-
1
-
-
77952903562
-
Signalling ballet in space and time
-
Kholodenko, B. N., Hancock, J. F. & Kolch, W. Signalling ballet in space and time. Nat. Rev. Mol. Cell Biol. 11, 414-426 (2010).
-
(2010)
Nat. Rev. Mol. Cell Biol.
, vol.11
, pp. 414-426
-
-
Kholodenko, B.N.1
Hancock, J.F.2
Kolch, W.3
-
3
-
-
0028872649
-
Specificity of receptor tyrosine kinase signaling: Transient versus sustained extracellular signal-regulated kinase activation
-
Marshall, C. J. Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activation. Cell 80, 179-185 (1995).
-
(1995)
Cell
, vol.80
, pp. 179-185
-
-
Marshall, C.J.1
-
4
-
-
0036051342
-
Molecular interpretation of ERK signal duration by immediate early gene products
-
Murphy, L. O., Smith, S., Chen, R. H., Fingar, D. C. & Blenis, J. Molecular interpretation of ERK signal duration by immediate early gene products. Nat. Cell Biol. 4, 556-564 (2002).
-
(2002)
Nat. Cell Biol.
, vol.4
, pp. 556-564
-
-
Murphy, L.O.1
Smith, S.2
Chen, R.H.3
Fingar, D.C.4
Blenis, J.5
-
5
-
-
77952902183
-
Ligand-specific c-Fos expression emerges from the spatiotemporal control of ErbB network dynamics
-
Nakakuki, T. et al. Ligand-specific c-Fos expression emerges from the spatiotemporal control of ErbB network dynamics. Cell 141, 884-896 (2010).
-
(2010)
Cell
, vol.141
, pp. 884-896
-
-
Nakakuki, T.1
-
6
-
-
73349139547
-
Cell fate decisions are specified by the dynamic ERK interactome
-
Von Kriegsheim, A. et al. Cell fate decisions are specified by the dynamic ERK interactome. Nat. Cell Biol. 11, 1458-1464 (2009).
-
(2009)
Nat. Cell Biol.
, vol.11
, pp. 1458-1464
-
-
Von Kriegsheim, A.1
-
7
-
-
79960064432
-
Raf family kinases: Old dogs have learned new tricks
-
Matallanas, D. et al. Raf family kinases: old dogs have learned new tricks. Genes Cancer 2, 232-260 (2011).
-
(2011)
Genes Cancer
, vol.2
, pp. 232-260
-
-
Matallanas, D.1
-
8
-
-
84855497573
-
Signal control through Raf: In sickness and in health
-
Osborne, J. K., Zaganjor, E. & Cobb, M. H. Signal control through Raf: in sickness and in health. Cell Res. 22, 14-22 (2012).
-
(2012)
Cell Res.
, vol.22
, pp. 14-22
-
-
Osborne, J.K.1
Zaganjor, E.2
Cobb, M.H.3
-
9
-
-
0034944380
-
Raf-1 promotes cell survival by antagonizing apoptosis signal-regulating kinase 1 through a MEK-ERK independent mechanism
-
Chen, J., Fujii, K., Zhang, L., Roberts, T. & Fu, H. Raf-1 promotes cell survival by antagonizing apoptosis signal-regulating kinase 1 through a MEK-ERK independent mechanism. Proc. Natl Acad. Sci. USA 98, 7783-7788 (2001).
-
(2001)
Proc. Natl Acad. Sci. USA
, vol.98
, pp. 7783-7788
-
-
Chen, J.1
Fujii, K.2
Zhang, L.3
Roberts, T.4
Fu, H.5
-
10
-
-
11144267126
-
Role of the kinase MST2 in suppression of apoptosis by the proto-oncogene product Raf-1
-
O'Neill, E., Rushworth, L., Baccarini, M. & Kolch, W. Role of the kinase MST2 in suppression of apoptosis by the proto-oncogene product Raf-1. Science 306, 2267-2270 (2004).
