CD4+ T cells transfer resistance against Citrobacter rodentium-induced infectious colitis by induction of Th 1 immunity

Scandinavian Journal of Immunology

Volumn 67, Issue 3, 2008, Pages 238-244

  Spahn, T W ^a,b   Ross, M ^b   Von Eiff, C ^b   Maaser, C ^b   Spieker, T ^b   Kannengiesser, K ^b   Domschke, W ^b   Kucharzik, T ^b  

^a MarienHospital Osnabruck   (Germany)

^b UNIVERSITY HOSPITAL MÜNSTER   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CD3 ANTIGEN; IMMUNOGLOBULIN A; IMMUNOGLOBULIN G; INTERLEUKIN 17;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CD4+ T LYMPHOCYTE; CELL TRANSFER; CITROBACTER RODENTIUM; COLITIS; CONTROLLED STUDY; CYTOKINE RELEASE; DISEASE SEVERITY; ENZYME LINKED IMMUNOSORBENT ASSAY; INTESTINE EPITHELIUM; MOUSE; NONHUMAN; PRIORITY JOURNAL; REINFECTION; SPLEEN CELL; TH1 CELL;

ADOPTIVE TRANSFER; ANIMALS; ANTIBODIES, BACTERIAL; CD4-POSITIVE T-LYMPHOCYTES; CITROBACTER RODENTIUM; COLITIS; ENTEROBACTERIACEAE INFECTIONS; FEMALE; FLOW CYTOMETRY; IMMUNOGLOBULIN A; INTERFERON TYPE II; INTERLEUKIN-10; INTERLEUKIN-17; INTERLEUKIN-2; MICE; MICE, INBRED BALB C; TH1 CELLS;

EID: 38849178169     PISSN: 03009475     EISSN: 13653083     Source Type: Journal    
DOI: 10.1111/j.1365-3083.2007.02063.x     Document Type: Article

References (17)

1. Nataro JP, Kaper JB. Diarrheagenic Escherichia coli. Clin Microbiol Rev 1998 11 : 142 201.
2. Barthold SW, Coleman GL, Jacoby RO, Livestone EM, Jonas AM. Transmissible murine colonic hyperplasia. Vet Pathol 1978 15 : 223 36.
3. Ghaem-Maghami M, Simmons CP, Daniell S et al. Intimin-specific immune responses prevent bacterial colonization by the attaching-effacing pathogen Citrobacter rodentium. Infect Immun 2001 69 : 5597 605.
4. Maaser C, Housley MP, Iimura M et al. Clearance of Citrobacter rodentium requires B cells but not secretory immunoglobulin A (IgA) or IgM antibodies. Infect Immun 2004 72 : 3315 24.
5. Simmons CP, Goncalves NS, Ghaem-Maghami M et al. Impaired resistance and enhanced pathology during infection with a noninvasive, attaching-effacing enteric bacterial pathogen, Citrobacter rodentium, in mice lacking IL-12 or IFN-gamma. J Immunol 2002 168 : 1804 12.
6. Mangan PR, Harrington LE, O'Quinn DB et al. Transforming growth factor-beta induces development of the T(H)17 lineage. Nature 2006 441 : 231 4.
7. Elson CO, Cong Y, Weaver CT et al. Monoclonal anti-interleukin 23 reverses active colitis in a T cell-mediated model in mice. Gastroenterlogy 2007 132 : 2359 70.
8. deVos T, Dick TA. A rapid method to determine the isotype and specificity of coproantibodies in mice infected with Trichinella or fed cholera toxin. J Immunol Methods 1991 141 : 285 8.
9. Barthold SW. The microbiology of transmissible murine colonic hyperplasia. Lab Anim Sci 1980 30 : 167 73.
10. Simmons CP, Clare S, Ghaem-Maghami M et al. Central role for B lymphocytes and CD4(+) T cells in immunity to infection by the attaching and effacing pathogen Citrobacter rodentium. Infect Immun 2003 71 : 5077 86.
11. Bry L, Brenner MB. Critical role of T cell-dependent serum antibody, but not the gut-associated lymphoid tissue, for surviving acute mucosal infection with Citrobacter rodentium, an attaching and effacing pathogen. J Immunol 2004 172 : 433 41.
12. Higgins LM, Frankel G, Douce G, Dougan G, MacDonald TT. Citrobacter rodentium infection in mice elicits a mucosal Th1 cytokine response and lesions similar to those in murine inflammatory bowel disease. Infect Immun 1999 67 : 3031 9.
13. Oppmann B, Lesley R, Blom B et al. Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12. Immunity 2000 13 : 715 25.
14. Happel KI, Dubin PJ, Zheng M et al. Divergent roles of IL-23 and IL-12 in host defense against Klebsiella pneumoniae. J Exp Med 2005 202 : 761 9.
15. Uren TK, Wijburg OL, Simmons C et al. Vaccine-induced protection against gastrointestinal bacterial infections in the absence of secretory antibodies. Eur J Immunol 2005 35 : 180 8.
16. Goncalves NS, Ghaem-Maghami M, Monteleone G et al. Critical role for tumor necrosis factor alpha in controlling the number of lumenal pathogenic bacteria and immunopathology in infectious colitis. Infect Immun 2001 69 : 6651 9.
17. Spahn TW, Maaser C, Eckmann L et al. The lymphotoxin-beta receptor is critical for control of murine Citrobacter rodentium-induced colitis. Gastroenterology 2004 127 : 1463 73.