Leptin in chronic kidney disease: A link between hematopoiesis, bone metabolism, and nutrition

International Urology and Nephrology

Volumn 46, Issue 6, 2014, Pages 1169-1174

  Zhang, Jingjing ^a   Wang, Ningning ^a  

^a NANJING MEDICAL UNIVERSITY   (China)

Author keywords

Bone metabolism; Chronic kidney disease; Hematopoiesis; Leptin; Nutrition

Indexed keywords

CINACALCET; LEPTIN; LEPTIN RECEPTOR; OBRA RECEPTOR; OBRB RECEPTOR; OBRC RECEPTOR; OBRD RECEPTOR; OBRE RECEPTOR; OBRF RECEPTOR; UNCLASSIFIED DRUG; VITAMIN D;

BONE METABOLISM; CHRONIC KIDNEY DISEASE; HEMATOPOIESIS; HORMONE BLOOD LEVEL; HUMAN; KIDNEY GRAFT; NUTRITION; REVIEW; UREMIA; ANEMIA; BLOOD; BONE; BONE DISEASES, METABOLIC; CHRONIC KIDNEY FAILURE; COMPLICATION; DYSLIPIDEMIAS; MALNUTRITION; METABOLISM; NUTRITIONAL STATUS; PHYSIOLOGY;

ANEMIA; BONE AND BONES; BONE DISEASES, METABOLIC; DYSLIPIDEMIAS; HEMATOPOIESIS; HUMANS; LEPTIN; MALNUTRITION; NUTRITIONAL STATUS; RECEPTORS, LEPTIN; RENAL INSUFFICIENCY, CHRONIC;

EID: 84903588184     PISSN: 03011623     EISSN: 15732584     Source Type: Journal    
DOI: 10.1007/s11255-013-0623-8     Document Type: Review

References (56)

