Discovery of a Novel Compound with Anti-Venezuelan Equine Encephalitis Virus Activity That Targets the Nonstructural Protein 2

PLoS Pathogens

Volumn 10, Issue 6, 2014, Pages

  Chung, Dong Hoon ^a,b   Jonsson, Colleen B ^a,b   Tower, Nichole A ^c   Chu, Yong Kyu ^b   Sahin, Ergin ^a,b   Golden, Jennifer E ^d   Noah, James W ^c   Schroeder, Chad E ^d   Sotsky, Julie B ^b   Sosa, Melinda I ^c   Cramer, Daniel E ^b   McKellip, Sara N ^c   Rasmussen, Lynn ^c   White, E Lucile ^c   Schmaljohn, Connie S ^e   Julander, Justin G ^f   Smith, Jeffrey M ^e   Filone, Claire Marie ^g   Connor, John H ^g   Sakurai, Yasuteru ^h   Davey, Robert A ^h   more..

^a University of Louisville School of Medicine   (United States)

^b UNIVERSITY OF LOUISVILLE   (United States)

^c SOUTHERN RESEARCH INSTITUTE   (United States)

^d UNIVERSITY OF KANSAS   (United States)

^e UNITED STATES ARMY MEDICAL RESEARCH INSTITUTE OF INFECTIOUS DISEASES   (United States)

^f UTAH STATE UNIVERSITY   (United States)

^g BOSTON UNIVERSITY   (United States)

^h SOUTHWEST FOUNDATION FOR BIOMEDICAL RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIVIRUS AGENT; CID15997213; NONSTRUCTURAL PROTEIN 2; UNCLASSIFIED DRUG; VIRUS RNA; QUINAZOLINONE DERIVATIVE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIVIRAL ACTIVITY; ANTIVIRAL RESISTANCE; ARTICLE; CELL PROTECTION; CONTROLLED STUDY; CYTOTOXICITY ASSAY; DRUG EFFICACY; DRUG IDENTIFICATION; DRUG SCREENING; DRUG SYNTHESIS; GENE MUTATION; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PROGENY; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SINGLE DRUG DOSE; STRUCTURE ACTIVITY RELATION; VALIDATION PROCESS; VENEZUELAN EQUINE ENCEPHALITIS; VENEZUELAN EQUINE ENCEPHALOMYELITIS ALPHAVIRUS; VIRUS CULTURE; VIRUS GENOME; VIRUS REPLICATION; WESTERN BLOTTING; ANIMAL; C3H MOUSE; CELL LINE; CHLOROCEBUS AETHIOPS; DISEASE MODEL; DRUG EFFECTS; ENCEPHALOMYELITIS, VENEZUELAN EQUINE; GENETICS; HAMSTER; SPECIES DIFFERENCE; VENEZUELAN EQUINE ENCEPHALITIS VIRUS; VERO CELL LINE; VIRAL PLAQUE ASSAY; VIROLOGY;

ANIMALS; ANTIVIRAL AGENTS; CELL LINE; CERCOPITHECUS AETHIOPS; CRICETINAE; DISEASE MODELS, ANIMAL; DRUG RESISTANCE, VIRAL; ENCEPHALITIS VIRUS, VENEZUELAN EQUINE; ENCEPHALOMYELITIS, VENEZUELAN EQUINE; HIGH-THROUGHPUT SCREENING ASSAYS; MICE; MICE, INBRED C3H; QUINAZOLINONES; SPECIES SPECIFICITY; STRUCTURE-ACTIVITY RELATIONSHIP; VERO CELLS; VIRAL PLAQUE ASSAY; VIRUS REPLICATION;

EID: 84903458261     PISSN: 15537366     EISSN: 15537374     Source Type: Journal    
DOI: 10.1371/journal.ppat.1004213     Document Type: Article

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