Structural characterization of the mechanism through which human glutamic acid decarboxylase auto-activates

Bioscience Reports

Volumn 33, Issue 1, 2013, Pages 137-149

  Langendorf, Christopher G ^a   Tuck, Kellie L ^a   Key, Trevor L G ^a   Fenalti, Gustavo ^a,b   Pike, Robert N ^a   Rosado, Carlos J ^a   Wong, Anders S M ^a   Buckle, Ashley M ^a   Law, Ruby H P ^a   Whisstock, James C ^a  

^a MONASH UNIVERSITY   (Australia)

^b SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

Auto inactivation, catalytic loop, chimaera, C terminal domain, glutamic acid decarboxylase, X ray crystallography

Indexed keywords

GLUTAMATE DECARBOXYLASE 65; GLUTAMATE DECARBOXYLASE 67; ISOENZYME;

ARTICLE; CARBOXY TERMINAL SEQUENCE; CHIMERA; COMPARATIVE STUDY; CONTROLLED STUDY; CRYSTAL STRUCTURE; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME AUTO INACTIVATION; ENZYME CATALYTIC LOOP; ENZYME CONFORMATION; ENZYME INACTIVATION; ENZYME STRUCTURE; MUTATIONAL ANALYSIS; PROTEIN MOTIF; STRUCTURE ANALYSIS;

CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; ENZYME ACTIVATION; ENZYME STABILITY; GLUTAMATE DECARBOXYLASE; GLUTAMIC ACID; HUMANS; ISOENZYMES; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT FUSION PROTEINS; REPRODUCIBILITY OF RESULTS; SACCHAROMYCES CEREVISIAE;

CHIMAERIFORMES;

EID: 84872718995     PISSN: 01448463     EISSN: 15734935     Source Type: Journal    
DOI: 10.1042/BSR20120111     Document Type: Article

References (30)

