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Volumn 58, Issue 7, 2014, Pages 1474-1490

Nicotinamide treatment ameliorates the course of experimental colitis mediated by enhanced neutrophil-specific antibacterial clearance

Author keywords

Bacterial killing; Colitis; Inflammation; Nicotinamide

Indexed keywords

ANTIINFECTIVE AGENT; CALGRANULIN; CCAAT ENHANCER BINDING PROTEIN; CEBPE PROTEIN, HUMAN; DEXTRAN SULFATE; NICOTINAMIDE;

EID: 84903535307     PISSN: 16134125     EISSN: 16134133     Source Type: Journal    
DOI: 10.1002/mnfr.201300818     Document Type: Article
Times cited : (32)

References (52)
  • 1
    • 78149484622 scopus 로고    scopus 로고
    • In vivo deficiency of both C/EBPbeta and C/EBPepsilon results in highly defective myeloid differentiation and lack of cytokine response
    • Akagi, T., Thoennissen, N. H., George, A., Crooks, G. et al., In vivo deficiency of both C/EBPbeta and C/EBPepsilon results in highly defective myeloid differentiation and lack of cytokine response. PloS One 2010, 5, e15419.
    • (2010) PloS One , vol.5
    • Akagi, T.1    Thoennissen, N.H.2    George, A.3    Crooks, G.4
  • 2
    • 84864223775 scopus 로고    scopus 로고
    • Transcription factor CCAAT/enhancer-binding protein alpha and critical circadian clock downstream target gene PER2 are highly deregulated in diffuse large B-cell lymphoma
    • Thoennissen, N. H., Thoennissen, G. B., Abbassi, S., Nabavi-Nouis, S. et al., Transcription factor CCAAT/enhancer-binding protein alpha and critical circadian clock downstream target gene PER2 are highly deregulated in diffuse large B-cell lymphoma. Leuk. Lymphoma 2012, 53, 1577-1585.
    • (2012) Leuk. Lymphoma , vol.53 , pp. 1577-1585
    • Thoennissen, N.H.1    Thoennissen, G.B.2    Abbassi, S.3    Nabavi-Nouis, S.4
  • 3
    • 84865963692 scopus 로고    scopus 로고
    • C/EBPepsilon mediates nicotinamide-enhanced clearance of Staphylococcus aureus in mice
    • Kyme, P., Thoennissen, N. H., Tseng, C. W., Thoennissen, G. B. et al., C/EBPepsilon mediates nicotinamide-enhanced clearance of Staphylococcus aureus in mice. J. Clin. Invest. 2012, 122, 3316-3329.
    • (2012) J. Clin. Invest. , vol.122 , pp. 3316-3329
    • Kyme, P.1    Thoennissen, N.H.2    Tseng, C.W.3    Thoennissen, G.B.4
  • 4
    • 27644566447 scopus 로고    scopus 로고
    • Biologic therapy for inflammatory bowel disease
    • Ardizzone, S., Bianchi Porro, G., Biologic therapy for inflammatory bowel disease. Drugs 2005, 65, 2253-2286.
    • (2005) Drugs , vol.65 , pp. 2253-2286
    • Ardizzone, S.1    Bianchi Porro, G.2
  • 5
    • 34547176642 scopus 로고    scopus 로고
    • Unravelling the pathogenesis of inflammatory bowel disease
    • Xavier, R. J., Podolsky, D. K., Unravelling the pathogenesis of inflammatory bowel disease. Nature 2007, 448, 427-434.
    • (2007) Nature , vol.448 , pp. 427-434
    • Xavier, R.J.1    Podolsky, D.K.2
  • 6
    • 35348982262 scopus 로고    scopus 로고
    • Mouse models of inflammatory bowel disease
    • Wirtz, S., Neurath, M. F., Mouse models of inflammatory bowel disease. Adv. Drug. Deliv. Rev. 2007, 59, 1073-1083.
