Metabolomics approach to assessing plasma 13- and 9-hydroxy-octadecadienoic acid and linoleic acid metabolite responses to 75-km cycling

American Journal of Physiology - Regulatory Integrative and Comparative Physiology

Volumn 307, Issue 1, 2014, Pages

  Nieman, David C ^a   Shanely, R Andrew ^a   Luo, Beibei ^b   Meaney, Mary Pat ^a   Dew, Dustin A ^a   Pappan, Kirk L ^c  

^a APPALACHIAN STATE UNIVERSITY   (United States)

^b SHANGHAI UNIVERSITY OF SPORT   (China)

^c METABOLON INC   (United States)

Author keywords

Exercise; Inflammation; Linoleate; Metabolites; Oxidative stress

Indexed keywords

13 HYDROXY OCTADECADIENOIC; 9 HYDROXY OCTADECADIENOIC; FATTY ACID; GRANULOCYTE COLONY STIMULATING FACTOR; INTERLEUKIN 10; INTERLEUKIN 6; INTERLEUKIN 8; ISOPROSTANE DERIVATIVE; LINOLEIC ACID; MONOCYTE CHEMOTACTIC PROTEIN 1; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ADULT; ARTICLE; BICYCLE; BICYCLE ERGOMETER; BLOOD SAMPLING; CLINICAL ARTICLE; CONTROLLED STUDY; CYCLING; EXERCISE; FATTY ACID BLOOD LEVEL; FATTY ACID METABOLISM; FATTY ACID OXIDATION; GAS CHROMATOGRAPHY; HUMAN; INFLAMMATION; LIQUID CHROMATOGRAPHY; MALE; MASS SPECTROMETRY; METABOLOMICS; OXIDATIVE STRESS; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

EXERCISE; INFLAMMATION; LINOLEATE; METABOLITES; OXIDATIVE STRESS;

ADULT; BICYCLING; BIOLOGICAL MARKERS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CYTOKINES; ENERGY METABOLISM; F2-ISOPROSTANES; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; HUMANS; INFLAMMATION MEDIATORS; LINOLEIC ACIDS; LINOLEIC ACIDS, CONJUGATED; MALE; METABOLOMICS; MIDDLE AGED; OXIDATION-REDUCTION; OXIDATIVE STRESS; PHYSICAL EXERTION; TANDEM MASS SPECTROMETRY; TIME FACTORS;

EID: 84903639094     PISSN: 03636119     EISSN: 15221490     Source Type: Journal    
DOI: 10.1152/ajpregu.00092.2014     Document Type: Article

References (39)

