The tumor suppressive role of CAMK2N1 in castration-resistant prostate cancer

Oncotarget

Volumn 5, Issue 11, 2014, Pages 3611-3621

  Wang, Tao ^a   Liu, Zhuo ^a   Guo, Shuiming ^a   Wu, Licheng ^a   Li, Mingchao ^a   Yang, Jun ^a   Chen, Ruibao ^a   Xu, Hua ^a   Cai, Shaoxin ^a   Chen, Hui ^a   Li, Weiyong ^a   Wang, Liang ^a   Hu, Zhiquan ^a   Zhuang, Qianyuan ^a   Xu, Shaohua ^b   Wang, Liping ^b   Liu, Jihong ^a   Ye, Zhangqun ^a   Ji, Jun Yuan ^c   Wang, Chenguang ^b   Chen, Ke ^a   more..

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^b THOMAS JEFFERSON UNIVERSITY   (United States)

^c TEXAS A M COLLEGE OF MEDICINE   (United States)

Author keywords

CAMK2N1; Prostate cancer; Tumor suppressor

Indexed keywords

CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE II INHIBITOR 1; EPIDERMAL GROWTH FACTOR RECEPTOR 2; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; SOMATOMEDIN C; TUMOR PROTEIN; UNCLASSIFIED DRUG; VASCULOTROPIN; CAMK2N1 PROTEIN, HUMAN; PROTEIN;

ANIMAL TISSUE; APOPTOSIS; ARTICLE; CAMK2N1 GENE; CANCER INHIBITION; CANCER STAGING; CASTRATION RESISTANT PROSTATE CANCER; CELL CYCLE G1 PHASE; CELL CYCLE PROGRESSION; CELL PROLIFERATION; CONTROLLED STUDY; DOWN REGULATION; ERBB2 GENE; FEMALE; GENE EXPRESSION REGULATION; GENE OVEREXPRESSION; GENOME ANALYSIS; HUMAN; HUMAN CELL; HUMAN TISSUE; IGF 1 GENE; IMMUNOHISTOCHEMISTRY; IN VIVO STUDY; MALE; NONHUMAN; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; TUMOR GENE; UPREGULATION; VEGF GENE; ANIMAL; DISEASE COURSE; GENETICS; METABOLISM; NUDE MOUSE; PATHOLOGY; PHYSIOLOGY; TUMOR SUPPRESSOR GENE; XENOGRAFT;

ANIMALS; APOPTOSIS; CELL PROLIFERATION; DISEASE PROGRESSION; GENES, TUMOR SUPPRESSOR; HETEROGRAFTS; HUMANS; MALE; MICE, NUDE; PROSTATIC NEOPLASMS, CASTRATION-RESISTANT; PROTEINS; RNA, MESSENGER; SIGNAL TRANSDUCTION;

EID: 84903539329     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.1968     Document Type: Article

References (22)

