Nano-transfersomal ciprofloxacin loaded vesicles for non-invasive trans-tympanic ototopical delivery: In-vitro optimization, ex-vivo permeation studies, and in-vivo assessment

International Journal of Pharmaceutics

Volumn 472, Issue 1-2, 2014, Pages 304-314

  Al Mahallawi, Abdulaziz Mohsen ^a   Khowessah, Omneya Mohammed ^a   Shoukri, Raguia Ali ^a  

^a CAIRO UNIVERSITY   (Egypt)

Author keywords

Acute otitis media; Ex vivo tympanic membrane permeation; In vivo drug deposition studies; Thin film hydration; Transfersomes

Indexed keywords

CHOLIC ACID; CIPROFLOXACIN; PHOSPHOLIPID; ANTIINFECTIVE AGENT; DRUG CARRIER; NANOPARTICLE; PHOSPHATIDYLCHOLINE;

ACUTE OTITIS MEDIA; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; DRUG FORMULATION; DRUG PENETRATION; EAR; EARDRUM; EX VIVO STUDY; FACTORIAL DESIGN; FILM; HYDROPHILICITY; IN VITRO STUDY; IN VIVO STUDY; LIPOPHILICITY; MALE; MIDDLE EAR; NONHUMAN; PRIORITY JOURNAL; RABBIT; SKIN; ANIMAL; CHEMISTRY; DRUG STABILITY; MEDICINAL CHEMISTRY; METABOLISM; PERMEABILITY; TOPICAL DRUG ADMINISTRATION;

ADMINISTRATION, TOPICAL; ANIMALS; ANTI-BACTERIAL AGENTS; CHEMISTRY, PHARMACEUTICAL; CIPROFLOXACIN; DRUG CARRIERS; DRUG STABILITY; MALE; NANOPARTICLES; PERMEABILITY; PHOSPHATIDYLCHOLINES; RABBITS; SKIN; SODIUM CHOLATE; TYMPANIC MEMBRANE;

EID: 84903716680     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2014.06.041     Document Type: Article

References (55)

