Human hepatocyte transplantation in patients with hepatic failure awaiting a graft

European Surgical Research

Volumn 50, Issue 3-4, 2013, Pages 273-281

  Pareja, E ^a   Gomez Lechon, M J ^a,c   Cortes, M ^a   Bonora Centelles, A ^a,c   Castell, J V ^a,b,c   Mir, J ^a  

^a HOSPITAL UNIVERSITARIO LA FE   (Spain)

^b UNIVERSITY OF VALENCIA   (Spain)

^c INSTITUTO DE SALUD CARLOS III   (Spain)

Author keywords

Chronic liver disease; Cryopreservation; End stage liver disease; Hepatocyte transplantation; Liver transplantation

Indexed keywords

AMMONIA; BILIRUBIN; ANTIBIOTIC AGENT; FRESH FROZEN PLASMA; LACTULOSE; METHYLPREDNISOLONE; TACROLIMUS;

ACUTE ON CHRONIC LIVER FAILURE; ADULT; AMMONIA BLOOD LEVEL; ANALYTICAL PARAMETERS; ANEMIA; ARTICLE; ASCITES; BILIRUBIN BLOOD LEVEL; BLOOD CLOTTING DISORDER; BLOOD EXAMINATION; CASE REPORT; CELL VIABILITY; CLINICAL ASSESSMENT; COMA; DISEASE SEVERITY; END STAGE LIVER DISEASE; ESOPHAGUS VARICES BLEEDING; EUPHORIA; EYE JAUNDICE; FOLLOW UP; FOOT EDEMA; GRAFT DYSFUNCTION; HEPATIC ENCEPHALOPATHY; HEPATITIS C; HEPATOCYTE TRANSPLANTATION; HOSPITAL ADMISSION; HUMAN; HYPERBILIRUBINEMIA; INTENSIVE CARE UNIT; JAUNDICE; KIDNEY FAILURE; KIDNEY FUNCTION; LIVER CELL; LIVER CIRRHOSIS; LIVER FUNCTION; LIVER GRAFT; LIVER TRANSPLANTATION; MALE; PARACENTESIS; PRIORITY JOURNAL; RECURRENT INFECTION; RETRANSPLANTATION; THROMBOCYTOPENIA; UPPER GASTROINTESTINAL BLEEDING; AGED; ANAMNESIS; BLOOD ANALYSIS; BLOOD CHEMISTRY; COMPUTER ASSISTED TOMOGRAPHY; DOPPLER ECHOGRAPHY; ENDOTRACHEAL INTUBATION; FEMALE; HEPATITIS C VIRUS; HUMAN CELL; IMMUNOSUPPRESSIVE TREATMENT; LIVER FAILURE; LIVER FUNCTION TEST; LIVER GRAFT REJECTION; MIDDLE AGED; NEUROLOGIC EXAMINATION; ORGAN TRANSPLANTATION; PATIENT MONITORING; PHYSICAL EXAMINATION; POSTOPERATIVE INFECTION; STEROID THERAPY; VERY ELDERLY;

ADULT; AMMONIA; END STAGE LIVER DISEASE; HEPATITIS C, CHRONIC; HEPATOCYTES; HUMANS; LIVER FUNCTION TESTS; LIVER TRANSPLANTATION; MALE; MIDDLE AGED; REOPERATION; TIME FACTORS; WAITING LISTS;

EID: 84879173244     PISSN: 0014312X     EISSN: 14219921     Source Type: Journal    
DOI: 10.1159/000351332     Document Type: Article

References (27)

