Cofactor-dependent conformational heterogeneity of GAD65 and its role in autoimmunity and neurotransmitter homeostasis

Proceedings of the National Academy of Sciences of the United States of America

Volumn 111, Issue 25, 2014, Pages

  Kass, Itamar ^a   Hoke, David E ^a   Costa, Mauricio G S ^b   Reboul, Cyril F ^a   Porebski, Benjamin T ^a   Cowieson, Nathan P ^c   Leh, Hervé ^d   Pennacchietti, Eugenia ^e   McCoey, Julia ^a   Kleifeld, Oded ^a   Voltattorni, Carla Borri ^f   Langley, David ^g   Roome, Brendan ^g   Mackay, Ian R ^a   Christ, Daniel ^g   Perahia, David ^d   Buckle, Malcolm ^d   Paiardini, Alessandro ^e   De Biase, Daniela ^e   Buckle, Ashley M ^a  

^a MONASH UNIVERSITY   (Australia)

^b INSTITUTO OSWALDO CRUZ   (Brazil)

^c AUSTRALIAN SYNCHROTRON   (Australia)

^d CNRS   (France)

^e SAPIENZA UNIVERSITY OF ROME   (Italy)

^f UNIVERSITY OF VERONA   (Italy)

^g GARVAN INSTITUTE OF MEDICAL RESEARCH   (Australia)

Author keywords

Autoepitopes; Conformational dynamics; GABA biosynthesis; Immunogenicity; Normal mode analysis

Indexed keywords

GLUTAMATE DECARBOXYLASE 65; GLUTAMATE DECARBOXYLASE 67; NEUROTRANSMITTER;

ANTIBODY BLOOD LEVEL; ANTIBODY PRODUCTION; ANTIGEN BINDING; ARTICLE; AUTOIMMUNITY; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; CRYSTAL STRUCTURE; ENZYME CONFORMATION; EPITOPE MAPPING; IMMUNOLOGICAL TOLERANCE; MOLECULAR DYNAMICS; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN HOMEOSTASIS; PROTEIN SYNTHESIS; X RAY CRYSTALLOGRAPHY;

AUTOEPITOPES; CONFORMATIONAL DYNAMICS; GABA BIOSYNTHESIS; IMMUNOGENICITY; NORMAL MODE ANALYSIS;

AUTOANTIBODIES; AUTOIMMUNITY; DIABETES MELLITUS, TYPE 1; GAMMA-AMINOBUTYRIC ACID; GLUTAMATE DECARBOXYLASE; HOMEOSTASIS; HUMANS; MOLECULAR DYNAMICS SIMULATION; NEUROTRANSMITTER AGENTS; PROTEIN MULTIMERIZATION; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84903461226     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1403182111     Document Type: Article

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