Enterovirus 71 inhibits cellular type I interferon signaling by downregulating JAK1 protein expression

Viral Immunology

Volumn 27, Issue 6, 2014, Pages 267-276

  Liu, Ying ^a   Zhang, Zhe ^a   Zhao, Xinghui ^a   Yu, Rui ^a   Zhang, Xiaopeng ^a   Wu, Shipo ^a   Liu, Ju ^a   Chi, Xiangyang ^a   Song, Xiaohong ^a   Fu, Ling ^a   Yu, Yingqun ^b   Hou, Lihua ^a   Chen, Wei ^a  

^a BEIJING INSTITUTE OF BIOTECHNOLOGY   (China)

^b BEIJING INSTITUTE OF MICROBIOLOGY AND EPIDEMIOLOGY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA INTERFERON RECEPTOR; ALPHA2B INTERFERON; BETA INTERFERON; JANUS KINASE 1; PROTEIN KINASE TYK2; PROTEIN TYROSINE PHOSPHATASE INHIBITOR; STAT1 PROTEIN; STAT2 PROTEIN; SUPPRESSOR OF CYTOKINE SIGNALING 1; SUPPRESSOR OF CYTOKINE SIGNALING 3; UNCLASSIFIED DRUG; VIRUS PROTEIN; VIRUS PROTEIN 2A; VIRUS PROTEIN 2C; ALPHA BETA INTERFERON RECEPTOR; IFNAR1 PROTEIN, HUMAN; INTERFERON; JAK1 PROTEIN, HUMAN; PROTEIN SUBUNIT; PROTEIN TYROSINE PHOSPHATASE; STAT1 PROTEIN, HUMAN; STAT2 PROTEIN, HUMAN;

ARTICLE; DOWN REGULATION; DRUG MECHANISM; ENTEROVIRUS 71; ENTEROVIRUS INFECTION; ENZYME DEGRADATION; ENZYME REPRESSION; FETUS LUNG; FLOW CYTOMETRY; HUMAN; HUMAN CELL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RHABDOMYOSARCOMA; SIGNAL TRANSDUCTION; VIRUS INHIBITION; WESTERN BLOTTING; ANIMAL; CELL LINE; CHLOROCEBUS AETHIOPS; ENTEROVIRUS; FIBROBLAST; GENETICS; METABOLISM; PHOSPHORYLATION; PHYSIOLOGY; PROTEIN SUBUNIT; VERO CELL LINE;

ANIMALS; CELL LINE; CERCOPITHECUS AETHIOPS; DOWN-REGULATION; ENTEROVIRUS A, HUMAN; FIBROBLASTS; HUMANS; INTERFERON TYPE I; JANUS KINASE 1; PHOSPHORYLATION; PROTEIN SUBUNITS; PROTEIN TYROSINE PHOSPHATASES; RECEPTOR, INTERFERON ALPHA-BETA; RHABDOMYOSARCOMA; SIGNAL TRANSDUCTION; STAT1 TRANSCRIPTION FACTOR; STAT2 TRANSCRIPTION FACTOR; VERO CELLS;

EID: 84903731155     PISSN: 08828245     EISSN: 15578976     Source Type: Journal    
DOI: 10.1089/vim.2013.0127     Document Type: Article

References (42)

