Ischemic preconditioning improves oxygen saturation and attenuates hypoxic pulmonary vasoconstriction at high altitude

High Altitude Medicine and Biology

Volumn 15, Issue 2, 2014, Pages 155-161

  Foster, Gary P ^a   Giri, Paresh C ^b   Rogers, Douglas M ^b   Larson, Sophia R ^b   Anholm, James D ^a  

^a Jerry L Pettis Memorial VA Medical Center   (United States)

^b LOMA LINDA UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

arterial oxygen saturation; athletes at altitude; hypoxic pulmonary vasoconstriction

Indexed keywords

PLACEBO; BIOLOGICAL MARKER; OXYGEN;

ADULT; ALTITUDE; ARTERIAL OXYGEN SATURATION; ARTICLE; CONTROLLED STUDY; CROSSOVER PROCEDURE; EXERCISE; FEMALE; HUMAN; HUMAN EXPERIMENT; HYPOXIA; HYPOXIC LUNG VASOCONSTRICTION; ISCHEMIC PRECONDITIONING; LUNG ARTERY PRESSURE; LUNG PRESSURE; MALE; NORMAL HUMAN; OXYGEN SATURATION; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SYSTOLIC BLOOD PRESSURE; ALTITUDE DISEASE; ANOXIA; BLOOD; COMPLICATION; HYPERTENSION, PULMONARY; LUNG; MIDDLE AGED; OXIMETRY; SINGLE BLIND PROCEDURE; VASCULARIZATION; VASOCONSTRICTION;

ADULT; ALTITUDE; ALTITUDE SICKNESS; ANOXIA; BIOLOGICAL MARKERS; CROSS-OVER STUDIES; FEMALE; HEALTHY VOLUNTEERS; HUMANS; HYPERTENSION, PULMONARY; ISCHEMIC PRECONDITIONING; LUNG; MALE; MIDDLE AGED; OXIMETRY; OXYGEN; SINGLE-BLIND METHOD; VASOCONSTRICTION;

EID: 84903594499     PISSN: 15270297     EISSN: 15578682     Source Type: Journal    
DOI: 10.1089/ham.2013.1137     Document Type: Article

References (49)

