Early epigenetic downregulation of WNK2 kinase during pancreatic ductal adenocarcinoma development

Oncogene

Volumn 33, Issue 26, 2014, Pages 3401-3410

  Dutruel, C ^a   Bergmann, F ^b   Rooman, I ^c   Zucknick, M ^a   Weichenhan, D ^a   Geiselhart, L ^a   Kaffenberger, T ^a   Rachakonda, P S ^a   Bauer, A ^a   Giese, N ^d   Hong, C ^e   Xie, H ^a   Costello, J F ^e   Hoheisel, J ^a   Kumar, R ^a   Rehli, M ^f   Schirmacher, P ^b   Werner, J ^d   Plass, C ^a   Popanda, O ^a   Schmezer, P ^a   more..

^a GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^b UNIVERSITY HOSPITAL HEIDELBERG   (Germany)

^c GARVAN INSTITUTE OF MEDICAL RESEARCH   (Australia)

^d UNIVERSITY OF HEIDELBERG   (Germany)

^e UNIVERSITY OF CALIFORNIA   (United States)

^f UNIVERSITY HOSPITAL REGENSBURG   (Germany)

Author keywords

chronic pancreatitis; CpG island methylation; genome wide screen; pancreatic cancer; pancreatic intraepithelial neoplasia

Indexed keywords

MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHOTRANSFERASE; UNCLASSIFIED DRUG; WNK2 KINASE; PROTEIN SERINE THREONINE KINASE; WNK2 PROTEIN, HUMAN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER PATIENT; CELL GROWTH ASSAY; CELL PROLIFERATION; CHRONIC PANCREATITIS; CONTROLLED STUDY; CPG ISLAND; DEMETHYLATION; DNA METHYLATION; DOWN REGULATION; EPIGENETICS; GENE OVEREXPRESSION; GENE SILENCING; HUMAN; HUMAN CELL; HUMAN TISSUE; MOUSE; NONHUMAN; PANCREAS ADENOCARCINOMA; PANCREAS ADENOMA; PATHOGENESIS; PRIORITY JOURNAL; PROMOTER REGION; TISSUE MICROARRAY; TUMOR SUPPRESSOR GENE; WNK2 GENE; ANIMAL; BIOSYNTHESIS; DNA MICROARRAY; FEMALE; GENE EXPRESSION REGULATION; GENETIC EPIGENESIS; GENETICS; MALE; PANCREAS CARCINOMA; PANCREAS TUMOR; PATHOLOGY; TRANSGENIC MOUSE; TUMOR CELL LINE;

ANIMALS; CARCINOMA, PANCREATIC DUCTAL; CELL LINE, TUMOR; CELL PROLIFERATION; CPG ISLANDS; DNA METHYLATION; DOWN-REGULATION; EPIGENESIS, GENETIC; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MALE; MICE; MICE, TRANSGENIC; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PANCREATIC NEOPLASMS; PANCREATITIS, CHRONIC; PROMOTER REGIONS, GENETIC; PROTEIN-SERINE-THREONINE KINASES; RNA, MESSENGER;

EID: 84903594134     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/onc.2013.312     Document Type: Article

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