Mycophenolate mofetil and sirolimus in hepatocyte transplantation in an experimental model of toxic acute liver failure

Journal of Investigative Surgery

Volumn 27, Issue 4, 2014, Pages 205-213

  Loukopoulos, Ioannis ^a   Sfiniadakis, Ioannis ^b   Pillai, Andrew ^c   Konstantoulakis, Manousos ^a   Androulakis, Georgios ^a   Bonatsos, Vassilios ^a   Zografos, Georgios ^a   Papalois, Apostolos ^d  

^a UNIVERSITY OF ATHENS   (Greece)

^b ATHENS NAVAL HOSPITAL   (Greece)

^c GUY'S AND ST THOMAS' NHS FOUNDATION TRUST   (United Kingdom)

^d ELPEN Pharmaceuticals   (Greece)

Author keywords

Experimental; Hepatocyte; Model; Mycophenolate mofetil; Sirolimus; Transplantation

Indexed keywords

ALKALINE PHOSPHATASE; BILIRUBIN; CREATININE; CYCLOSPORIN; DIMETHYLNITROSAMINE; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; RAPAMYCIN; IMMUNOSUPPRESSIVE AGENT; MYCOPHENOLIC ACID;

ACUTE LIVER FAILURE; ALLOTRANSPLANTATION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; EXPERIMENTAL STUDY; GRAFT RECIPIENT; HEPATOCYTE TRANSPLANTATION; IMMUNOSUPPRESSIVE TREATMENT; LIVER CELL; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SPLEEN; SURVIVAL; ANALOGS AND DERIVATIVES; ANIMAL; DISEASE MODEL; EVALUATION STUDY; GRAFT REJECTION; LEWIS RAT; LIVER FAILURE, ACUTE; MORTALITY; PATHOLOGY; TRANSPLANTATION; WISTAR RAT;

ANIMALS; DISEASE MODELS, ANIMAL; GRAFT REJECTION; HEPATOCYTES; IMMUNOSUPPRESSIVE AGENTS; LIVER FAILURE, ACUTE; MALE; MYCOPHENOLIC ACID; RATS, INBRED LEW; RATS, WISTAR; SIROLIMUS; SPLEEN;

EID: 84903790363     PISSN: 08941939     EISSN: 15210553     Source Type: Journal    
DOI: 10.3109/08941939.2013.879967     Document Type: Article

References (34)