-
(2004)
Science
, vol.306
, pp. 2267-2270
-
-
O'Neill, E.1
Rushworth, L.2
Baccarini, M.3
Kolch, W.4
-
11
-
-
15444376695
-
Raf-1 regulates Rho signaling and cell migration
-
Ehrenreiter, K. et al. Raf-1 regulates Rho signaling and cell migration. J. Cell Biol. 168, 955-964 (2005).
-
(2005)
J. Cell Biol.
, vol.168
, pp. 955-964
-
-
Ehrenreiter, K.1
-
12
-
-
84866601389
-
Protein kinases of the Hippo pathway: Regulation and substrates
-
Avruch, J. et al. Protein kinases of the Hippo pathway: regulation and substrates. Semin. Cell Dev. Biol. 23, 770-784 (2012).
-
(2012)
Semin. Cell Dev. Biol.
, vol.23
, pp. 770-784
-
-
Avruch, J.1
-
13
-
-
77958494807
-
LATS tumor suppressor: A new governor of cellular homeostasis
-
Visser, S. & Yang, X. LATS tumor suppressor: a new governor of cellular homeostasis. Cell Cycle 9, 3892-3903 (2010).
-
(2010)
Cell Cycle
, vol.9
, pp. 3892-3903
-
-
Visser, S.1
Yang, X.2
-
14
-
-
34748812613
-
RASSF1A elicits apoptosis through an MST2 pathway directing proapoptotic transcription by the p73 tumor suppressor protein
-
Matallanas, D. et al. RASSF1A elicits apoptosis through an MST2 pathway directing proapoptotic transcription by the p73 tumor suppressor protein. Mol. Cell 27, 962-975 (2007).
-
(2007)
Mol. Cell
, vol.27
, pp. 962-975
-
-
Matallanas, D.1
-
15
-
-
70349174971
-
The RASSF proteins in cancer; From epigenetic silencing to functional characterization
-
Richter, A. M., Pfeifer, G. P. & Dammann, R. H. The RASSF proteins in cancer; from epigenetic silencing to functional characterization. Biochim. Biophys. Acta 1796, 114-128 (2009).
-
(2009)
Biochim. Biophys. Acta
, vol.1796
, pp. 114-128
-
-
Richter, A.M.1
Pfeifer, G.P.2
Dammann, R.H.3
-
16
-
-
66449103527
-
Rassf family of tumor suppressor polypeptides
-
Avruch, J. et al. Rassf family of tumor suppressor polypeptides. J. Biol. Chem. 284, 11001-11005 (2009).
-
(2009)
J. Biol. Chem.
, vol.284
, pp. 11001-11005
-
-
Avruch, J.1
-
17
-
-
76249097011
-
Proapoptotic Kinase MST2 Coordinates Signaling Crosstalk between RASSF1A Raf-1 and Akt
-
Romano, D. et al. Proapoptotic kinase MST2 coordinates signaling crosstalk between RASSF1A, Raf-1, and Akt. Cancer Res. 70, 1195-1203 (2010).
-
(2010)
Cancer Res.
, vol.70
, pp. 1195-1203
-
-
Romano, D.1
-
18
-
-
78650724753
-
Hippo signaling: Growth control and beyond
-
Halder, G. & Johnson, R. L. Hippo signaling: growth control and beyond. Development 138, 9-22 (2011).
-
(2011)
Development
, vol.138
, pp. 9-22
-
-
Halder, G.1
Johnson, R.L.2
-
19
-
-
84895929894
-
An evolutionary shift in the regulation of the Hippo pathway between mice and flies
-
Bossuyt, W. et al. An evolutionary shift in the regulation of the Hippo pathway between mice and flies. Oncogene 33, 1218-1228 (2014).
-
(2014)
Oncogene
, vol.33
, pp. 1218-1228
-
-
Bossuyt, W.1
-
20
-
-
0028948382
-
Multiple Ras functions can contribute to mammalian cell transformation
-
White, M. A. et al. Multiple Ras functions can contribute to mammalian cell transformation. Cell 80, 533-541 (1995).
-
(1995)
Cell
, vol.80
, pp. 533-541
-
-
White, M.A.1
-
21
-
-
0030911052
-
Role of phosphoinositide 3-OH kinase in cell transformation and control of the actin cytoskeleton by Ras
-
Rodriguez-Viciana, P. et al. Role of phosphoinositide 3-OH kinase in cell transformation and control of the actin cytoskeleton by Ras. Cell 89, 457-467 (1997).