1. National Kidney F (2002) K/DOQI clinical practice guidelines for chronic kidney disease: evaluation, classification, and stratification. Am J Kidney Dis Off J Natl Kidney Found 39:S1-266
2. John R, Webb M, Young A, Stevens PE (2004) Unreferred chronic kidney disease: a longitudinal study. Am J Kidney Dis Off J Natl Kidney Found 43:825-835 (Pubitemid 38529620)
3. Eustace JA, Astor B, Muntner PM, Ikizler TA, Coresh J (2004) Prevalence of acidosis and inflammation and their association with low serum albumin in chronic kidney disease. Kidney Int 65:1031-1040 (Pubitemid 38251079)
4. Xue JL, St Peter WL, Ebben JP, Everson SE, Collins AJ (2002) Anemia treatment in the pre-ESRD period and associated mortality in elderly patients. Am J Kidney Dis Off J Natl Kidney Found 40:1153-1161 (Pubitemid 35403126)
5. Briley LP, Szczech LA (2006) Leptin and renal disease. Semin Dial 19:54-59 (Pubitemid 43479011)
6. Auwerx J, Staels B (1998) Leptin. Lancet 351:737-742 (Pubitemid 28106955)
7. Cock TA, Auwerx J (2003) Leptin: cutting the fat off the bone. Lancet 362:1572-1574
8. Zhang Y, Proenca R, Maffei M, Barone M, Leopold L, Friedman JM (1994) Positional cloning of the mouse obese gene and its human homologue. Nature 372:425-432 (Pubitemid 24365442)
9. Reseland JE, Syversen U, Bakke I, Qvigstad G, Eide LG, Hjertner O, Gordeladze JO, Drevon CA (2001) Leptin is expressed in and secreted from primary cultures of human osteoblasts and promotes bone mineralization. J Bone Miner Res Off J Am Soc Bone Miner Res 16:1426-1433 (Pubitemid 32675194)
10. Mutabaruka MS, Aoulad Aissa M, Delalandre A, Lavigne M, Lajeunesse D (2010) Local leptin production in osteoarthritis subchondral osteoblasts may be responsible for their abnormal phenotypic expression. Arthritis Res Ther 12:R20
11. Taichman RS, Hauschka PV (1992) Effects of interleukin-1 beta and tumor necrosis factor-alpha on osteoblastic expression of osteocalcin and mineralized extracellular matrix in vitro. Inflammation 16:587-601
12. Laharrague P, Larrouy D, Fontanilles AM, Truel N, Campfield A, Tenenbaum R, Galitzky J, Corberand JX, Penicaud L, Casteilla L (1998) High expression of leptin by human bone marrow adipocytes in primary culture. FASEB J Off Publ Fed Am Soc Exp Biol 12:747-752 (Pubitemid 28247154)
13. Barreto FC, Barreto DV, Liabeuf S, Drueke TB, Massy ZA (2009) Effects of uremic toxins on vascular and bone remodeling. Semin Dial 22:433-437
14. Margetic S, Gazzola C, Pegg GG, Hill RA (2002) Leptin: a review of its peripheral actions and interactions. Int J Obes Rel Metab Disord J Int Assoc Study Obes 26:1407-1433 (Pubitemid 36007818)
15. Dalamaga M, Chou SH, Shields K, Papageorgiou P, Polyzos SA, Mantzoros CS (2013) Leptin at the intersection of neuroendocrinology and metabolism: current evidence and therapeutic perspectives. Cell Metab 18:29-42
16. Mak RH, Cheung W, Cone RD, Marks DL (2006) Leptin and inflammation-associated cachexia in chronic kidney disease. Kidney Int 69:794-797
17. Aminzadeh MA, Pahl MV, Barton CH, Doctor NS, Vaziri ND (2009) Human uraemic plasma stimulates release of leptin and uptake of tumour necrosis factor-alpha in visceral adipocytes. Nephrol Dial Transpl Off Publ Eur Dial Transpl Assoc Eur Renal Assoc 24:3626-3631
18. Kalbacher E, Koppe L, Zarrouki B, Pillon NJ, Fouque D, Soulage CO (2011) Human uremic plasma and not urea induces exuberant secretion of leptin in 3T3-L1 adipocytes. J Ren Nutr Off J Council Renal Nutr Natl Kidney Found 21:72-75
19. Ho KJ, Xue H, Mauro CR, Nguyen B, Yu P, Tao M, Seidman MA, Brunelli SM, Ozaki CK (2013) Impact of uremia on human adipose tissue phenotype. J Surg Res 179:175-182
20. Silva M, Vale B, Lemos C, Torres M, Bregman R (2013) Body adiposity index assess body fat with high accuracy in nondialyzed chronic kidney disease patients.Obesity (Silver Spring) 21:546-552
21. Ruhl CE, Harris TB, Ding J, Goodpaster BH, Kanaya AM, Kritchevsky SB, Simonsick EM, Tylavsky FA, Everhart JE (2007) Body mass index and serum leptin concentration independently estimate percentage body fat in older adults. Am J Clin Nutr 85:1121-1126 (Pubitemid 46557930)
