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Volumn , Issue , 2012, Pages 219-240

Small animal imaging for accelerating drug development, and comparison to other techniques

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EID: 84986626909     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1142/9789814317740_0009     Document Type: Chapter
Times cited : (2)

References (50)
  • 1
    • 25144466630 scopus 로고    scopus 로고
    • Positron emission tomography imaging of small animals in anticancer drug development
    • Aboagye EO. Positron emission tomography imaging of small animals in anticancer drug development. Mol Imag Biol 2005; 7: 53-58.
    • (2005) Mol Imag Biol , vol.7 , pp. 53-58
    • Aboagye, E.O.1
  • 3
    • 34247152448 scopus 로고    scopus 로고
    • Functional PET imaging in cancer drug development
    • Avril N, Propper D. Functional PET imaging in cancer drug development. Future Oncol 2007; 3: 215-228.
    • (2007) Future Oncol , vol.3 , pp. 215-228
    • Avril, N.1    Propper, D.2
  • 4
    • 0037742189 scopus 로고    scopus 로고
    • 3/-deoxy-3/-[18F] Fluorothymidine as a new marker for monitoring tumor response to antiproliferative therapy in vivo with positron emission tomography
    • /-[18F] Fluorothymidine as a new marker for monitoring tumor response to antiproliferative therapy in vivo with positron emission tomography. Cancer Res 2003; 63: 3791-3798.
    • (2003) Cancer Res , vol.63 , pp. 3791-3798
    • Barthel, H.1    Cleij, M.C.2
  • 5
    • 34249739046 scopus 로고    scopus 로고
    • In vivo mouse imaging and spectroscopy in drug discovery
    • Beckmann N, Kneuer R, et al. In vivo mouse imaging and spectroscopy in drug discovery. NMR Biomed 2007; 20: 154-185.
    • (2007) NMR Biomed , vol.20 , pp. 154-185
    • Beckmann, N.1    Kneuer, R.2
  • 6
    • 0346594332 scopus 로고    scopus 로고
    • In vivo molecular-genetic imaging: Multi-modality nuclear and optical combinations
    • Blasberg RG. In vivo molecular-genetic imaging: multi-modality nuclear and optical combinations. Nucl Med Biol 2003; 30: 879-888.
    • (2003) Nucl Med Biol , vol.30 , pp. 879-888
    • Blasberg, R.G.1
  • 7
    • 38849182399 scopus 로고    scopus 로고
    • Application of PET/CT in the development of novel anticancer drugs
    • Boss DS, Olmos RV, et al. Application of PET/CT in the development of novel anticancer drugs. Oncolog 2008; 13: 25-38.
    • (2008) Oncolog , vol.13 , pp. 25-38
    • Boss, D.S.1    Olmos, R.V.2
  • 8
    • 0035032805 scopus 로고    scopus 로고
    • Fundamentals of positron emission tomography and application in preclinical drug development
    • Cherry SR. Fundamentals of positron emission tomography and application in preclinical drug development. J Clinic Pharmacol 2001; 41: 482-491.
    • (2001) J Clinic Pharmacol , vol.41 , pp. 482-491
    • Cherry, S.R.1
  • 9
    • 1142263259 scopus 로고    scopus 로고
    • In vivo molecular and genomic imaging: New challenges for imaging physics
    • Cherry SR. In vivo molecular and genomic imaging: new challenges for imaging physics. Phys Med Biol 2004; 49: R13-R48.
    • (2004) Phys Med Biol , vol.49 , pp. R13-R48
    • Cherry, S.R.1
  • 10
    • 0242329769 scopus 로고    scopus 로고
    • In vitro selectivity, in vivo biodistribution and tumour uptake of annexin V radiolabelled with a positron emitted radioisotope
    • Collingridge DR, Glaser M, et al. In vitro selectivity, in vivo biodistribution and tumour uptake of annexin V radiolabelled with a positron emitted radioisotope. Br J Cancer 2003; 89: 1327-1333.
    • (2003) Br J Cancer , vol.89 , pp. 1327-1333
    • Collingridge, D.R.1    Glaser, M.2
  • 11
    • 2442482962 scopus 로고    scopus 로고
    • Key factors in the rising cost of new drug discovery and development
    • Dickson M, Gagnon JP. Key factors in the rising cost of new drug discovery and development. Nat Rev Drug Discov 2004; 3: 417-429.