1. Aaronson PI, Robertson TP, Knock GA, et al. (2006). Hypoxic pulmonary vasoconstriction: Mechanisms and controversies. J Physiol 570:53-58.
2. Albert TJ, and Swenson ER. (2014). Peripheral chemoreceptor responsiveness and hypoxic pulmonary vasoconstriction in humans. High Alt Med Biol 15:15-20.
3. Ali ZA, Callaghan CJ, Lim E, et al. (2007). Remote ischemic preconditioning reduces myocardial and renal injury after elective abdominal aortic aneurysm repair: A randomized controlled trial. Circulation 116:198-105.
4. Anholm JD, and Foster GP. (2011). Con: Hypoxic pulmonary vasoconstriction is not a limiting factor of exercise at high altitude. High Alt Med Biol 12:313-317.
5. Auchampach JA, Jin X, Moore J, et al. (2004). Comparison of three different A1 adenosine receptor antagonists on infarct size and multiple cycle ischemic preconditioning in anesthetized dogs. J Pharmacol Exp Ther 308:846-856.
6. Bailey DM, Dehnert C, Luks AM, et al. (2010). High-altitude pulmonary hypertension is associated with a free radical-mediated reduction in pulmonary nitric oxide bioavailability. J Physiol 588:4837-4847.
7. Balanos GM, Dorrington KL, and Robbins PA. (2002). Des-ferrioxamine elevates pulmonary vascular resistance in humans: Potential for involvement of HIF-1. J Appl Physiol 92:2501-2507.
8. Berger MM, Dehnert C, Bailey DM, et al. (2009). Transpul-monary plasma ET-1 and nitrite differences in high altitude pulmonary hypertension. High Alt Med Biol 10:17-24.
9. Birnbaum Y, Hale SL, and Kloner RA. (1997). Ischemic preconditioning at a distance: Reduction of myocardial infarct size by partial reduction of blood supply combined with rapid stimulation of the gastrocnemius muscle in the rabbit. Circulation 96:1641-1646.
10. Bolli R, Manchikalapudi S, Tang XL, Takano H, Qiu Y, Guo Y, Zhang Q, and Jadoon AK. (1997). The protective effect of late preconditioning against myocardial stunning in conscious rabbits is mediated by nitric oxide synthase. Evidence that nitric oxide acts both as a trigger and as a mediator of the late phase of ischemic preconditioning. Circ Res 81:1094-1107.
11. Botker HE, Kharbanda R, Schmidt MR, et al. (2010). Remote ischaemic conditioning before hospital admission, as a complement to angioplasty, and effect on myocardial salvage in patients with acute myocardial infarction: A randomised trial. Lancet 375:727-734.
12. Christie J, Sheldahl LM, Tristani FE, Sagar KB, Ptacin MJ, and Wann S. (1987). Determination of stroke volume and cardiac output during exercise: Comparison of two-dimensional and Doppler echocardiography, Fick oximetry, and thermodilu-tion. Circulation 76:539-547.
13. Connolly MJ, and Aaronson PI. (2010). Cell redox state and hypoxic pulmonary vasoconstriction: Recent evidence and possible mechanisms. Respir Physiol Neurobiol 174:165-174.
14. Dave KR, Saul I, Prado R, Busto R, and Perez-Pinzon MA. (2006). Remote organ ischemic preconditioning protect brain from ischemic damage following asphyxial cardiac arrest. Neurosci Lett 404:170-175.
15. Duplain H, Vollenweider L, Delabays A, Nicod P, Bartsch P, and Scherrer U. (1999). Augmented sympathetic activation during short-term hypoxia and high-altitude exposure in subjects susceptible to high-altitude pulmonary edema. Circulation 99:1713-1718.
16. Eckle T, Kohler D, Lehmann R, El Kasmi K, and Eltzschig HK. (2008). Hypoxia-inducible factor-1 is central to cardioprotection: A new paradigm for ischemic preconditioning. Circulation 118:166-175.
17. Faoro V, Boldingh S, Moreels M, et al. (2009). Bosentan decreases pulmonary vascular resistance and improves exercise capacity in acute hypoxia. Chest 135:1215-1222.
18. Foster GP, Westerdahl DE, Foster LA, Hsu JV, and Anholm JD. (2011). Ischemic preconditioning of the lower extremity attenuates the normal hypoxic increase in pulmonary artery systolic pressure. Respir Physiol Neurobiol 179:248-253.
19. Gho BC, Schoemaker RG, van den Doel MA, Duncker DJ, and Verdouw PD. (1996). Myocardial protection by brief ischemia in noncardiac tissue. Circulation 94:2193-2200.
20. Ghofrani HA, Reichenberger F, Kohstall MG, et al. (2004). Sildenafil increased exercise capacity during hypoxia at low altitudes and at Mount Everest base camp: A randomized, double-blind, placebo-controlled crossover trial. Ann Intern Med 141:169-177.
21. Hausenloy DJ, Mwamure PK, Venugopal V, et al. (2007). Effect of remote ischaemic preconditioning on myocardial injury in patients undergoing coronary artery bypass graft surgery: A randomised controlled trial. Lancet 370:575-579.
22. Hausenloy DJ, and Yellon DM. (2010). The second window of preconditioning (SWOP) where are we now? Cardiovasc Drugs Ther 24:235-254.
23. Hsu AR, Barnholt KE, Grundmann NK, Lin JH, McCallum SW, and Friedlander AL. (2006). Sildenafil improves cardiac output and exercise performance during acute hypoxia, but not normoxia. J Appl Physiol 100:2031-2040.
