Transpulmonary plasma ET-1 and nitrite differences in high altitude pulmonary hypertension

High Altitude Medicine and Biology

Volumn 10, Issue 1, 2009, Pages 17-24

  Berger, Marc M ^a   Dehnert, Christoph ^a   Bailey, Damian M ^b   Luks, Andrew M ^c   Menold, Elmar ^a   Castell, Christian ^a   Schendler, Guido ^a   Faoro, Vitalie ^d   Mairbäurl, Heimo ^a   Bärtsch, Peter ^a   Swenson, Erik R ^c  

^a UNIVERSITY OF HEIDELBERG   (Germany)

^b UNIVERSITY OF GLAMORGAN   (United Kingdom)

^c UNIVERSITY OF WASHINGTON   (United States)

^d FREE UNIVERSITY OF BRUSSELS   (Belgium)

Author keywords

Edema; Endothelin 1; HAPE; Hypoxemia; Nitric oxide

Indexed keywords

DEXAMETHASONE; ENDOTHELIN 1; IBUPROFEN; NIFEDIPINE; NITRIC OXIDE; NITRITE; PARACETAMOL;

ADULT; ALTITUDE; ALTITUDE DISEASE; ARTERIAL BLOOD; ARTERY CATHETER; ARTICLE; BIOAVAILABILITY; BLOOD GAS ANALYSIS; BLOOD SAMPLING; CENTRAL VEIN; CENTRAL VENOUS CATHETER; FEMALE; HIGH ALTITUDE PULMONARY HYPERTENSION; HUMAN; LUNG ARTERY PRESSURE; LUNG BLOOD FLOW; MALE; MOUNTAINEERING; NORMAL HUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN TRANSPORT; PULMONARY HYPERTENSION; RADIAL ARTERY; REDUCTION; SYSTOLIC BLOOD PRESSURE; VASOCONSTRICTION; VENOUS BLOOD;

ADULT; ALTITUDE; ANOXIA; BLOOD GAS ANALYSIS; ENDOTHELIN-1; FEMALE; HUMANS; HYPERTENSION, PULMONARY; LUNG; MALE; MOUNTAINEERING; NITRITES; OXYGEN; SYSTOLE;

EID: 62549151304     PISSN: 15270297     EISSN: None     Source Type: Journal    
DOI: 10.1089/ham.2008.1053     Document Type: Article

References (29)