1. G. Abdelbary Ocular ciprofloxacin hydrochloride mucoadhesive chitosan-coated liposomes Pharm. Dev. Technol. 16 2011 44 56
2. G. Abdelbary, and N. El-Gendy Niosome-encapsulated gentamicin for ophthalmic controlled delivery AAPS PharmSciTech 9 2008 740 747
3. M.H. Aburahma, and G.A. Abdelbary Novel diphenyl dimethyl bicarboxylate provesicular powders with enhanced hepatocurative activity: preparation, optimization, in vitro/in vivo evaluation Int. J. Pharm. 422 2012 139 150
4. M.H. Ali, D.J. Kirby, A.R. Mohammed, and Y. Perrie Solubilisation of drugs within liposomal bilayers: alternatives to cholesterol as a membrane stabilising agent J. Pharm. Pharmacol. 62 2010 1646 1655
5. P. Arunothayanun, M.S. Bernard, D.Q. Craig, I.F. Uchegbu, and A.T. Florence The effect of processing variables on the physical characteristics of non-ionic surfactant vesicles (niosomes) formed from a hexadecyl diglycerol ether Int. J. Pharm. 201 2000 7 14 (Pubitemid 30364965)
6. E.B. Basalious, N. Shawky, and S.M. Badr-Eldin SNEDDS containing bioenhancers for improvement of dissolution and oral absorption of lacidipine. I: development and optimization Int. J. Pharm. 391 2010 203 211
7. M. Basha, S.H. Abd El-Alim, R.N. Shamma, and G.E. Awad Design and optimization of surfactant-based nanovesicles for ocular delivery of Clotrimazole J. Liposome Res. 23 2013 203 210
8. D.M. Campoli-Richards, J.P. Monk, A. Price, P. Benfield, P.A. Todd, and A. Ward Ciprofloxacin. A review of its antibacterial activity, pharmacokinetic properties and therapeutic use Drugs 35 1988 373 447
9. G. Cevc Polymorphism of the bilayer membranes in the ordered phase and the molecular origin of the lipid pretransition and rippled lamellae Biochim. Biophys. Acta 1062 1991 59 69
10. G. Cevc, and G. Blume Lipid vesicles penetrate into intact skin owing to the transdermal osmotic gradients and hydration force Biochim. Biophys. Acta 1104 1992 226 232
11. G. Cevc, and G. Blume Hydrocortisone and dexamethasone in very deformable drug carriers have increased biological potency, prolonged effect, and reduced therapeutic dosage Biochim. Biophys. Acta (BBA) - Biomembr. 1663 2004 61 73 (Pubitemid 38625580)
12. G. Cevc, D. Gebauer, J. Stieber, A. Schatzlein, and G. Blume Ultraflexible vesicles, transfersomes, have an extremely low pore penetration resistance and transport therapeutic amounts of insulin across the intact mammalian skin Biochim. Biophys. Acta 1368 1998 201 215 (Pubitemid 28031874)
13. G. Cevc, U. Vierl, and S. Mazgareanu Functional characterisation of novel analgesic product based on self-regulating drug carriers Int. J. Pharm. 360 2008 18 28
14. C.P. Dora, S.K. Singh, S. Kumar, A.K. Datusalia, and A. Deep Development and characterization of nanoparticles of glibenclamide by solvent displacement method Acta Pol. Pharm. 67 2010 283 290
15. S. Duangjit, P. Opanasopit, T. Rojanarata, and T. Ngawhirunpat Characterization and in vitro skin permeation of meloxicam-loaded liposomes versus transfersomes J. Drug Deliv. 2011 418316
16. G.M. El Maghraby, A.C. Williams, and B.W. Barry Oestradiol skin delivery from ultradeformable liposomes: refinement of surfactant concentration Int. J. Pharm. 196 2000 63 74 (Pubitemid 30089515)
17. G.M. El Zaafarany, G.A. Awad, S.M. Holayel, and N.D. Mortada Role of edge activators and surface charge in developing ultradeformable vesicles with enhanced skin delivery Int. J. Pharm. 397 2010 164 172
18. S. Esposito, G. D'Errico, and C. Montanaro Topical and oral treatment of chronic otitis media with ciprofloxacin. A preliminary study Arch. Otolaryngol. Head Neck Surg. 116 1990 557 559 (Pubitemid 20172536)
