, R. P.; Jiang, S.; Ashraf, M. Cardiac progenitors derived from reprogrammed mesenchymal stem cells contribute to angiomyogenic repair of the infarcted heart Basic Res. Cardiol. 2012, 107, 301
18. Jeon, K.; Lim, H.; Kim, J. H.; Thuan, N. V.; Park, S. H.; Lim, Y. M.; Choi, H. Y.; Lee, E. R.; Kim, J. H.; Lee, M. S.; Cho, S. G. Differentiation and transplantation of functional pancreatic beta cells generated from induced pluripotent stem cells derived from a type 1 diabetes mouse model Stem Cells Develop. 2012, 21, 2642-2655
19. Glass, C.; Singla, D. K. Microrna-1 transfected embryonic stem cells enhance cardiac myocyte differentiation and inhibit apoptosis by modulating the pten/akt pathway in the infarcted heart Am. J. Physiol.: Heart Circ. Physiol. 2011, 301, H2038-2049
20. Singla, D. K.; Singla, R. D.; McDonald, D. E. Factors released from embryonic stem cells inhibit apoptosis in h9c2 cells through pi3k/akt but not erk pathway Am. J. Physiol.: Heart Circ. Physiol. 2008, 295, H907-913
21. Timmers, L.; Lim, S. K.; Hoefer, I. E.; Arslan, F.; Lai, R. C.; van Oorschot, A. A.; Goumans, M. J.; Strijder, C.; Sze, S. K.; Choo, A.; Piek, J. J.; Doevendans, P. A.; Pasterkamp, G.; de Kleijn, D. P. Human mesenchymal stem cell-conditioned medium improves cardiac function following myocardial infarction Stem Cell Res. 2011, 6, 206-214
22. Cai, L.; Li, W.; Wang, G.; Guo, L.; Jiang, Y.; Kang, Y. J. Hyperglycemia-induced apoptosis in mouse myocardium: Mitochondrial cytochrome c-mediated caspase-3 activation pathway Diabetes 2002, 51, 1938-1948
23. Ma, B.; Xiong, X.; Chen, C.; Li, H.; Xu, X.; Li, X.; Li, R.; Chen, G.; Dackor, R. T.; Zeldin, D. C.; Wang, D. W. Cardiac-specific overexpression of cyp2j2 attenuates diabetic cardiomyopathy in male streptozotocin-induced diabetic mice Endocrinology 2013, 154, 2843-2856
24. Lin, P.; Chen, L.; Yang, N.; Sun, Y.; Xu, Y. X. Evaluation of stem cell differentiation in diabetic rats transplanted with bone marrow mesenchymal stem cells Transplant. Proc. 2009, 41, 1891-1893
25. Xu, Y. X.; Chen, L.; Hou, W. K.; Lin, P.; Sun, L.; Sun, Y.; Dong, Q. Y.; Liu, J. B.; Fu, Y. L. Mesenchymal stem cells treated with rat pancreatic extract secrete cytokines that improve the glycometabolism of diabetic rats Transplant. Proc. 2009, 41, 1878-1884
26. Cai, L.; Kang, Y. J. Cell death and diabetic cardiomyopathy Cardiovasc. Toxicol. 2003, 3, 219-228
27. Rajesh, M.; Batkai, S.; Kechrid, M.; Mukhopadhyay, P.; Lee, W. S.; Horvath, B.; Holovac, E.; Cinar, R.; Liaudet, L.; Mackie, K.; Hasko, G.; Pacher, P. Cannabinoid 1 receptor promotes cardiac dysfunction, oxidative stress, inflammation, and fibrosis in diabetic cardiomyopathy Diabetes 2012, 61, 716-727
28. Dhingra, S.; Sharma, A. K.; Singla, D. K.; Singal, P. K. P38 and erk1/2 mapks mediate the interplay of tnf-alpha and il-10 in regulating oxidative stress and cardiac myocyte apoptosis Am. J. Physiol.: Heart Circ. Physiol. 2007, 293, H3524-3531
29. Aki, T.; Yamaguchi, K.; Fujimiya, T.; Mizukami, Y. Phosphoinositide 3-kinase accelerates autophagic cell death during glucose deprivation in the rat cardiomyocyte-derived cell line h9c2 Oncogene 2003, 22, 8529-8535
30. Singal, P. K.; Bello-Klein, A.; Farahmand, F.; Sandhawalia, V. Oxidative stress and functional deficit in diabetic cardiomyopathy Adv. Exp. Med. Biol. 2001, 498, 213-220
31. Aydemir-Koksoy, A.; Bilginoglu, A.; Sariahmetoglu, M.; Schulz, R.; Turan, B. Antioxidant treatment protects diabetic rats from cardiac dysfunction by preserving contractile protein targets of oxidative stress J. Nutr. Biochem. 2010, 21, 827-833
32. Adeghate, E.; Singh, J. Structural changes in the myocardium during diabetes-induced cardiomyopathy. Heart Failure Rev. 2013, in press.
33. Ye, G.; Metreveli, N. S.; Donthi, R. V.; Xia, S.; Xu, M.; Carlson, E. C.; Epstein, P. N. Catalase protects cardiomyocyte function in models of type 1 and type 2 diabetes Diabetes 2004, 53, 1336-1343
34. Singla, D. K.; Singla, R. D.; Lamm, S.; Glass, C. Tgf-beta2 treatment enhances cytoprotective factors released from embryonic stem cells and inhibits apoptosis in infarcted myocardium Am. J. Physiol.: Heart Circ. Physiol. 2011, 300, H1442-1450
35. Wilson, T.; Stark, C.; Holmbom, J.; Rosling, A.; Kuusilehto, A.; Tirri, T.; Penttinen, R.; Ekholm, E. Fate of bone marrow-derived stromal cells after intraperitoneal infusion or implantation into femoral bone defects in the host animal J. Tissue Eng. 2010, 2010, 345806
36. Wang, N.; Shao, Y.; Mei, Y.; Zhang, L.; Li, Q.; Li, D.; Shi, S.; Hong, Q.; Lin, H.; Chen, X. Novel mechanism for mesenchymal stem cells in attenuating peritoneal adhesion: Accumulating in the lung and secreting tumor necrosis factor alpha-stimulating gene-6 Stem Cell Res. Ther. 2012, 3, 51