Deoxynivalenol exposure assessment in young children in Tanzania

Molecular Nutrition and Food Research

Volumn 58, Issue 7, 2014, Pages 1574-1580

  Srey, Chou ^a,b   Kimanya, Martin E ^c,d   Routledge, Michael N ^b   Shirima, Candida P ^c   Gong, Yun Yun ^a,b  

^a QUEEN'S UNIVERSITY BELFAST   (United Kingdom)

^b UNIVERSITY OF LEEDS   (United Kingdom)

^c Tanzania Food and Drugs Authority   (Tanzania)

^d NELSON MANDELA AFRICAN INSTITUTION OF SCIENCE AND TECHNOLOGY   (Tanzania)

Author keywords

Biomarkers; Children; Deoxynivalenol; Exposure assessment

Indexed keywords

BETA GLUCURONIDASE; BIOLOGICAL MARKER; TRICHOTHECENE DERIVATIVE; VOMITOXIN;

ANALYSIS; CHEMISTRY; DIET; ENVIRONMENTAL EXPOSURE; FEMALE; FOLLOW UP; FOOD CONTAMINATION; FOOD CONTROL; HUMAN; INFANT; LIQUID CHROMATOGRAPHY; MAIZE; MALE; MASS SPECTROMETRY; METABOLISM; MULTIVARIATE ANALYSIS; RISK ASSESSMENT; TANZANIA; URINE; WEANING;

BIOLOGICAL MARKERS; CHROMATOGRAPHY, LIQUID; DIET; ENVIRONMENTAL EXPOSURE; FEMALE; FOLLOW-UP STUDIES; FOOD CONTAMINATION; FOOD MICROBIOLOGY; GLUCURONIDASE; HUMANS; INFANT; MALE; MASS SPECTROMETRY; MULTIVARIATE ANALYSIS; RISK ASSESSMENT; TANZANIA; TRICHOTHECENES; WEANING; ZEA MAYS;

EID: 84903535138     PISSN: 16134125     EISSN: 16134133     Source Type: Journal    
DOI: 10.1002/mnfr.201400012     Document Type: Article

References (31)

