Octanal-induced inflammatory responses in cells relevant for lung toxicity: Expression and release of cytokines in A549 human alveolar cells

Human and Experimental Toxicology

Volumn 33, Issue 7, 2014, Pages 710-721

  Song, M K ^a,b   Lee, H S ^a   Choi, H S ^a   Shin, C Y ^a   Kim, Y J ^c   Park, Y K ^b   Ryu, J C ^a  

^a Korea Institute of Science and Technology   (South Korea)

^b Korea University   (South Korea)

^c SolarLight Ltd   (South Korea)

Author keywords

cytokine; Gene Ontology (GO); inflammation; microarray; Octanal; pulmonary toxicity

Indexed keywords

ALDEHYDE; INTERLEUKIN 6; INTERLEUKIN 8; OCTANAL; UNCLASSIFIED DRUG; AIR POLLUTANT; AUTACOID; CAPRYLIC ALDEHYDE; CYTOKINE; IL6 PROTEIN, HUMAN; IL8 PROTEIN, HUMAN; MESSENGER RNA;

ADENOCARCINOMA CELL LINE; ARTICLE; CONTROLLED STUDY; CYTOKINE RELEASE; CYTOKINE RESPONSE; DNA MICROARRAY; GENE EXPRESSION; GENE IDENTIFICATION; GENE ONTOLOGY; HUMAN; HUMAN CELL; IN VITRO STUDY; INFLAMMATION; LUNG ADENOCARCINOMA; LUNG ALVEOLUS CELL; LUNG ALVEOLUS EPITHELIUM; LUNG TOXICITY; NUCLEOTIDE SEQUENCE; PNEUMONIA; PRIORITY JOURNAL; PROTEIN EXPRESSION; TRANSCRIPTOMICS; AIR POLLUTANT; BIOLOGY; CELL SURVIVAL; CHEMICALLY INDUCED; DOSE RESPONSE; DRUG EFFECTS; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENETIC DATABASE; GENETICS; IMMUNOLOGY; LUNG ALVEOLUS; METABOLISM; PROCEDURES; TOXICITY; TUMOR CELL LINE;

AIR POLLUTANTS; ALDEHYDES; CELL LINE, TUMOR; CELL SURVIVAL; COMPUTATIONAL BIOLOGY; CYTOKINES; DATABASES, GENETIC; DOSE-RESPONSE RELATIONSHIP, DRUG; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; HUMANS; INFLAMMATION MEDIATORS; INTERLEUKIN-6; INTERLEUKIN-8; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PNEUMONIA; PULMONARY ALVEOLI; RNA, MESSENGER;

EID: 84903522930     PISSN: 09603271     EISSN: 14770903     Source Type: Journal    
DOI: 10.1177/0960327113506722     Document Type: Article

References (56)