22. Leal VO, Lobo JC, Stockler-Pinto MB, Farage NE, Calixto A, Geloneze B, Mafra D (2012) Apelin: a peptide involved in cardiovascular risk in hemodialysis patients? Ren Fail 34:577-581
23. Confavreux CB (2011) Bone: from a reservoir of minerals to a regulator of energy metabolism. Kidney Int 79:S14-S19
24. Thomas T, Gori F, Khosla S, Jensen MD, Burguera B, Riggs BL (1999) Leptin acts on human marrow stromal cells to enhance differentiation to osteoblasts and to inhibit differentiation to adipocytes. Endocrinology 140:1630-1638 (Pubitemid 29149231)
25. Cornish J, Callon KE, Bava U, Lin C, Naot D, Hill BL, Grey AB, Broom N, Myers DE, Nicholson GC, Reid IR (2002) Leptin directly regulates bone cell function in vitro and reduces bone fragility in vivo. J Endocrinol 175:405-415 (Pubitemid 35414387)
26. Coen G, Ballanti P, Fischer MS, Balducci A, Calabria S, Colamarco L, Di Zazzo G, Lifrieri F, Manni M, Sardella D, Nofroni I, Bonucci E (2003) Serum leptin in dialysis renal osteodystrophy. Am J Kidney Dis Off J Natl Kidney Found 42:1036-1042 (Pubitemid 37322920)
27. Ahmadi F, Salari S, Maziar S, Esfahanian F, Khazaeipour Z, Ranjbarnovin N (2013) Relationship between serum leptin levels and bone mineral density and bone metabolic markers in patients on hemodialysis. Saudi J Kidney Dis Transpl Off Publ Saudi Center Organ Transpl Saudi Arab 24:41-47
28. Zoccali C, Panuccio V, Tripepi G, Cutrupi S, Pizzini P, Mallamaci F (2004) Leptin and biochemical markers of bone turnover in dialysis patients. J Nephrol 17:253-260 (Pubitemid 38779779)
29. Polymeris A, Doumouchtsis K, Grapsa E (2012) Bone mineral density and bone metabolism in hemodialysis patients. Correlation with PTH, 25OHD3 and leptin. Nefrologia: Publicacion Oficial de la Sociedad Espanola Nefrologia 32:73-78
30. Ghazali A, Grados F, Oprisiu R, Bunea D, Moriniere P, El Esper N, El Esper I, Brazier M, Souberbielle JC, Fournier A, Thomas T (2003) Bone mineral density directly correlates with elevated serum leptin in haemodialysis patients. Nephrol Dial Transpl Off Publ Eur Dial Transpl Assoc Eur Renal Assoc 18:1882-1890 (Pubitemid 37098562)
31. Kokot F, Chudek J, Karkoszka H, Adamczak M, Wiecek A, Klimek D (1999) Does PTH influence leptin concentration in haemodialysed uraemic patients? Nephron 82:372-373 (Pubitemid 29385320)
32. Merabet E, Dagogo-Jack S, Coyne DW, Klein S, Santiago JV, Hmiel SP, Landt M (1997) Increased plasma leptin concentration in end-stage renal disease. J Clin Endocrinol Metab 82:847-850 (Pubitemid 27106599)
33. Axelsson J, Qureshi AR, Heimburger O, Lindholm B, Stenvinkel P, Barany P (2005) Body fat mass and serum leptin levels influence epoetin sensitivity in patients with ESRD. Am J Kidney Dis Off J Natl Kidney Found 46:628-634 (Pubitemid 41383940)
34. Nasri H (2006) Association of serum leptin with anemia in maintenance hemodialysis patients. Saudi J Kidney Dis Transpl Off Publ Saudi Center Organ Transpl Saudi Arab 17:521-525
35. Kotanko P, Thijssen S, Levin NW (2008) Association between erythropoietin responsiveness and body composition in dialysis patients. Blood Purif 26:82-89
36. Cohen B, Novick D, Rubinstein M (1996) Modulation of insulin activities by leptin. Science 274:1185-1188 (Pubitemid 26389283)
37. Gainsford T, Willson TA, Metcalf D, Handman E, McFarlane C, Ng A, Nicola NA, Alexander WS, Hilton DJ (1996) Leptin can induce proliferation, differentiation, and functional activation of hemopoietic cells. Proc Natl Acad Sci USA 93:14564-14568 (Pubitemid 26419007)
38. Umemoto Y, Tsuji K, Yang FC, Ebihara Y, Kaneko A, Furukawa S, Nakahata T (1997) Leptin stimulates the proliferation of murine myelocytic and primitive hematopoietic progenitor cells. Blood 90:3438-3443 (Pubitemid 27473413)
39. Mikhail AA, Beck EX, Shafer A, Barut B, Gbur JS, Zupancic TJ, Schweitzer AC, Cioffi JA, Lacaud G, Ouyang B, Keller G, Snodgrass HR (1997) Leptin stimulates fetal and adult erythroid and myeloid development. Blood 89:1507-1512 (Pubitemid 27097441)