1. Andrejeva J, Young DF, Goodbourn S, and Randall RE. Degradation of STAT1 and STAT2 by the V proteins of simian virus 5 and human parainfluenza virus type 2, respectively: consequences for virus replication in the presence of alpha/beta and gamma interferons. J Virol 2002;76:2159-2167. (Pubitemid 34150683)
2. Charoenthongtrakul S, Zhou Q, Shembade N, et al. Human T cell leukemia virus type 1 Tax inhibits innate antiviral signaling via NF-kappaB-dependent induction of SOCS1. J Virol 2011;85:6955-6962.
3. Chee AV, and Roizman B. Herpes simplex virus 1 gene products occlude the interferon signaling pathway at multiple sites. J Virol 2004;78:4185-4196. (Pubitemid 38437224)
4. Darnell JE Jr, Kerr IM, and Stark GR. Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins. Science 1994;264:1415-1421. (Pubitemid 24217131)
5. Dinwiddie DL, and Harrod KS. Human metapneumovirus inhibits IFN-alpha signaling through inhibition of STAT1 phosphorylation. Am J Respir Cell Mol Biol 2008;38: 661-670. (Pubitemid 351841567)
6. Dong C, Zafrullah M, Mixson-Hayden T, et al. Suppression of interferon-alpha signaling by hepatitis E virus. Hepatology 2012;55:1324-1332.
7. Endo TA, Masuhara M, Yokouchi M, et al. A new protein containing an SH2 domain that inhibits JAK kinases. Nature 1997;387:921-924. (Pubitemid 27289595)
8. Evans JD, Crown RA, Sohn JA, and Seeger C. West Nile virus infection induces depletion of IFNAR1 protein levels. Viral Immunol 2011;24:253-263.
9. Fu XY, Schindler C, Improta T, et al. The proteins of ISGF-3, the interferon alpha-induced transcriptional activator, define a gene family involved in signal transduction. Proc Nat Acad Sci U S A 1992;89:7840-7843.
10. Gauzzi MC, Velazquez L, McKendry R, et al. Interferonalpha-dependent activation of Tyk2 requires phosphorylation of positive regulatory tyrosines by another kinase. J Biol Chem 1996;271:20494-20500. (Pubitemid 26281822)
11. Gordon JA. Use of vanadate as protein-phosphotyrosine phosphatase inhibitor. Methods Enzymol 1991;201:477-482.
12. Guo JT, Hayashi J, and Seeger C. West Nile virus inhibits the signal transduction pathway of alpha interferon. J Virol 2005;79:1343-1350. (Pubitemid 40459081)
13. Hung HC, Wang HC, Shih SR, et al. Synergistic inhibition of enterovirus 71 replication by interferon and rupintrivir. J Infect Dis 2011;203:1784-1790.
14. Katze MG, He Y, Gale M Jr. Viruses and interferon: a fight for supremacy. Nat Rev Immunol 2002;2:675-687. (Pubitemid 37328725)
15. Kuo RL, Kung SH, Hsu YY, and Liu WT. Infection with enterovirus 71 or expression of its 2A protease induces apoptotic cell death. J Gen Virol 2002;83:1367-1376.
16. Lei X, Sun Z, Liu X, et al. Cleavage of the adaptor protein TRIF by enterovirus 71 3C inhibits antiviral responses mediated by Toll-like receptor 3. J Virol 2011;85:8811-8818.
17. Liu L, Zhang Y, Wang J, et al. Study of the integrated immune response induced by an inactivated EV71 vaccine. PloS One 2013;8:e54451.
18. Lu J, Yi L, Zhao J, et al. Enterovirus 71 disrupts interferon signaling by reducing the level of interferon receptor 1. J Virol 2012;86:3767-3776.
19. McMinn PC. An overview of the evolution of enterovirus 71 and its clinical and public health significance. FEMS Microbiol Rev 2002;26:91-107. (Pubitemid 34454778)
20. Pauli EK, Schmolke M, Wolff T, et al. Influenza A virus inhibits type I IFN signaling via NF-kappaB-dependent induction of SOCS-3 expression. PLoS Pathog 2008; 4:e1000196.
21. Qu L, Feng Z, Yamane D, et al. Disruption of TLR3 signaling due to cleavage of TRIF by the hepatitis A virus protease-polymerase processing intermediate, 3CD. PLoS Pathog 2011;7:e1002169.