    • (2004) Nat Rev Drug Discov , vol.3 , pp. 417-429
    • Dickson, M.1    Gagnon, J.P.2
  • 12
    • 0036441844 scopus 로고    scopus 로고
    • The value of improving the productivity of the drug development process: Faster times and better decisions
    • DiMasi JA. The value of improving the productivity of the drug development process: Faster times and better decisions. Pharmacoeconomics 2002;20:1-10.
    • (2002) Pharmacoeconomics , vol.20 , pp. 1-10
    • Dimasi, J.A.1
  • 13
    • 0037403554 scopus 로고    scopus 로고
    • The use of PET and knockout mice in the drug discovery process
    • Eckelman WC. The use of PET and knockout mice in the drug discovery process. Drug Discov Today 2003; 8: 404-410.
    • (2003) Drug Discov Today , vol.8 , pp. 404-410
    • Eckelman, W.C.1
  • 14
    • 0033955702 scopus 로고    scopus 로고
    • PET-determination of robalzotan (NAD-299) induced 5-HT(1A) receptor occupancy in the monkey brain
    • Farde L, Andrée B, et al. PET-determination of robalzotan (NAD-299) induced 5-HT(1A) receptor occupancy in the monkey brain. Neuropsychopharmacology 2000; 22: 422-429.
    • (2000) Neuropsychopharmacology , vol.22 , pp. 422-429
    • Farde, L.1    Rée, B.2
  • 15
    • 0035403775 scopus 로고    scopus 로고
    • Biologic responses to low doses of ionizing radiation: Detriments versus hormesis
    • Feinendegen LE, Pollycove M. Biologic responses to low doses of ionizing radiation: detriments versus hormesis. J Nucl Med 2001; 42: 17N-27N.
    • (2001) J Nucl Med , vol.42 , pp. 17N-27N
    • Feinendegen, L.E.1    Pollycove, M.2
  • 16
    • 4644258365 scopus 로고    scopus 로고
    • Radiation dose estimate in small animal SPECT and PET
    • Funk T, Sun M, et al. Radiation dose estimate in small animal SPECT and PET. Med Phys 2004; 31: 2680-2686.
    • (2004) Med Phys , vol.31 , pp. 2680-2686
    • Funk, T.1    Sun, M.2
  • 17
    • 33746058605 scopus 로고    scopus 로고
    • Molecular imaging strategies for drug discovery and development
    • Gross S, Piwnica-Worms D. Molecular imaging strategies for drug discovery and development. Current Opinion Biol 2006; 10: 334-342.
    • (2006) Current Opinion Biol , vol.10 , pp. 334-342
    • Gross, S.1    Piwnica-Worms, D.2
  • 18
    • 43549110738 scopus 로고    scopus 로고
    • Positron emission tomography imaging in dementia
    • Herholz K, Carter SF, et al. Positron emission tomography imaging in dementia. Br J Radiol 2007; 80: S160-S167.
    • (2007) Br J Radiol , vol.80 , pp. S160-S167
    • Herholz, K.1    Carter, S.F.2
  • 19
    • 0034743489 scopus 로고    scopus 로고
    • Can [15O] water be used to evaluate drugs?
    • 15O] water be used to evaluate drugs? J Clin Pharmacol 2001; Suppl.: 11S-20S.
    • (2001) J Clin Pharmacol
    • Herscovitch, P.1
  • 20
    • 34247208168 scopus 로고    scopus 로고
    • Multimodality molecular imaging of glioblastoma growth inhibition with vasculature-targeting fusion toxin VEGF121/rGel
    • Hsu AR, Cai W, et al. Multimodality molecular imaging of glioblastoma growth inhibition with vasculature-targeting fusion toxin VEGF121/rGel. J Nucl Med 2007; 48: 445-454.
    • (2007) J Nucl Med , vol.48 , pp. 445-454
    • Hsu, A.R.1    Cai, W.2
  • 21
    • 27944471285 scopus 로고    scopus 로고
    • Binding of the positron emission tomography tracer Pittsburg compound-B reflects the amount of amyloid-beta in Alzheimer’s disease brain but not in transgenic mouse brain
    • Klunk WE, Loprest BJ, et al. Binding of the positron emission tomography tracer Pittsburg compound-B reflects the amount of amyloid-beta in Alzheimer’s disease brain but not in transgenic mouse brain. J Neurosci 2005; 25: 10598-10606.