-
(1997)
Cell
, vol.89
, pp. 457-467
-
-
Rodriguez-Viciana, P.1
-
22
-
-
0037040867
-
Dephosphorylation of Ser-259 regulates Raf-1 membrane association
-
Kubicek, M. et al. Dephosphorylation of Ser-259 regulates Raf-1 membrane association. J. Biol. Chem. 277, 7913-7919 (2002).
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 7913-7919
-
-
Kubicek, M.1
-
23
-
-
0037080956
-
Regulation of Raf-1 activation and signalling by dephosphorylation
-
Dhillon, A. S., Meikle, S., Yazici, Z., Eulitz, M. & Kolch, W. Regulation of Raf-1 activation and signalling by dephosphorylation. EMBO J. 21, 64-71 (2002).
-
(2002)
EMBO J.
, vol.21
, pp. 64-71
-
-
Dhillon, A.S.1
Meikle, S.2
Yazici, Z.3
Eulitz, M.4
Kolch, W.5
-
24
-
-
0035811597
-
Protein phosphatases 1 and 2A promote Raf-1 activation by regulating 14-3-3 interactions
-
Jaumot, M. & Hancock, J. F. Protein phosphatases 1 and 2A promote Raf-1 activation by regulating 14-3-3 interactions. Oncogene 20, 3949-3958 (2001).
-
(2001)
Oncogene
, vol.20
, pp. 3949-3958
-
-
Jaumot, M.1
Hancock, J.F.2
-
25
-
-
0036236897
-
Cyclic AMP-dependent kinase regulates Raf-1 kinase mainly by phosphorylation of serine 259
-
Dhillon, A. S. et al. Cyclic AMP-dependent kinase regulates Raf-1 kinase mainly by phosphorylation of serine 259. Mol. Cell. Biol. 22, 3237-3246 (2002).
-
(2002)
Mol. Cell. Biol.
, vol.22
, pp. 3237-3246
-
-
Dhillon, A.S.1
-
26
-
-
0041529686
-
Protein kinase A blocks Raf-1 activity by stimulating 14-3-3 binding and blocking Raf-1 interaction with Ras
-
Dumaz, N. & Marais, R. Protein kinase A blocks Raf-1 activity by stimulating 14-3-3 binding and blocking Raf-1 interaction with Ras. J. Biol. Chem. 278, 29819-29823 (2003).
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 29819-29823
-
-
Dumaz, N.1
Marais, R.2
-
27
-
-
33846562882
-
And feedback regulation of Raf-1 signaling
-
Dhillon, A. S., von Kriegsheim, A., Grindlay, J. & Kolch, W. Phosphatase and feedback regulation of Raf-1 signaling. Cell Cycle 6, 3-7 (2007).
-
(2007)
Cell Cycle
, vol.6
, pp. 3-7
-
-
Dhillon, A.S.1
Von Kriegsheim, A.2
Grindlay, J.3
Phosphatase, K.W.4
-
28
-
-
0842288229
-
Signaling switches and bistability arising from multisite phosphorylation in protein kinase cascades
-
Markevich, N. I., Hoek, J. B. & Kholodenko, B. N. Signaling switches and bistability arising from multisite phosphorylation in protein kinase cascades. J. Cell Biol. 164, 353-359 (2004).
-
(2004)
J. Cell Biol.
, vol.164
, pp. 353-359
-
-
Markevich, N.I.1
Hoek, J.B.2
Kholodenko, B.N.3
-
29
-
-
78650635354
-
The mammalian MAPK/ERK pathway exhibits properties of a negative feedback amplifier
-
Sturm, O. E. et al. The mammalian MAPK/ERK pathway exhibits properties of a negative feedback amplifier. Sci. Signal. 3, ra90 (2010).
-
(2010)
Sci. Signal.
