Molecular gerontology: From homeodynamics to hormesis

Current Pharmaceutical Design

Volumn 20, Issue 18, 2014, Pages 3036-3039

  Rattan, Suresh I S ^a  

^a AARHUS UNIVERSITY   (Denmark)

Author keywords

Aging; Anti aging; Homeodynamics; Hormesis; Hormetics; Stress

Indexed keywords

AGING; ARTICLE; BIOLOGY; CELL AGING; CELL COMMUNICATION; CELL SURVIVAL; DAILY LIFE ACTIVITY; GERONTOLOGY; HORMESIS; HUMAN; LONGEVITY; ONSET AGE; PHENOTYPE; PRIORITY JOURNAL; STRESS; AGE; ANIMAL; DRUG DESIGN; GERIATRICS; HOMEOSTASIS; PHYSIOLOGICAL STRESS; PHYSIOLOGY;

AGE FACTORS; AGING; ANIMALS; DRUG DESIGN; GERIATRICS; HOMEOSTASIS; HORMESIS; HUMANS; STRESS, PHYSIOLOGICAL;

EID: 84903738761     PISSN: 13816128     EISSN: 18734286     Source Type: Journal    
DOI: 10.2174/13816128113196660708     Document Type: Article

References (53)

1. Holliday R. Aging is no longer an unsolved problem in biology. Ann NY Acad Sci 2006; 1067: 1-9.
2. Rattan SIS. Increased molecular damage and heterogeneity as the basis of aging. Biol Chem 2008; 389: 267-72.
3. Holliday R, Rattan SI. Longevity mutants do not establish any "new science" of ageing. Biogerontology 2010; 11: 507-11.
4. Rattan SIS. Homeostasis, homeodynamics, and aging. In: Birren J, editor. Encyclopedia of Gerontology. 2nd edition ed. UK: Elsevier Inc.; 2007. p. 696-9.
5. Rattan SIS. Biogerontology: from here to where? The Lord Cohen Medal Lecture-2011. Biogerontology 2012; 13: 83-91.
6. Yates FE. Order and complexity in dynamical systems: homeodynamics as a generalized mechanics for biology. Math Comput Model 1994; 19: 49-74.
7. Rattan SIS. Theories of biological aging: genes, proteins and free radicals. Free Rad Res 2006; 40: 1230-8.
8. Rattan SIS. Biogerontology: the next step. Ann NY Acad Sci 2000; 908: 282-90.
9. Carnes BA. What is lifespan regulation and why does it exist? Biogerontology 2011; 12: 367-74.
10. Carnes BA, Olshansky SJ, Grahn D. Biological evidence for limits to the duration of life. Biogerontology 2003; 4: 31-45.
11. Olshansky SJ, Biggs S, Achenbaum WA, et al. The global agenda council on the ageing society: policy principles. Global Policy 2011; 2: 97-105.
12. Martin GM. Modalities of gene action predicted by the classical evolutionary theory of aging. Ann NY Acad Sci 2007; 1100: 14-20.
13. Holliday R. Genes and the evolution of longevities. Biogerontology 2009; 10: 1-2.
14. Rattan SIS, Singh R. Gene therapy in aging. Gene Therapy 2009; 16: 3-9.
15. Rattan SIS. Gerontogenes: real or virtual? FASEB J 1995; 9: 284-6.
16. Blagosklonny MV. Aging: ROS or TOR. Cell Cycle 2008; 7: 3344-54.
17. Blagosklonny MV. Progeria, rapamycin and normal aging: recent breakthrough. Aging (Albany NY) 2011; 3: 685-91.
18. Trindade LS, Balduino A, Aigaki T, Heddle JG. Senemorphism: a novel perspective on aging patterns and its implication for dietrelated biology. Biogerontology 2012; 13: 457-66.
19. Holliday R. The extreme arrogance of anti-aging medicine. Biogerontology 2009; 10: 223-8.
20. Le Bourg E. Antioxidants and aging in human beings. In: Rattan SIS, editor. Aging Interventions and Therapies. Singapore: World Scientific Publishers 2005; p. 85-107.
21. Zs-Nagy I. Is consensus in anti-aging medical intervention an elusive expectation or a realistic goal? Arch Gerontol Geriatr 2009; 48: 271-5.
22. Rizvi SI, Jha R. Strategies for the discovery of anti-aging compounds. Expert Opin Drug Discov 2011; 6: 89-102.
23. Rattan SIS. Ageing, gerontogenes, and hormesis. Ind J Exp Biol 2000; 38: 1-5.
24. Rattan SIS. Hormesis in biogerontology. Crit Rev Toxicol 2001; 31: 663-4.
25. Rattan SIS. Applying hormesis in aging research and therapy. Hum Exp Toxicol 2001; 20: 281-5.
26. Rattan SIS. Mechanisms of hormesis through mild heat stress on human cells. Ann NY Acad Sci 2004; 1019: 554-8.
27. Rattan SIS. Hormesis in aging. Ageing Res Rev 2008; 7: 63-78.