    • (2005) J Neurosci , vol.25 , pp. 10598-10606
    • Klunk, W.E.1    Loprest, B.J.2
  • 22
    • 0037264608 scopus 로고    scopus 로고
    • A guide to drug discovery: Target selection in drug discovery
    • Knowles J, Gromo G. A guide to drug discovery: target selection in drug discovery. Nat Rev Drug Discov 2003; 2: 63-69.
    • (2003) Nat Rev Drug Discov , vol.2 , pp. 63-69
    • Knowles, J.1    Gromo, G.2
  • 23
    • 33748886664 scopus 로고    scopus 로고
    • Non-invasive in vivo imaging in small animal research
    • Koo V, Hamilton PW, et al. Non-invasive in vivo imaging in small animal research. Cel Oncol2006; 28: 127-139.
    • Cel Oncol2006 , vol.28 , pp. 127-139
    • Koo, V.1    Hamilton, P.W.2
  • 24
    • 27144549889 scopus 로고    scopus 로고
    • Mass effect of injected dose in small rodent imaging by SPECT and PET
    • Kung M, Kung HF. Mass effect of injected dose in small rodent imaging by SPECT and PET. Nucl Med Biol 2005; 32: 673-678.
    • (2005) Nucl Med Biol , vol.32 , pp. 673-678
    • Kung, M.1    Kung, H.F.2
  • 25
    • 0141557958 scopus 로고    scopus 로고
    • Biodistribution, radiation dose estimate, and in vivo Pgp modulation studies of 18F-paclitaxel in nonhuman primates
    • 18F-paclitaxel in nonhuman primates. J Nucl Med 2003; 44: 1330-1339.
    • (2003) J Nucl Med , vol.44 , pp. 1330-1339
    • Kurdziel, K.1    Kiesewetter, D.2
  • 26
    • 33745050401 scopus 로고    scopus 로고
    • Using positron emission tomography to facilitate CNS drug development
    • Lee C-M, Farde L. Using positron emission tomography to facilitate CNS drug development. Trends Pharmacol Sci 2006; 27: 310-316.
    • (2006) Trends Pharmacol Sci , vol.27 , pp. 310-316
    • Lee, C.-M.1    Farde, L.2
  • 27
    • 0034491130 scopus 로고    scopus 로고
    • Optimizing the science of drug development: Opportunities for better candidate selection and accelerated evaluation in humans
    • Lesko LJ, Rowland M, et al. Optimizing the science of drug development: opportunities for better candidate selection and accelerated evaluation in humans. Pharm Res 2000; 17: 1335-1344.
    • (2000) Pharm Res , vol.17 , pp. 1335-1344
    • Lesko, L.J.1    Rowland, M.2
  • 29
    • 33746418088 scopus 로고    scopus 로고
    • Simplified quantification of small animal [18F] FDG PET studies using a standard arterial input function
    • 18F] FDG PET studies using a standard arterial input function. Eur J Nucl Med Mol Imag 2006; 33: 948-954.
    • (2006) Eur J Nucl Med Mol Imag , vol.33 , pp. 948-954
    • Meyer, P.T.1    Circiumaru, V.2
  • 30
    • 8844264509 scopus 로고    scopus 로고
    • Rat-PET study without anesthesia: Anesthetics modify the dopamine D1 receptor binding in rat brain
    • Momosaki S, Hatano K, et al. Rat-PET study without anesthesia: anesthetics modify the dopamine D1 receptor binding in rat brain. Synapse 2004; 54: 207-213.
    • (2004) Synapse , vol.54 , pp. 207-213
    • Momosaki, S.1    Hatano, K.2
  • 31
    • 65549170007 scopus 로고    scopus 로고
    • Radiopharmaceuticals for oncology drug development: A pharmaceutical industry perspective
    • Murphy PS, Bergström M. Radiopharmaceuticals for oncology drug development: a pharmaceutical industry perspective. Curr Pharm Dis 2009; 15: 957-965.
    • (2009) Curr Pharm Dis , vol.15 , pp. 957-965
    • Murphy, P.S.1    Bergström, M.2
  • 32
    • 0034972262 scopus 로고    scopus 로고
    • The biological application of small animal PET imaging
    • Myers R. The biological application of small animal PET imaging. Nucl Med Biol 2001; 28: 585-593.
