-
1
-
-
0034915569
-
Detection and direct genomic sequencing of multiple rare unknown flanking DNA in highly complex samples
-
doi:10.1089/104303401750148649
-
Schmidt, M. et al. Detection and direct genomic sequencing of multiple rare unknown flanking DNA in highly complex samples. Hum Gene Ther. 12, 743-749 doi:10.1089/104303401750148649 (2001).
-
(2001)
Hum Gene Ther
, vol.12
, pp. 743-749
-
-
Schmidt, M.1
-
2
-
-
36749052217
-
High-resolution insertion-site analysis by linear amplification-mediated PCR (LAM-PCR)
-
doi:nmeth1103 [pii] 10.1038/nmeth1103
-
Schmidt, M. et al. High-resolution insertion-site analysis by linear amplification-mediated PCR (LAM-PCR). Nat Methods. 4, 1051-1057 doi:nmeth1103 [pii] 10.1038/nmeth1103 (2007).
-
(2007)
Nat Methods
, vol.4
, pp. 1051-1057
-
-
Schmidt, M.1
-
3
-
-
0037162715
-
HIV-1 integration in the human genome favors active genes and local hotspots
-
Schroeder, A. R. et al. HIV-1 integration in the human genome favors active genes and local hotspots. Cell. 110, 521-529 (2002).
-
(2002)
Cell
, vol.110
, pp. 521-529
-
-
Schroeder, A.R.1
-
4
-
-
0037841763
-
Transcription start regions in the human genome are favored targets for MLV integration
-
Wu, X., Li, Y., Crise, B., & Burgess, S. M. Transcription start regions in the human genome are favored targets for MLV integration. Science. 300, 1749-1751 (2003).
-
(2003)
Science
, vol.300
, pp. 1749-1751
-
-
Wu, X.1
Li, Y.2
Crise, B.3
Burgess, S.M.4
-
5
-
-
0036404918
-
Common physical properties of DNA affecting target site selection of sleeping beauty and other Tc1/mariner transposable elements
-
doi:S0022283602009919 [pii]
-
Vigdal, T. J., Kaufman, C. D., Izsvak, Z., Voytas, D. F., & Ivics, Z. Common physical properties of DNA affecting target site selection of sleeping beauty and other Tc1/mariner transposable elements. J Mol Biol. 323, 441-452 doi:S0022283602009919 [pii] (2002).
-
(2002)
J Mol Biol
, vol.323
, pp. 441-452
-
-
Vigdal, T.J.1
Kaufman, C.D.2
Izsvak, Z.3
Voytas, D.F.4
Ivics, Z.5
-
6
-
-
33745684269
-
Retroviral DNA integration: Viral and cellular determinants of target-site selection
-
doi:06-PLPA-RA-0089R1 [pii] 10.1371/journal.ppat.0020060
-
Lewinski, M. K. et al. Retroviral DNA integration: viral and cellular determinants of target-site selection. PLoS Pathog. 2, e60 doi:06-PLPA-RA-0089R1 [pii] 10.1371/journal.ppat.0020060 (2006).
-
(2006)
PLoS Pathog
, vol.2
-
-
Lewinski, M.K.1
-
7
-
-
0024431684
-
In vivo footprinting of a muscle specific enhancer by ligation mediated PCR
-
Mueller, P. R., & Wold, B. In vivo footprinting of a muscle specific enhancer by ligation mediated PCR. Science. 246, 780-786 (1989).
-
(1989)
Science
, vol.246
, pp. 780-786
-
-
Mueller, P.R.1
Wold, B.2
-
8
-
-
0024584243
-
Novel use of polymerase chain reaction to amplify cellular DNA adjacent to an integrated provirus
-
Silver, J., & Keerikatte, V. Novel use of polymerase chain reaction to amplify cellular DNA adjacent to an integrated provirus. Journal of virology. 63, 1924-1928 (1989).