19. H. Faden, L. Duffy, and M. Boeve Otitis media: back to basics Pediatr. Infect. Dis. J. 17 1998 1105 1112 quiz 1112-1113
20. J.Y. Fang, S.Y. Yu, P.C. Wu, Y.B. Huang, and Y.H. Tsai In vitro skin permeation of estradiol from various proniosome formulations Int. J. Pharm. 215 2001 91 99
21. J.Y. Fang, T.L. Hwang, Y.L. Huang, and C.L. Fang Enhancement of the transdermal delivery of catechins by liposomes incorporating anionic surfactants and ethanol Int. J. Pharm. 310 2006 131 138
22. I. Gomez-Pinto, E. Cubero, S.G. Kalko, V. Monaco, G. van der Marel, J.H. van Boom, M. Orozco, and C. Gonzalez Effect of bulky lesions on DNA: solution structure of a DNA duplex containing a cholesterol adduct J. Biol. Chem. 279 2004 24552 24560 (Pubitemid 38725321)
23. P.N. Gupta, V. Mishra, A. Rawat, P. Dubey, S. Mahor, S. Jain, D.P. Chatterji, and S.P. Vyas Non-invasive vaccine delivery in transfersomes, niosomes and liposomes: a comparative study Int. J. Pharm. 293 2005 73 82 (Pubitemid 40381082)
24. P.N. Gupta, V. Mishra, P. Singh, A. Rawat, P. Dubey, S. Mahor, and S.P. Vyas Tetanus toxoid-loaded transfersomes for topical immunization J. Pharm. Pharmacol. 57 2005 295 301 (Pubitemid 40314427)
25. Y. Hao, F. Zhao, N. Li, Y. Yang, and K. Li Studies on a high encapsulation of colchicine by a niosome system Int. J. Pharm. 244 2002 73 80 (Pubitemid 35245447)
26. Y. Hiruta, Y. Hattori, K. Kawano, Y. Obata, and Y. Maitani Novel ultra-deformable vesicles entrapped with bleomycin and enhanced to penetrate rat skin J. Control. Release 113 2006 146 154 (Pubitemid 43928150)
27. X. Khoo, E.J. Simons, H.H. Chiang, J.M. Hickey, V. Sabharwal, S.I. Pelton, J.J. Rosowski, R. Langer, and D.S. Kohane Formulations for trans-tympanic antibiotic delivery Biomaterials 34 2013 1281 1288
28. E. Koulich, P.S. Roland, and K.S. Pawlowski Comparison of systemic and otic administration of ofloxacin Laryngoscope 120 2010 2083 2088
29. E.H. Lee, A. Kim, Y.K. Oh, and C.K. Kim Effect of edge activators on the formation and transfection efficiency of ultradeformable liposomes Biomaterials 26 2005 205 210 (Pubitemid 38789103)
30. S.C. Lee, K.E. Lee, J.J. Kim, and S.H. Lim The effect of cholesterol in the liposome bilayer on the stabilization of incorporated Retinol J. Liposome Res. 15 2005 157 166
31. F. Legent, P. Bordure, C. Beauvillain, and P. Berche Controlled prospective study of oral ciprofloxacin versus amoxycillin/clavulanic acid in chronic suppurative otitis media in adults Chemotherapy 40 1994 16 23 (Pubitemid 24293493)
32. W. Lei, C. Yu, H. Lin, and X. Zhou Development of tacrolimus-loaded transfersomes for deeper skin penetration enhancement and therapeutic effect improvement in vivo Asian J. Pharm. Sci. 8 2013 336 345
33. X. Liang, G. Mao, and K.Y. Ng Mechanical properties and stability measurement of cholesterol-containing liposome on mica by atomic force microscopy J. Colloid Interface Sci. 278 2004 53 62 (Pubitemid 39094475)
34. F. Maestrelli, M.L. Gonzalez-Rodriguez, A.M. Rabasco, and P. Mura Preparation and characterisation of liposomes encapsulating ketoprofen- cyclodextrin complexes for transdermal drug delivery Int. J. Pharm. 298 2005 55 67 (Pubitemid 40834315)
35. P. Marchisio, E. Nazzari, S. Torretta, S. Esposito, and N. Principi Medical prevention of recurrent acute otitis media: an updated overview Expert Rev. Anti Infect. Ther. 2014
36. A.C. Moffat, M.D. Osselton, and B. Widdop Monographs: ciprofloxacin J. Watts, Clarke's Analysis of Drugs and Poisons 4th ed. 2011 Pharmaceutical Press London 1111 1113
37. J. Moore, and H. Flanner Mathematical comparison of curves with an emphasis on in-vitro dissolution profiles Pharm. Technol. 20 1996 64 74 (Pubitemid 126450495)