    • (2001) Nucl Med Biol , vol.28 , pp. 585-593
    • Myers, R.1
  • 33
    • 0034307112 scopus 로고    scopus 로고
    • A confirmatory prognostic study on oxygenation status and loco-regional control in advanced head and neck squamous cell carcinoma treated by radiation therapy
    • Nordsmark M, Overgaard J. A confirmatory prognostic study on oxygenation status and loco-regional control in advanced head and neck squamous cell carcinoma treated by radiation therapy. Radiother Oncol 2000; 57: 39-43.
    • (2000) Radiother Oncol , vol.57 , pp. 39-43
    • Nordsmark, M.1    Overgaard, J.2
  • 35
    • 2342617500 scopus 로고    scopus 로고
    • Monitoring of therapy in androgen-dependent prostata tumor by measuring tumor proliferation
    • Oyama N, Ponde DE, et al. Monitoring of therapy in androgen-dependent prostata tumor by measuring tumor proliferation. J Nucl Med 2004; 45: 519-525.
    • (2004) J Nucl Med , vol.45 , pp. 519-525
    • Oyama, N.1    Ponde, D.E.2
  • 36
    • 0042899083 scopus 로고    scopus 로고
    • Blood-brain barrier drug targeting: The future of brain drug development
    • Pardridge WM. Blood-brain barrier drug targeting: the future of brain drug development. Mol Interv 2003; 3: 90-105.
    • (2003) Mol Interv , vol.3 , pp. 90-105
    • Pardridge, W.M.1
  • 37
    • 33846907183 scopus 로고    scopus 로고
    • Mapping the amphetamine-evoked changes in [11C]raclopride binding in living rat using small animal PET: Modulation by MAO-inhibition
    • Pedersen K, Simonsen M, et al. Mapping the amphetamine-evoked changes in [11C]raclopride binding in living rat using small animal PET: modulation by MAO-inhibition. Neuroimage 2007; 35: 38-46.
    • (2007) Neuroimage , vol.35 , pp. 38-46
    • Pedersen, K.1    Simonsen, M.2
  • 38
    • 3042643738 scopus 로고    scopus 로고
    • Science, pharmacoeconomics and ethics in drug R&D: A sustainable future scenario?
    • Preziosi P. Science, pharmacoeconomics and ethics in drug R & D: a sustainable future scenario? Nat Rev Drug Discov 2004; 3: 521-526.
    • (2004) Nat Rev Drug Discov , vol.3 , pp. 521-526
    • Preziosi, P.1
  • 39
    • 39049183365 scopus 로고    scopus 로고
    • The role of PET scanning in determining pharmacoselective doses in oncology drug development
    • Price P. The role of PET scanning in determining pharmacoselective doses in oncology drug development. Ernst Schering Res Found Workshop 2007; 59:185-193.
    • (2007) Ernst Schering Res Found Workshop , vol.59 , pp. 185-193
    • Price, P.1
  • 40
    • 48749127610 scopus 로고    scopus 로고
    • Small animal PET in preclinical studies: Opportunities and challenges
    • Riemann B, Schäfers KP, et al. Small animal PET in preclinical studies: opportunities and challenges. QJ Nucl Med Mol Imag 2008; 52: 215-221.
    • (2008) QJ Nucl Med Mol Imag , vol.52 , pp. 215-221
    • Riemann, B.1    Schäfers, K.P.2
  • 41
    • 0037569527 scopus 로고    scopus 로고
    • [(18)]FDG PET monitoring of tumor response to chemotherapy: Does [(18)F]FDG uptake correlate with the viable tumor cell fraction?
    • Spaepen K, Stroobants S, et al. [(18)]FDG PET monitoring of tumor response to chemotherapy: does [(18)F]FDG uptake correlate with the viable tumor cell fraction? Eur J Nucl Med Mol Imag 2003; 30: 682-688.
    • (2003) Eur J Nucl Med Mol Imag , vol.30 , pp. 682-688
    • Spaepen, K.1    Stroobants, S.2
  • 42
    • 20044390414 scopus 로고    scopus 로고
    • A kinetic model for dynamic [18F]-Fmizo PET data to analyse tumour hypoxia
    • Thorwarth D, Eschmann SM, et al. A kinetic model for dynamic [18F]-Fmizo PET data to analyse tumour hypoxia. Phys Med Biol 2005; 50: 2209-2224.