    • (2007) Adv. Drug. Deliv. Rev. , vol.59 , pp. 1073-1083
    • Wirtz, S.1    Neurath, M.F.2
  • 7
    • 84860241737 scopus 로고    scopus 로고
    • Innate immune dysfunction in inflammatory bowel disease
    • Gersemann, M., Wehkamp, J., Stange, E. F., Innate immune dysfunction in inflammatory bowel disease. J. Intern. Med. 2012, 271, 421-428.
    • (2012) J. Intern. Med. , vol.271 , pp. 421-428
    • Gersemann, M.1    Wehkamp, J.2    Stange, E.F.3
  • 8
    • 0037048904 scopus 로고    scopus 로고
    • Treatment of active Crohn's disease with recombinant human granulocyte-macrophage colony-stimulating factor
    • Dieckgraefe, B. K., Korzenik, J. R., Treatment of active Crohn's disease with recombinant human granulocyte-macrophage colony-stimulating factor. Lancet 2002, 360, 1478-1480.
    • (2002) Lancet , vol.360 , pp. 1478-1480
    • Dieckgraefe, B.K.1    Korzenik, J.R.2
  • 9
    • 84864270714 scopus 로고    scopus 로고
    • ACE2 links amino acid malnutrition to microbial ecology and intestinal inflammation
    • Hashimoto, T., Perlot, T., Rehman, A., Trichereau, J. et al., ACE2 links amino acid malnutrition to microbial ecology and intestinal inflammation. Nature 2012, 487, 477-481.
    • (2012) Nature , vol.487 , pp. 477-481
    • Hashimoto, T.1    Perlot, T.2    Rehman, A.3    Trichereau, J.4
  • 11
    • 0032726370 scopus 로고    scopus 로고
    • Citrobacter rodentium espB is necessary for signal transduction and for infection of laboratory mice
    • Newman, J. V., Zabel, B. A., Jha, S. S., Schauer, D. B., Citrobacter rodentium espB is necessary for signal transduction and for infection of laboratory mice. Infect. Immun. 1999, 67, 6019-6025.
    • (1999) Infect. Immun. , vol.67 , pp. 6019-6025
    • Newman, J.V.1    Zabel, B.A.2    Jha, S.S.3    Schauer, D.B.4
  • 12
    • 0027254194 scopus 로고
    • Nicotinamide pharmacokinetics in humans and mice: a comparative assessment and the implications for radiotherapy
    • Horsman, M. R., Hoyer, M., Honess, D. J., Dennis, I. F., Overgaard, J., Nicotinamide pharmacokinetics in humans and mice: a comparative assessment and the implications for radiotherapy. Radiother. Oncol. 1993, 27, 131-139.
    • (1993) Radiother. Oncol. , vol.27 , pp. 131-139
    • Horsman, M.R.1    Hoyer, M.2    Honess, D.J.3    Dennis, I.F.4    Overgaard, J.5
  • 13
    • 33748908067 scopus 로고    scopus 로고
    • Protecting axonal degeneration by increasing nicotinamide adenine dinucleotide levels in experimental autoimmune encephalomyelitis models
    • Kaneko, S., Wang, J., Kaneko, M., Yiu, G. et al., Protecting axonal degeneration by increasing nicotinamide adenine dinucleotide levels in experimental autoimmune encephalomyelitis models. J. Neurosci. 2006, 26, 9794-9804.
    • (2006) J. Neurosci. , vol.26 , pp. 9794-9804
    • Kaneko, S.1    Wang, J.2    Kaneko, M.3    Yiu, G.4
  • 14
    • 80052864077 scopus 로고    scopus 로고
    • The tripeptide KdPT protects from intestinal inflammation and maintains intestinal barrier function
    • Bettenworth, D., Buyse, M., Bohm, M., Mennigen, R. et al., The tripeptide KdPT protects from intestinal inflammation and maintains intestinal barrier function. Am. J. Pathol. 2011, 179, 1230-1242.
