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Volumn 83, Issue , 2014, Pages 581-593
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Design, synthesis and structure-activity relationships of novel 4-phenoxyquinoline derivatives containing pyridazinone moiety as potential antitumor agents
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Author keywords
4 Phenoxyquinoline derivatives; Antitumor activity; c Met inhibitors; Synthesis
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Indexed keywords
1 (2,4 DICHLOROPHENYL) N [3 FLUORO 4 [[6 METHOXY 7 [3 (4 METHYLPIPERIDIN 1 YL)PROPOXY]QUINOLIN 4 YL]OXY]PHENYL] 4 METHYL 6 OXO 1,6 DIHYDROPYRIDAZINE 3 CARBOXAMIDE;
1 (3,4 DIFLUOROPHENYL) N [3 FLUORO 4 [[6 METHOXY 7 (3 MORPHOLINOPROPOXY)QUINOLIN 4 YL]OXY]PHENYL] 4 METHYL 6 OXO 1,6 DIHYDROPYRIDAZINE 3 CARBOXAMIDE;
3 FLUORO 4 [6 METHOXY 7 (3 MORPHOLINOPROPOXY)QUINOLIN 4 YLOXY]ANILINE;
3 FLUORO 4 [6 METHOXY 7 [3 (4 METHYLPIPERAZINE 1 YL)PROPOXY]QUINOLIN 4 YL OXY]ANILINE;
3 FLUORO 4 [6 METHOXY 7 [3 (4 METHYLPIPERDINE 1 YL)PROPOXY]QUINOLIN 4-YL OXY]AN;
3 FLUORO 4 [6 METHOXY 7 [3 (PIPERDINE 1 YL)PROPOXY]QUINOLIN 4 YLOXY]ANILINE;
3 FLUORO 4 [6 METHOXY 7 [3 (PYRROLIDIN 1 YL)PROPOXY]QUINOLIN 4 YLOXY]ANILINE;
3 OXO 2 (2 PHENYLHYDRAZONO)BUTANOIC ACID ETHYL ESTER;
3 OXO 2 [2 (2 METHYLPHENYL)HYDRAZONO]BUTANOIC ACID ETHYL ESTER;
3 OXO 2 [2 (2,4 DICHLOROPHENYL)HYDRAZONO]BUTANOIC ACID ETHYL ESTER;
3 OXO 2 [2 (3 FLUOROPHENYL)HYDRAZONO]BUTANOIC ACID ETHYL ESTER;
3 OXO 2 [2 (3,4 DIFLUOROPHENYL)HYDRAZONO]BUTANOIC ACID ETHYL ESTER;
3 OXO 2 [2 (4 CHLOROPHENYL)HYDRAZONO]BUTANOIC ACID ETHYL ESTER;
3 OXO 2 [2 (4 METHOXYPHENYL)HYDRAZONO]BUTANOIC ACID ETHYL ESTER;
3 OXO 2 [2 [2 (TRIFLUOROMETHOXY)PHENYL]HYDRAZONO]BUTANOIC ACID ETHYL ESTER;
3 OXO 2 [2 [2 (TRIFLUOROMETHYL)PHENYL]HYDRAZONO]BUTANOIC ACID ETHYL ESTER;
4 PHENOXYQUINOLINE DERIVATIVE;
ANTINEOPLASTIC AGENT;
ETHYL 4 METHYL 6 OXO 1 (2 METHYLPHENYL) 1,6 DIHYDROPYRIDAZINE 3 CARBOXYLATE;
ETHYL 4 METHYL 6 OXO 1 PHENYL 1,6 DIHYDROPYRIDAZINE 3 CARBOXYLATE;
ETHYL 4 METHYL 6 OXO 1 [2 (TRIFLUOROMETHOXY)PHENYL] 1,6 DIHYDROPYRIDAZINE 3 CARBOXYLATE;
ETHYL 4 METHYL 6 OXO 1 [2 (TRIFLUOROMETHYL)PHENYL] 1,6 DIHYDROPYRIDAZINE 3 CARBOXYLATE;
N [3 FLUORO 4 [[6 METHOXY 7 (3 MORPHOLINOPROPOXY)QUINOLIN 4 YL]OXY]PHENYL] 4 METHYL 6 OXO 1 [2 (TRIFLUOROMETHYL)PHENYL] 1,6 DIHYDROPYRIDAZINE 3 CARBOXAMIDE;
N [3 FLUORO 4 [[6 METHOXY 7 [3 (4 METHYLPIPERAZIN 1 YL)PROPOXY]QUINOLIN 4 YL]OXY]PHENYL] 4 METHYL 6 OXO 1 [2 (TRIFLUOROMETHOXY)PHENYL] 1,6 DIHYDROPYRIDAZINE 3 CARBOXAMIDE;
N [3 FLUORO 4 [[6 METHOXY 7 [3 (PIPERIDIN 1 YL)PROPOXY]QUINOLIN 4 YL]OXY]PHENYL] 4 METHYL 6 OXO 1 [2 (TRIFLUOROMETHYL)PHENYL] 1,6 DIHYDROPYRIDAZINE 3 CARBOXAMIDE;
N [3 FLUORO 4 [[6 METHOXY 7 [3 (PYRROLIDIN 1 YL)PROPOXY]QUINOLIN 4 YL]OXY]PHENYL] 4 METHYL 6 OXO 1 [2 (TRIFLUOROMETHYL)PHENYL] 1,6 DIHYDROPYRIDAZINE 3 CARBOXAMIDE;
PROTEIN TYROSINE KINASE INHIBITOR;
PYRIDAZINONE DERIVATIVE;
QUINOLINE DERIVATIVE;
UNCLASSIFIED DRUG;
UNINDEXED DRUG;
FORETINIB;
N [3 FLUORO 4 [[6 METHOXY 7 [3 (4 METHYLPIPERAZIN 1 YL)PROPOXY]QUINOLIN 4 YL]OXYPHENYL] 4 METHYL 6 OXO 1 [2 (TRIFLUOROMETHOXY)PHENYL] 1,6 DIHYDROPYRIDAZINE 3 CARBOXAMIDE;
PYRIDAZINE;
PYRIDAZINE DERIVATIVE;
SCATTER FACTOR RECEPTOR;
ANTIPROLIFERATIVE ACTIVITY;
ARTICLE;
CANCER CELL LINE;
CONTROLLED STUDY;
CYTOTOXICITY;
DRUG CYTOTOXICITY;
DRUG DESIGN;
DRUG POTENCY;
DRUG SELECTIVITY;
DRUG SYNTHESIS;
ELECTRON TRANSPORT;
ENZYME ACTIVITY;
ENZYME INHIBITION;
HT 29 CELL LINE;
HUMAN;
HUMAN CELL;
IC 50;
IN VITRO STUDY;
STRUCTURE ACTIVITY RELATION;
IC50;
ANTAGONISTS AND INHIBITORS;
CELL PROLIFERATION;
CHEMISTRY;
DRUG EFFECTS;
SYNTHESIS;
TUMOR CELL LINE;
ANTINEOPLASTIC AGENTS;
CELL LINE, TUMOR;
CELL PROLIFERATION;
CHEMISTRY TECHNIQUES, SYNTHETIC;
DRUG DESIGN;
HUMANS;
PROTO-ONCOGENE PROTEINS C-MET;
PYRIDAZINES;
QUINOLINES;
STRUCTURE-ACTIVITY RELATIONSHIP;
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EID: 84903784895
PISSN: 02235234
EISSN: 17683254
Source Type: Journal
DOI: 10.1016/j.ejmech.2014.06.068 Document Type: Article |
Times cited : (32)
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References (31)
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