1. Bourdonck KJ, Mitchell MW, Nemet L, Keresztes L, Nyska A, Shinar D, Rosenstock M. Discovery of metabolomics biomarkers for early detection of nephrotoxicity. Toxicol Pathol 37: 280-291, 2009.
2. Collino S, Montoliu I, Martin FP, Scherer M, Mari D, Salvioli S, Bucci L, Ostan R, Monti D, Biagi E, Brigidi P, Franceschi C, Rezzi S. Metabolic signatures of extreme longevity in northern Italian centenarians reveal a complex remodeling of lipids, amino acids, and gut microbiota metabolism. PLos One 8: e56564, 2013.
3. Dandona P, Mohanty P, Ghanim H, Aljada A, Browne R, Hamouda W, Prabhala A, Afzal A, Garg R. The suppressive effect of dietary restriction and weight loss in the obese on the generation of reactive oxygen species by leukocytes, lipid peroxidation, and protein carbonylation. J Clin Endocrinol Metab 86: 355-362, 2001.
4. DeHaven CD, Evans AM, Dai H, Lawton KA. Organization of GC/MS and LC/MS metabolomics data into chemical libraries. J Cheminform 2: doi:10.1186/1758-2946-2-9, 2012.
5. Edwards LM, Lawler NG, Nikolic SB, Peters JM, Horne J, Wilson R, Davies NW, Sharman JE. Metabolomics reveals increased isoleukotoxin diol (12,13-DHOME) in human plasma after acute Intralipid infusion. J Lipid Res 53: 1979-1986, 2012.
6. Evans AM, DeHaven CD, Barrett T, Mitchell M, Milgram E. Integrated, nontargeted ultrahigh performance liquid chromatography/electrospray ionization tandem mass spectrometry platform for the identification and relative quantification of the small-molecule complement of biological systems. Anal Chem 81: 6656-6667, 2009.
7. Gaskins AJ, Rovner AJ, Mumford SL, Yeung E, Browne RW, Trevisan M, Perkins NJ, Wactawski-Wende J, Schisterman EF. Bio-Cycle study group. Adherence to a mediterranean diet and plasma concentrations of lipid peroxidation in premenopausal women. Am J Clin Nutr 92: 1461-1467, 2010.
8. Gomes EC, Silva AN, de Oliveira MR. Oxidants, antioxidants, and the beneficial roles of exercise-induced production of reactive species. Oxid Med Cell Longev 2012: 756132. doi:10.1155/2012/756132, 2012.
9. Halliwell KJ, Fielding BA, Samra JS, Humphreys SM, Frayn KN. Release of individual fatty acids from human adipose tissue in vivo after an overnight fast. J Lipid Res 37: 1842-1848, 1996.
10. Henricks PA, Engels F, van der Vliet H, Nijkamp FP. 9-and 13-hydroxy-linoleic acid possess chemotactic activity for bovine and human polymorphonuclear leukocytes. Prostaglandins 41: 21-27, 1991.
11. Horowitz JF. Fatty acid mobilization from adipose tissue during exercise. Trends Endocrinol Metab 14: 386-392, 2003.
12. Itoh T, Fairall L, Amin K, Inaba Y, Szanto A, Balint BL, Nagy L, Yamamoto K, Schwabe JW. Structural basis for the activation of PPARgamma by oxidized fatty acids. Nat Struct Mol Biol 15: 924-931, 2008.
13. Jacobs KA, Krauss RM, Fattor JA, Horning MA, Friedlander AL, Bauer TA, Hagobian TA, Wolfel EE, Brooks GA. Endurance training has little effect on active muscle free fatty acid, lipoprotein cholesterol, or triglyceride net balances. Am J Physiol Endocrinol Metab 291: E656-E665, 2006.
14. Jira W, Spiteller G, Carson W, Schramm A. Strong increase in hydroxy fatty acids derived from linoleic acid in human low density lipoproteins of atherosclerotic patients. Chem Phys Lipids 91: 1-11, 1998.
15. Kokatnur MG, Oalmann MC, Johnson WD, Malcom GT, Strong JP. Fatty acid composition of human adipose tissue from two anatomical sites in a biracial community. Am J Clin Nutr 32: 2198-2205, 1979.
16. Ku G, Thomas CE, Akeson AL, Jackson RL. Induction of interleukin 1 beta expression from human peripheral blood monocyte-derived macrophages by 9-hydroxyoctadecadienoic acid. J Biol Chem 267: 14183-14188, 1992.
17. Lehmann WD, Stephan M, Fürstenberger G. Profiling assay for lipoxygenase products of linoleic and arachidonic acid by gas chromatographymass spectrometry. Anal Biochem 204: 158-170, 1992.
18. 2-isoprostanes as a reliable index of oxidative stress in vivo using gas chromatography-mass spectrometry (GC-MS) method. Free Radic Biol Med 47: 1101-1107, 2009.
