3-Aminoazetidin-2-one derivatives as N-acylethanolamine acid amidase (NAAA) inhibitors suitable for systemic administration

ChemMedChem

Volumn 9, Issue 7, 2014, Pages 1602-1614

  Fiasella, Annalisa ^a   Nuzzi, Andrea ^a   Summa, Maria ^a   Armirotti, Andrea ^a   Tarozzo, Glauco ^a   Tarzia, Giorgio ^b   Mor, Marco ^c   Bertozzi, Fabio ^a   Bandiera, Tiziano ^a   Piomelli, Daniele ^a,d  

^a ISTITUTO ITALIANO DI TECNOLOGIA   (Italy)

^b UNIVERSITY OF URBINO   (Italy)

^c UNIVERSITY OF PARMA   (Italy)

^d UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

cysteine hydrolase; inhibitors; N acylethanolamine acid amidase; structure activity relationships; lactams

Indexed keywords

1 HEPTYL 3 [2 OXOAZETIDIN 3 YL]UREA; 2 METHYL N [2 OXOAZETIDIN 3 YL]NONANAMIDE; 2,2 DIMETHYL N [2 OXOAZETIDIN 3 YL]NONANAMIDE; 3 (NONYLAMINO)AZETIDIN 2 ONE; 3 AMINOAZETIDIN 2 ONE DERIVATIVE; 3 PHENYL N [2 OXOAZETIDIN 3 YL]PROPANAMIDE; 4 BUTYL N [2 OXOAZETIDIN 3 YL]BENZAMIDE; 5 PHENYL N [2 OXOAZETIDIN 3 YL]PENTANAMIDE; 6 CYCLOHEXYL N [2 OXOAZETIDIN 3 YL]HEXANAMIDE; 7 PHENYL [2 OXOAZETIDIN 3 YL]HEPTANAMIDE; AMIDE; AZETIDINE DERIVATIVE; BETA LACTAM DERIVATIVE; FATTY ACID AMIDASE INHIBITOR; N (2 OXOCYCLOBUTYL)NONANAMIDE; N (AZETIDIN 3 YL)NONANAMIDE; N ACYLETHANOLAMINE ACID AMIDASE INHIBITOR; N METHYL N [2 OXOAZETIDIN 3 YL]NONANAMIDE; N [1 METHYL 2 OXO AZETIDIN 3 YL]NONANAMIDE; N [2 OXOAZETIDIN 3 YL] 4 PHENYLBENZAMIDE; N [2 OXOAZETIDIN 3 YL] 4 PHENYLBUTANAMIDE; N [2 OXOAZETIDIN 3 YL] 6 PHENYLHEXANAMIDE; N [2 OXOAZETIDIN 3 YL]DECANAMIDE; N [2 OXOAZETIDIN 3 YL]HEPTANAMIDE; N [2 OXOAZETIDIN 3 YL]NON 3 ENAMIDE; N [2 OXOAZETIDIN 3 YL]NONANAMIDE; N [2 OXOAZETIDIN 3 YL]OCTANAMIDE; N [2 OXOAZETIDIN 3 YL]UNDECANAMIDE; N [2 OXOPYRROLIDIN 3 YL]NONANAMIDE; UNCLASSIFIED DRUG; [3 HYDROXY 2 (NONANOYLAMINO) 3 OXO PROPYL]AMMONIUM CHLORIDE; 2-AZETIDINONE; AMIDASE; ENZYME INHIBITOR; NAAA PROTEIN, HUMAN; PROTEIN BINDING;

ALKYLATION; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CHEMICAL REACTION; CHEMICAL STRUCTURE; CLINICAL EVALUATION; DRUG BIOAVAILABILITY; DRUG POTENCY; DRUG STABILITY; DRUG SYNTHESIS; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; PROTEIN HYDROLYSIS; RAT; STRUCTURE ACTIVITY RELATION; SYSTEMIC THERAPY; ANIMAL; ANTAGONISTS AND INHIBITORS; CHEMISTRY; HALF LIFE TIME; METABOLISM; SYNTHESIS;

AMIDOHYDROLASES; ANIMALS; AZETIDINES; ENZYME INHIBITORS; HALF-LIFE; HUMANS; MICE; PROTEIN BINDING; RATS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84903751228     PISSN: 18607179     EISSN: 18607187     Source Type: Journal    
DOI: 10.1002/cmdc.201300546     Document Type: Article

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