New design of a flow-through permeation cell for studying in vitro permeation studies across biological membranes

Journal of Controlled Release

Volumn 45, Issue 1, 1997, Pages 41-47

  Tanojo, Hanafi ^a   Roemelé, Peter E H ^a   Van Veen, Gé H ^b   Stieltjes, Hans ^a   Junginger, Hans E ^a   Boddé, Harry E ^a  

^a LEIDEN UNIVERSITY   (Netherlands)

^b LEIDEN UNIVERSITY   (Netherlands)

Author keywords

Diffusion cell; Flow through system; In vitro permeation study; Transdermal drug delivery

Indexed keywords

4 AMINOBENZOIC ACID;

ARTICLE; ARTIFICIAL MEMBRANE; DIFFUSION CHAMBER; HUMAN; HUMAN TISSUE; IN VITRO STUDY; MEMBRANE PERMEABILITY; PRIORITY JOURNAL; SKIN PERMEABILITY; STRATUM CORNEUM; TRANSDERMAL DRUG ADMINISTRATION;

EID: 0031036481     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0168-3659(96)01543-X     Document Type: Article

References (14)

1. B.W. Barry, Dermatological Formulations. Percutaneous Absorption, Marcel Dekker, New York, 1983.
2. T.J. Franz, Percutaneous absorption on the relevance of in vitro data, J. Invest. Dermatol. 64 (1975) 190-195.
3. R.L. Bronaugh and R.F. Stewart, Methods for in vitro percutaneous absorption studies IV: the flow-through diffusion cell, J. Pharm. Sci. 74 (1985) 64-67.
4. E.R. Cooper, Increased skin permeability for lipophilic molecules, J. Pharm. Sci. 73 (1984) 1153-1156.
5. H.L.G.M. Tiemessen, H.E. Boddé, M.V. Koppen, W.C. Bauer and H.E. Junginger, A two-chambered diffusion cell with improved flow-through characteristics for studying the drug permeability of biological membranes, Acta Pharm. Technol. 34 (1988) 99-101.
6. T.J. Franz, The finite dose technique as a valid in vitro model for the study of percutaneous absorption in man. In: J.W.H. Mali (Ed.), Current Problems in Dermatology, Vol. 7, Karger, Basle, 1978, pp. 58-68.
7. E. Touitou and L. Abed, The permeation behavior of several membranes with potential use in the design of transdermal devices, Pharm. Acta Helv. 60 (1985) 193-198.
8. W.Q. Liang, R.V. Peterson and S.W. Kim, Drug permeation through polymer-skin membrane, Acta Pharm. Technol. 31 (1985) 210-214.
9. W.J. Addicks, G.L. Flynn and N. Weiner, Validation of a flow-through diffusion cell for use in transdermal research, Pharm. Res. 4 (1987) 337-341.
10. J. Sclafani, J. Nightingale, P. Liu and T. Kurihara-Bergstrom, Flow-through system effects on in vitro analysis of transdermal system, Pharm. Res. 10 (1993) 1521-1526.
11. H.K. Choi and J.T. Angello, Mathematical analysis and optimization of a flow-through diffusion cell system, Pharm. Res. 11 (1994) 595-599.
12. H. Tanojo, J.A. Bouwstra, H.E. Junginger and H.E. Boddé, Subzero thermal analysis of human stratum corneum, Pharm. Res. 11 (1994) 1610-1616.
13. H. Tanojo, H.E. Junginger and H.E. Boddé, Influence of pH on the intensity and stability of the fluorescence of p-aminobenzoic acid in aqueous solutions, Eur. J. Pharm. Sci. (1996) in press.
14. J.R. Bond and B.W. Barry, Hairless mouse skin is limited as a model for assessing the effects of penetration enhancers in human skin, J. Invest. Dermatol. 90 (1988) 810-813.