L-ascorbate attenuates the endotoxin-induced production of inflammatory mediators by inhibiting MAPK activation and NF- κB translocation in cortical neurons/glia cocultures

PLoS ONE

Volumn 9, Issue 7, 2014, Pages

  Huang, Ya Ni ^a   Lai, Chien Cheng ^b   Chiu, Chien Tsai ^c   Lin, Jhen Jhe ^d   Wang, Jia Yi ^d  

^a Hsin Sheng College of Medicine Care and Management   (Taiwan)

^b FAR EASTERN MEMORIAL HOSPITAL   (Taiwan)

^c EN CHU KONG HOSPITAL   (Taiwan)

^d TAIPEI MEDICAL UNIVERSITY   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; ASCORBIC ACID; BACTERIUM LIPOPOLYSACCHARIDE; CXCL2 CHEMOKINE; I KAPPA B ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 6; MACROPHAGE INFLAMMATORY PROTEIN 2; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; NITRIC OXIDE; ANTIOXIDANT; LIPOPOLYSACCHARIDE;

ANIMAL CELL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; ASTROCYTE; BRAIN CELL; COCULTURE; COMBINATION CHEMOTHERAPY; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; GLIA CELL; INTRACELLULAR SIGNALING; MICROGLIA; MONOTHERAPY; NERVE CELL CULTURE; NERVOUS SYSTEM INFLAMMATION; NEWBORN; NONHUMAN; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN TRANSPORT; RAT; SIGNAL TRANSDUCTION; ANIMAL; BRAIN CORTEX; DRUG EFFECTS; GLIA; METABOLISM; NERVE CELL; PATHOLOGY; SPRAGUE DAWLEY RAT;

ANIMALS; ANTIOXIDANTS; ASCORBIC ACID; CEREBRAL CORTEX; COCULTURE TECHNIQUES; ENZYME ACTIVATION; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; LIPOPOLYSACCHARIDES; MAP KINASE SIGNALING SYSTEM; NEUROGLIA; NEURONS; NF-KAPPA B; PROTEIN TRANSPORT; RATS; RATS, SPRAGUE-DAWLEY;

EID: 84903624841     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0097276     Document Type: Article

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