Downregulation of immediate-early genes linking to suppression of neuronal plasticity in rats after 28-day exposure to glycidol

Toxicology and Applied Pharmacology

Volumn 279, Issue 2, 2014, Pages 150-162

  Akane, Hirotoshi ^a   Saito, Fumiyo ^b   Shiraki, Ayako ^a,c   Takeyoshi, Masahiro ^b   Imatanaka, Nobuya ^b   Itahashi, Megu ^a,c   Murakami, Tomoaki ^a   Shibutani, Makoto ^a  

^a TOKYO UNIVERSITY OF AGRICULTURE AND TECHNOLOGY   (Japan)

^b CHEMICALS EVALUATION AND RESEARCH INSTITUTE   (Japan)

^c GIFU UNIVERSITY   (Japan)

Author keywords

28 day oral toxicity study; Glycidol; Immediate early gene; Microarray; Neurogenesis; Neuronal plasticity

Indexed keywords

DRINKING WATER; GLYCIDOL;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN; BRAIN CORTEX; CELL GROWTH; CELL SURVIVAL; CELLULAR DISTRIBUTION; CEREBELLUM; CEREBELLUM VERMIS; CINGULATE GYRUS; CONTROLLED STUDY; CORPUS CALLOSUM; DENTATE GYRUS; DOWN REGULATION; GENE EXPRESSION; GENE EXPRESSION PROFILING; GLIA CELL; GRANULE CELL; HIPPOCAMPUS; IMMEDIATE EARLY GENE; IMMUNOHISTOCHEMISTRY; LIMBIC SYSTEM; MALE; NERVE CELL; NERVE CELL PLASTICITY; NERVE ENDING; NERVOUS SYSTEM DEVELOPMENT; NEURITE; NEUROPATHY; NEUROTOXICITY; NONHUMAN; PERIPHERAL NERVOUS SYSTEM; PROGENY; RAT; SYNAPTIC TRANSMISSION; WHITE MATTER;

28-DAY ORAL TOXICITY STUDY; GLYCIDOL; IMMEDIATE-EARLY GENE; MICROARRAY; NEUROGENESIS; NEURONAL PLASTICITY;

AGE FACTORS; ANIMALS; BRAIN; CYTOSKELETAL PROTEINS; DOSE-RESPONSE RELATIONSHIP, DRUG; DOWN-REGULATION; EPOXY COMPOUNDS; FEMALE; GENE EXPRESSION PROFILING; GENES, IMMEDIATE-EARLY; IMMUNOHISTOCHEMISTRY; MALE; MATERNAL EXPOSURE; NERVE TISSUE PROTEINS; NEUROGENESIS; NEURONAL PLASTICITY; NEURONS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PREGNANCY; PRENATAL EXPOSURE DELAYED EFFECTS; PROPANOLS; PROTO-ONCOGENE PROTEINS C-FOS; PROTO-ONCOGENE PROTEINS C-JUN; RATS; REAL-TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SYNAPTIC TRANSMISSION; TIME FACTORS;

EID: 84903785430     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2014.05.017     Document Type: Article

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