, vol.3
, pp. 90
-
-
Sturm, O.E.1
-
30
-
-
19944430124
-
Regulation of Raf-1 by direct feedback phosphorylation
-
Dougherty, M. K. et al. Regulation of Raf-1 by direct feedback phosphorylation. Mol. Cell 17, 215-224 (2005).
-
(2005)
Mol. Cell
, vol.17
, pp. 215-224
-
-
Dougherty, M.K.1
-
31
-
-
45749102418
-
Biochemical analysis of MST1 kinase: Elucidation of a C-terminal regulatory region
-
Anand, R., Kim, A. Y., Brent, M. & Marmorstein, R. Biochemical analysis of MST1 kinase: elucidation of a C-terminal regulatory region. Biochemistry 47, 6719-6726 (2008).
-
(2008)
Biochemistry
, vol.47
, pp. 6719-6726
-
-
Anand, R.1
Kim, A.Y.2
Brent, M.3
Marmorstein, R.4
-
32
-
-
0037044808
-
Mapping of MST1 kinase sites of phosphorylation. Activation and autophosphorylation
-
Glantschnig, H., Rodan, G. A. & Reszka, A. A. Mapping of MST1 kinase sites of phosphorylation. Activation and autophosphorylation. J. Biol. Chem. 277, 42987-42996 (2002).
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 42987-42996
-
-
Glantschnig, H.1
Rodan, G.A.2
Reszka, A.A.3
-
33
-
-
71649111253
-
ATM regulates a RASSF1Adependent DNA damage response
-
Hamilton, G., Yee, K. S., Scrace, S. & O'Neill, E. ATM regulates a RASSF1Adependent DNA damage response. Curr. Biol. 19, 2020-2025 (2009).
-
(2009)
Curr. Biol.
, vol.19
, pp. 2020-2025
-
-
Hamilton, G.1
Yee, K.S.2
Scrace, S.3
O'Neill, E.4
-
34
-
-
3242794878
-
Regulation of the MST1 kinase by autophosphorylation, by the growth inhibitory proteins, RASSF1 and NORE1, and by Ras
-
Praskova, M., Khoklatchev, A., Ortiz-Vega, S. & Avruch, J. Regulation of the MST1 kinase by autophosphorylation, by the growth inhibitory proteins, RASSF1 and NORE1, and by Ras. Biochem. J. 381, 453-462 (2004).
-
(2004)
Biochem. J.
, vol.381
, pp. 453-462
-
-
Praskova, M.1
Khoklatchev, A.2
Ortiz-Vega, S.3
Avruch, J.4
-
35
-
-
79953211893
-
The tumor suppressor RASSF1A prevents dephosphorylation of the mammalian STE20-like kinases MST1 and MST2
-
Guo, C., Zhang, X. & Pfeifer, G. P. The tumor suppressor RASSF1A prevents dephosphorylation of the mammalian STE20-like kinases MST1 and MST2. J. Biol. Chem. 286, 6253-6261 (2011).
-
(2011)
J. Biol. Chem.
, vol.286
, pp. 6253-6261
-
-
Guo, C.1
Zhang, X.2
Pfeifer, G.P.3
-
36
-
-
16444373346
-
The Ste20-like kinase Mst2 activates the human large tumor suppressor kinase Lats1
-
Chan, E. H. et al. The Ste20-like kinase Mst2 activates the human large tumor suppressor kinase Lats1. Oncogene 24, 2076-2086 (2005).
-
(2005)
Oncogene
, vol.24
, pp. 2076-2086
-
-
Chan, E.H.1
-
37
-
-
0032496358
-
The biochemical basis of an all-or-none cell fate switch in Xenopus oocytes
-
Ferrell, J. E. Jr & Machleder, E. M. The biochemical basis of an all-or-none cell fate switch in Xenopus oocytes. Science 280, 895-898 (1998).
-
(1998)
Science
, vol.280
, pp. 895-898
-
-
Ferrell Jr., J.E.1
MacHleder, E.M.2
-
38
-
-
0037373062
-
A Raf-1 mutant that dissociates MEK/extracellular signalregulated kinase activation from malignant transformation and differentiation but not proliferation
-
Dhillon, A. S. et al. A Raf-1 mutant that dissociates MEK/extracellular signalregulated kinase activation from malignant transformation and differentiation but not proliferation. Mol. Cell. Biol. 23, 1983-1993 (2003).
