FOXO1 inhibition yields functional insulin-producing cells in human gut organoid cultures

Nature Communications

Volumn 5, Issue , 2014, Pages

  Bouchi, Ryotaro ^a   Foo, Kylie S ^a,b   Hua, Haiqing ^a,b   Tsuchiya, Kyoichiro ^c   Ohmura, Yoshiaki ^a   Sandoval, P Rodrigo ^a   Ratner, Lloyd E ^a   Egli, Dieter ^a,b   Leibel, Rudolph L ^a   Accili, Domenico ^a  

^a Department of Medicine Columbia University College of Physicians and Surgns ^*  (United States)

^b New York Stem Cell Foundation Laboratory   (United States)

^c TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOREACTIVE INSULIN; SHORT HAIRPIN RNA; TRANSCRIPTION FACTOR FKHR; FORKHEAD TRANSCRIPTION FACTOR; FOXO1 PROTEIN, HUMAN; INSULIN;

DIABETES; DISEASE CONTROL; GENE EXPRESSION; HEALTH CARE; MUTATION; RNA; VIRUS;

ARTICLE; CYTOPLASM; ENZYME INHIBITION; HUMAN; IMMUNOCOMPETENT CELL; IMMUNOHISTOCHEMISTRY; INTESTINE; PANCREAS ISLET BETA CELL; PLURIPOTENT STEM CELL; PROTEIN LOCALIZATION; ANIMAL; CELL DIFFERENTIATION; CYTOLOGY; DOWN REGULATION; GASTROINTESTINAL TRACT; GENETICS; INDUCED PLURIPOTENT STEM CELL; METABOLISM; MOUSE; SECRETION (PROCESS);

ANIMALS; CELL DIFFERENTIATION; DOWN-REGULATION; FORKHEAD TRANSCRIPTION FACTORS; GASTROINTESTINAL TRACT; HUMANS; INDUCED PLURIPOTENT STEM CELLS; INSULIN; INSULIN-SECRETING CELLS; MICE; ORGANOIDS;

EID: 84903639116     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms5242     Document Type: Article

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