1. Wesson RN, Cameron AM. Stem cells in acute liver failure. Adv Surg. 2011;45:117-130. Review.
2. Papalois A, Arkadoupoulos N, Pataryas Th, et al. Combined hepatocyte-islet transplantation: an allograft model. Transpl Int. 1994;7(Suppl 1):S432-5.
3. Papalois A, Arkadopoulos N, Kostopanagiotou G, et al. Experimental xenotransplantation of fresh isolated and cryopreserved pig hepatocytes: a biochemical andmorphological study. Transplant Proc. 1997 Jun;29(4):2096-8. (Pubitemid 27265249)
4. Fox IJ, Chowdhury JR. Hepatocyte transplantation. Am J Transplant. 2004;4(Suppl 6):7-13. (Pubitemid 38282274)
5. Fisher RA, Bu D, Thompson M, Wolfe L, Ritter JK. Optimization of conditions for clinical human hepatocyte infusion. Cell Transplant. 2004;13(6):677-689. (Pubitemid 40116923)
6. KrishnaVanaja D, Sivakumar B, Jesudasan RA, et al. In vivo identification, survival, and functional efficacy of transplanted hepatocytes in acute liver failure mice modelby FISH. Cell Transplant. 1998;7(3):267-273. (Pubitemid 28280855)
7. Magee P et al. The metabolism of dimethylnitrosamine. Biochem J. 1956;64:676.
8. Tenant. Evaluation of the trypan blue technique for determination of cell viability. J Transplant. 1964;2(6): 685-694.
9. Guha C, Parashar B, Deb NJ, et al. Normal hepatocytes correct serum bilirubin after repopulation of Gunn rat liver subjected to irradiation/partial resection. Hepatology. 2002 Aug;36(2):354-362. (Pubitemid 34810354)
10. Park SM, Vo K, Lallier M, et al. Hepatocyte transplantation in the Long Evans Cinnamon rat model ofWilson's disease. Cell Transplant. 2006;15(1):13-22.
11. Kocken JM, Borel Rinkes IH, Bijma AM, et al. Correction of an inborn error of metabolism by intraportal hepatocyte transplantation in a dog model. Transplantation. 1996;62(3):358-364. (Pubitemid 26277342)
12. Mitry RR, Hughes RD, Aw MM, et al. Human hepatocyte isolation and relationship of cell viability to early graft function. Cell Transplant. 2003;12(1):69-74. (Pubitemid 36397317)
13. Mitry RR, Dhawan A, Hughes RD, et al. One liver, three recipients: segment IV from split-liver procedures as a source of hepatocytes for cell transplantation. Transplantation. 2004;77(10):1614-1616. (Pubitemid 38703047)
14. Dan YY, Riehle KJ, Lazaro C, et al. Isolation of multipotent progenitor cells from human fetal liver capable of differentiating into liver and mesenchymal lineages. Proc Natl Acad Sci USA. 2006;103(26):9912-9917. Epub 2006 Jun 16. (Pubitemid 43993597)
15. Avital I, Feraresso C, Aoki T, et al. Bone marrow-derived liver stem cell and mature hepatocyte engraftment in livers undergoing rejection. Surgery. 2002;132(2):384-390. (Pubitemid 35024789)
16. Schwerfeld-Bohr J, Chi H, Worm K, et al. Influence of hematopoietic stem cell-derived hepatocytes on liver regeneration after sex-mismatched liver transplantation in humans. J Invest Surg. 2012 Aug;25(4):220-226. doi: 10.3109/08941939.2011.627088. Epub 2012 May 9.
17. Palmes D, Qayumi AK, Spiegel HU. Liver bridging techniques in the treatment of acute liver failure. J Invest Surg. 2000;13(6):299-311. (Pubitemid 32046807)
18. Pareja E, Gomez-Lechon MJ, Cortes M, et al. Human hepatocyte transplantation in patients with hepatic failure awaiting a graft. Eur Surg Res. 2013;50(3-4):273-281. doi: 10.1159/000351332. Epub 2013 Jun 18.
19. Tsiolis I, Papalois A, Loukopoulos I, et al. Experimental isolation and transplantation of hepatocytes with the use of antibody against interleukin-2 receptor (daclizumab) as immunosuppressive agent. Transplant Proc. 2005;37(4):1929-1930. (Pubitemid 40790872)
20. Kontalexis S, PapaloisA, Bibidakis E, et al.Use of mycophenolate mofetil in the experimental allo-transplantation of hepatocytes in rats with fulminant hepatic failure. Transplant Proc. 2004;36(6):1739-1740. (Pubitemid 39200416)
21. Wu SL, Pan CE, Yu L, et al. Immunosuppression by combined use of cyclosporine and resveratrol in a rat liver transplantationmodel. Transplant Proc. 2005 Jun;37(5): 2354-2359. (Pubitemid 40956448)
22. Wu YM, Joseph B, Gupta S. Immunosuppression using the mTOR inhibition mechanism affects replacement of rat liver with transplanted cells. Hepatology. 2006;44(2): 410-419. (Pubitemid 44214880)
23. Stepkowski SM. Preclinical results of sirolimus treatment in transplant models. Transplant Proc. 2003;35(3 Suppl):219S-226S. (Pubitemid 36547947)
24. Fitzpatrick E, Mitry RR, Dhawan A. Human hepatocyte transplantation: State of the art. J Intern Med. 2009 Oct;266(4):339-357.
25. Arkadopoulos N, Papalois A, Pataryas TH, et al. Experimental transplantation of hepatocytes in cases of toxic acute liver failure. An allograft model. Transpl Int. 1994;7(Suppl 1):S171-S174.
26. Lytras D, Papalois A, Tsaroucha AK, et al. Xenotransplantation of hepatocytes in rats with acute liver failure using sirolimus for immunosuppression. J Int Med Res. 2010;38(2):546-557.
27. Ginesta MM, Mollevi DG, Serrano T, et al. Modulation of the pathology of late xenograft rejection by PAF-antagonist UR-12670 in the hamster-to-rat liver xenotransplant model. APMIS. 2003;111(3):371-381. (Pubitemid 36560536)
28. Newsome PN, Plevris JN, Nelson LJ, et al. Animal models of fulminant hepatic failure: A critical evaluation. Liver Transpl. 2000;6(1):21-31. Review. (Pubitemid 30123364)
29. Terblanche J, Hickman R. Animalmodels of fulminant hepatic failure. Dig Dis Sci. 1991;36(6):770-774. Review.
30. Guha C, Sharma A, Gupta S, et al. Amelioration of radiation-induced liver damage in partially hepatectomized rats by hepatocyte transplantation. Cancer Res. 1999;59(23):5871-5874. (Pubitemid 30004941)
31. Hughes RD, Mitry RR, Dhawan A. Current status of hepatocyte transplantation. Transplantation. 2012 Feb 27; 93(4):342-7.
32. Krause P, Wolff HA, Rave-Frank M, et al. Fractionated external beam radiotherapy as a suitable preparative regimen for hepatocyte transplantation after partial hepatectomy. Int J RadiatOncol Biol Phys. 2011; 80(4):1214-1219. Epub 2011 Apr 20.
33. Bonavita AG,Quaresma K, Cotta-de-Almeida V, Pinto MA, et al. Hepatocyte xenotransplantation for treating liver disease. Xenotransplantation. 2010 May-Jun;17(3):181-7.
34. Mei J, Sgroi A, Mai G, et al. Improved survival of fulminant liver failure by transplantation of microencapsulated cryopreserved porcine hepatocytes in mice. Cell Transplant. 2009;18(1):101-110.