-
(2003)
Mol. Cell. Biol.
, vol.23
, pp. 1983-1993
-
-
Dhillon, A.S.1
-
39
-
-
84908158843
-
Establishment of transgenic lines to monitor and manipulate Yap/Taz-Tead activity in zebrafish reveals both evolutionarily conserved and divergent functions of the Hippo pathway
-
Miesfeld, J. B. & Link, B. A. Establishment of transgenic lines to monitor and manipulate Yap/Taz-Tead activity in zebrafish reveals both evolutionarily conserved and divergent functions of the Hippo pathway. Mech. Dev. http://dx.doi.org/10.1016/ j.mod.2014.02.003 (2014).
-
(2014)
Mech. Dev.
-
-
Miesfeld, J.B.1
Link, B.A.2
-
40
-
-
0037417803
-
Hysteresis drives cell-cycle transitions in Xenopus laevis egg extracts
-
Sha, W. et al. Hysteresis drives cell-cycle transitions in Xenopus laevis egg extracts. Proc. Natl Acad. Sci. USA 100, 975-980 (2003).
-
(2003)
Proc. Natl Acad. Sci. USA
, vol.100
, pp. 975-980
-
-
Sha, W.1
-
41
-
-
34848893336
-
Bistability and oscillations in the Huang-Ferrell model of MAPK signaling
-
Qiao, L., Nachbar, R. B., Kevrekidis, I. G. & Shvartsman, S. Y. Bistability and oscillations in the Huang-Ferrell model of MAPK signaling. PLoS Comput. Biol. 3, 1819-1826 (2007).
-
(2007)
PLoS Comput. Biol.
, vol.3
, pp. 1819-1826
-
-
Qiao, L.1
Nachbar, R.B.2
Kevrekidis, I.G.3
Shvartsman, S.Y.4
-
42
-
-
33947304756
-
Substrate competition as a source of ultrasensitivity in the inactivation of Wee1
-
Kim, S. Y. & Ferrell, J. E. Jr Substrate competition as a source of ultrasensitivity in the inactivation of Wee1. Cell 128, 1133-1145 (2007).
-
(2007)
Cell
, vol.128
, pp. 1133-1145
-
-
Kim, S.Y.1
Ferrell Jr., J.E.2
-
43
-
-
33644524741
-
Cell-signalling dynamics in time and space
-
Kholodenko, B. N. Cell-signalling dynamics in time and space. Nat. Rev. Mol. Cell Biol. 7, 165-176 (2006).
-
(2006)
Nat. Rev. Mol. Cell Biol.
, vol.7
, pp. 165-176
-
-
Kholodenko, B.N.1
-
44
-
-
33947599132
-
Competition effects shape the response sensitivity and kinetics of phosphorylation cycles in cell signaling
-
Salazar, C. & Hofer, T. Competition effects shape the response sensitivity and kinetics of phosphorylation cycles in cell signaling. Ann. NY Acad. Sci. 1091, 517-530 (2006).
-
(2006)
Ann. NY Acad. Sci.
, vol.1091
, pp. 517-530
-
-
Salazar, C.1
Hofer, T.2
-
45
-
-
0025937489
-
Constitutive c-myc expression in an IL-3-dependent myeloid cell line suppresses cell cycle arrest and accelerates apoptosis
-
Askew, D. S., Ashmun, R. A., Simmons, B. C. & Cleveland, J. L. Constitutive c-myc expression in an IL-3-dependent myeloid cell line suppresses cell cycle arrest and accelerates apoptosis. Oncogene 6, 1915-1922 (1991).
-
(1991)
Oncogene
, vol.6
, pp. 1915-1922
-
-
Askew, D.S.1
Ashmun, R.A.2
Simmons, B.C.3
Cleveland, J.L.4
-
46
-
-
0026642195
-
Induction of apoptosis in fibroblasts by c-myc protein
-
Evan, G. I. et al. Induction of apoptosis in fibroblasts by c-myc protein. Cell 69, 119-128 (1992).
