Inhibited osteoclastic bone resorption through alendronate treatment in rats reduces severe osteoarthritis progression

Bone

Volumn 66, Issue , 2014, Pages 163-170

  Siebelt, M ^a   Waarsing, J H ^a   Groen, H C ^a   Muller C ^b   Koelewijn, S J ^a   de Blois, E ^a   Verhaar, J A N ^a   de Jong, M ^a   Weinans, H ^c,d  

^a ERASMUS MEDICAL CENTER   (Netherlands)

^b ETH Zurich   (Switzerland)

^c DELFT UNIVERSITY OF TECHNOLOGY   (Netherlands)

^d UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

Author keywords

Alendronate; Articular cartilage; Exercise; Osteoarthritis; Osteoclast; Subchondral bone

Indexed keywords

ALENDRONIC ACID; GLYCOSAMINOGLYCAN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE REMODELING; CARTILAGE MATRIX; COMPUTER ASSISTED TOMOGRAPHY; CONTROLLED STUDY; DISEASE COURSE; IN VIVO STUDY; MACROPHAGE ACTIVATION; MALE; MICRO-COMPUTED TOMOGRAPHY; NONHUMAN; OSTEOARTHRITIS; OSTEOCLAST; OSTEOLYSIS; OSTEOPHYTE; OSTEOSCLEROSIS; POROSITY; RAT; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY; SYNOVIUM; ANIMAL CELL; BONE ATROPHY; DISEASE SEVERITY; DRUG EFFECT; EXTRACELLULAR MATRIX; ANIMAL; ARTICULAR CARTILAGE; BODY WEIGHT; BONE; COMPLICATION; DRUG EFFECTS; PATHOLOGY; RADIOGRAPHY; WISTAR RAT;

ALENDRONATE; ANIMALS; BODY WEIGHT; BONE AND BONES; BONE RESORPTION; CARTILAGE, ARTICULAR; DISEASE PROGRESSION; MACROPHAGE ACTIVATION; MALE; OSTEOARTHRITIS; OSTEOCLASTS; RATS, WISTAR; SYNOVIAL MEMBRANE; X-RAY MICROTOMOGRAPHY;

EID: 84903448630     PISSN: 87563282     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bone.2014.06.009     Document Type: Article

References (52)

