Novel ultra-deformable vesicles entrapped with bleomycin and enhanced to penetrate rat skin

Journal of Controlled Release

Volumn 113, Issue 2, 2006, Pages 146-154

  Hiruta, Yuka ^a   Hattori, Yoshiyuki ^a   Kawano, Kumi ^a   Obata, Yasuko ^a   Maitani, Yoshie ^a  

^a HOSHI UNIVERSITY   (Japan)

Author keywords

Bleomycin; Skin permeation; Sodium cholate; Sterylglucoside; Ultra deformable vesicle

Indexed keywords

BIODIVERSITY; CONTROLLED DRUG DELIVERY; FLUORESCENCE; OPTICAL MICROSCOPY; PROTEINS; SKIN;

BLEOMYCIN; SKIN PERMEATION; SODIUM CHOLATE; STERYLGLUCOSIDE; ULTRA-DEFORMABLE VESICLE;

ALCOHOLS;

BLEOMYCIN; FLUORESCENT DYE; SITOGLUSIDE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONFOCAL LASER MICROSCOPY; CONTROLLED STUDY; DERMIS; DRUG DELIVERY SYSTEM; DRUG DISTRIBUTION; DRUG FORMULATION; DRUG PENETRATION; DRUG STABILITY; EPIDERMIS; MALE; NONHUMAN; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; RAT; SKIN; SKIN PENETRATION; STATISTICAL SIGNIFICANCE;

ANIMALS; BLEOMYCIN; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG CARRIERS; DRUG SYNERGISM; MALE; RATS; RATS, WISTAR; SKIN ABSORPTION;

EID: 33745261719     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jconrel.2006.04.016     Document Type: Article

References (26)

1. Barry B.W., and Bennett S.L. Effect of penetration enhancers on the permeation of mannitol, hydrocortisone and progesterone through human skin. J. Pharm. Pharmacol. 39 (1987) 535-546
2. Tojo K., Chiang C.C., and Chien Y.W. Drug permeation across the skin: effect of penetrant hydrophilicity. J. Pharm. Sci. 76 (1987) 123-126
3. Sharma A., and Sharma U.S. Liposomes in drug delivery: progress and limitations. Int. J. Pharm. 154 (1997) 123-140
4. Cevc G., Schatzlein A., Gebauer D., and Blume G. Ultrahighefficiency of drug and peptide transfer through intact skin by means of novel drug carriers, transfersomes. In: Bain K.R., Hadgkraft J., James W.J., and Water K.A. (Eds). Prediction of Percutaneous Penetration vol. 3b (1993), STS Publishing, Cardiff 226-236
5. Cevc G., and Blume G. Lipid vesicles penetrate into intact skin owing to the transdermal osmotic gradients and hydration force. Biochim. Biophys. Acta 1104 (1992) 226-232
6. Planas M.E., Gonzalez P., Rodriguez L., Sanchez S., and Cevc G. Noninvasive percutaneous induction of topical analgesia by a new type of drug carrier, and prolongation of local pain insensitivity by anesthetic liposomes. Anesth. Analg. 75 (1992) 615-621
7. Cevc G., and Blume G. Biological activity and characteristics of triamcinolone-acetonide formulated with the self-regulating drug carriers, transfersomes. Biochim. Biophys. Acta 1614 (2003) 156-164
8. El Maghraby G.M., Williams A.C., and Barry B.W. Oestradiol skin delivery from ultradeformable liposomes: refinement of surfactant concentration. Int. J. Pharm. 196 (2000) 63-74
9. Lau K.G., Chopra S., and Maitani Y. Entrapment of bleomycin in ultra-deformable liposomes. S.T.P. Pharma Sci. 13 (2003) 237-239
10. Lau K.G., Hattori Y., Chopra S., O'Toole E.A., Storey A., Nagai T., and Maitani Y. Ultra-deformable liposomes containing bleomycin: in vitro stability and toxicity on human cutaneous keratinocyte cell lines. Int. J. Pharm. 300 (2005) 4-12
11. Muramatsu K., Maitani Y., Takayama K., and Nagai T. The relationship between the rigidity of the liposomal membrane and the absorption of insulin after nasal administration of liposomes modified with an enhancer containing insulin in rabbits. Drug Dev. Ind. Pharm. 25 (1999) 1099-1105
12. Nakamura K., Takayama K., Nagai T., and Maitani Y. Regional intestinal absorption of FITC-dextran 4400 with nanoparticles based on beta-sitosterol beta-d-glucoside in rats. J. Pharm. Sci. 92 (2003) 311-318
13. Cevc G., Schatzlein A., and Blume G. Transdermal drug carriers: basic properties, optimization and transfer efficiency in the case of epicutaneously applied peptides. J. Control. Release 36 (1995) 3-16
14. Cevc G., Gebauer D., Stieber J., Schatzlein A., and Blume G. Ultraflexible vesicles, transfersomes, have an extremely low pore penetration resistance and transport therapeutic amounts of insulin across the intact mammalian skin. Biochim. Biophys. Acta 1368 (1998) 201-215
15. Perkins W.R., Minchey S.R., Ahl P.L., and Janoff A.S. The determination of liposome captured volume. Chem. Phys. Lipids 64 (1993) 197-217
16. Fiedler H.P., and Wachter J. High-performance liquid chromatographic determination of bleomycins. J. Chromatogr. 536 (1991) 343-347
17. Bangham A.D., Standish M.M., and Watkins J.C. Diffusion of univalent ions across the lamellae of swollen phospholipids. J. Mol. Biol. 13 (1965) 238-252
18. Bangham A.D. Membrane models with phospholipids. Prog. Biophys. Mol. Biol. 18 (1968) 29-95
19. van den Bergh B.A., Wertz P.W., Junginger H.E., and Bouwstra J.A. Elasticity of vesicles assessed by electron spin resonance, electron microscopy and extrusion measurements. Int. J. Pharm. 217 (2001) 13-24
20. Korstanje L.J., van Ginkel G., and Levine Y.K. Effects of steroid molecules on the dynamical structure of dioleoylphosphatidylcholine and digalactosyldiacylglycerol bilayers. Biochim. Biophys. Acta 1022 (1990) 155-162
21. Hofer C., Hartung R., Gobel R., Deering P., Lehmer A., and Breul J. New ultradeformable drug carriers for potential transdermal application of interleukin-2 and interferon-alpha: theoretic and practical aspects. World J. Surg. 24 (2000) 1187-1189
22. Cevc G., Blume G., Schatzlein A., Gebauer D., and Paul A. The skin: a pathway for systemic treatment with patches and lipid-based agent carriers. Adv. Drug Deliv. Rev. 18 (1996) 349-378
23. Blume A., Jansen M., Ghyczy M., and Gareiss J. Interaction of phospholipid liposomes with lipid model mixtures for stratum corneum lipids. Int. J. Pharm. 99 (1993) 219-228
24. Hofland H.E., Bouwstra J.A., Bodde H.E., Spies F., and Junginger H.E. Interactions between liposomes and human stratum corneum in vitro: freeze fracture electron microscopical visualization and small angle X-ray scattering studies. Br. J. Dermatol. 132 (1995) 853-866
25. Ninomiya R., Matsuoka K., and Moroi Y. Micelle formation of sodium chenodeoxycholate and solubilization into the micelles: comparison with other unconjugated bile salts. Biochim. Biophys. Acta 1634 (2003) 116-125
26. Sugioka H., Matsuoka K., and Moroi Y. Temperature effect on formation of sodium cholate micelles. J. Colloid Interface Sci. 259 (2003) 156-162