-
(1992)
Cell
, vol.69
, pp. 119-128
-
-
Evan, G.I.1
-
47
-
-
84255187573
-
Mutant K-Ras activation of the proapoptotic MST2 pathway is antagonized by wild-type K-Ras
-
Matallanas, D. et al. Mutant K-Ras activation of the proapoptotic MST2 pathway is antagonized by wild-type K-Ras. Mol. Cell 44, 893-906 (2011).
-
(2011)
Mol. Cell
, vol.44
, pp. 893-906
-
-
Matallanas, D.1
-
48
-
-
34547530823
-
Gain-of-function RAF1 mutations cause Noonan and LEOPARD syndromes with hypertrophic cardiomyopathy
-
Pandit, B. et al. Gain-of-function RAF1 mutations cause Noonan and LEOPARD syndromes with hypertrophic cardiomyopathy. Nat. Genet. 39, 1007-1012 (2007).
-
(2007)
Nat. Genet.
, vol.39
, pp. 1007-1012
-
-
Pandit, B.1
-
49
-
-
34547539552
-
Germline gain-of-function mutations in RAF1 cause Noonan syndrome
-
Razzaque, M. A. et al. Germline gain-of-function mutations in RAF1 cause Noonan syndrome. Nat. Genet. 39, 1013-1017 (2007).
-
(2007)
Nat. Genet.
, vol.39
, pp. 1013-1017
-
-
Razzaque, M.A.1
-
50
-
-
77149127346
-
Molecular and clinical analysis of RAF1 in Noonan syndrome and related disorders: Dephosphorylation of serine 259 as the essential mechanism for mutant activation
-
Kobayashi, T. et al. Molecular and clinical analysis of RAF1 in Noonan syndrome and related disorders: dephosphorylation of serine 259 as the essential mechanism for mutant activation. Hum. Mutat. 31, 284-294 (2010).
-
(2010)
Hum. Mutat.
, vol.31
, pp. 284-294
-
-
Kobayashi, T.1
-
51
-
-
84857938446
-
Comparative proteomic analysis of eleven common cell lines reveals ubiquitous but varying expression of most proteins
-
014050
-
Geiger, T., Wehner, A., Schaab, C., Cox, J. & Mann, M. Comparative proteomic analysis of eleven common cell lines reveals ubiquitous but varying expression of most proteins. Mol. Cell. Proteom. 11, M111 014050 (2012).
-
(2012)
Mol. Cell. Proteom.
, vol.11
-
-
Geiger, T.1
Wehner, A.2
Schaab, C.3
Cox, J.4
Mann, M.5
-
52
-
-
0029042701
-
Regulation of Raf-1 and Raf-1 mutants by Ras-dependent and Ras-independent mechanisms in vitro
-
Dent, P., Reardon, D. B., Morrison, D. K. & Sturgill, T. W. Regulation of Raf-1 and Raf-1 mutants by Ras-dependent and Ras-independent mechanisms in vitro. Mol. Cell. Biol. 15, 4125-4135 (1995).
-
(1995)
Mol. Cell. Biol.
, vol.15
, pp. 4125-4135
-
-
Dent, P.1
Reardon, D.B.2
Morrison, D.K.3
Sturgill, T.W.4
-
53
-
-
85047696339
-
The putative tumor suppressor RASSF1A homodimerizes and heterodimerizes with the Ras-GTP binding protein Nore1
-
Ortiz-Vega, S. et al. The putative tumor suppressor RASSF1A homodimerizes and heterodimerizes with the Ras-GTP binding protein Nore1. Oncogene 21, 1381-1390 (2002).
-
(2002)
Oncogene
, vol.21
, pp. 1381-1390
-
-
Ortiz-Vega, S.1
-
54
-
-
34548118343
-
Numerical modelling of label-structured cell population growth using CFSE distribution data
-
Luzyanina, T. et al. Numerical modelling of label-structured cell population growth using CFSE distribution data. Theor. Biol. Med. Model. 4, 26 (2007).
-
(2007)
Theor. Biol. Med. Model.
, vol.4
, pp. 26
-
-
Luzyanina, T.1
|