19. Markworth JF, Vella L, Lingard BS, Tull DL, Rupasinghe TW, Sinclair AJ, Maddipati KR, Cameron-Smith D. Human inflammatory and resolving lipid mediator responses to resistance exercise and ibuprofen treatment. Am J Physiol Regul Integr Comp Physiol 305: R1281-R1296, 2013.
20. Nieman DC, Shanely RA, Gillitt ND, Pappan KL, Lila MA. Serum metabolic signatures induced by a three-day intensified exercise period persist after 14 h of recovery in runners. J Proteome Res 12: 4577-4584, 2013.
21. Niki E. Biomarkers of lipid peroxidation in clinical material. Biochim Biophys Acta 1840: 809-817, 2014.
22. 2-isoprostane formation, measurement and interpretation: the role of exercise. Prog Lipid Res 50: 89-103, 2011.
23. O'Flaherty JT, Wooten RE, Samuel MP, Thomas MJ, Levine EA, Case LD, Akman SA, Edwards IJ. Fatty acid metabolites in rapidly proliferating breast cancer. PLos One 8: e63076, 2013.
24. Ogawa E, Owada Y, Ikawa S, Adachi Y, Egawa T, Nemoto K, Suzuki K, Hishinuma T, Kawashima H, Kondo H, Muto M, Aiba S, Okuyama R. Epidermal FABP (FABP5) regulates keratinocyte differentiation by 13(S)-HODE-mediated activation of the NF-κB signaling pathway. J Invest Dermatol 131: 604-612, 2011.
25. Pasman WJ, van Erk MJ, Klöpping WA, Pellis L, Wopereis S, Bijlsma S, Hendriks HF, Kardinaal AF. Nutrigenomics approach elucidates health-promoting effects of high vegetable intake in lean and obese men. Genes Nutr 8: 507-521, 2013.
26. Powers SK, Jackson MJ. Exercise-induced oxidative stress: cellular mechanisms and impact on muscle force production. Physiol Rev 88: 1243-1276, 2008.
27. Powers SK, Nelson WB, Hudson MB. Exercise-induced oxidative stress in humans: cause and consequences. Free Radic Biol Med 51: 942-950, 2011.
28. Rago B, Fu C. Development of a high-throughput ultra performance liquid chromatography-mass spectrometry assay to profile 18 eicosanoids as exploratory biomarkers for atherosclerotic diseases. J Chromatogr B Analyt Technol Biomed Life Sci 936: 25-32, 2013.
29. Ramsden CE, Ringel A, Feldstein AE, Taha AY, MacIntosh BA, Hibbeln JR, Majchrzak-Hong SF, Faurot KR, Rapoport SI, Cheon Y, Chung YM, Berk M, Mann JD. Lowering dietary linoleic acid reduces bioactive oxidized linoleic acid metabolites in humans. Prostaglandins Leukot Essent Fatty Acids 87: 135-141, 2012.
30. Roberts LJ, Milne GL. Isoprostanes. J Lipid Res 50, Suppl: S219-S223, 2009.
31. Sisemore MF, Zheng J, Yang JC, Thompson DA, Plopper CG, Cortopassi GA, Hammock BD. Cellular characterization of leukotoxin diolinduced mitochondrial dysfunction. Arch Biochem Biophys 392: 32-37, 2001.
32. Spindler SA, Clark KS, Callewaert DM, Reddy RG. Significance and immunoassay of 9-and 13-hydroxyoctadecadienoic acids. Biochem Biophys Res Commun 218: 187-191, 1996.
33. Spiteller G. Linoleic acid peroxidation-the dominant lipid peroxidation process in low density lipoprotein-and its relationship to chronic diseases. Chem Phys Lipids 95: 105-162, 1998.
34. Storey JD, Tibshirani R. Statistical significance for genomewide studies. Proc Natl Acad Sci USA 100: 9440-9445, 2003.
35. Terkeltaub R, Banka CL, Solan J, Santoro D, Brand K, Curtiss LK. Oxidized LDL induces monocytic cell expression of interleukin-8, a chemokine with T-lymphocyte chemotactic activity. Arterioscler Thromb 14: 47-53, 1994.
36. Thompson DA, Hammock BD. Dihydroxyoctadecamonoenoate esters inhibit the neutrophil respiratory burst. J Biosci 32: 279-291, 2007.
37. Vangaveti V, Baune BT, Kennedy RL. Hydroxyoctadecadienoic acids: novel regulators of macrophage differentiation and atherogenesis. Ther Adv Endocrinol Metab 1: 51-60, 2010.
38. Viswanathan S, Hammock BD, Newman JW, Meerarani P, Toborek M, Hennig B. Involvement of CYP 2C9 in mediating the proinflammatory effects of linoleic acid in vascular endothelial cells. J Am Coll Nutr 22: 502-510, 2003.
39. Yoshida Y, Kodai S, Takemura S, Minamiyama Y, Niki E. Simultaneous measurement of F2-isoprostane, hydroxyoctadecadienoic acid, hydroxyeicosatetraenoic acid, and hydroxycholesterols from physiological samples. Anal Biochem 379: 105-115, 2008.