22. Ramaswamy M, Shi L, Monick MM, et al. Specific inhibition of type I interferon signal transduction by respiratory syncytial virus. Am J Respir Cell Mol Biol 2004;30:893-900. (Pubitemid 38736915)
23. Ramaswamy M, Shi L, Varga SM, et al. Respiratory syncytial virus nonstructural protein 2 specifically inhibits type I interferon signal transduction. Virology 2006;344:328-339. (Pubitemid 43049621)
24. Rane SG, and Reddy EP. Janus kinases: components of multiple signaling pathways. Oncogene 2000;19:5662-5679.
25. Ren J, Kolli D, Liu T, et al. Human metapneumovirus inhibits IFN-beta signaling by downregulating Jak1 and Tyk2 cellular levels. PloS One 2011;6:e24496.
26. Sasaki A, Yasukawa H, Suzuki A, et al. Cytokine-inducible SH2 protein-3 (CIS3/SOCS3) inhibits Janus tyrosine kinase by binding through the N-terminal kinase inhibitory region as well as SH2 domain. Genes Cells 1999;4:339-351. (Pubitemid 29359449)
27. Schindler C, and Darnell JE Jr. Transcriptional responses to polypeptide ligands: the JAK-STAT pathway. Ann Rev Biochem 1995;64:621-651.
28. Schindler C, Shuai K, Prezioso VR, and Darnell JE Jr. Interferon-dependent tyrosine phosphorylation of a latent cytoplasmic transcription factor. Science 1992;257:809-813.
29. Shuai K, and Liu B. Regulation of JAK-STAT signalling in the immune system. Nat Rev Immunol 2003;3:900-911. (Pubitemid 37411719)
30. Shuai K, Schindler C, Prezioso VR, and Darnell JE Jr. Activation of transcription by IFN-gamma: tyrosine phosphorylation of a 91-kD DNA binding protein. Science 1992;258:1808-1812. (Pubitemid 23087351)
31. Silvennoinen O, Ihle JN, Schlessinger J, and Levy DE. Interferon-induced nuclear signalling by Jak protein tyrosine kinases. Nature 1993;366:583-585. (Pubitemid 24036001)
32. Simmons JD, White LJ, Morrison TE, et al. Venezuelan equine encephalitis virus disrupts STAT1 signaling by distinct mechanisms independent of host shutoff. J Virol 2009;83:10571-10581.
33. Stark GR, Kerr IM, Williams BR, et al. How cells respond to interferons. Ann Rev Biochem 1998;67:227-264. (Pubitemid 28411130)
34. Strebovsky J, Walker P, and Dalpke AH. Suppressor of cytokine signaling proteins as regulators of innate immune signaling. Front Biosci (Landmark Ed) 2012;17:1627-1639.
35. Taylor KE, and Mossman KL. Recent advances in understanding viral evasion of type I interferon. Immunology 2013;138:190-197.
36. Uetani K, Hiroi M, Meguro T, et al. Influenza A virus abrogates IFN-gamma response in respiratory epithelial cells by disruption of the Jak/Stat pathway. Eur J Immunol 2008;38:1559-1573.
37. Wang B, Xi X, Lei X, et al. Enterovirus 71 protease 2A(pro) targets MAVS to inhibit anti-viral type I interferon responses. PLoS Pathog 2013;9:e1003231.
38. Wong SS, Yip CC, Lau SK, and Yuen KY. Human enterovirus 71 and hand, foot and mouth disease. Epidemiol Infect 2010;138:1071-1089.
39. Wu KX, Ng MM, and Chu JJ. Developments towards antiviral therapies against enterovirus 71. Drug Discov Today 2010;15:1041-1051.
40. Yi L, Lu J, Kung HF, and He ML. The virology and developments toward control of human enterovirus 71. Crit Rev Microbiol 2011;37:313-327.
41. Yoshimura A, Naka T, and Kubo M. SOCS proteins, cytokine signalling and immune regulation. Nat Rev Immunol 2007;7:454-465. (Pubitemid 46834848)
42. Young DF, Didcock L, Goodbourn S, and Randall RE. Paramyxoviridae use distinct virus-specific mechanisms to circumvent the interferon response. Virology 2000;269:383-390. (Pubitemid 30210911)