    • (2011) Am. J. Pathol. , vol.179 , pp. 1230-1242
    • Bettenworth, D.1    Buyse, M.2    Bohm, M.3    Mennigen, R.4
  • 16
    • 21244434677 scopus 로고    scopus 로고
    • Inactivation of CD11b in a mouse transgenic model protects against sepsis-induced lung PMN infiltration and vascular injury
    • Gao, X. P., Liu, Q., Broman, M., Predescu, D. et al., Inactivation of CD11b in a mouse transgenic model protects against sepsis-induced lung PMN infiltration and vascular injury. Physiol. Genom. 2005, 21, 230-242.
    • (2005) Physiol. Genom. , vol.21 , pp. 230-242
    • Gao, X.P.1    Liu, Q.2    Broman, M.3    Predescu, D.4
  • 17
    • 7644235586 scopus 로고    scopus 로고
    • The lymphotoxin-beta receptor is critical for control of murine Citrobacter rodentium-induced colitis
    • Spahn, T. W., Maaser, C., Eckmann, L., Heidemann, J. et al., The lymphotoxin-beta receptor is critical for control of murine Citrobacter rodentium-induced colitis. Gastroenterology 2004, 127, 1463-1473.
    • (2004) Gastroenterology , vol.127 , pp. 1463-1473
    • Spahn, T.W.1    Maaser, C.2    Eckmann, L.3    Heidemann, J.4
  • 18
    • 38849178169 scopus 로고    scopus 로고
    • CD4+ T cells transfer resistance against Citrobacter rodentium-induced infectious colitis by induction of Th 1 immunity
    • Spahn, T. W., Ross, M., von Eiff, C., Maaser, C. et al., CD4+ T cells transfer resistance against Citrobacter rodentium-induced infectious colitis by induction of Th 1 immunity. Scand. J. Immunol. 2008, 67, 238-244.
    • (2008) Scand. J. Immunol. , vol.67 , pp. 238-244
    • Spahn, T.W.1    Ross, M.2    von Eiff, C.3    Maaser, C.4
  • 19
    • 0031736096 scopus 로고    scopus 로고
    • Chronic experimental colitis induced by dextran sulphate sodium (DSS) is characterized by Th1 and Th2 cytokines
    • Dieleman, L. A., Palmen, M. J., Akol, H., Bloemena, E. et al., Chronic experimental colitis induced by dextran sulphate sodium (DSS) is characterized by Th1 and Th2 cytokines. Clin. Exp. Immunol. 1998, 114, 385-391.
    • (1998) Clin. Exp. Immunol. , vol.114 , pp. 385-391
    • Dieleman, L.A.1    Palmen, M.J.2    Akol, H.3    Bloemena, E.4
  • 20
    • 22944462082 scopus 로고    scopus 로고
    • Staphylococcus aureus golden pigment impairs neutrophil killing and promotes virulence through its antioxidant activity
    • Liu, G. Y., Essex, A., Buchanan, J. T., Datta, V. et al., Staphylococcus aureus golden pigment impairs neutrophil killing and promotes virulence through its antioxidant activity. J. Exp. Med. 2005, 202, 209-215.
    • (2005) J. Exp. Med. , vol.202 , pp. 209-215
    • Liu, G.Y.1    Essex, A.2    Buchanan, J.T.3    Datta, V.4
  • 21
    • 33749011189 scopus 로고    scopus 로고
    • Animal models of inflammatory bowel disease: lessons from enteric infections
    • Eckmann, L., Animal models of inflammatory bowel disease: lessons from enteric infections. Ann. N. Y. Acad. Sci. 2006, 1072, 28-38.
