Pharmacokinetic characterization of oxymatrine and matrine in rats after oral administration of radix Sophorae tonkinensis extract and oxymatrine by sensitive and robust UPLC-MS/MS method

Journal of Pharmaceutical and Biomedical Analysis

Volumn 83, Issue , 2013, Pages 179-185

  Tang, Lan ^a,b   Dong, Ling Na ^a   Peng, Xiao Juan ^a   Li, Ye ^a   Shi, Jian ^a   Zhou, Fu Yuan ^a   Liu, Zhong Qiu ^a,b  

^a SOUTHERN MEDICAL UNIVERSITY   (China)

^b GUANGZHOU UNIVERSITY OF CHINESE MEDICINE   (China)

Author keywords

Matrine; Oxymatrine; Pharmacokinetics; Radix Sophorae tonkinensis; UPLC MS MS

Indexed keywords

MATRINE; OXYMATRINE; PLANT EXTRACT; SOPHORAE TONKINENSIS EXTRACT; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; CONCENTRATION RESPONSE; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG PROTEIN BINDING; DRUG TRANSFORMATION; IN VITRO STUDY; IN VIVO STUDY; LEGUME; LIMIT OF QUANTITATION; MAXIMUM PLASMA CONCENTRATION; NONHUMAN; PRIORITY JOURNAL; RAT; SOPHORAE TONKINENSIS; TANDEM MASS SPECTROMETRY; TIME TO MAXIMUM PLASMA CONCENTRATION; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY;

ADMINISTRATION, ORAL; ALKALOIDS; ANIMALS; AREA UNDER CURVE; BIOLOGICAL AVAILABILITY; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; PLANT EXTRACTS; PLANT ROOTS; QUINOLIZINES; RATS; RATS, SPRAGUE-DAWLEY; SOPHORA; TANDEM MASS SPECTROMETRY;

EID: 84878784564     PISSN: 07317085     EISSN: 1873264X     Source Type: Journal    
DOI: 10.1016/j.jpba.2013.05.003     Document Type: Article

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