    • (2005) Phys Med Biol , vol.50 , pp. 2209-2224
    • Thorwarth, D.1    Eschmann, S.M.2
  • 43
    • 33846416959 scopus 로고    scopus 로고
    • Distribution of the 5-HT1A receptor antagonist [18F] FPWAY in blood and brain of the rat with and without isoflurane anaesthesia
    • 18F] FPWAY in blood and brain of the rat with and without isoflurane anaesthesia. Eur J Nucl Med Mol Imag 2007; 34: 259-266.
    • (2007) Eur J Nucl Med Mol Imag , vol.34 , pp. 259-266
    • Tokugawa, J.1    Ravasi, L.2
  • 44
    • 27744561925 scopus 로고    scopus 로고
    • Positron Emission Tomography: Applications in drug discovery and drug development
    • Wang J, Mauer L. Positron Emission Tomography: applications in drug discovery and drug development. Curr Top Med Chem 2005; 5: 1053-1075.
    • (2005) Curr Top Med Chem , vol.5 , pp. 1053-1075
    • Wang, J.1    Mauer, L.2
  • 45
    • 60549083251 scopus 로고    scopus 로고
    • Pre-clinical PET/MR: Technological advances and new perspectives in biomidical research
    • Wehrl HF, Judenhofer MS, et al. Pre-clinical PET/MR: technological advances and new perspectives in biomidical research. Eur J Nucl Mol Imag 2009; 36: S56-S68.
    • (2009) Eur J Nucl Mol Imag , vol.36 , pp. S56-S68
    • Wehrl, H.F.1    Judenhofer, M.S.2
  • 46
    • 58149380025 scopus 로고    scopus 로고
    • Animal models of Alzheimers's disease: Therapeutic implications
    • Woodruff-Pak DS. Animal models of Alzheimers's disease: therapeutic implications. J Alzheimers Dis 2008; 15: 507-521.
    • (2008) J Alzheimers Dis , vol.15 , pp. 507-521
    • Woodruff-Pak, D.S.1
  • 47
    • 19644391013 scopus 로고    scopus 로고
    • Evaluation of 18F-annexin V as a PET imaging agent in an animal model of apoptosis
    • Yagle KJ, Eary JF, et al. Evaluation of 18F-annexin V as a PET imaging agent in an animal model of apoptosis. J Nucl Med 2005; 46: 658-666.
    • (2005) J Nucl Med , vol.46 , pp. 658-666
    • Yagle, K.J.1    Eary, J.F.2
  • 48
    • 0037267313 scopus 로고    scopus 로고
    • Knockouts model the 100 best-selling drugs: Will they model the next 100?
    • Zambrowicz BP, Sands AT. Knockouts model the 100 best-selling drugs: will they model the next 100? Nat Rev Drug Discov 2003; 2: 38-51.
    • (2003) Nat Rev Drug Discov , vol.2 , pp. 38-51
    • Zambrowicz, B.P.1    Sands, A.T.2
  • 49
    • 1642512305 scopus 로고    scopus 로고
    • Iodine-124-labaled iodo-azomycin-galactoside imaging of tumor hypoxia in mice with serial microPET scanning
    • Zanzonico P, O'Donoghue J, et al. Iodine-124-labaled iodo-azomycin-galactoside imaging of tumor hypoxia in mice with serial microPET scanning. Eur J Nucl Med Mol Imag 2004; 31: 117-128.
    • (2004) Eur J Nucl Med Mol Imag , vol.31 , pp. 117-128
    • Zanzonico, P.1    O'Donoghue, J.2
  • 50
    • 33749015485 scopus 로고    scopus 로고
    • Longitudinally quantitative 2-deoxy-2-[18F] fluoro-D-glucose micro positron emission tomography imaging for efficacy of new anticancer drugs: A case study with bortezomib in prostate cancer murine model
    • Zhang Y, Saylor M, et al. Longitudinally quantitative 2-deoxy-2-[18F] fluoro-D-glucose micro positron emission tomography imaging for efficacy of new anticancer drugs: a case study with bortezomib in prostate cancer murine model. Mol Imag Biol 2006; 8: 300-308.
    • (2006) Mol Imag Biol , vol.8 , pp. 300-308
    • Zhang, Y.1    Saylor, M.2


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