    • (2006) Ann. N. Y. Acad. Sci. , vol.1072 , pp. 28-38
    • Eckmann, L.1
  • 22
    • 0347364688 scopus 로고    scopus 로고
    • Critical role of T cell-dependent serum antibody, but not the gut-associated lymphoid tissue, for surviving acute mucosal infection with Citrobacter rodentium, an attaching and effacing pathogen
    • Bry, L., Brenner, M. B., Critical role of T cell-dependent serum antibody, but not the gut-associated lymphoid tissue, for surviving acute mucosal infection with Citrobacter rodentium, an attaching and effacing pathogen. J. Immunol. 2004, 172, 433-441.
    • (2004) J. Immunol. , vol.172 , pp. 433-441
    • Bry, L.1    Brenner, M.B.2
  • 24
    • 18544381583 scopus 로고    scopus 로고
    • CCAAT/enhancer binding protein epsilon: changes in function upon phosphorylation by p38 MAP kinase
    • Williamson, E. A., Williamson, I. K., Chumakov, A. M., Friedman, A. D., Koeffler, H. P., CCAAT/enhancer binding protein epsilon: changes in function upon phosphorylation by p38 MAP kinase. Blood 2005, 105, 3841-3847.
    • (2005) Blood , vol.105 , pp. 3841-3847
    • Williamson, E.A.1    Williamson, I.K.2    Chumakov, A.M.3    Friedman, A.D.4    Koeffler, H.P.5
  • 26
    • 34447269492 scopus 로고    scopus 로고
    • Development of fatal colitis in FVB mice infected with Citrobacter rodentium
    • Borenshtein, D., Nambiar, P. R., Groff, E. B., Fox, J. G., Schauer, D. B., Development of fatal colitis in FVB mice infected with Citrobacter rodentium. Infect. Immun. 2007, 75, 3271-3281.
    • (2007) Infect. Immun. , vol.75 , pp. 3271-3281
    • Borenshtein, D.1    Nambiar, P.R.2    Groff, E.B.3    Fox, J.G.4    Schauer, D.B.5
  • 27
    • 0038443912 scopus 로고    scopus 로고
    • Host susceptibility to the attaching and effacing bacterial pathogen Citrobacter rodentium
    • Vallance, B. A., Deng, W., Jacobson, K., Finlay, B. B., Host susceptibility to the attaching and effacing bacterial pathogen Citrobacter rodentium. Infect. Immun. 2003, 71, 3443-3453.
    • (2003) Infect. Immun. , vol.71 , pp. 3443-3453
    • Vallance, B.A.1    Deng, W.2    Jacobson, K.3    Finlay, B.B.4
  • 28
    • 33748449456 scopus 로고    scopus 로고
    • Citrobacter rodentium infection causes both mitochondrial dysfunction and intestinal epithelial barrier disruption in vivo: role of mitochondrial associated protein (Map)
    • Ma, C., Wickham, M. E., Guttman, J. A., Deng, W. et al., Citrobacter rodentium infection causes both mitochondrial dysfunction and intestinal epithelial barrier disruption in vivo: role of mitochondrial associated protein (Map). Cell Microbiol. 2006, 8, 1669-1686.
    • (2006) Cell Microbiol. , vol.8 , pp. 1669-1686
    • Ma, C.1    Wickham, M.E.2    Guttman, J.A.3    Deng, W.4
  • 29
    • 0033022537 scopus 로고    scopus 로고
    • Citrobacter rodentium infection in mice elicits a mucosal Th1 cytokine response and lesions similar to those in murine inflammatory bowel disease
    • Higgins, L. M., Frankel, G., Douce, G., Dougan, G., MacDonald, T. T., Citrobacter rodentium infection in mice elicits a mucosal Th1 cytokine response and lesions similar to those in murine inflammatory bowel disease. Infect. Immun. 1999, 67, 3031-3039.
