The physiological basis of reduced V̇o2max in Operation Everest II

High Altitude Medicine and Biology

Volumn 11, Issue 3, 2010, Pages 209-215

  Wagner, Peter D ^a  

^a UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

Author keywords

cardiac output; diffusion; exercise; hypoxemia; ventilation

Indexed keywords

HEMOGLOBIN;

AIR CONDITIONING; ARTERIAL OXYGEN SATURATION; CAPILLARY FLOW; EXERCISE; HEART OUTPUT; HEMOGLOBIN BLOOD LEVEL; HYPOXIA; LUNG CIRCULATION; LUNG DIFFUSION; LUNG VENTILATION; MOUNTAINEERING; MUSCLE CAPILLARY; OXYGEN DIFFUSION; OXYGEN TRANSPORT; PRIORITY JOURNAL; REVIEW; TRANSPORT KINETICS; VENOUS OXYGEN TENSION;

ADAPTATION, PHYSIOLOGICAL; ALTITUDE; ANOXIA; HEMOGLOBINS; HUMANS; MOUNTAINEERING; NEPAL; OXYGEN CONSUMPTION; PHYSICAL ENDURANCE; PHYSICAL EXERTION; VENTRICULAR FUNCTION, LEFT;

EID: 77957727198     PISSN: 15270297     EISSN: None     Source Type: Journal    
DOI: 10.1089/ham.2009.1058     Document Type: Review

References (37)