1. Sarin SK, Kumar A, Almeida JA, et al: Acute-on-chronic liver failure: consensus recommendations of the Asian Pacific Association for the study of the liver (APASL). Hepatol Int 2009; 3: 269-282.
2. García-Martínez R, Córdoba J: Acute-on-chronic liver failure: the brain. Curr Opin Crit Care 2011; 17: 177-183.
3. Matesanz R, Dominguez-Gil B, Coll E, et al: Spanish experience as a leading country: what kind of measures were taken? Transplant Int 2011; 24: 333-340.
4. Phua J, Lee KH: Liver support devices. Curr Opin Crit Care 2008; 14: 208-215. (Pubitemid 351498788)
5. Lafuente S, Bertran MJ, Escorsell A: Artificial liver support. Literature review. Med Clin (Barc) 2011; 136: 484-487.
6. Bilir BM, Guinette D, Karrer F, et al: Hepatocyte transplantation in acute liver failure. Liver Transpl 2000; 6: 32-40. (Pubitemid 30123365)
7. Strom SC, Fisher RA, Thompson MT, et al: Hepatocyte transplantation as a bridge to orthotopic liver transplantation in terminal liver failure. Transplantation 1997; 6: 559-569. (Pubitemid 27102626)
8. Bilir M, Guenette D, Ostrowska A: Percutaneous hepatocyte transplantation (PHT) in liver failure. Hepatology 1997; 26: 494A.
9. Bilir M, Durham J, Krystal J: Transjugular intra-portal transplantation of cryopreserved human hepatocytes in a patient with acute liver failure. Hepatology 1996; 728A.
10. Puppi J, Strom SC, Hughes RD, et al: Improving the techniques for human hepatocyte transplantation: report from a consensus meeting in London. Cell Transplant 2012; 21: 1-10.
11. Fisher RA, Strom SC: Human hepatocyte transplantation: worldwide results. Transplantation 2006; 82: 441-449. (Pubitemid 44290247)
12. Soriano H, Wood RP, Kang DC: Hepatocellular transplantation (HCT) in children with fulminant liver failure (FLT). Hepatology 1997; 26: 443A.
13. Strom SC, Chowdhury JR, Fox IJ: Hepatocyte transplantation for the treatment of human disease. Semin Liver Dis 1999; 19: 39-48. (Pubitemid 29220830)
14. Schneider A, Attaran M, Meier PN, et al: Hepatocyte transplantation in an acute liver failure due to mushroom poisoning. Transplantation 2006; 82: 1115-1116. (Pubitemid 44632133)
15. Habibullah CM, Syed IH, Qamar A, et al: Human fetal hepatocyte transplantation in patients with fulminant hepatic failure. Transplantation 1994; 58: 951-952. (Pubitemid 24333289)
16. Strom SC, Fisher RA, Rubinstein WS, et al: Transplantation of human hepatocytes. Transplant Proc 1997; 29: 2103-2106. (Pubitemid 27265252)
17. Mito M, Kusano M, Kawaura Y: Hepatocyte transplantation in man. Transplant Proc 1992; 24: 3052-3053. (Pubitemid 23011826)
18. Ribes-Koninckx C, Pareja Ibars E, Agrasot MA, Bonora-Centelles A, Polo Miquel B, Vila Carbó JJ, Donat Aliaga E, Mir Pallardó J, Gómez-Lechón MJ, Castell JV: Clinical outcome of hepatocyte transplantation in four pediatric patients with inherited metabolic diseases. Cell Transplant 2012; 21: 2267-2282.
19. Donato MT, Lahoz A, Montero S, et al: Functional assessment of the quality of human hepatocyte preparations for cell transplantation. Cell Transplant 2008; 17: 1211-1219.
20. Serralta A, Donato MT, Martinez A, et al: Influence of preservation solution on the isolation and culture of human hepatocytes from liver grafts. Cell Transplant 2005; 14: 837-843. (Pubitemid 43152988)
21. Gomez-Lechon MJ, Lahoz A, Jimenez N, et al: Evaluation of drug-metabolizing and functional competence of human hepatocytes incubated under hypothermia in different media for clinical infusion. Cell Transplant 2008; 17: 887-897.
22. Ferenci P, Lockwood A, Mullen K, et al: Hepatic encephalopathy- definition, nomenclature, diagnosis, and quantification: final report of the working party at the 11th World Congresses of Gastroenterology, Vienna, 1998. Hepatology 2002; 35: 716-721. (Pubitemid 34183979)
23. Conn Ho LM: West-Haven Criteria for the assessment of mental state in hepatic encephalopathy; in Jones EA, Meijer AJ, Chamuleau RAFM (eds): Encephalopathy and Nitrogen Metabolism in Liver Failure. Baltimore, Williams and Wilkins, 1979, pp 435-442.
24. Meyburg J, Hoerster F, Schmidt J, et al: Monitoring of intraportal liver cell application in children. Cell Transplant 2010; 19: 629-638.
25. Hughes RD, Mitry RR, Dhawan A: Current status of hepatocyte transplantation. Transplantation 2012; 93: 342-347.
26. Terry C, Dhawan A, Mitry RR, et al: Optimization of the cryopreservation and thawing protocol for human hepatocytes for use in cell transplantation. Liver Transpl 2010; 16: 229-237.
27. Lahoz A, Donato MT, Montero S, et al: A new in vitro approach for the simultaneous determination of phase I and phase II enzymatic activities of human hepatocyte preparations. Rapid Commun Mass Spectrom 2008; 22: 240-244. (Pubitemid 351156137)