-
(1989)
Journal of Virology
, vol.63
, pp. 1924-1928
-
-
Silver, J.1
Keerikatte, V.2
-
9
-
-
71549135258
-
Comprehensive genomic access to vector integration in clinical gene therapy
-
doi:nm.2057 [pii] 10.1038/nm.2057
-
Gabriel, R. et al. Comprehensive genomic access to vector integration in clinical gene therapy. Nature medicine. 15, 1431-1436 doi:nm.2057 [pii] 10.1038/nm.2057 (2009).
-
(2009)
Nature Medicine
, vol.15
, pp. 1431-1436
-
-
Gabriel, R.1
-
10
-
-
34347337597
-
Multiarm high-throughput integration site detection: Limitations of LAM-PCR technology and optimization for clonal analysis
-
doi:10.1089/scd.2007.0015
-
Harkey, M. A. et al. Multiarm high-throughput integration site detection: limitations of LAM-PCR technology and optimization for clonal analysis. Stem Cells Dev. 16, 381-392 doi:10.1089/scd.2007.0015 (2007).
-
(2007)
Stem Cells Dev
, vol.16
, pp. 381-392
-
-
Harkey, M.A.1
-
11
-
-
44349158394
-
DNA bar coding and pyrosequencing to analyze adverse events in therapeutic gene transfer
-
doi:gkn125 [pii] 10.1093/nar/gkn125
-
Wang, G. P. et al. DNA bar coding and pyrosequencing to analyze adverse events in therapeutic gene transfer. Nucleic acids research. 36, e49 doi:gkn125 [pii] 10.1093/nar/gkn125 (2008).
-
(2008)
Nucleic Acids Research
, vol.36
-
-
Wang, G.P.1
-
12
-
-
77955220225
-
Genome-wide high-throughput integrome analyses by nrLAM-PCR and next-generation sequencing
-
Paruzynski, A. et al. Genome-wide high-throughput integrome analyses by nrLAM-PCR and next-generation sequencing. Nat. Protocols. 5, 1379-1395 (2010).
-
(2010)
Nat. Protocols
, vol.5
, pp. 1379-1395
-
-
Paruzynski, A.1
-
13
-
-
51349090473
-
Insertional oncogenesis in 4 patients after retrovirus-mediated gene therapy of SCID-X1
-
doi:10.1172/JCI35700
-
Hacein-Bey-Abina, S. et al. Insertional oncogenesis in 4 patients after retrovirus-mediated gene therapy of SCID-X1. J Clin Invest118, 3132-3142 doi:10.1172/JCI35700 (2008).
-
(2008)
J Clin Invest
, vol.118
, pp. 3132-3142
-
-
Hacein-Bey-Abina, S.1
-
14
-
-
0142084745
-
LMO2-associated clonal T cell proliferation in two patients after gene therapy for SCID-X1
-
Hacein-Bey-Abina, S. et al. LMO2-associated clonal T cell proliferation in two patients after gene therapy for SCID-X1. Science. 302, 415-419 (2003).
-
(2003)
Science
, vol.302
, pp. 415-419
-
-
Hacein-Bey-Abina, S.1
-
15
-
-
51349158298
-
Insertional mutagenesis combined with acquired somatic mutations causes leukemogenesis following gene therapy of SCID-X1 patients
-
doi:10.1172/JCI35798
-
Howe, S. J. et al. Insertional mutagenesis combined with acquired somatic mutations causes leukemogenesis following gene therapy of SCID-X1 patients. J Clin Invest118, 3143-3150 doi:10.1172/JCI35798 (2008).
-
(2008)
J Clin Invest
, vol.118
, pp. 3143-3150
-
-
Howe, S.J.1
-
16
-
-
70449427834
-
Hematopoietic stem cell gene therapy with a lentiviral vector in X-linked adrenoleukodystrophy
-
doi:326/5954/818 [pii] 10.1126/science.1171242
-
Cartier, N. et al. Hematopoietic stem cell gene therapy with a lentiviral vector in X-linked adrenoleukodystrophy. Science. 326, 818-823 doi:326/5954/818 [pii] 10.1126/science.1171242 (2009).