28. Southam CM, Ehrlich J. Effects of extracts of western red-cedar heartwood on certain wood-decaying fungi in culture. Phytopathology 1943; 33: 517-24.
29. Calabrese EJ, Bachmann KA, Bailer AJ, et al. Biological stress response terminology: integrating the concepts of adaptive response and preconditioning stress within a hormetic dose-response framework. Toxicol Appl Pharmacol 2007; 222: 122-8.
30. Rattan SI. Rationale and methods of discovering hormetins as drugs for healthy ageing. Expert Opin Drug Discov 2012; 7: 439-48.
31. Demirovic D, Rattan SIS. Establishing cellular stress response profiles as biomarkers of homeodynamics, health and hormesis. Exp Gerontol 2013; 48: 94-98.
32. Calabrese EJ, Iavicoli I, Calabrese V. Hormesis: why it is important to biogerontologists. Biogerontology 2012; 13: 215-35.
33. Chirumbolo S. Possible role of NF-kB in hormesis during ageing. Biogerontology 2012; 13.
34. Rattan SIS, Demirovic D. Hormesis and aging. In: Mattson MP, Calabrese E, editors. Hormesis: a revolution in biology, toxicology and medicine. New York: Springer; 2009. p. 153-75.
35. Rattan SIS, Demirovic D. Hormesis can and does work in humans. Dose Response 2010; 8: 58-63.
36. Rattan SIS, Demirovic D. Hormesis as a mechanism for the antiaging effects of calorie restriction. In: Everitte AV, Rattan SIS, Le Couteur DG, de Cabo R, editors. Calorie Restriction, Aging and Longevity. Dordrecht: Springer 2010; p. 233-45.
37. Le Bourg E, Malod K, Massou I. The NF-kappaB-like factor DIF could explain some positive effects of a mild stress on longevity, behavioral aging, and resistance to strong stresses in Drosophila melanogaster. Biogerontology 2012; 13: 445-55.
38. Candow DG, Forbes SC, Little JP, Cornish SM, Pinkoski C, Chilibeck PD. Effect of nutritional interventions and resistance exercise on aging muscle mass and strength. Biogerontology 2012; 13: 345-58.
39. Mattson MP, Calabrese E, editors. Hormesis-a revolution in biology, toxicology and medicine. New York: Springer; 2010.
40. Rattan SIS, Fernandes RA, Demirovic D, Dymek B, Lima CF. Heat stress and hormetin-induced hormesis in human cells: effects on aging, wound healing, angiogenesis and differentiation. Doseresponse 2009; 7: 93-103.
41. Le Bourg E, Rattan SIS, editors. Mild stress and healthy aging: applying hormesis in aging research and interventions. Dordrecht, The Netherlands.: Springer; 2008.
42. Rattan SIS, Kryzch V, Schnebert S, Perrier E, Carine Nizard C. Hormesis-based anti-aging products: a case study of a novel cosmetic. Dose Response 2012; in press.
43. Verbeke P, Fonager J, Clark BFC, Rattan SIS. Heat shock response and ageing: mechanisms and applications. Cell Biol Int 2001; 25: 845-57.
44. Liberek K, Lewandowska A, Zietkiewicz S. Chaperones in control of protein disaggregation. EMBO J 2008; 27: 328-35.
45. Banhegyi G, Baumeister P, Benedetti A, et al. Endoplasmic reticulum stress. Ann N Y Acad Sci 2007; 1113: 58-71.
46. Yoshida H. ER stress and diseases. FEBS J 2007; 274: 630-58.
47. Basaiawmoit RV, Rattan SIS. Cellular stress and protein misfolding during aging. Methods Mol Biol 2010; 648: 107-17.
48. Markaki M, Tavernarakis N. The role of autophagy in genetic pathways influencing ageing. Biogerontology 2011; 12: 376-385.
49. Fulop T, Larbi A, Witkowski JM, et al. Aging, frailty and agerelated diseases. Biogerontology 2010; 11: 547-63.
50. Hubbard VM, Valdor R, Macian F, Cuervo AM. Selective autophagy in the maintenance of cellular homeostasis in aging organisms. Biogerontology 2012; 13: 21-35
51. Montesanto A, Lagani V, Martino C, et al. A novel, populationspecific approach to define frailty. Age 2010; 32: 385-95.
52. Mitnitski, A, Song, X, Rockwood, K. Assessing biological aging: the origin of deficit accumulation. Biogerontology 2013; 14: 709-717.
53. Rattan, S.I.S. Healthy ageing, but what is health? Biogerontology 2013: 14: 673-677.