Pharmacokinetic study of multiple active constituents from Kushen-Gancao Decoction after oral administration in rat by HPLC-MS/MS

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 965, Issue , 2014, Pages 19-26

  Wang, Qinhui ^a   Shi, Lei ^a   Tang, Xiuling ^a   Wang, Qingwei ^a   Dang, Xueliang ^a   Zhang, Yan ^a  

^a FOURTH MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

Glycyrrhetinic acid; Glycyrrhizic acid; HPLC MS MS; Matrine; Oxymatrine; Pharmacokinetic

Indexed keywords

BODY FLUIDS; ELECTROSPRAY IONIZATION; PHARMACOKINETICS; RATS;

GLYCYRRHETINIC ACIDS; GLYCYRRHIZIC ACID; HPLC-MS/MS; MATRINE; OXYMATRINE;

DRUG PRODUCTS;

ANTIVIRUS AGENT; GLYCYRRHETINIC ACID; GLYCYRRHIZIC ACID; HERBACEOUS AGENT; KUSHEN GANCAO DECOCTION; MATRINE; OXYMATRINE; UNCLASSIFIED DRUG; ALKALOID; QUINOLIZINE DERIVATIVE;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; CHINESE HERB; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG EFFECT; DRUG HALF LIFE; DRUG SAFETY; DRUG STABILITY; GLYCYRRHIZA; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LIMIT OF QUANTITATION; MAXIMUM PLASMA CONCENTRATION; MEASUREMENT ACCURACY; NONHUMAN; PLANT ROOT; PRIORITY JOURNAL; RADIX GLYCYRRHIZA; RAT; SIGNAL NOISE RATIO; SOPHORA FLAVESCENS; TANDEM MASS SPECTROMETRY; TIME TO MAXIMUM PLASMA CONCENTRATION; ANIMAL; BLOOD; CHEMISTRY; ORAL DRUG ADMINISTRATION; PROCEDURES; REPRODUCIBILITY; SENSITIVITY AND SPECIFICITY; SPRAGUE DAWLEY RAT; STATISTICAL MODEL;

ADMINISTRATION, ORAL; ALKALOIDS; ANIMALS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DRUGS, CHINESE HERBAL; GLYCYRRHETINIC ACID; GLYCYRRHIZIC ACID; LINEAR MODELS; QUINOLIZINES; RATS; RATS, SPRAGUE-DAWLEY; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; TANDEM MASS SPECTROMETRY;

EID: 84903487771     PISSN: 15700232     EISSN: 1873376X     Source Type: Journal    
DOI: 10.1016/j.jchromb.2014.05.038     Document Type: Article

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