1. Allemann Y., Sartori C., Lepori M., Pierre S., Melot C., Naeije R., Scherrer U., and Maggiorini M. (2000). Echocardiographic and invasive measurements of pulmonary artery pressure correlate closely at high altitude. Am. J. Physiol. Heart Circ. Physiol. 279:H2013-2016.
2. Bärtsch P., Bailey D.M., Berger M.M., Knauth M., and Baumgartner R.W. (2004). Acute mountain sickness: controversies and advances. High Alt. Med. Biol. 5:110-124.
3. Berger M.M., Hesse C., Dehnert C., Siedler H., Kleinbongard P., Bardenheuer H.J., Kelm M., Bärtsch P., and Haefeli W.E. (2005). Hypoxia impairs systemic endothelial function in individuals prone to high-altitude pulmonary edema. Am. J. Respir. Crit. Care Med. 172:763-767.
4. Blood A.B., and Power G.G. (2007). In vitro and in vivo kinetic handling of nitrite in blood: effects of varying hemoglobin oxygen saturation. Am. J. Physiol. Heart Circ. Physiol. 293:H1508-1517.
5. Busch T., Bärtsch P., Pappert D., Grünig E., Hildebrandt W., Elser H., Falke K.J., and Swenson E.R. (2001). Hypoxia decreases exhaled nitric oxide in mountaineers susceptible to high-altitude pulmonary edema. Am. J. Respir. Crit. Care Med. 163:368-373.
6. Cicinelli E., Ignarro L.J., Schonauer L.M., Matteo M.G., Galantino P., and Falco N. (1999). Different plasma levels of nitric oxide in arterial and venous blood. Clin. Physiol. 19:440-442.
7. Corsten S.A., van Dijk B., Bakker N.C., de Lange J.J., and Scheffer G.J. (1994). Central venous catheter placement using the ECG-guided Cavafix-Certodyn SD catheter. J. Clin. Anesthesiol. 6:469-472.
8. Cosby K., Partovi K.S., Crawford J.H., Patel R.P., Reiter C.D., Martyr S., Yang B.K., Waclawiw M.A., Zalos G., Xu X., Huang K.T., Shields H., Kim-Shapiro D.B., Schechter A.N., Cannon R.O., 3rd, and Gladwin M.T. (2003). Nitrite reduction to nitric oxide by deoxyhemoglobin vasodilates the human circulation. Nat. Med. 9:1498-1505.
9. 2 gradients. Proc. Natl. Acad. Sci. U S A. 102:5709-5714.
10. Duplain H., Sartori C., Lepori M., Egli M., Allemann Y., Nicod P., and Scherrer U. (2000). Exhaled nitric oxide in high-altitude pulmonary edema: role in the regulation of pulmonary vascular tone and evidence for a role against inflammation. Am. J. Respir. Crit. Care Med. 162:221-224.
11. Dupuis J., Cernacek P., Tardif J.C., Stewart D.J., Gosselin G., Dyrda I., Bonan R., and Crepeau J. (1998). Reduced pulmonary clearance of endothelin-1 in pulmonary hypertension. Am. Heart J. 135:614-620.
12. Erzurum S.C., Ghosh S., Janocha A.J., Xu W., Bauer S., Bryan N.S., Tejero J., Hemann C., Hille R., Stuehr D.J., Feelisch M., and Beall C.M. (2007). Higher blood flow and circulating NO products offset high-altitude hypoxia among Tibetans. Proc. Natl. Acad. Sci. U S A. 104:17593-17598.
13. Gladwin M.T., Schechter A.N., Kim-Shapiro D.B., Patel R.P., Hogg N., Shiva S., Cannon R.O., 3rd, Kelm M., Wink D.A., Espey M.G., Oldfield E.H., Pluta R.M., Freeman B.A., Lancaster J.R., Jr., Feelisch M., and Lundberg J.O. (2005). The emerging biology of the nitrite anion. Nat. Chem. Biol. 1:308-314.
14. Gladwin M.T., Shelhamer J.H., Schechter A.N., Pease-Fye M.E., Waclawiw M.A., Panza J.A., Ognibene F.P., and Cannon R.O., 3rd. (2000). Role of circulating nitrite and S-nitrosohemoglobin in the regulation of regional blood flow in humans. Proc. Natl. Acad. Sci. U.S A. 97:11482-11487.
15. Goerre S., Wenk M., Bärtsch P., Lüscher T.F., Niroomand F., Hohenhaus E., Oelz O., and Reinhart, W.H. (1995). Endothelin-1 in pulmonary hypertension associated with high-altitude exposure. Circulation. 91:359-364.
16. Kleinbongard P., Dejam A., Lauer T., Rassaf T., Schindler A., Picker O., Scheeren T., Godecke A., Schrader J., Schulz R., Heusch G., Schaub G.A., Bryan N.S., Feelisch M., and Kelm M. (2003). Plasma nitrite reflects constitutive nitric oxide synthase activity in mammals. Free Radical Biol. Med. 35:790-796.
17. Kleinbongard P., Rassaf T., Dejam A., Kerber S., and Kelm M. (2002). Griess method for nitrite measurement of aqueous and protein-containing samples. Methods Enzymol. 359:158-168.
18. Lang C.C., Karlin P., Haythe J., Tsao L., and Mancini D.M. (2007). Ease of noninvasive measurement of cardiac output coupled with peak VO2 determination at rest and during exercise in patients with heart failure. Am. J. Cardiol. 99:404-405.
19. Maggiorini M., Brunner-La Rocca H.P., Peth S., Fischler M., Bohm T., Bernheim A., Kiencke S., Bloch K.E., Dehnert C., Naeije R., Lehmann T., Bärtsch P., and Mairbäurl H. (2006). Both tadalafil and dexamethasone may reduce the incidence of high-altitude pulmonary edema: a randomized trial. Ann. Intern. Med. 145:497-506.
20. Modesti P.A., Vanni S., Morabito M., Modesti A., Marchetta M., Gamberi T., Sofi F., Savia G., Mancia G., Gensini G.F., and Parati G. (2006). Role of endothelin-1 in exposure to high altitude: Acute Mountain Sickness and Endothelin-1 (ACME-1) study. Circulation. 114:1410-1416.
21. Morrell N.W., Nijran K.S., Biggs T., and Seed W.A. (1995). Magnitude and time course of acute hypoxic pulmonary vasoconstriction in man. Respir. Physiol. 100:271-281.
22. Rassaf T., Heiss C., Hendgen-Cotta U., Balzer J., Matern S., Kleinbongard P., Lee A., Lauer T., and Kelm M. (2006). Plasma nitrite reserve and endothelial function in the human forearm circulation. Free Radical Biol. Med. 41:295-301.
23. Shaw S.G., Schmid M., and Casty A. (2000). Critical factors in the radioimmunoassay of endothelin-1, endothelin-3, and big endothelin-1 in human plasma. Ann. Biochem. 278:143-149.
24. Swenson E.R., Maggiorini M., Mongovin S., Gibbs J.S., Greve I., Mairbäurl H., and Bärtsch P. (2002). Pathogenesis of high-altitude pulmonary edema: inflammation is not an etiologic factor. JAMA. 287:2228-2235.
25. Tanigawa K., Bellomo R., Kellum J.A., Kim Y.M., Zar H., Lancaster J.R., Jr., Pinsky M.R., and Ondulick B. (1999). Nitric oxide metabolism in canine sepsis: relation to regional blood flow. J. Crit. Care 14:186-190.
26. Wagner O.F., Christ G., Wojta J., Vierhapper H., Parzer S., Nowotny P.J., Schneider B., Waldhausl, W., and Binder, B.R. (1992). Polar secretion of endothelin-1 by cultured endothelial cells. J. Biol. Chem. 267:16066-16068.
27. Wilkens, H., Bauer M., Forestier N., Konig J., Eichler A., Schneider S., Schafers H.J., and Sybrecht G.W. (2003). Influence of inhaled iloprost on transpulmonary gradient of big endothelin in patients with pulmonary hypertension. Circulation. 107:1509-1513.
28. Wu, T. and Kayser, B. (2006). High altitude adaptation in Tibetans. High Alt. Med. Biol. 7:193-208.
29. Yoshibayashi, M. Nishioka, K., Nakao, K., Saito, Y., Matsumura, M., Ueda, T., Temma, S., Shirakami, G., Imura, H. and Mikawa, H. (1991). Plasma endothelin concentrations in patients with pulmonary hypertension associated with congenital heart defects. Evidence for increased production of endothelin in pulmonary circulation. Circulation. 84:2280-2285.