1. Capitani, G., De Biase, D., Aurizi, C., Gut, H., Bossa, F. and Grutter, M. G. (2003) Crystal structure and functional analysis of Escherichia coli glutamate decarboxylase. EMBO J. 22, 4027-4037
2. Gut, H., Pennacchietti, E., John, R. A., Bossa, F., Capitani, G., De Biase, D. and Grutter, M. G. (2006) Escherichia coli acid resistance: pH-sensing, activation by chloride and autoinhibition in GadB. EMBO J. 25, 2643-2651
3. Asada, H., Kawamura, Y., Maruyama, K., Kume, H., Ding, R-G., Kanbara, N., Kuzume, H., Sanbo, M., Yagi, T. and Obata, K. (1997) Cleft palate and decreased brain ? -aminobutyric acid in mice lacking the 67-kDa isoform of glutamic acid decarboxylase. Proc. Natl. Acad. Sci. U.S.A. 94, 6496-6499
4. Erlander, M. G. and Tobin, A. J. (1991) The structural and functional heterogeneity of glutamic acid decarboxylase: a review. Neurochem. Res. 16, 215-226
5. Fagiolini, M., Fritschy, J-M., Low, K., Mohler, H., Rudolph, U. and Hensch, T. K. (2004) Specific GABAA circuits for visual cortical plasticity. Science 303, 1681-1683
6. Ge, S., Goh, E. L. K., Sailor, K. A., Kitabatake, Y., Ming, G-L. and Song, H. (2006) GABA regulates synaptic integration of newly generated neurons in the adult brain. Nature 439, 589-593
7. Kash, S., Johnston, R. S., Tecott, L. H., Noebels, J. L., Mayfield, R. D., Hanahan, D. and Baekkeskov, S. (1997) Epilepsy in mice deficient in the 65-kDa isoform of glutamic acid decarboxylase. Proc. Natl. Acad. Sci. U.S.A. 94, 14060-14065
8. Nakatsu, Y., Tyndale, R. F., DeLorey, T. M., Durham-Pierre, D., Gardner, J. M., McDanel, H. J., Nguyen, Q., Wagstaff, J., Lalando, M., Sikela, J. M. et al. (1993) A cluster of three GABAA receptor subunit genes is deleted in a neurological mutant of the mouse p locus. Nature 364, 448-450
9. Akbarian, S. and Huang, H-S. (2006) Molecular and cellular mechanisms of altered GAD1/GAD67 expression in schizophrenia and related disorders. Brain Res. Rev. 52, 293-304
10. Kaplitt, M. G., Feigin, A., Tang, C., Fitzsimons, H. L., Mattis, P., Lawlor, P. A., Bland, R. J., Young, D., Strybing, K., Eidelberg, D. and During, M. J. (2007) Safety and tolerability of gene therapy with an adeno-associated virus (AAV) borne GAD gene for Parkinson's disease: an open label, phase I trial. Lancet 369, 2097-2105
11. Lanoue, A. C., Dumitriu, A., Myers, R. H. and Soghomonian, J-J. (2010) Decreased glutamic acid decarboxylase mRNA expression in prefrontal cortex in Parkinson's disease. Exp. Neurol. 226, 207-217
12. Perry, T. L., Buchanan, J., Kish, S. J. and Hansen, S. (1979) ? -Aminobutyric acid deficiency in brain of schizophrenic. Lancet 313, 237-239
13. Thompson, M., Weickert, C. S., Wyatt, E. and Webster, M. J. (2009) Decreased glutamic acid decarboxylase67 mRNA expression in multiple brain areas of patients with schizophrenia and mood disorders. J. Psychiatr. Res. 43, 970-977
14. Treiman, D. M. (2001) GABAergic Mechanisms in Epilepsy. Epilepsia. 42, 8-12
15. Vaiva, G., Thomas, P., Ducrocq, F., Fontaine, M., Boss, V., Devos, P., Rascle, C., Cottencin, O., Brunet, A., Laffrargue, P. and Goudemand, M. (2004) Low posttrauma GABA plasma levels as a predictive factor in the development of acute posttraumatic stress disorder. Biol. Psychiatry 55, 250-254
16. Fenalti, G., Law, R. H. P., Buckle, A. M., Langendorf, C., Tuck, K., Rosado, C. J., Faux, N. G., Mahmood, K., Hampe, C. S., Banga, J. P. et al. (2007) GABA production by glutamic acid decarboxylase is regulated by a dynamic catalytic loop. Nat. Struct. Mol. Biol. 14, 280-286
17. Battaglioli, G., Liu, H. and Martin, D. L. (2003) Kinetic differences between the isoforms of glutamate decarboxylase: implications for the regulation of GABA synthesis. J. Neurochem. 86, 879-887
18. Evans, P. (2006) Scaling and assessment of data quality. Acta Crystallogr., Sect. D: Biol. Crystallogr. 62, 72-82
19. Potterton, E., Briggs, P., Turkenburg, M. and Dodson, E. (2003) A graphical user interface to the CCP4 program suite. Acta Crystallogr., Sect. D: Biol. Crystallogr. 59, 1131-1137
20. Collaborative Computational Project, N. (1994) The CCP4 suite: programs for protein crystallography. Acta Crystallogr. D 50, 760-763
21. Bricogne, G., Blanc, E., Brandl, M., Flensburg, C., Keller, P., Paciorek, W., Roversi, P., Sharff, A., Smart, O. S., Vonrhein, C. and Womack, T. O. (2011) BUSTER. 2.9 Ed., Global Phasing Ltd, Cambridge, U.K.
22. McCoy, A. J., Storoni, L. C. and Read, R. J. (2004) Simple algorithm for a maximum-likelihood SAD function. Acta Crystallogr., Sect. D: Biol. Crystallogr. 60, 1220-1228
23. Murshudov, G. N., Vagin, A. A. and Dodson, E. J. (1997) Refinement of macromolecular structures by the maximum-likelihood method. Acta Crystallogr., Sect. D: Biol. Crystallogr. 53, 240-255
24. Painter, J. and Merritt, E. A. (2006) Optimal description of a protein structure in terms of multiple groups undergoing TLS motion. Acta Crystallogr. D 62, 439-450
25. Emsley, P. and Cowtan, K. (2004) Coot: model-building tools for molecular graphics. Acta Crystallogr., Sect. D: Biol. Crystallogr. 60, 2126-2132
26. Davis, I. W., Leaver-Fay, A., Chen, V. B., Block, J. N., Kapral, G. J., Wang, X., Murray, L. W., Arendall, 3rd, W. B., Snoeyink, J., Richardson, J. S. and Richardson, D. C. (2007) MolProbity: all-atom contacts and structure validation for proteins and nucleic acids. Nucleic Acids Res. 35, W375-383
27. DeLano, W. L. (2002) The PyMOL User's Manual (2002) DeLano Scientific, San Carlos, CA
28. Konagurthu, A. S., Whisstock, J. C., Stuckey, P. J. and Lesk, A. M. (2006) MUSTANG: a multiple structural alignment algorithm. Proteins 64, 559-574
29. Chen, V. B., Arendall III, W. B., Headd, J. J., Keedy, D. A., Immormino, R. M., Kapral, G. J., Murray, L. W., Richardson, J. S. and Richardson, D. C. (2010) MolProbity: all-atom structure validation for macromolecular crystallography. Acta Crystallogr., Sect. D: Biol. Crystallogr. 66, 12-21
30. Martin, D. L. and Rimvall, K. (1993) Regulation of ? -aminobutyric acid synthesis in the brain. J. Neurochem. 60, 395-407