Assessment of oral toxicity and safety of 9-cis-UAB30, a potential chemopreventive agent, in rat and dog studies

Drug and Chemical Toxicology

Volumn 34, Issue 3, 2011, Pages 300-310

  Lindeblad, Matthew ^a   Kapetanovic, Izet M ^b   Kabirov, Kasim K ^a   Dinger, Nancy ^a   Mankovskaya, Irina ^a   Morrisey, Robert ^c   Martín Jiménez, Tomas ^d   Lyubimov, Alexander ^a,b  

^a UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

^c Charles River Company   (United States)

^d UNIVERSITY OF TENNESSEE   (United States)

Author keywords

9 cis UAB30; Beagle dog; chemoprevention; oral; rat; rexinoid; toxicity

Indexed keywords

8 (3',4' DIHYDRO 1'(2H)NAPHTHALEN 1' YLIDENE) 3,7 DIMETHYL 2,4,6 OCTATRIENOIC ACID; ALBUMIN; ALKALINE PHOSPHATASE; ANTINEOPLASTIC AGENT; ASPARTATE AMINOTRANSFERASE; FIBRINOGEN; GLOBULIN; GLYCOGEN; UNCLASSIFIED DRUG;

ALBUMIN BLOOD LEVEL; ALKALINE PHOSPHATASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; CONTROLLED STUDY; CYTOPLASM; DOG; DOSE RESPONSE; DRUG BLOOD LEVEL; DRUG HALF LIFE; DRUG SAFETY; FEMALE; FIBRINOGEN BLOOD LEVEL; HEART INJURY; HEPATOMEGALY; HISTOPATHOLOGY; LIVER CELL; LIVER LEVEL; LIVER WEIGHT; MALE; MEDIASTINUM DISEASE; NEOVASCULARIZATION (PATHOLOGY); NEUROTOXICITY; NONHUMAN; PERIAORTIC MEDIASTINUM INFLAMMATION; PROTHROMBIN TIME; RAT; TOXICITY TESTING;

ADMINISTRATION, ORAL; ANIMALS; ANTICARCINOGENIC AGENTS; DOGS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG TOXICITY; FATTY ACIDS, UNSATURATED; FEMALE; MALE; NAPHTHALENES; NO-OBSERVED-ADVERSE-EFFECT LEVEL; ORGAN SIZE; ORGAN SPECIFICITY; RATS; SPECIES SPECIFICITY; TOXICITY TESTS, CHRONIC;

CANIS FAMILIARIS; RATTUS; RODENTIA;

EID: 79958227281     PISSN: 01480545     EISSN: 15256014     Source Type: Journal    
DOI: 10.3109/01480545.2010.536771     Document Type: Article

References (13)

1. Barbui, T., Finazzi, G., Falanga, A. (1998). The impact of all-transretinoic acid on the coagulopathy of acute promyelocytic leukemia. Blood 91:3093-3102. (Pubitemid 28193856)
2. Dileepan, K. N., Singh, V. N., Ramachandran, C. K. (1977). Early effects of hypervitaminosis A on gluconeogenic activity and amino acid metabolizing enzymes of rat liver. J Nutr 107:1809-1815. (Pubitemid 8206368)
3. Duvic, M., Martin, A.G., Kim, Y., Olsen, E., Wood G. S., Crowley, C. A., et al. (2001). Phase 2 and 3 clinical trial of oral bexarotene (Targretin capsules) for the treatment of refractory or persistent early-stage cutaneous T-cell lymphoma. Arch Dermatol 137:581-593. (Pubitemid 32458440)
4. Grubbs, C. J., Hill, D. L., Bland, K. I., Beenken, S. W., Lin, T. H., Eto, I., Atigadda, V. R., et al. (2003). 9cUAB30, an RXR-specific retinoid, and/or tamoxifen in the prevention of methylnitrosourea-induced mammary cancers. Cancer Lett 201:17-24. (Pubitemid 37297993)
5. Hansen, N. J., Wylie, R. C., Phipps, S. M., Love, W. K., Andrews, L. G., Tollefsbol, T. O. (2007). The low-toxicity 9-cis UAB30 novel retinoid down-regulates the DNA methyltransferases and has anti-telomerase activity in human breast cancer cells. Int J Oncol 30:641-650.
6. Jackson, J. P., Kabirov, K. K., Kapetanovic, I. M., Lyubimov, A. (2009). In vitro assessment of P450 induction potential of novel chemopreventive agents SR13668, 9-cis-UAB30, and pentamethylchromanol in primary cultures of human hepatocytes. Chem Biol Interact 179:263-272.
7. Krishnaraj, R., Lyubimov, A., Detrisac, C., Kapetanovic, I., Crowell, J., Brouillette, W., et al. (2005). Oral toxicity study of a retinoic acid analogue, 9-cis-UAB-30, in rats. Toxicologist 364.
8. Lammer, E. J., Chen, D. T., Hoar, R. M., Agnish, N. D., Benke, P. J., Braun, J. T., et al. (1985). Retinoic acid embryopathy. NEJM 313:837-841. (Pubitemid 15250197)
9. Lettinga, K. D., Gutter, W., Van Noorden, C. J., Schellens, J. P., Frederiks, W. M. (1996). Early effects of high doses of retinol (vitamin A) on the in situ cellular metabolism in rat liver. Liver 16:1-11.
10. Love, W. K., Deangelis, J. T., Berletch, J. B., Phipps, S. M., Andrews, L. G., Brouillette, W. J., et al. (2008). The novel retinoid, 9cUAB30, inhibits telomerase and induces apoptosis in HL60 cells. Transl Oncol 1:148-152.
11. Perea, G., Salar, A., Altes, A., Brunet, S., Sierra, J. (2000). Acute hepatomegaly with severe liver toxicity due to all-trans retinoic acid. Haematologica 85:551-552. (Pubitemid 30428584)
12. Roenigk, H. H., Jr. (1988). Liver toxicity of retinoid therapy. J Am Acad Dermatol 19(1 Pt 2):199-208.
13. Singh VN, Singh M and Venkitasubramanian TA (1969). Early effects of feeding excess vitamin A: mechanism of fatty liver production in rats. J Lipid Res 10(4): 395-401.