1. Suri S., Walsh D.A. Osteochondral alterations in osteoarthritis. Bone 2012, 51(2):204-211.
2. Marijnissen A.C., van Roermund P.M., Verzijl N., Tekoppele J.M., Bijlsma J.W., Lafeber F.P. Steady progression of osteoarthritic features in the canine groove model. Osteoarthritis Cartilage 2002, 10:282-289.
3. Mastbergen S.C., Marijnissen A.C., Vianen M.E., van Roermund P.M., Bijlsma J.W., Lafeber F.P. The canine 'groove' model of osteoarthritis is more than simply the expression of surgically applied damage. Osteoarthritis Cartilage 2006, 14:39-46.
4. Batiste D.L., Kirkley A., Laverty S., Thain L.M., Spouge A.R., Holdsworth D.W. Ex vivo characterization of articular cartilage and bone lesions in a rabbit ACL transection model of osteoarthritis using MRI and micro-CT. Osteoarthritis Cartilage 2004, 12:986-996.
5. Pastoureau P.C., Chomel A.C., Bonnet J. Evidence of early subchondral bone changes in the meniscectomized guinea pig. A densitometric study using dual-energy X-ray absorptiometry subregional analysis. Osteoarthritis Cartilage 1999, 7:466-473.
6. Westacott C.I., Webb G.R., Warnock M.G., Sims J.V., Elson C.J. Alteration of cartilage metabolism by cells from osteoarthritic bone. Arthritis Rheum 1997, 40:1282-1291.
7. Saag K.G., Emkey R., Schnitzer T.J., Brown J.P., Hawkins F., Goemaere S., et al. Alendronate for the prevention and treatment of glucocorticoid-induced osteoporosis. Glucocorticoid-Induced Osteoporosis Intervention Study Group. N Engl J Med 1998, 339:292-299.
8. Muehleman C., Green J., Williams J.M., Kuettner K.E., Thonar E.J., Sumner D.R. The effect of bone remodeling inhibition by zoledronic acid in an animal model of cartilage matrix damage. Osteoarthritis Cartilage 2002, 10:226-233.
9. Hayami T., Pickarski M., Wesolowski G.A., McLane J., Bone A., Destefano J., et al. The role of subchondral bone remodeling in osteoarthritis: reduction of cartilage degeneration and prevention of osteophyte formation by alendronate in the rat anterior cruciate ligament transection model. Arthritis Rheum 2004, 50:1193-1206.
10. Agnello K.A., Trumble T.N., Chambers J.N., Seewald W., Budsberg S.C. Effects of zoledronate on markers of bone metabolism and subchondral bone mineral density in dogs with experimentally induced cruciate-deficient osteoarthritis. Am J Vet Res 2005, 66:1487-1495.
11. Sniekers Y.H., Weinans H., van Osch G.J., van Leeuwen J.P. Oestrogen is important for maintenance of cartilage and subchondral bone in a murine model of knee osteoarthritis. Arthritis Res Ther 2010, 12:R182.
12. Strassle B.W., Mark L., Leventhal L., Piesla M.J., Jian Li X., Kennedy J.D., et al. Inhibition of osteoclasts prevents cartilage loss and pain in a rat model of degenerative joint disease. Osteoarthritis Cartilage 2010, 18:1319-1328.
13. Bingham C.O., Buckland-Wright J.C., Garnero P., Cohen S.B., Dougados M., Adami S., et al. Risedronate decreases biochemical markers of cartilage degradation but does not decrease symptoms or slow radiographic progression in patients with medial compartment osteoarthritis of the knee: results of the two-year multinational knee osteoarthritis structural arthritis study. Arthritis Rheum 2006, 54:3494-3507.
14. Buckland-Wright J.C., Messent E.A., Bingham C.O., Ward R.J., Tonkin C. A 2yr longitudinal radiographic study examining the effect of a bisphosphonate (risedronate) upon subchondral bone loss in osteoarthritic knee patients. Rheumatology (Oxford) 2007, 46:257-264.
15. Saag K.G. Bisphosphonates for osteoarthritis prevention: "Holy Grail" or not?. Ann Rheum Dis 2008, 67:1358-1359.
16. Spector T.D., Conaghan P.G., Buckland-Wright J.C., Garnero P., Cline G.A., Beary J.F., et al. Effect of risedronate on joint structure and symptoms of knee osteoarthritis: results of the BRISK randomized, controlled trial [ISRCTN01928173]. Arthritis Res Ther 2005, 7:R625-R633.