1. Karavitakis M, Winkler MH, Abel PD, Hazell S, Ahmed HU. Focal therapy for prostate cancer: opportunities and uncertainties. Discov Med. 2011; 12(64): 245-55.
2. So A, Gleave M, Hurtado-Col A, Nelson C. Mechanisms of the development of androgen independence in prostate cancer. World J Urol. 2005; 23(1): 1-9.
3. Devlin HL, Mudryj M. Progression of prostate cancer: multiple pathways to androgen independence. Cancer Lett. 2009; 274(2): 177-186.
4. Mohla S, Stearns V, Sathyamoorthy N, Rosenfeld MG., Nelson P. The biology of hormone refractory breast and prostate cancer: An NCI workshop report. Cancer Biol Ther. 2009; 8(21): 1975-1985.
5. Bhandari MS, Petrylak DP, Hussain M. Clinical trials in metastatic prostate cancer-has there been real progress in the past decade. Eur J Cancer. 2005; 41(6): 941-953.
6. Chang BH, Mukherji S, Soderling TR. Characterization of a calmodulin kinase II inhibitor protein in brain. Proc Natl Acad Sci U S A. 1998; 95(18): 10890-10895.
7. Zhang J, Li N, Yu J, Zhang W, Cao X. Molecular cloning and characterization of a novel calcium/calmodulin-dependent protein kinase II inhibitor from human dendritic cells. Biochem Biophys Res Commun. 2001; 285(2): 229-234.
8. Ling KH, Hewitt CA, Beissbarth T, Hyde L, Cheah PS, Smyth G.K, Tan SS, Hahn CN, Thomas T, Thomas PQ, Scott HS. Spatiotemporal regulation of multiple overlapping sense and novel natural antisense transcripts at the Nrgn and Camk2n1 gene loci during mouse cerebral corticogenesis. Cereb Cortex. 2001; 21(3): 683-697.
9. Rokhlin OW, Taghiyev AF, Bayer KU, Bumcrot D, Koteliansk VE, Glover RA, Cohen MB. Calcium/calmodulin dependent kinase II plays an important role in prostate cancer cell survival. Cancer Biol Ther. 2007; 6(5), 732-742.
10. Franklin RA, McCubrey JA. The involvement of CaM-KII in insulin induced cell proliferation. Cell Cycle. 2009; 8(13):1979.
11. Salzano M, Rusciano MR, Russo E, Bifulco M, Postiglione L, Vitale M. Calcium/calmodulin-dependent protein kinase II (CaMKII) phosphorylates Raf-1 at serine 338 and mediates Ras-stimulated Raf-1 activation. Cell Cycle. 2012; 11(11):2100-2106.
12. Gao H, Ouyang X, Banach-Petrosky WA, Gerald WL, Shen MM, Abate-Shen C. Combinatorial activities of Akt and B-Raf/Erk signaling in a mouse model of androgen-independent prostate cancer. Proc Natl Acad Sci U S A. 2006; 103(39): 14477-14482.
13. Kinkade CW, Castillo-Martin M, Puzio-Kuter A, Yan J, Foster TH, Gao H, Sun Y, Ouyang X, Gerald WL, Cordon-Cardo C, Abate-Shen C. Targeting AKT/mTOR and ERK MAPK signaling inhibits hormone-refractory prostate cancer in a preclinical mouse model. J Clin Invest. 2008; 118(9): 3051-3064.
14. Dillin A, Crawford DK, Kenyon C. Timing requirements for insulin/IGF-1 signaling in C. elegans. Science. 2000; 298(5594): 830-834.
15. Shin-Kang S, Ramsauer VP, Lightner J, Chakraborty K, Stone W, Campbell S, Reddy SA, Krishnan K. Tocotrienols inhibit AKT and ERK activation and suppress pancreatic cancer cell proliferation by suppressing the ErbB2 pathway. Free Radic Biol Med. 2011; 51(6): 1164-1174.
16. Ellis L, Ku SY, Ramakrishnan S, Lasorsa E, Azabdaftari G, Godoy A, Pili R. Combinatorial antitumor effect of HDAC and the PI3K-Akt-mTOR pathway inhibition in a Pten defecient model of prostate cancer. Oncotarget. 2013 Dec;4(12):2225-36.
17. Chan JM, Stampfer MJ, Giovannucci E, Gann PH, Ma J, Wilkinson P, Hennekens CH, Pollak M. Plasma insulin-like growth factor-I and prostate cancer risk: a prospective study. Science. 1998; 279(5350): 563-566.
18. Gao L, Blair LA, Salinas GD, Needleman LA, Marshall J. Insulin-like growth factor-1 modulation of CaV1.3 calcium channels depends on Ca2+ release from IP3-sensitive stores and calcium/calmodulin kinase II phosphorylation of the alpha1 subunit EF hand. J Neurosci. 2006; 26(23): 6259-6268.
19. Liu M, Ju X, Willmarth NE, Casimiro MC, Ojeifo J, Sakamaki T, Katiyar S, Jiao X, Popov VM, Yu Z, Wu K, Joyce D, Wang C, Pestell RG. Nuclear factor-kappaB enhances ErbB2-induced mammary tumorigenesis and neoangiogenesis in vivo. Am J Pathol. 2009; 174(5): 1910-1920.
20. Chen K, Wu K, Cai S, Zhang W, Zhou J, Wang J, Ertel A, Li Z, Rui H, Quong A, Lisanti MP, Tozeren A, Tanes C, Addya S, Gormley M, Wang C, McMahon SB, Pestell RG. Dachshund binds p53 to block the growth of lung adenocarcinoma cells. Cancer Res. 2013; 73(11): 3262-3274.
21. Chen K, Wu K, Gormley M, Ertel A, Wang J, Zhang W, Zhou J, Disante G., Li Z, Rui H, Quong, AA, McMahon SB, Deng H, Lisanti MP, Wang C, Pestell RG. Acetylation of the cell-fate factor dachshund determines p53 binding and signaling modules in breast cancer. Oncotarget. 2013; 4(6), 923-935.
22. Giorno F, Wolters-Arts M, Grillo S, Scharf KD, Vriezen WH, Mariani C. Developmental and heat stress-regulated expression of HsfA2 and small heat shock proteins in tomato anthers. J Exp Bot. 2010; 61(2): 453-462.