24. Jaberansari MT, Baxter GF, Muller CA, Latouf SE, Roth E, Opie LH, and Yellon DM. (2001). Angiotensin-converting enzyme inhibition enhances a subthreshold stimulus to elicit delayed preconditioning in pig myocardium. J Am Coll Car-diol 37:1996-2001.
25. Ketabchi F, Ghofrani HA, Schermuly RT, et al. (2012). Effects of hypercapnia and NO synthase inhibition in sustained hypoxic pulmonary vasoconstriction. Respir Res 13:7.
26. Kharbanda RK, Mortensen UM, White PA, et al. (2002). Transient limb ischemia induces remote ischemic preconditioning in vivo. Circulation 106:2881-2883.
27. Kitabatake A, Inoue M, Asao M, et al. (1983). Noninvasive evaluation of pulmonary hypertension by a pulsed Doppler technique. Circulation 68:302-309.
28. Marber MS, Latchman DS, Walker JM, and Yellon DM. (1993). Cardiac stress protein elevation 24 hours after brief ischemia or heat stress is associated with resistance to myocardial infarction. Circulation 88:1264-1272.
29. Mentzer RM, Jr, Rubio R, and Berne RM. (1975). Release of adenosine by hypoxic canine lung tissue and its possible role in pulmonary circulation. Am J Physiol 229:1625-1631.
30. Murry CE, Jennings RB, and Reimer KA. (1986). Preconditioning with ischemia: A delay of lethal cell injury in ischemic myocardium. Circulation 74:1124-1136.
31. Naeije R. (2010). Physiological adaptation of the cardiovascular system to high altitude. Prog Cardiovasc Dis 52:456-466.
32. Naeije R. (2011). Pro: Hypoxic pulmonary vasoconstriction is a limiting factor of exercise at high altitude. High Alt Med Biol 12:309-312.
33. Naeije R, Huez S, Lamotte M, Retailleau K, Neupane S, Abramowicz D, and Faoro V. (2010). Pulmonary artery pressure limits exercise capacity at high altitude. Eur Respir J 36:1049-1055.
34. Olfert IM, Loeckinger A, Treml B, et al. (2011). Sildenafil and bosentan improve arterial oxygenation during acute hypoxic exercise: A controlled laboratory trial. Wilderness Environ Med 22:211-221.
35. Przyklenk K, Bauer B, Ovize M, Kloner RA, and Whittaker P. (1993). Regional ischemic 'preconditioning' protects remote virgin myocardium from subsequent sustained coronary occlusion. Circulation 87:893-899.
36. Reeves JT, Groves BM, Sutton JR, et al. (1987). Operation Everest II: Preservation of cardiac function at extreme altitude. J Appl Physiol 63:531-539.
37. Rudski LG, Lai WW, Afilalo J, et al. (2010). Guidelines for the echocardiographic assessment of the right heart in adults: A report from the American Society of Echocardiography endorsed by the European Association of Echocardiography, a registered branch of the European Society of Cardiology, and the Canadian Society of Echocardiography. J Am Soc Echocardiogr 23:685-713.
38. Russell PC, Emery CJ, Cai YN, Barer GR, and Howard P. (1990). Enhanced reactivity to bradykinin, angiotensin I and the effect of captopril in the pulmonary vasculature of chronically hypoxic rats. Eur Respir J 3:779-785.
39. Shiva S, Huang Z, Grubina R, et al. (2007). Deoxymyoglobin is a nitrite reductase that generates nitric oxide and regulates mitochondrial respiration. Circ Res 100:654-661.
40. Sutton JR, and Houston CS. (1992). The Lake Louise Consensus on the Definition and Quantification of Altitude Illness. In: Hypoxia and Mountain Medicine. Sutton JR CG, Houston CS, ed. Queen City Printers, Burlington, Vermont.
41. Swenson ER. (2013). Hypoxic pulmonary vasoconstriction. High Alt Med Biol 14:101-110.
42. Sylvester JT, Shimoda LA, Aaronson PI, and Ward JP. (2012). Hypoxic pulmonary vasoconstriction. Physiol Rev 92:367-520.
43. Vanden Hoek TL, Becker LB, Shao Z, Li C, and Schumacker PT. (1998). Reactive oxygen species released from mitochondria during brief hypoxia induce preconditioning in cardiomyocytes. J Biol Chem 273:18092-18098.
44. Wagner PD. (1996). Determinants of maximal oxygen transport and utilization. Annu Rev Physiol 58:21-50.
45. Wagner PD. (2010). The physiological basis of reduced VO2-max in Operation Everest II. High Alt Med Biol 11:209-215.
46. Wagner PD, Sutton JR, Reeves JT, Cymerman A, Groves BM, and Malconian MK. (1987). Operation Everest II: Pulmonary gas exchange during a simulated ascent of Mt. Everest. J Appl Physiol 63:2348-2359.
47. Weyman A. (1994). Doppler Estimation of Volumetric Flow. In: Principles and Practice of Echocardiography. Weyman A, ed. Lea & Febiger, Malvern, Pennsylvania. pp 963.
48. Yellon DM, and Downey JM. (2003). Preconditioning the myocardium: From cellular physiology to clinical cardiology. Physiol Rev 83:1113-1151.
49. Yock PG, and Popp RL. (1984). Noninvasive estimation of right ventricular systolic pressure by Doppler ultrasound in patients with tricuspid regurgitation. Circulation 70:657-662.