The incidence and clinical symptomatology of Clostridium difficile infections in a community setting in a cohort of Danish patients attending general practice

European Journal of Clinical Microbiology and Infectious Diseases

Volumn 33, Issue 6, 2014, Pages 957-967

  Soes L M ^a,b,e   Holt, H M ^c   Bottiger B ^a,d   Nielsen, H V ^a   Torpdahl, M ^a   Nielsen, E M ^a   Ethelberg, S ^a   Molbak K ^a   Andreasen, V ^b   Kemp, M ^c   Olsen, K E P ^a  

^a STATENS SERUM INSTITUT   (Denmark)

^b ROSKILDE UNIVERSITY   (Denmark)

^c ODENSE UNIVERSITY HOSPITAL   (Denmark)

^d LUND UNIVERSITY HOSPITAL   (Sweden)

^e HVIDOVRE HOSPITAL   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTIC AGENT; CLOSTRIDIUM DIFFICILE TOXIN A; CLOSTRIDIUM DIFFICILE TOXIN B; BACTERIAL TOXIN;

ADOLESCENT; ADULT; AGED; ANTIBIOTIC THERAPY; ARTICLE; BACTERIAL STRAIN; BACTERIUM CULTURE; CHILD; CLOSTRIDIUM DIFFICILE; CLOSTRIDIUM DIFFICILE INFECTION; COHORT ANALYSIS; COMMUNITY; CONTROLLED STUDY; DIARRHEA; DISEASE DURATION; FECES; FEMALE; FEVER; GENE EXPRESSION PROFILING; GENERAL PRACTICE; GROUPS BY AGE; HOSPITAL PATIENT; HUMAN; INCIDENCE; INFANT; MAJOR CLINICAL STUDY; MALE; MEDICAL LEAVE; ONSET AGE; OUTCOME VARIABLE; PREDICTIVE VALUE; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RIBOTYPING; STOMACH PAIN; SYMPTOMATOLOGY; VOMITING; WEIGHT REDUCTION; CLASSIFICATION; CLOSTRIDIUM INFECTIONS; COMMUNITY-ACQUIRED INFECTIONS; DENMARK; EPIDEMIOLOGY; GENETICS; ISOLATION AND PURIFICATION; MIDDLE AGED; PATHOLOGY; PEPTOCLOSTRIDIUM DIFFICILE; POLYMERASE CHAIN REACTION; PRESCHOOL CHILD; VERY ELDERLY; YOUNG ADULT;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; BACTERIAL TOXINS; CHILD; CHILD, PRESCHOOL; CLOSTRIDIUM DIFFICILE; CLOSTRIDIUM INFECTIONS; COHORT STUDIES; COMMUNITY-ACQUIRED INFECTIONS; DENMARK; DIARRHEA; FEMALE; GENERAL PRACTICE; HUMANS; INCIDENCE; INFANT; MALE; MIDDLE AGED; POLYMERASE CHAIN REACTION; RIBOTYPING; YOUNG ADULT;

EID: 84903760718     PISSN: 09349723     EISSN: 14354373     Source Type: Journal    
DOI: 10.1007/s10096-013-2033-3     Document Type: Article

References (45)

