Inhibition of Janus kinase signaling during controlled mechanical ventilation prevents ventilation-induced diaphragm dysfunction

FASEB Journal

Volumn 28, Issue 7, 2014, Pages 2790-2803

  Smith, Ira J ^a   Godinez, Guillermo L ^a   Singh, Baljit K ^a   McCaughey, Kelly M ^a   Alcantara, Raniel R ^a   Gururaja, Tarikere ^a   Ho, Melissa S ^a   Nguyen, Henry N ^a   Friera, Annabelle M ^a   White, Kathy A ^a   McLaughlin, John R ^a   Hansen, Derek ^a   Romero, Jason M ^a   Baltgalvis, Kristen A ^a   Claypool, Mark D ^a   Li, Wei ^a   Lang, Wayne ^a   Yam, George C ^a   Gelman, Marina S ^a   Ding, Rongxian ^a   Yung, Stephanie L ^a   Creger, Daniel P ^a   Chen, Yan ^a   Singh, Rajinder ^a   Smuder, Ashley J ^b   Wiggs, Michael P ^b   Kwon, Oh Sung ^b   Sollanek, Kurt J ^b   Powers, Scott K ^b   Masuda, Esteban S ^a   Taylor, Vanessa C ^a   Payan, Donald G ^a   Kinoshita, Taisei ^a   Kinsella, Todd M ^a   more..

^a RIGEL PHARMACEUTICALS INC   (United States)

^b UNIVERSITY OF FLORIDA   (United States)

Author keywords

Mitochondria; Muscle wasting; Oxidative stress; STAT3

Indexed keywords

CYCLINE; HISTONE H3; INTERLEUKIN 6; JANUS KINASE 1; JANUS KINASE 3; JANUS KINASE INHIBITOR; LACTATE DEHYDROGENASE; MESSENGER RNA; MYOGENIC FACTOR 5; MYOGENIN; R 545; SERINE; STAT3 PROTEIN; SUPPRESSOR OF CYTOKINE SIGNALING 3; TUBULIN; TYROSINE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; ARTIFICIAL VENTILATION; CONTROLLED STUDY; DIAPHRAGM DISEASE; DIAPHRAGM MUSCLE; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; MALE; MITOCHONDRIAL RESPIRATION; MITOCHONDRION; MUSCLE ATROPHY; MUSCLE CONTRACTILITY; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT; WESTERN BLOTTING;

MITOCHONDRIA; MUSCLE WASTING; OXIDATIVE STRESS; STAT3;

ANIMALS; DIAPHRAGM; INTERLEUKIN-6; JANUS KINASES; MALE; MITOCHONDRIA; MUSCLE WEAKNESS; MUSCULAR ATROPHY; OXIDATIVE STRESS; PHOSPHORYLATION; PROTEOLYSIS; RATS; RATS, SPRAGUE-DAWLEY; RESPIRATION, ARTIFICIAL; SERINE; SIGNAL TRANSDUCTION; STAT3 TRANSCRIPTION FACTOR; TYROSINE;

EID: 84903689122     PISSN: 08926638     EISSN: 15306860     Source Type: Journal    
DOI: 10.1096/fj.13-244210     Document Type: Article

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