38. K. Moribe, K. Maruyama, and M. Iwatsuru Encapsulation characteristics of nystatin in liposomes: effects of cholesterol and polyethylene glycol derivatives Int. J. Pharm. 188 1999 193 202 (Pubitemid 29486722)
39. M.S. Nagarsenker, V.Y. Londhe, and G.D. Nadkarni Preparation and evaluation of liposomal formulations of tropicamide for ocular delivery Int. J. Pharm. 190 1999 63 71 (Pubitemid 29467473)
40. A. Paul, G. Cevc, and B.K. Bachhawat Transdermal immunisation with an integral membrane component, gap junction protein, by means of ultradeformable drug carriers, transfersomes Vaccine 16 1998 188 195 (Pubitemid 27520997)
41. J.A. Rosenfeld, and G. Clarity Acute otitis media in children Prim. Care: Clinics Office Practice 23 1996 677 686 (Pubitemid 26427234)
42. H.A. Salama, A.A. Mahmoud, A.O. Kamel, M. Abdel Hady, and G.A. Awad Brain delivery of olanzapine by intranasal administration of transfersomal vesicles J. Liposome Res. 22 2012 336 345
43. H.A. Salama, A.A. Mahmoud, A.O. Kamel, M. Abdel Hady, and G.A. Awad Phospholipid based colloidal poloxamer-nanocubic vesicles for brain targeting via the nasal route Colloids Surf. B Biointerfaces 100 2012 146 154
44. R.N. Shamma, and I. Elsayed Transfersomal lyophilized gel of buspirone HCl: formulation, evaluation and statistical optimization J. Liposome Res. 23 2013 244 254
45. L.N. Shen, Y.T. Zhang, Q. Wang, L. Xu, and N.P. Feng Enhanced in vitro and in vivo skin deposition of apigenin delivered using ethosomes Int. J. Pharm. 460 2014 280 288
46. A.L. Silva, F. Alexandrino, L.M. Verissimo, L.F. Agnez-Lima, L.C. Egito, A.G. de Oliveira, and E.S. do Egito Physical factors affecting plasmid DNA compaction in stearylamine-containing nanoemulsions intended for gene delivery Pharmaceuticals (Basel) 5 2012 643 654
47. Simons, E.J., Hoare, T.R., Kohane, D.S., Langer, R.S., 2011. Tympanic membrane permeating ear drops and uses thereof. US Patents.
48. H. Tanojo, P.E.H. Roemelé, G.H. van Veen, H. Stieltjes, H.E. Junginger, and H.E. Boddé New design of a flow-through permeation cell for studying in vitro permeation studies across biological membranes J. Control. Release 45 1997 41 47 (Pubitemid 27055791)
49. J.P. Thomas, R. Berner, T. Zahnert, and S. Dazert Acute otitis media-a structured approach Dtsch Arztebl Int. 111 2014 151 160
50. K. Thornton, F. Parrish, and C. Swords Topical vs. systemic treatments for acute otitis media Pediatr. Nurs. 267 2011 242
51. B.A. van den Bergh, P.W. Wertz, H.E. Junginger, and J.A. Bouwstra Elasticity of vesicles assessed by electron spin resonance, electron microscopy and extrusion measurements Int. J. Pharm. 217 2001 13 24 (Pubitemid 32268629)
52. K.R. Vinod, S. Anbazhagan, M.S. Kumar, S. Sandhya, D. Banji, and A.P. Rani Developing ultra deformable vesicular transportation of a bioactive alkaloid in pursuit of vitiligo therapy Asian Pac. J. Trop. Dis. 2 2012 301 306
53. G.M. Wall, D.W. Stroman, P.S. Roland, and J. Dohar Ciprofloxacin 0.3%/dexamethasone 0.1% sterile otic suspension for the topical treatment of ear infections: a review of the literature Pediatr. Infect. Dis. J. 28 2009 141 144
54. R. Zeisig, K. Shimada, S. Hirota, and D. Arndt Effect of sterical stabilization on macrophage uptake in vitro and on thickness of the fixed aqueous layer of liposomes made from alkylphosphocholines Biochim. Biophys. Acta 1285 1996 237 245 (Pubitemid 26403082)
55. L. Zeng, L. Zhang, Z. Hu, E.A. Ehle, Y. Chen, L. Liu, and M. Chen Systematic review of evidence-based guidelines on medication therapy for upper respiratory tract infection in children with AGREE instrument PLoS One 9 2014 e87711