40. Cano N, Fiaccadori E, Tesinsky P, Toigo G, Druml W, Dgem Kuhlmann M, Mann H, Horl WH, Espen (2006) ESPEN guidelines on enteral nutrition: adult renal failure. Clin Nutr 25:295-310 (Pubitemid 43811687)
41. Cheu C, Pearson J, Dahlerus C, Lantz B, Chowdhury T, Sauer PF, Farrell RE, Port FK, Ramirez SP (2013) Association between oral nutritional supplementation and clinical outcomes among patients with ESRD. Clinical J Am Soc Nephrol CJASN 8:100-107
42. Pecoits-Filho R, Lindholm B, Stenvinkel P (2003) End-stage renal disease: a state of chronic inflammation and hyperleptinemia. Eur J Clin Invest 33:527-528 (Pubitemid 36754220)
43. Odamaki M, Furuya R, Yoneyama T, Nishikino M, Hibi I, Miyaji K, Kumagai H (1999) Association of the serum leptin concentration with weight loss in chronic hemodialysis patients. Am J Kidney Dis Off J Natl Kidney Found 33:361-368 (Pubitemid 29072241)
44. Aguilera A, Bajo MA, Rebollo F, Diez JJ, Diaz C, Paiva A, Codoceo R, Selgas R (2002) Leptin as a marker of nutrition and cardiovascular risk in peritoneal dialysis patients. Adv Perit Dial Conf Perit Dial 18:212-217
45. Taskapan MC, Taskapan H, Sahin I, Keskin L, Atmaca H, Ozyalin F (2007) Serum leptin, resistin, and lipid levels in patients with end stage renal failure with regard to dialysis modality. Ren Fail 29:147-154
46. Rodriguez-Carmona A, Perez Fontan M, Cordido F, Garcia Falcon T, Garcia-Buela J (2000) Hyperleptinemia is not correlated with markers of protein malnutrition in chronic renal failure. A cross-sectional study in predialysis, peritoneal dialysis and hemodialysis patients. Nephron 86:274-280
47. Hryszko T, Brzosko S, Rydzewska-Rosolowska A, Koc-Zorawska E, Naumnik B, Mysliwiec M (2012) Effect of secondary hyperparathyroidism treatment with cinacalcet on selected adipokines and markers of endothelial injury in hemodialysis patients: a preliminary report. Pol Arch Med Wewn 122:148-153
48. Ulutas O, Taskapan H, Taskapan MC, Temel I (2013) Vitamin D deficiency, insulin resistance, serum adipokine, and leptin levels in peritoneal dialysis patients. Int Urol Nephrol 45:879-884
49. Rossi AS, Lombardo YB, Lacorte JM, Chicco AG, Rouault C, Slama G, Rizkalla SW (2005) Dietary fish oil positively regulates plasma leptin and adiponectin levels in sucrose-fed, insulinresistant rats. Am J Physiol Regul Integr Comp Physiol 289:R486-R494 (Pubitemid 41060504)
50. Guebre-Egziabher F, Debard C, Drai J, Denis L, Pesenti S, Bienvenu J, Vidal H, Laville M, Fouque D (2013) Differential dose effect of fish oil on inflammation and adipose tissue gene expression in chronic kidney disease patients. Nutrition 29:730-736
51. Iglesias P, Diez JJ, Fernandez-Reyes MJ, Bajo MA, Aguilera A, Mendez J, Codoceo R, Selgas R (2002) Effects of short-term recombinant human growth hormone therapy on plasma leptin concentrations in dialysis patients. Nephrol Dial Transp Off Publ Eur Dial Transpl Assoc Eur Ren Assoc 17:260-264 (Pubitemid 34157140)
52. Fouque D, Juillard L, Lasne Y, Tabakian A, Laville M, Joly MO, Laville M (1998) Acute leptin regulation in end-stage renal failure: the role of growth hormone and IGF-1. Kidney Int 54:932-937 (Pubitemid 28397412)
53. Rammohan M, Kalantar-Zadeh K, Liang A, Ghossein C (2005) Megestrol acetate in a moderate dose for the treatment of malnutrition-inflammation complex in maintenance dialysis patients. J Ren Nutr Off J Council Ren Nutr Natl Kidney Found 15:345-355 (Pubitemid 40917294)
54. Nicoletto BB, Souza GC, Goncalves LF, Costa C, Perry IS, Manfro RC (2012) Leptin, insulin resistance, and metabolic changes 5 years after renal transplantation. J Ren Nutr Off J Council Ren Nutr Natl Kidney Found 22:440-449
55. Kayacan SM, Yildiz A, Kazancioglu R, Sahin S, Sever MS, Ark E (2003) The changes in serum leptin, body fat mass and insulin resistance after renal transplantation. Clin Transpl 17:63-68 (Pubitemid 36621649)
56. Souza GC, Costa C, Scalco R, Goncalves LF, Manfro RC (2008) Serum leptin, insulin resistance, and body fat after renal transplantation. J Ren Nutr Off J Council Ren Nutr Natl Kidney Found 18:479-488