1. Bernstein JA, Alexis N, Bacchus H, et al. The health effects of non-industrial indoor air pollution. J Allergy Clin Immunol. 2008 ; 121: 585-591
2. Baumann MGD, Lorenz LF, Batterman SA, et al. Aldehyde emissions from particleboard and medium density fiberboard products. Forest Prod J. 2000 ; 50: 75-82
3. Nazaroff WW, Weschler CJ. Cleaning products and air fresheners: exposure to primary and secondary air pollutants. Atmos Environ. 2004 ; 38: 2841-2865
4. O'Brien PJ, Siraki AG, Shangari N, et al. Aldehyde sources, metabolism, molecular toxicity mechanisms, and possible effects on human health. Crit Rev Toxicol. 2005 ; 35: 609-662
5. Fujimaki H, Yamamoto S, Tin-Tin-Win-Shwe, et al. Effect of long-term exposure to low-level toluene on airway inflammatory response in mice. Toxicol Lett. 2007 ; 168: 132-139
6. Jung WW, Kim EM, Lee EH, et al. Formaldehyde exposure induces airway inflammation by increasing eosinophil infiltrations through the regulation of reactive oxygen species production. Environ Toxicol Pharmacol. 2007 ; 24: 174-182
7. Lecureur V, Arzel M, Ameziane S, et al. MAPK- and PKC/CREB-dependent induction of interleukin-11 by the environmental contaminant formaldehyde in human bronchial epithelial cells. Toxicology. 2012 ; 292: 13-22
8. Bein K, Leikauf GD. Acrolein: a pulmonary hazard. Mol Nutr Food Res. 2011 ; 55: 1342-1360
9. Tang MS, Wang HT, Hu Y, et al. Acrolein induced DNA damage, mutagenicity and effect on DNA repair. Mol Nutr Food Res. 2011 ; 55: 1291-1300
10. Oyama T, Isse T, Ogawa M, et al. Susceptibility to inhalation toxicity of acetaldehyde in Aldh2 knockout mice. Front Biosci. 2007 ; 12: 1927-1934
11. Wolkoffa P, Schneidera T, Kildesøa J, et al. Risk in cleaning: chemical and physical exposure. Sci Total Environ. 1998 ; 215: 135-156
12. Fullana A, Carbonell-Barrachina AA, Sidhu S. Volatile aldehyde emissions from heated cooking oils. J Sci Food Agr. 2004 ; 84: 2015-2021
13. Maddalena RL, Russell M, Sullivan DP, et al
14. Sarigiannis DA, Karakitsios SP, Gotti A, et al. Exposure to major volatile organic compounds and carbonyls in European indoor environments and associated health risk. Environ Int. 2011 ; 37: 743-765
15. Clayton GD, Clayton FE Patty's Industrial Hygiene and Toxicology Volume 2A, 2B, 2C: Toxicology. 2 A, 2B, 2C: Toxicology. 3rd ed. New York, NY: John Wiley Sons, 1981-1982, p. 2633. New York, NY: John Wiley Sons ; 1981-1982: 2633.
16. NIOSH. NOES: National Occupational Exposure Survey conducted from 1981-1983. Estimated numbers of employees potentially exposed to specific agents by 2-digit standard industrial classification (SIC), http://www.cdc.gov/noes/ (accessed February 2009).
17. Antus B. Assessment of airway inflammation in chronic obstructive pulmonary disease: biomarkers in exhaled breath condensate. Orvosi Hetilap. 2012 ; 153: 843-851
18. Dong W, Simeonova PP, Gallucci R, et al. Toxic metals stimulate inflammatory cytokines in hepatocytes through oxidative stress mechanisms. Toxicol Appl Pharmacol. 1998 ; 151: 359-366
19. Hetland RB, Cassee FR, Refsnes M, et al. Release of inflammatory cytokines, cell toxicity and apoptosis in epithelial lung cells after exposure to ambient air particles of different size fractions. Toxicol Vitro. 2004 ; 18: 203-212
20. Burns AR, Simon SI, Kukielka GL, et al. Chemotactic factors stimulate CD18-dependent canine neutrophil adherence and motility on lung fibroblasts. J Immunol. 1996 ; 156: 3389-3401
21. Lazarus SC. Role of inflammation and inflammatory mediators in airways disease. Am J Med. 1986 ; 81: 2-7
22. Murtaugh MP, Baarsch MJ, Zhou Y, et al. Inflammatory cytokines in animal health and disease. Vet Immunol Immunopathol. 1996 ; 54: 45-55
23. Donnelly LE, Barnes PJ. Chemokine receptors as therapeutic targets in chronic obstructive pulmonary disease. Trends Pharmacol Sci. 2006 ; 27: 546-553
24. Wang F, Li C, Liu W, et al. Effect of exposure to volatile organic compounds (VOCs) on airway inflammatory response in mice. Toxicol Sci. 2012 ; 37: 739-748
25. Wolkoff P, Wilkins CK, Clausen PA, et al. Organic compounds in office environments - sensory irritation, odor, measurements and the role of reactive chemistry. Indoor Air. 2006 ; 16: 7-19
26. Chung KF. Inflammatory mediators in chronic obstructive pulmonary disease. Current Drug Target -Inflam Allergy. 2005 ; 4: 619-625
27. Davies DE, Holgate ST. Asthma: the importance of epithelial mesenchymal communication in pathogenesis. Inflammation and the airway epithelium in asthma. Int J Biochem Cell Biol. 2002 ; 34: 1520-1526
28. Mosmann T. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J Immunol Method. 1983 ; 65: 55-63
29. Yim WC, Keum C, Kim S, et al. Identification of novel 17-estradiol (E2) target genes using crossexperiment gene expression datasets. Toxicol Environ Health Sci. 2010 ; 2: 25-38
30. Benjamini Y, Hochberg Y. Controlling the false discovery rate: a practical and powerful approach to multiple testing. J R Stat Soc Series B. 1995 ; 57: 289-300