    • (1999) Infect. Immun. , vol.67 , pp. 3031-3039
    • Higgins, L.M.1    Frankel, G.2    Douce, G.3    Dougan, G.4    MacDonald, T.T.5
  • 30
    • 80051826190 scopus 로고    scopus 로고
    • Interactions with M cells and macrophages as key steps in the pathogenesis of enterohemorrhagic Escherichia coli infections
    • Etienne-Mesmin, L., Chassaing, B., Sauvanet, P., Denizot, J. et al., Interactions with M cells and macrophages as key steps in the pathogenesis of enterohemorrhagic Escherichia coli infections. PLoS One 2011, 6, e23594.
    • (2011) PLoS One , vol.6
    • Etienne-Mesmin, L.1    Chassaing, B.2    Sauvanet, P.3    Denizot, J.4
  • 31
    • 78649988873 scopus 로고    scopus 로고
    • Tumor necrosis factor blockade for treatment of inflammatory bowel disease: efficacy and safety
    • Ngo, B., Farrell, C. P., Barr, M., Wolov, K. et al., Tumor necrosis factor blockade for treatment of inflammatory bowel disease: efficacy and safety. Curr. Mol. Pharmacol. 2010, 3, 145-152.
    • (2010) Curr. Mol. Pharmacol. , vol.3 , pp. 145-152
    • Ngo, B.1    Farrell, C.P.2    Barr, M.3    Wolov, K.4
  • 32
    • 84862286661 scopus 로고    scopus 로고
    • Immunosuppression in inflammatory bowel disease: how much is too much
    • Cohen, B. L., Torres, J., Colombel, J. F., Immunosuppression in inflammatory bowel disease: how much is too much? Curr. Opin. Gastroenterol. 2012, 28, 341-348.
    • (2012) Curr. Opin. Gastroenterol. , vol.28 , pp. 341-348
    • Cohen, B.L.1    Torres, J.2    Colombel, J.F.3
  • 33
    • 84858793037 scopus 로고    scopus 로고
    • Anti-TNF monoclonal antibodies in inflammatory bowel disease: pharmacokinetics-based dosing paradigms
    • Ordas, I., Mould, D. R., Feagan, B. G., Sandborn, W. J., Anti-TNF monoclonal antibodies in inflammatory bowel disease: pharmacokinetics-based dosing paradigms. Clin. Pharmacol. Ther. 2012, 91, 635-646.
    • (2012) Clin. Pharmacol. Ther. , vol.91 , pp. 635-646
    • Ordas, I.1    Mould, D.R.2    Feagan, B.G.3    Sandborn, W.J.4
  • 34
    • 46349102893 scopus 로고    scopus 로고
    • Reduced alpha-defensin expression is associated with inflammation and not NOD2 mutation status in ileal Crohn's disease
    • Simms, L. A., Doecke, J. D., Walsh, M. D., Huang, N. et al., Reduced alpha-defensin expression is associated with inflammation and not NOD2 mutation status in ileal Crohn's disease. Gut 2008, 57, 903-910.
    • (2008) Gut , vol.57 , pp. 903-910
    • Simms, L.A.1    Doecke, J.D.2    Walsh, M.D.3    Huang, N.4
  • 35
    • 78751653584 scopus 로고    scopus 로고
    • Reduction of disulphide bonds unmasks potent antimicrobial activity of human beta-defensin 1
    • Schroeder, B. O., Wu, Z., Nuding, S., Groscurth, S. et al., Reduction of disulphide bonds unmasks potent antimicrobial activity of human beta-defensin 1. Nature 2011, 469, 419-423.
    • (2011) Nature , vol.469 , pp. 419-423
    • Schroeder, B.O.1    Wu, Z.2    Nuding, S.3    Groscurth, S.4
  • 36
    • 34347262689 scopus 로고    scopus 로고
    • Chemically induced mouse models of intestinal inflammation
    • Wirtz, S., Neufert, C., Weigmann, B., Neurath, M. F., Chemically induced mouse models of intestinal inflammation. Nat. Protoc. 2007, 2, 541-546.