1. JECFA (Joint FAO/WHO Expert Committee on Food Additives). Seventy-second Meeting, World Health Organization, Rome. 2010, Vol. 16, pp. 1-16.
2. Pestka, J. J., Smolinski, A. T., Deoxynivalenol: toxicology and potential effects on humans. J. Toxicol. Environ. Health B Crit. Rev. 2005, 8, 39-69.
3. IARC (International Agency for Research on Cancer). Improving Public Health through Mycotoxin Control. IARC Scientific Publication no. 158, IARC Press, Lyon, France 2012.
4. Shirima, C. P., Kimanya, M. E., Kinabo, J. L., Routledge, M. N. et al., Dietary exposure to aflatoxin and fumonisin among Tanzanian children as determined using biomarkers of exposure. Mol. Nutr. Food. Res. 2013, 57, 1874-1881.
5. Meky, F. A., Turner, P. C., Ashcroft, A. E., Miller, J. D. et al., Development of a urinary biomarker of human exposure to deoxynivalenol. Food Chem. Toxicol. 2003, 41, 265-273.
6. Turner, P. C., Burley, V. J., Rothwell, J. A., White, K. L. et al., Dietary wheat reduction decreases the level of urinary deoxynivalenol in UK adults. J. Expo. Sci. Environ. Epidemiol. 2008, 18, 392-399.
7. Turner, P. C., Rothwell, J. A., White, K. L., Gong, Y. Y. et al., Urinary deoxynivalenol is correlated with cereal intake in individuals from the United Kingdom. Environ. Health Perspect. 2008, 116, 21-25.
8. Ediage, E. N., Di Mavungu, J. D., Song, S., Sioen, I. et al., Multimycotoxin analysis in urines to assess infant exposure: a case study in Cameroon. Environ. Int. 2013, 57-58, 50-59.
9. Piekkola, S., Turner, P. C., Abdel-Hamid, M., Ezzat, S. et al., Characterisation of aflatoxin and deoxynivalenol exposure among pregnant Egyptian women. Food Addit. Contam. Part A. Chem. Anal. Control Expo. Risk Assess. 2012, 6, 962-971.
10. Sarkanj, B., Warth, B., Uhlig, S., Abia, W. A. et al., Urinary analysis reveals high deoxynivalenol exposure in pregnant women from Croatia. Food Chem. Toxicol. 2013, 62, 231-237.
11. Shephard, G. S., Burger, H. M., Gambacorta, L., Gong, Y. Y. et al., Multiple mycotoxin exposure determined by urinary biomarkers in rural subsistence farmers in the former Transkei, South Africa. Food Chem. Toxicol. 2013, 25, 217-225.
12. Warth, B., Sulyok, M., Fruhmann, P., Berthiller, F. et al., Assessment of human deoxynivalenol exposure using an LC-MS/MS based biomarker method. Toxicol. Lett. 2012, 211, 85-90.
13. Leblanc, J. C., Tard, A., Volatier, J. L., Verger, P., Estimated dietary exposure to principal food mycotoxins from the first French Total Diet Study. Food Addit. Contam. 2005, 7, 652-672.
14. Schothorst, R. C., Jekel, A. A., Van Egmond, H. P., De Mul, A. et al., Determination of trichothecenes in duplicate diets of young children by capillary gas chromatography with mass spectrometric detection. Food Addit. Contam. 2005, 22, 48-55.
15. Sirot, V., Fremy, J. M., Leblanc, J. C., Dietary exposure to mycotoxins and health risk assessment in the second French total diet study. Food Chem. Toxicol. 2013, 52, 1-11.
16. EFSA (European Food Safety Authority). Deoxynivalenol in food and feed: occurrence and exposure. EFSA J. 2013, 11, 3379, 56 pp.
17. Pestka, J. J, Deoxynivalenol: toxicity, mechanisms and animal health risks. Anim. Feed Sci. Technol. 2007, 137, 283-298.
18. Turner, P. C., Hopton, R. P., White, K. L., Fisher, J. et al., Assessment of deoxynivalenol metabolite profiles in UK adults. Food Chem. Toxicol. 2011, 49, 132-135.
19. Wu, X., Murphy, P., Cunnick, J., Hendrich, S., Synthesis and characterization of deoxynivalenol glucuronide: its comparative immunotoxicity with deoxynivalenol. Food Chem. Toxicol. 2007, 45, 1846-55.
20. Haga, M., Sakata, T., Daily salt intake of healthy Japanese infants of 3-5 years based on sodium excretion in 24-hour urine. J. Nutr. Sci. Vitaminol. 2010, 56, 305-310.
21. Oldenburg, E., Schittenhelm, S., Effect of plant water deficit on the deoxynivalenol concentration in Fusarium-infected maize kernels. Mycotoxin Res. 2012, 28, 229-236.
22. Jajic, I. M., Abramovic, B. F., Juric, V. B., Krostovic, S. Z., Presence of deoxynivalenol in maize of vojvodina. Proc. Nat. Sci. 2007, 113, 135-142.
23. Turner, P. C., Gong, Y. Y., Pourshams, A., Jafari, E. et al., A pilot survey for Fusarium mycotoxin biomarkers in women from Golestan, northern Iran. World Mycotoxin 2012, 5, 195-199.
24. Solfrizzo, M., Gambacorta, L., Lattanzio, V. M., Powers, S. et al., Simultaneous LC-MS/MS determination of aflatoxin M1, ochratoxin A, deoxynivalenol, de-epoxydeoxynivalenol, α and β-zearalenols and fumonisin B1 in urine as a multi-biomarker method to assess exposure to mycotoxins. Anal. Bioanal. Chem. 2011, 9, 2831-2841.
25. Lattanzio, V. M., Solfrizzo, M., De Girolamo, A., Chulze, S. N. et al., LC-MS/MS characterization of the urinary excretion profile of the mycotoxin deoxynivalenol in human and rat. J. Chromatogr B Analyt. Technol. Biomed. Life Sci. 2011, 11-12, 707-715.
26. Turner, P. C., White, K. L., Burley, V. J., Hopton, R. P. et al., A comparison of deoxynivalenol intake and urinary deoxynivalenol in UK adults. Biomarkers 2010, 15, 553-562.
27. Goyarts, T., Dänicke, S., Bioavailability of the Fusarium toxin deoxynivalenol (DON) from naturally contaminated wheat for the pig. Toxicol. Lett. 2006, 163, 171-182.
28. Dänicke, S., Valenta, H., Döll, S., Ganter, M. et al., On the effectiveness of a detoxifying agent in preventing fusario-toxicosis in fattening pigs. Anim. Feed Sci. Technol. 2004, 114, 141-157.
29. Dänicke, S., Valenta, H., Klobasa, F., Döll, S. et al., Effects of graded levels of Fusarium toxin contaminated wheat in diets for fattening pigs on growth performance, nutrient digestibility, deoxynivalenol balance and clinical serum characteristics. Arch. Anim. Nutr. 2004, 58, 1-17.
30. Eriksen, G. S., Pettersson, H., Lindberg, J. E., Absorption, metabolism and excretion of 3-acetyl DON in pigs. Arch. Anim. Nutr. 2003, 57, 335-345.
31. Makri A., Goveia M., Balbus J., Parkin R. Children's susceptibility to chemicals: a review by developmental stage. J. Toxicol. Environ. Health B Crit. Rev. 2004, 7, 417-435.