-
(2009)
Science
, vol.326
, pp. 818-823
-
-
Cartier, N.1
-
17
-
-
79955114567
-
Hepatocyte-targeted expression by integrase-defective lentiviral vectors induces antigen-specific tolerance in mice with low genotoxic risk
-
doi:10.1002/hep.24230
-
Matrai, J. et al. Hepatocyte-targeted expression by integrase-defective lentiviral vectors induces antigen-specific tolerance in mice with low genotoxic risk. Hepatology. 53, 1696-1707 doi:10.1002/hep.24230 (2011).
-
(2011)
Hepatology
, vol.53
, pp. 1696-1707
-
-
Matrai, J.1
-
18
-
-
49149113894
-
Adeno-associated virus vector genomes persist as episomal chromatin in primate muscle
-
doi:10.1128/JVI.00649-08 JVI.00649-08 [pii]
-
Penaud-Budloo, M. et al. Adeno-associated virus vector genomes persist as episomal chromatin in primate muscle. Journal of virology. 82, 7875-7885 doi:10.1128/JVI.00649-08 JVI.00649-08 [pii] (2008).
-
(2008)
Journal of Virology
, vol.82
, pp. 7875-7885
-
-
Penaud-Budloo, M.1
-
19
-
-
84880289352
-
A largely random AAV integration profile after LPLD gene therapy
-
doi:10.1038/nm.3230 nm.3230 [pii]
-
Kaeppel, C. et al. A largely random AAV integration profile after LPLD gene therapy. Nature medicine. 19, 889-891 doi:10.1038/nm.3230 nm.3230 [pii] (2013).
-
(2013)
Nature Medicine
, vol.19
, pp. 889-891
-
-
Kaeppel, C.1
-
20
-
-
84866978628
-
Retargeting sleeping beauty transposon insertions by engineered zinc finger DNA-binding domains
-
doi:10.1038/mt.2012.126 mt2012126 [pii]
-
Voigt, K. et al. Retargeting sleeping beauty transposon insertions by engineered zinc finger DNA-binding domains. Mol Ther. 20, 1852-1862 doi:10.1038/mt.2012.126 mt2012126 [pii] (2012).
-
(2012)
Mol Ther
, vol.20
, pp. 1852-1862
-
-
Voigt, K.1
-
21
-
-
33644822908
-
Effective gene therapy with nonintegrating lentiviral vectors
-
doi:nm1365 [pii] 10.1038/nm1365
-
Yanez-Munoz, R. J. et al. Effective gene therapy with nonintegrating lentiviral vectors. Nature medicine. 12, 348-353 doi:nm1365 [pii] 10.1038/nm1365 (2006).
-
(2006)
Nature Medicine
, vol.12
, pp. 348-353
-
-
Yanez-Munoz, R.J.1
-
22
-
-
78149482538
-
Stem-Cell Gene Therapy for the Wiskott-Aldrich Syndrome
-
doi:10.1056/NEJMoa1003548
-
Boztug, K. et al. Stem-Cell Gene Therapy for the Wiskott-Aldrich Syndrome. N Engl J Med. 363, 1918-1927 doi:10.1056/NEJMoa1003548 (2010).
-
(2010)
N Engl J Med
, vol.363
, pp. 1918-1927
-
-
Boztug, K.1
-
23
-
-
34249906359
-
Vector integration is nonrandom and clustered and influences the fate of lymphopoiesis in SCID-X1 gene therapy
-
doi:10.1172/JCI31659
-
Deichmann, A. et al. Vector integration is nonrandom and clustered and influences the fate of lymphopoiesis in SCID-X1 gene therapy. J Clin Invest. 117, 2225-2232 doi:10.1172/JCI31659 (2007).