    • (2007) Nat. Protoc. , vol.2 , pp. 541-546
    • Wirtz, S.1    Neufert, C.2    Weigmann, B.3    Neurath, M.F.4
  • 37
    • 84866914800 scopus 로고    scopus 로고
    • Lactobacillus reuteri maintains a functional mucosal barrier during DSS treatment despite mucus layer dysfunction
    • Dicksved, J., Schreiber, O., Willing, B., Petersson, J. et al., Lactobacillus reuteri maintains a functional mucosal barrier during DSS treatment despite mucus layer dysfunction. PLoS One 2012, 7, e46399.
    • (2012) PLoS One , vol.7
    • Dicksved, J.1    Schreiber, O.2    Willing, B.3    Petersson, J.4
  • 39
    • 79955555545 scopus 로고    scopus 로고
    • The utility of biomarkers in the diagnosis and therapy of inflammatory bowel disease
    • Lewis, J. D., The utility of biomarkers in the diagnosis and therapy of inflammatory bowel disease. Gastroenterology 2011, 140, 1817-1826 e1812.
    • (2011) Gastroenterology , vol.140
    • Lewis, J.D.1
  • 40
    • 17044404692 scopus 로고    scopus 로고
    • Cathelicidin mediates innate intestinal defense against colonization with epithelial adherent bacterial pathogens
    • Iimura, M., Gallo, R. L., Hase, K., Miyamoto, Y. et al., Cathelicidin mediates innate intestinal defense against colonization with epithelial adherent bacterial pathogens. J. Immunol. 2005, 174, 4901-4907.
    • (2005) J. Immunol. , vol.174 , pp. 4901-4907
    • Iimura, M.1    Gallo, R.L.2    Hase, K.3    Miyamoto, Y.4
  • 41
    • 36549048075 scopus 로고    scopus 로고
    • Utility of the Citrobacter rodentium infection model in laboratory mice
    • Borenshtein, D., McBee, M. E., Schauer, D. B., Utility of the Citrobacter rodentium infection model in laboratory mice. Curr. Opin. Gastroenterol. 2008, 24, 32-37.
    • (2008) Curr. Opin. Gastroenterol. , vol.24 , pp. 32-37
    • Borenshtein, D.1    McBee, M.E.2    Schauer, D.B.3
  • 42
    • 34250814435 scopus 로고    scopus 로고
    • TLR signaling mediated by MyD88 is required for a protective innate immune response by neutrophils to Citrobacter rodentium
    • Lebeis, S. L., Bommarius, B., Parkos, C. A., Sherman, M. A., Kalman, D., TLR signaling mediated by MyD88 is required for a protective innate immune response by neutrophils to Citrobacter rodentium. J. Immunol. 2007, 179, 566- 577.
    • (2007) J. Immunol. , vol.179 , pp. 566-577
    • Lebeis, S.L.1    Bommarius, B.2    Parkos, C.A.3    Sherman, M.A.4    Kalman, D.5
  • 43
    • 77950251400 scopus 로고    scopus 로고
    • A human gut microbial gene catalogue established by metagenomic sequencing
    • Qin, J., Li, R., Raes, J., Arumugam, M. et al., A human gut microbial gene catalogue established by metagenomic sequencing. Nature 2010, 464, 59-65.
    • (2010) Nature , vol.464 , pp. 59-65
    • Qin, J.1    Li, R.2    Raes, J.3    Arumugam, M.4
  • 44
    • 84889681706 scopus 로고    scopus 로고
    • Western diet induces dysbiosis with increased E coli in CEABAC10 mice, alters host barrier function favouring AIEC colonisation
    • Martinez-Medina, M., Denizot, J., Dreux, N., Robin, F. et al., Western diet induces dysbiosis with increased E coli in CEABAC10 mice, alters host barrier function favouring AIEC colonisation. Gut 2014, 63, 116-124.