31. Song MK, Yoon JS, Song M, et al. Gene expression analysis identifies DNA damage-related markers of benzo[a]pyrene exposure in HepG2 human hepatocytes. Toxicol Environ Health Sci. 2012 ; 4: 19-29
32. Song MK, Choi HS, Lee HS, et al. Analysis of microRNA and mRNA expression profiles highlights alterations in modulation of the MAPK pathway under octanal exposure. Environmental Toxicology and Pharmacology. 2013; under review ;:
33. Munshi UK, Niu JO, Siddiq MM, et al. Elevation of interleukin-8 and interleukin-6 precedes the influx of neutrophols in tracheal aspirates from preterm infants who develop bronchopulmonary dysplasia. Pediatr Pulmonol. 1997 ; 24: 331-336
34. The U.S. Environmental Protection Agency's Strategic Plan for Evaluating the Toxicity of Chemicals. Washington, D.C: U.S. Environmental Protection Agency ; 2009 :
35. Song MK., Kim YJ, Song M, et al. Gene expression analysis identifies potential biomarkers of phenanthrene in human hepatocytes (HepG2). Toxicol Environ Health Sci. 2011 ; 3: 30-38
36. Roggen EL, Soni NK, Verheyen GR. Respiratory immunotoxicity: an in vitro assessment. Toxicol Vitro. 2006 ; 20: 1249-1264
37. Feltens R, Mogel I, Roder-Stolinski C, et al. Chlorobenzene induces oxidative stress in human lung epithelial cells in vitro. Toxicol Appl Pharmacol. 2010 ; 242: 100-108
38. Koehler C, Ginzkey C, Friehs G, et al. Aspects of nitrogen dioxide toxicity in environmental urban concentrations in human nasal epithelium. Toxicol Appl Pharmacol. 2010 ; 245: 219-225
39. Kastner PE, Casset A, Pons F. Formaldehyde interferes with airway epithelium integrity and functions in a dose- and time-dependent manner. Toxicol Lett. 2011 ; 200: 109-116
40. Persoz C, Achard S, Leleu C, et al. An in vitro model to evaluate the inflammatory response after gaseous formaldehyde exposure of lung epithelial cells. Toxicol Lett. 2010 ; 195: 99-105
41. Pariselli F, Sacco MG, Rembges D. An optimized method for in vitro exposure of human derived lung cells to volatile chemicals. Exp Toxicol Pathol. 2009 ; 61: 33-39
42. Song MK, Kim YJ, Song M, et al. Formation of a 3,4-diol-1,2-epoxide metabolite of benz[a]anthracene with cytotoxicity and genotoxicity in a human in vitro hepatocyte culture system. Environ Toxicol Pharmacol. 2012 ; 33: 212-225
43. Cheah NP, Pennings JL, Vermeulen JP, et al. In vitro effects of aldehydes present in tobacco smoke on gene expression in human lung alveolar epithelial cells. Toxicol Vitro. 2013 ; 27: 1072-1081
44. Jorens PG, Van Damme J, De Backer W, et al. Interleukin 8 (IL-8) in the bronchoalveolar lavage fluid from patients with eh adult respiratory distress syndrome (ARDS) and patients at the risk for ARDS. Cytokine. 1992 ; 4: 592-597
45. Keatings VM, Collins PD, Scott DM, et al. Differences in interleukin-8 and tumor necrosis factor-a in induced sputum from patients with chronic obstructive pulmonary disease or asthma. Am J Respir Crit Care Med. 1996 ; 153: 530-534
46. Groneck P, Goetze-Speer B, Oppermann M, et al. Association of pulmonary inflammation and increased microvascular permeability during the development of bronchopulmonary dysplasia: a sequential analysis of inflammatory mediators in respiratory fluids of high risk preterm infants. Pediatrics. 1994 ; 93: 712-718
47. Hybertson BM, Lee YM, Repine JE. Phagocytes and acute lung injury: dual roles for interleukin-1. Ann NY Acad Sci. 1997 ; 832: 266-273
48. Pugin J, Ricou B, Steinberg KP, et al. Proinflammatory activity in bronchoalveolar lavage fluids from patients with ARDS, a prominent role for interleukin-1. Am J Respir Crit Care Med. 1996 ; 153: 1850-1856
49. Kishimoto T. IL-6: from its discovery to clinical applications. Int Immunol. 2010 ; 22: 347-352
50. Yokoyama A, Kohno N, Fujino S, et al. Circulating interleukin-6 levels in patients with bronchial asthma. Am J Respir Crit Care Med. 1995 ; 151: 1354-1358
51. Larsson K. Inflammatory markers in COPD. Clin Respir J. 2008 ; 2 (Suppl). 84-87
52. Folkesson HG, Matthay MA, Hebert CA, et al. Acid aspirationinduced lung injury in rabbits is mediated by interleukin-8-dependent mechanisms. J Clin Invest. 1995 ; 96: 107-116
53. Rager JE, Smeester L, Jaspers I, et al. Epigenetic changes induced by air toxics: formaldehyde exposure alters miRNA expression profiles in human lung cells. Environ Health Perspect. 2011 ; 119: 494-500
54. Bianchi M, Martucci C, Biella G, et al. Increased substance P and tumor necrosis factor-level in the paws following formalin injection in rat tail. Brain Res. 2004 ; 1019: 255-258
55. Rosendahl A, Pardali E, Speletas M, et al. Activation of bone morphogenetic protein/Smad signaling in bronchial epithelial cells during airway inflammation. Am J Respir Crit Mol Biol. 2002 ; 27: 160-169
56. Yamada M, Kubo H, Kobayashi S, et al. The increase in surface CXCR4 expression on lung extravascular neutrophils and its effects on neutrophils during endotoxin-induced lung injury. Cell Mol Immunol. 2011 ; 8: 305-314