17. Carbone L.D., Nevitt M.C., Wildy K., Barrow K.D., Harris F., Felson D., et al. The relationship of antiresorptive drug use to structural findings and symptoms of knee osteoarthritis. Arthritis Rheum 2004, 50:3516-3525.
18. Lohmander S. Can treatment with risedronate benefit patients with knee osteoarthritis?. Nat Clin Pract Rheumatol 2007, 3:198-199.
19. Wachsmuth L., Engelke K. High-resolution imaging of osteoarthritis using microcomputed tomography. Methods Mol Med 2004, 101:231-248.
20. Botter S.M., van Osch G.J., Waarsing J.H., Day J.S., Verhaar J.A., Pols H.A., et al. Quantification of subchondral bone changes in a murine osteoarthritis model using micro-CT. Biorheology 2006, 43:379-388.
21. Botter S.M., van Osch G.J., Waarsing J.H., van der Linden J.C., Verhaar J.A., Pols H.A., et al. Cartilage damage pattern in relation to subchondral plate thickness in a collagenase-induced model of osteoarthritis. Osteoarthritis Cartilage 2008, 16:506-514.
22. Botter S.M., Glasson S.S., Hopkins B., Clockaerts S., Weinans H., van Leeuwen J.P., et al. ADAMTS5-/- mice have less subchondral bone changes after induction of osteoarthritis through surgical instability: implications for a link between cartilage and subchondral bone changes. Osteoarthritis Cartilage 2009, 17:636-645.
23. Boyd S.K., Muller R., Leonard T., Herzog W. Long-term periarticular bone adaptation in a feline knee injury model for post-traumatic experimental osteoarthritis. Osteoarthritis Cartilage 2005, 13:235-242.
24. Botter S.M., van Osch G.J., Clockaerts S., Waarsing J.H., Weinans H., van Leeuwen J.P. Osteoarthritis induction leads to early and temporal subchondral plate porosity in the tibial plateau of mice: an in vivo microfocal computed tomography study. Arthritis Rheum 2011, 63:2690-2699.
25. Siebelt M., Groen H.C., Koelewijn S.J., de Blois E., Sandker M., Waarsing J.H., et al. Increased physical activity severely induces osteoarthritic changes in knee joints with papain induced sulphate-glycosaminoglycan depleted cartilage. Arthritis Res Ther 2014, 16:R32.
26. Piscaer T.M., Sandker M., van der Jagt O.P., Verhaar J.A., de Jong M., Weinans H. Real-time assessment of bone metabolism in small animal models for osteoarthritis using multi pinhole-SPECT/CT. Osteoarthritis Cartilage 2013, 21:882-888.
27. Murat N., Karadam B., Ozkal S., Karatosun V., Gidener S. Quantification of papain-induced rat osteoarthritis in relation to time with the Mankin score. Acta Orthop Traumatol Turc 2007, 41:233-237.
28. Fuchs R.K., Phipps R.J., Burr D.B. Recovery of trabecular and cortical bone turnover after discontinuation of risedronate and alendronate therapy in ovariectomized rats. J Bone Miner Res 2008, 23:1689-1697.
29. Palmer A.W., Guldberg R.E., Levenston M.E. Analysis of cartilage matrix fixed charge density and three-dimensional morphology via contrast-enhanced microcomputed tomography. Proc Natl Acad Sci U S A 2006, 103:19255-19260.
30. Waarsing J.H., Day J.S., Weinans H. An improved segmentation method for in vivo microCT imaging. J Bone Miner Res 2004, 19:1640-1650.
31. van der Jagt O.P., van der Linden J.C., Schaden W., van Schie H.T., Piscaer T.M., Verhaar J.A., et al. Unfocused extracorporeal shock wave therapy as potential treatment for osteoporosis. J Orthop Res 2009, 27:1528-1533.
32. Low P.S., Henne W.A., Doorneweerd D.D. Discovery and development of folic-acid-based receptor targeting for imaging and therapy of cancer and inflammatory diseases. Acc Chem Res 2008, 41:120-129.
33. Turk M.J., Breur G.J., Widmer W.R., Paulos C.M., Xu L.C., Grote L.A., et al. Folate-targeted imaging of activated macrophages in rats with adjuvant-induced arthritis. Arthritis Rheum 2002, 46:1947-1955.
34. Xia W., Hilgenbrink A.R., Matteson E.L., Lockwood M.B., Cheng J.X., Low P.S. A functional folate receptor is induced during macrophage activation and can be used to target drugs to activated macrophages. Blood 2009, 113:438-446.