1. Bartlett JG (2008) Historical perspectives on studies of Clostridium difficile and C. difficile infection. Clin Infect Dis 46(Suppl 1):S4-S11
2. Norén T, Akerlund T, Bäck E, Sjöberg L, Persson I, Alriksson I et al (2004) Molecular epidemiology of hospital-associated and community-acquired Clostridium difficile infection in a Swedish county. J Clin Microbiol 42:3635-3643 (Pubitemid 39045692)
3. Khanna S, Pardi DS, Aronson SL, Kammer PP, Orenstein R, St Sauver JL et al (2012) The epidemiology of community-acquired Clostridium difficile infection: a population-based study. Am J Gastroenterol 107:89-95
4. Søes LM, Brock I, Persson S, Simonsen J, Pribil Olsen KE, Kemp M (2012) Clinical features of Clostridium difficile infection and molecular characterization of the isolated strains in a cohort of Danish hospitalized patients. Eur J Clin Microbiol Infect Dis 31:185-192. doi:10.1007/s10096-011- 1292-0
5. Barbut F, Gariazzo B, Bonné L, Lalande V, Burghoffer B, Luiuz R et al (2007) Clinical features of Clostridium difficile-associated infections and molecular characterization of strains: results of a retrospective study, 2000-2004. Infect Control Hosp Epidemiol 28:131-139 (Pubitemid 46374152)
6. Bauer MP, Notermans DW, van Benthem BHB, Brazier JS, Wilcox MH, Rupnik M et al (2011) Clostridium difficile infection in Europe: a hospital-based survey. Lancet 377(9759):63-73. doi:10.1016/S0140-6736(10)61266-4
7. Bauer MP, Veenendaal D, Verhoef L, Bloembergen P, van Dissel JT, Kuijper EJ (2009) Clinical and microbiological characteristics of community-onset Clostridium difficile infection in The Netherlands. Clin Microbiol Infect 15:1087-1092. doi:10.1111/j.1469-0691.2009.02853.x
8. Jangi S, Lamont JT (2010) Asymptomatic colonization by Clostridium difficile in infants: implications for disease in later life. J Pediatr Gastroenterol Nutr 51:2-7. doi:10.1097/MPG.0b013e3181d29767
9. Viscidi R, Willey S, Bartlett JG (1981) Isolation rates and toxigenic potential of Clostridium difficile isolates from various patient populations. Gastroenterology 81:5-9 (Pubitemid 11078473)
10. McFarland LV, Brandmarker SA, Guandalini S (2000) Pediatric Clostridium difficile: a phantom menace or clinical reality? J Pediatr Gastroenterol Nutr 31:220-231
11. Zilberberg MD, Tillotson GS, McDonald C (2010) Clostridium difficile infections among hospitalized children, United States, 1997-2006. Emerg Infect Dis 16:604-609
12. Kim J, Smathers SA, Prasad P, Leckerman KH, Coffin S, Zaoutis T (2008) Epidemiological features of Clostridium difficile-associated disease among inpatients at children's hospitals in the United States, 2001-2006. Pediatrics 122:1266-1270
13. Blom M, Meyer A, Gerner-Smidt P, Gaarslev K, Espersen F (1999) Evaluation of Statens Serum Institut enteric medium for detection of enteric pathogens. J Clin Microbiol 37:2312-2316 (Pubitemid 29277797)
14. Hutchinson DN, Bolton FJ (1984) Improved blood free selective medium for the isolation of Campylobacter jejuni from faecal specimens. J Clin Pathol 37:956-957
15. Persson S, Olsen KEP, Scheutz F, Krogfelt KA, Gerner-Smidt P (2007) A method for fast and simple detection of major diarrhoeagenic Escherichia coli in the routine diagnostic laboratory. Clin Microbiol Infect 13:516-524. doi:10.1111/j.1469-0691.2007.01692.x (Pubitemid 46563502)
16. Kageyama T, Kojima S, Shinohara M, Uchida K, Fukushi S, Hoshino FB et al (2003) Broadly reactive and highly sensitive assay for Norwalk-like viruses based on real-time quantitative reverse transcription-PCR. J Clin Microbiol 41:1548-1557 (Pubitemid 36428103)
17. Johnsen CK, Midgley S, Böttiger B (2009) Genetic diversity of sapovirus infections in Danish children 2005-2007. J Clin Virol 46:265-269. doi:10.1016/j.jcv.2009.07.008
18. Pang XL, Lee B, Boroumand N, Leblanc B, Preiksaitis JK, Yu Ip CC (2004) Increased detection of rotavirus using a real time reverse transcription- polymerase chain reaction (RT-PCR) assay in stool specimens from children with diarrhea. J Med Virol 72:496-501. doi:10.1002/jmv.20009 (Pubitemid 38133992)
19. Logan C, O'Leary JJ, O'Sullivan N (2006) Real-time reverse transcription-PCR for detection of rotavirus and adenovirus as causative agents of acute viral gastroenteritis in children. J Clin Microbiol 44:3189-3195. doi:10.1128/JCM.00915-06 (Pubitemid 44413750)
20. Logan C, O'Leary JJ, O'Sullivan N (2007) Real-time reverse transcription PCR detection of norovirus, sapovirus and astrovirus as causative agents of acute viral gastroenteritis. J Virol Methods 146:36-44. doi:10.1016/j.jviromet. 2007.05.031 (Pubitemid 350030936)
21. Stensvold CR, Nielsen HV (2012) Comparison of microscopy and PCR for detection of intestinal parasites in Danish patients supports an incentive for molecular screening platforms. J Clin Microbiol 50:540-541. doi:10.1128/JCM. 06012-11
22. Persson S, Torpdahl M, Olsen KE (2008) New multiplex PCR method for the detection of Clostridium difficile toxin A (tcdA) and toxin B (tcdB) and the binary toxin (cdtA/cdtB) genes applied to a Danish strain collection. Clin Microbiol Infect 14:1057-1064 (Pubitemid 352748847)