    • (2014) Gut , vol.63 , pp. 116-124
    • Martinez-Medina, M.1    Denizot, J.2    Dreux, N.3    Robin, F.4
  • 45
    • 34047252362 scopus 로고    scopus 로고
    • Adherent-invasive Escherichia coli isolated from Crohn's disease patients induce granulomas in vitro
    • Meconi, S., Vercellone, A., Levillain, F., Payre, B. et al., Adherent-invasive Escherichia coli isolated from Crohn's disease patients induce granulomas in vitro. Cellular Microbiol. 2007, 9, 1252-1261.
    • (2007) Cellular Microbiol. , vol.9 , pp. 1252-1261
    • Meconi, S.1    Vercellone, A.2    Levillain, F.3    Payre, B.4
  • 46
    • 0014817520 scopus 로고
    • An evaluation of niacinamide in the treatment of childhood schizophrenia
    • Greenbaum, G. H., An evaluation of niacinamide in the treatment of childhood schizophrenia. Am. J. Psychiatry 1970, 127, 89-92.
    • (1970) Am. J. Psychiatry , vol.127 , pp. 89-92
    • Greenbaum, G.H.1
  • 47
    • 0015181325 scopus 로고
    • Megavitamin B-3 therapy for schizophrenia
    • Hoffer, A., Megavitamin B-3 therapy for schizophrenia. Can. Psychiatr. Assoc. J. 1971, 16, 499-504.
    • (1971) Can. Psychiatr. Assoc. J. , vol.16 , pp. 499-504
    • Hoffer, A.1
  • 48
    • 0023929394 scopus 로고
    • High dose nicotinamide in the treatment of necrobiosis lipoidica
    • Handfield-Jones, S., Jones, S., Peachey, R., High dose nicotinamide in the treatment of necrobiosis lipoidica. Br. J. Dermatol. 1988, 118, 693-696.
    • (1988) Br. J. Dermatol. , vol.118 , pp. 693-696
    • Handfield-Jones, S.1    Jones, S.2    Peachey, R.3
  • 49
    • 0348015990 scopus 로고
    • Studies of nicotinic acid use in hypercholesteremia. Changes in hepatic function, carbohydrate tolerance, and uric acid metabolism
    • Parsons, W. B., Jr., Studies of nicotinic acid use in hypercholesteremia. Changes in hepatic function, carbohydrate tolerance, and uric acid metabolism. Arch. Intern. Med. 1961, 107, 653-667.
    • (1961) Arch. Intern. Med. , vol.107 , pp. 653-667
    • Parsons Jr., W.B.1
  • 50
    • 0033752240 scopus 로고    scopus 로고
    • Safety of high-dose nicotinamide: a review
    • Knip, M., Douek, I. F., Moore, W. P., Gillmor, H. A. et al., Safety of high-dose nicotinamide: a review. Diabetologia 2000, 43, 1337-1345.
    • (2000) Diabetologia , vol.43 , pp. 1337-1345
    • Knip, M.1    Douek, I.F.2    Moore, W.P.3    Gillmor, H.A.4
  • 51
    • 0031665078 scopus 로고    scopus 로고
    • Pharmacokinetics of nicotinamide in cancer patients treated with accelerated radiotherapy: the experience of the Co-operative Group of Radiotherapy of the European Organization for Research and Treatment of Cancer
    • Bernier, J., Stratford, M. R., Denekamp, J., Dennis, M. F. et al., Pharmacokinetics of nicotinamide in cancer patients treated with accelerated radiotherapy: the experience of the Co-operative Group of Radiotherapy of the European Organization for Research and Treatment of Cancer. Radiother. Oncol. 1998, 48, 123-133.
    • (1998) Radiother. Oncol. , vol.48 , pp. 123-133
    • Bernier, J.1    Stratford, M.R.2    Denekamp, J.3    Dennis, M.F.4


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