35. Müller C., Vlahov I.R., Santhapuram H.K., Leamon C.P., Schibli R. Tumor targeting using 67Ga-DOTA-Bz-folate-investigations of methods to improve the tissue distribution of radiofolates. Nucl Med Biol 2011, 38:715-723.
36. Thote T., Lin A.S., Raji Y., Moran S., Stevens H.Y., Hart M., et al. Localized 3D analysis of cartilage composition and morphology in small animal models of joint degeneration. Osteoarthritis Cartilage 2013, 21:1132-1141.
37. Silvast T.S., Jurvelin J.S., Lammi M.J., Toyras J. pQCT study on diffusion and equilibrium distribution of iodinated anionic contrast agent in human articular cartilage-associations to matrix composition and integrity. Osteoarthritis Cartilage 2009, 17:26-32.
38. Waarsing J.H., Day J.S., Verhaar J.A., Ederveen A.G., Weinans H. Bone loss dynamics result in trabecular alignment in aging and ovariectomized rats. J Orthop Res 2006, 24:926-935.
39. Klein-Nulend J., Bacabac R.G., Bakker A.D. Mechanical loading and how it affects bone cells: the role of the osteocyte cytoskeleton in maintaining our skeleton. Eur Cell Mater 2012, 24:278-291.
40. van Hove R.P., Nolte P.A., Vatsa A., Semeins C.M., Salmon P.L., Smit T.H., et al. Osteocyte morphology in human tibiae of different bone pathologies with different bone mineral density-is there a role for mechanosensing?. Bone 2009, 45:321-329.
41. Power J., Poole K.E., van Bezooijen R., Doube M., Caballero-Alias A.M., Lowik C., et al. Sclerostin and the regulation of bone formation: effects in hip osteoarthritis and femoral neck fracture. J Bone Miner Res 2010, 25:1867-1876.
42. Chan B.Y., Fuller E.S., Russell A.K., Smith S.M., Smith M.M., Jackson M.T., et al. Increased chondrocyte sclerostin may protect against cartilage degradation in osteoarthritis. Osteoarthritis Cartilage 2011, 19:874-885.
43. Pap G., Eberhardt R., Sturmer I., Machner A., Schwarzberg H., Roessner A., et al. Development of osteoarthritis in the knee joints of Wistar rats after strenuous running exercise in a running wheel by intracranial self-stimulation. Pathol Res Pract 1998, 194:41-47.
44. Felson D.T., Zhang Y. An update on the epidemiology of knee and hip osteoarthritis with a view to prevention. Arthritis Rheum 1998, 41:1343-1355.
45. Laslett L.L., Kingsbury S.R., Hensor E.M., Bowes M.A., Conaghan P.G. Effect of bisphosphonate use in patients with symptomatic and radiographic knee osteoarthritis: data from the Osteoarthritis Initiative. Ann Rheum Dis 2014, 73(5):824-830.
46. Scanzello C.R., Goldring S.R. The role of synovitis in osteoarthritis pathogenesis. Bone 2012, 51:249-257.
47. Ayral X., Pickering E.H., Woodworth T.G., Mackillop N., Dougados M. Synovitis: a potential predictive factor of structural progression of medial tibiofemoral knee osteoarthritis-results of a 1year longitudinal arthroscopic study in 422 patients. Osteoarthritis Cartilage 2005, 13:361-367.
48. Roemer F.W., Guermazi A., Felson D.T., Niu J., Nevitt M.C., Crema M.D., et al. Presence of MRI-detected joint effusion and synovitis increases the risk of cartilage loss in knees without osteoarthritis at 30-month follow-up: the MOST study. Ann Rheum Dis 2011, 70:1804-1809.
49. Roelofs A.J., Thompson K., Ebetino F.H., Rogers M.J., Coxon F.P. Bisphosphonates: molecular mechanisms of action and effects on bone cells, monocytes and macrophages. Curr Pharm Des 2010, 16:2950-2960.
50. Adams C.S., Horton W.E. Chondrocyte apoptosis increases with age in the articular cartilage of adult animals. Anat Rec 1998, 250:418-425.
51. Horton W.E., Feng L., Adams C. Chondrocyte apoptosis in development, aging and disease. Matrix Biol 1998, 17:107-115.
52. Pomonis J.D., Boulet J.M., Gottshall S.L., Phillips S., Sellers R., Bunton T., et al. Development and pharmacological characterization of a rat model of osteoarthritis pain. Pain 2005, 114:339-346.