23. O'Neill GL, Ogunsola FT, Brazier JS, Duerden BI (1996) Modification of a PCR ribotyping method for application as a routine typing scheme for Clostridium difficile. Anaerobe 2:205-209. doi:10.1006/anae.1996.0028 (Pubitemid 26336409)
24. Stubbs SL, Brazier JS, O'Neill GL, Duerden BI (1999) PCR targeted to the 16S-23S rRNA gene intergenic spacer region of Clostridium difficile and construction of a library consisting of 116 different PCR ribotypes. J Clin Microbiol 37:461-463 (Pubitemid 29056430)
25. Kuijper EJ, Coignard B, Tüll P; ESCMID Study Group for Clostridium difficile; EU Member States; European Centre for Disease Prevention and Control (2006) Emergence of Clostridium difficile-associated disease in North America and Europe. Clin Microbiol Infect 12(Suppl 6):2-18 (Pubitemid 44362038)
26. McDonald LC, Coignard B, Dubberke E, Song X, Horan T, Kutty PK; Ad Hoc Clostridium difficile Surveillance Working Group (2007) Recommendations for surveillance of Clostridium difficile-associated disease. Infect Control Hosp Epidemiol 28:140-145 (Pubitemid 46374153)
27. Statistics Denmark. Home page at: http://www.dst.dk/en.aspx
28. Pedersen CB, Gøtzsche H, Møller JO, Mortensen PB (2006) The Danish Civil Registration System. A cohort of eight million persons. Dan Med Bull 53:441-449 (Pubitemid 44816920)
29. Riley TV, Wetherall F, Bowman J, Mogyorosy J, Golledge CL (1991) Diarrheal disease due to Clostridium difficile in general practice. Pathology 23:346-349
30. Bartlett JG (1994) Clostridium difficile: history of its role as an enteric pathogen and the current state of knowledge about the organism. Clin Infect Dis 18(Suppl 4):S265-S272
31. Bolton RP, Tait SK, Dear PR, Losowsky MS (1984) Asymptomatic neonatal colonisation by Clostridium difficile. Arch Dis Child 59:466-472 (Pubitemid 14105909)
32. Boenning DA, Fleisher GR, Campos JM, Hulkower CW, Quinlan RW (1982) Clostridium difficile in a pediatric outpatient population. Pediatr Infect Dis 1:336-338 (Pubitemid 13136513)
33. Kutty PK, Woods CW, Sena AC, Benoit SR, Naggie S, Frederick J et al (2010) Risk factors for and estimated incidence of community-associated Clostridium difficile infection, North Carolina, USA. Emerg Infect Dis 16:197-204
34. Karlström O, Fryklund B, Tullus K, Burman LG (1998) A prospective nationwide study of Clostridium difficile-associated diarrhea in Sweden. The Swedish C. difficile Study Group. Clin Infect Dis 26:141-145 (Pubitemid 28068168)
35. Wilcox MH, Mooney L, Bendall R, Settle CD, Fawley WN (2008) A case-control study of community-associated Clostridium difficile infection. J Antimicrob Chemother 62:388-396 (Pubitemid 351984787)
36. Bryant K, McDonald LC (2009) Clostridium difficile infections in children. Pediatr Infect Dis J 28:145-146. doi:10.1097/INF.0b013e318198c984
37. Rousseau C, Lemée L, Le Monnier A, Poilane I, Pons JL, Collignon A (2011) Prevalence and diversity of Clostridium difficile strains in infants. J Med Microbiol 60:1112-1118
38. Søes LM, Holt HM, Böttiger B, Nielsen HV, Andreasen V, Kemp M et al (2013) Risk factors for Clostridium difficile infection in the community: a case-control study in patients in general practice, Denmark, 2009-2011. Epidemiol Infect 27:1-12. doi:10.1017/S0950268813002380
39. Pang XL, Honma S, Nakata S, Vesikari T (2000) Human caliciviruses in acute gastroenteritis of young children in the community. J Infect Dis 181(Suppl 2):S288-S294 (Pubitemid 30395082)
40. Tvede M, Schiøtz PO, Krasilnikoff PA (1990) Incidence of Clostridium difficile in hospitalized children. A prospective study. Acta Paediatr Scand 79:292-299 (Pubitemid 20088490)
41. Klein EJ, Boster DR, Stapp JR, Wells JG, Qin X, Clausen CR et al (2006) Diarrhea etiology in a Children's Hospital Emergency Department: a prospective cohort study. Clin Infect Dis 43(7):807-813 (Pubitemid 44435504)
42. McFarland LV, Surawicz CM, Stamm WE (1990) Risk factors for Clostridium difficile carriage and C. difficile-associated diarrhea in a cohort of hospitalized patients. J Infect Dis 162:678-684 (Pubitemid 20266159)
43. Crobach MJ, Dekkers OM, Wilcox MH, Kuijper EJ (2009) European Society of Clinical Microbiology and Infectious Diseases (ESCMID): data review and recommendations for diagnosing Clostridium difficile-infection (CDI). Clin Microbiol Infect 15:1053-1066
44. Cohen SH, Gerding DN, Johnson S, Kelly CP, Loo VG, McDonald LC et al (2010) Clinical practice guidelines for Clostridium difficile infection in adults: 2010 update by the Society for Healthcare Epidemiology of America (SHEA) and the Infectious Diseases Society of America (IDSA). Infect Control Hosp Epidemiol 31:431-455. doi:10.1086/651706
45. Planche TD, Davies KA, Coen PG, Finney JM, Monahan IM, Morris KA et al (2013) Differences in outcome according to Clostridium difficile testing method: a prospective multicentre diagnostic validation study of C difficile infection. Lancet Infect Dis 13:936-945. doi:10.1016/S1473-3099(13)70200-7