-
(2007)
J Clin Invest
, vol.117
, pp. 2225-2232
-
-
Deichmann, A.1
-
24
-
-
34547651095
-
Gammaretrovirus-mediated correction of SCID-X1 is associated with skewed vector integration site distribution in vivo
-
doi:10.1172/JCI31661
-
Schwarzwaelder, K. et al. Gammaretrovirus-mediated correction of SCID-X1 is associated with skewed vector integration site distribution in vivo. J Clin Invest. 117, 2241-2249 doi:10.1172/JCI31661 (2007).
-
(2007)
J Clin Invest
, vol.117
, pp. 2241-2249
-
-
Schwarzwaelder, K.1
-
25
-
-
80052766645
-
An unbiased genome-wide analysis of zinc-finger nuclease specificity
-
doi:10.1038/nbt.1948 nbt.1948 [pii]
-
Gabriel, R. et al. An unbiased genome-wide analysis of zinc-finger nuclease specificity. Nat Biotechnol. 29, 816-823 doi:10.1038/nbt.1948 nbt.1948 [pii] (2011).
-
(2011)
Nat Biotechnol
, vol.29
, pp. 816-823
-
-
Gabriel, R.1
-
26
-
-
80053904142
-
Distinct types of tumor-initiating cells form human colon cancer tumors and metastases
-
doi:10.1016/j.stem.2011.08.010 S1934-5909(11)00391-2 [pii]
-
Dieter, S. M. et al. Distinct types of tumor-initiating cells form human colon cancer tumors and metastases. Cell Stem Cell. 9, 357-365 doi:10.1016/j.stem.2011.08.010 S1934-5909(11)00391-2 [pii] (2011).
-
(2011)
Cell Stem Cell
, vol.9
, pp. 357-365
-
-
Dieter, S.M.1
-
27
-
-
33745108790
-
Hematopoietic stem cell gene transfer in a tumor-prone mouse model uncovers low genotoxicity of lentiviral vector integration
-
Montini, E. et al. Hematopoietic stem cell gene transfer in a tumor-prone mouse model uncovers low genotoxicity of lentiviral vector integration. Nature biotechnology. 24, 687-696 (2006).
-
(2006)
Nature Biotechnology
, vol.24
, pp. 687-696
-
-
Montini, E.1
-
28
-
-
84865339944
-
Stable long-term blood formation by stem cells in murine steady-state hematopoiesis
-
doi:10.1002/stem.1151
-
Zavidij, O. et al. Stable long-term blood formation by stem cells in murine steady-state hematopoiesis. Stem Cells. 30, 1961-1970 doi:10.1002/stem.1151 (2012).
-
(2012)
Stem Cells
, vol.30
, pp. 1961-1970
-
-
Zavidij, O.1
-
29
-
-
84866446850
-
Thymus-autonomous T cell development in the absence of progenitor import
-
doi:10.1084/jem.20120846 jem.20120846 [pii]
-
Martins, V. C. et al. Thymus-autonomous T cell development in the absence of progenitor import. J Exp Med. 209, 1409-1417 doi:10.1084/jem.20120846 jem.20120846 [pii] (2012).
-
(2012)
J Exp Med
, vol.209
, pp. 1409-1417
-
-
Martins, V.C.1
-
30
-
-
84867744253
-
Bioinformatic clonality analysis of next-generation sequencing-derived viral vector integration sites
-
doi:10.1089/hgtb.2011.219 [pii] 10.1089/hgtb.2011.219
-
Arens, A. et al. Bioinformatic clonality analysis of next-generation sequencing-derived viral vector integration sites. Hum Gene Ther Methods. 23, 111-118 doi:10.1089/hgtb.2011.219 [pii] 10.1089/hgtb.2011.219 (2012).
-
(2012)
Hum Gene Ther Methods
, vol.23
, pp. 111-118
-
-
Arens, A.1
|