Quantitative single-molecule localization microscopy combined with rule-based modeling reveals ligand-induced TNF-R1 reorganization toward higher-order oligomers

Histochemistry and Cell Biology

Volumn 142, Issue 1, 2014, Pages 91-101

  Fricke, Franziska ^a   Malkusch, Sebastian ^a   Wangorsch, Gaby ^b   Greiner, Johannes F ^c   Kaltschmidt, Barbara ^c   Kaltschmidt, Christian ^c   Widera, Darius ^c   Dandekar, Thomas ^b   Heilemann, Mike ^a,d  

^a GOETHE UNIVERSITY   (Germany)

^b UNIVERSITY OF WÜRZBURG   (Germany)

^c BIELEFELD UNIVERSITY   (Germany)

^d UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

dSTORM; Modeling; PALM; Receptor clustering; Super resolution microscopy; Systems biology; TNF receptor I

Indexed keywords

LIGAND; OLIGOMER; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR RECEPTOR 1; RECOMBINANT PROTEIN;

APOPTOSIS; ARTICLE; BASEMENT MEMBRANE; BINDING AFFINITY; CELL MEMBRANE; DIMERIZATION; HUMAN; HUMAN CELL; IN VITRO STUDY; INTERMETHOD COMPARISON; LIGAND BINDING; MICROSCOPY; OLIGOMERIZATION; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; QUANTITATIVE SINGLE MOLECULE LOCALIZATION MICROSCOPY; SYSTEMS BIOLOGY; CHEMICAL STRUCTURE; CHEMISTRY; DRUG EFFECTS; FLUORESCENCE MICROSCOPY; HELA CELL LINE; METABOLISM; MOLECULAR IMAGING; PROCEDURES; PROTEIN MULTIMERIZATION;

CELL MEMBRANE; HELA CELLS; HUMANS; LIGANDS; MICROSCOPY, FLUORESCENCE; MODELS, MOLECULAR; MOLECULAR IMAGING; PROTEIN MULTIMERIZATION; RECEPTORS, TUMOR NECROSIS FACTOR, TYPE I; RECOMBINANT PROTEINS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84903711331     PISSN: 09486143     EISSN: 1432119X     Source Type: Journal    
DOI: 10.1007/s00418-014-1195-0     Document Type: Article

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