1. Amann M., Eldridge M. W., Lovering A. T., Stickland M. K., Pegelow D. F., and Dempsey J. A. (2006). Arterial oxygenation influences central motor output and exercise performance via effects on peripheral locomotor muscle fatigue in humans. J. Physiol. 575:937-952.
2. 2 independent of ventilatory acclimatization at 4, 300 m. J. Appl. Physiol. 66:2733-2738.
3. Bogaard H. J., Hopkins S. R., Yamaya Y., Niizeki K., Ziegler M. G., and Wagner P. D. (2002). Role of the autonomic nervous system in the reduced maximal cardiac output at altitude. J. Appl. Physiol. 93:271-279.
4. Boushel R., Radegran G., Calbet J. A. L., Sondergaard H., Wagner P. D., and Saltin B. (2001). Parasympathetic neural activity accounts for the lowering of exercise heart rate at high altitude. Circulation. 104:1785-1791.
5. Calbet J. A., Lundby C., Sander M., Robach P., Saltin B., and Boushel R. (2006). Effects of ATP-induced leg vasodilation on VO2 peak and leg O2 extraction during maximal exercise in humans. Am. J. Physiol. Reg. Int. Comp. Physiol. 91:447-R453.
6. Calbet J. A. L., Boushel R., Radegran G., Sondergaard H., Wagner P. D., and Saltin B. (2003). Why is VO2max after acclimatization still reduced despite normalization of arterial O2 content? Am. J. Physiol. 84:304-R316.
7. Calbet J. A. L., and Lundby C. (2009). Air to muscle O2 delivery during exercise at altitude. High Alt. Med. Biol. 10:123-134.
8. Calbet J. A. L., Radegran G., Boushel R., Sondergaard H., Saltin B., and Wagner P. D. (2002). Effect of blood haemoglobin on VO2MAX and cardiovascular function in lowlanders acclimatized to 5260 m. J. Physiol. 545:715-728.
9. Cymerman A., Reeves J. T., Sutton J. R., Rock P. B., Groves B. M., Malconian M. K., Young P. M., Wagner P. D., and Houston C. S. (1989). Operation Everest II: maximal oxygen uptake at extreme altitude. J. Appl. Physiol. 66:2446-2453.
10. 2 delivery in dog muscle in situ. J. Appl. Physiol. 70:2656-2662.
11. Houston C. S., Sutton J. R., Cymerman A., and Reeves J. T. (1987). Operation Everest II: man at extreme altitude. J. Appl. Physiol. 63:877-882.
12. Klausen K. (1966). Cardiac output in man in rest and work during and after acclimatization to 3, 800 m. J. Appl. Physiol. 21:609-616.
13. Lundby C., Boushel R., Robach P., Moller K., Saltin B., and Calbet J. A. (2008). During hypoxic exercise some vasoconstriction is needed to match O2 delivery with O2 demand at the microcirculatory level. J. Physiol. 586:123-130.
14. Lundby C., Thomsen J. J., Boushel R., Koskolou M., Warberg J., Calbet J. A., and Robach P. (2007). Erythropoietin treatment elevates haemoglobin concentration by increasing red cell volume and depressing plasma volume. J. Physiol. 578:309-314.
15. Moore L. G., Cymerman A., Shao-Yung H., McCullough R. E., McCullough R. G., Rock P. B., Young A., Young P. M., Bloedow D., Weil J. V., and Reeves J. T. (1986). Propranolol does not impair exercise oxygen uptake in normal men at high altitude. J. Appl. Physiol. 61:1935-1941.
16. Piiper J., and Scheid P. (1981). Model for capillary-alveolar equilibration with special reference to O2 uptake in hypoxia. Respir. Physiol. 46:193-208.
17. Reeves J. T., Groves B. M., Sutton J. R., Wagner P. D., Cymerman A., Malconian M. K., Rock P. B., Young P. M., and Houston C. S. (1987). Operation Everest II: preservation of cardiac function at extreme altitude. J. Appl. Physiol. 63:531-539.
18. Richardson R. S., Haseler L. J., Nygren A. T., Bluml S., and Frank L. R. (2001). Local perfusion and metabolic demand during exercise: a noninvasive MRI method of assessment. J. Appl. Physiol. 91:1845-1853.
19. Richardson R. S., Noyszewski E. A., Kendrick K. F., Leigh J. S., and Wagner P. D. (1995). Myoglobin O2 desaturation during exercise: evidence of limited O2 transport. J. Clin. Invest. 96:1916-1926.
20. 2 delivery in dog muscle in situ. J. Appl. Physiol. 84:995-1002.
21. Robach P., Calbet J. A. L., Thomsen J. J., Boushel R., Mollard P., Rasmussen P., and Lundby C. (2008). The ergogenic effect of recombinant human erythropoietin on VO2max depends on the severity of arterial hypoxemia. PLoS One: 2996.
22. Roca J., Hogan M. C., Story D., Bebout D. E., Haab P., Gonzalez R., Ueno O., and Wagner P. D. (1989). Evidence for tissue diffusion limitation of VO2max in normal humans. J. Appl. Physiol. 67:291-299.
23. Sarnquist F., Schoene R., Hackett P., and Townes B. (1986). Hemodilution of polycythemic mountaineers: Effects of relative polycythemia. Aviat. Space Environ. Med. 57:313-317.
24. Schaffartzik W., Barton E. D., Poole D. C., Tsukimoto K., Hogan M. C., Bebout D. E., and Wagner P. D. (1993). Effect of reduced hemoglobin concentration on leg oxygen uptake during maximal exercise in humans. J. Appl. Physiol. 75:491-498.
25. Scott G. R., and Milsom W. K. (2006). Flying high: a theoretical analysis of the factors limiting exercise performances in birds at altitude. Respir. Physiol. Neurobiol. 154:284-301.
26. Sutton J. R., Reeves J. T., Wagner P. D., Groves B. M., Cymerman A., Malconian M. K., Rock P. B., Young P. M., Walter S. D., and Houston C. S. (1988). Operation Everest II: oxygen transport during exercise at extreme simulated altitude. J. Appl. Physiol. 64:1309-1321.
27. Tufts D. A., Haas J. D., Beard J. L., and Spielvogel H. (1985). Distribution of hemoglobin and functional consequences of anemia in adult males at high altitude. Am. J. Clin. Nutr. 42:1-11.
28. 2max. Respir. Physiol. 93:221-237.
29. 2max at sea level and altitude. Respir. Physiol. 106:329-343.
30. Wagner P. D. (2001). Gas exchange. In: High Altitude: An Exploration of Human Adaptation. T. F. Hornbein and R. B. Schoene, ed. Marcel Dekker, New York; p. 199-234.
31. Wagner P. D., Gale G. E., Moon R. E., Torre-Bueno J. R., Stolp W. B., and Saltzman H. A. (1986). Pulmonary gas exchange in humans exercising at sea level and simulated altitude. J. Appl. Physiol. 61:260-270.
32. Wagner P. D., Sutton J. R., Reeves J. T., Cymerman A., Groves B. M., and Malconian M. K. (1987). Operation Everest II: pulmonary gas exchange during a simulated ascent of Mt. Everest. J. Appl. Physiol. 63:2348-2359.
33. Weibel, E. R. (1984). The Pathway for Oxygen. Structure and Function in the Mammalian Respiratory System. Harvard University Press, Cambridge, MA.
34. West, J. B. (1998). High Life: A History of High-Altitude Physiology and Medicine, 1st ed. Oxford University Press, New York; 60 p.
35. West J. B., Lahiri S., Maret K. H., Peters R. M., and Pizzo P. J. (1983). Barometric pressures at extreme altitudes on Mt. Everest: physiological significance. J. Appl. Physiol. 54:1188-1194.
36. West J. B., and Wagner P. D. (1980). Predicted gas exchange on the summit of Mt. Everest. Respir. Physiol. 42:1-16.
37. 2 transport in high altitude polycythemia. J. Appl. Physiol. 59:1495-1502.