Glycosylation inhibitors efficiently inhibit P-selectin-mediated cell adhesion to endothelial cells

PLoS ONE

Volumn 9, Issue 6, 2014, Pages

  Ghoshal, Pushpankur ^a   Rajendran, Mythilypriya ^a   Odo, Nadine ^a   Ikuta, Tohru ^a  

^a MEDICAL COLLEGE OF GEORGIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CASTANOSPERMINE; GLYCOPEPTIDASE; MONOCLONAL ANTIBODY; PADGEM PROTEIN; PROTEASOME; PROTEIN KINASE B; SHORT HAIRPIN RNA; THROMBIN; TUNICAMYCIN; UBIQUITIN;

ARTICLE; CELL ADHESION; CELL HYPOXIA; CELL SURFACE; CONTROLLED STUDY; DOWN REGULATION; DRUG INHIBITION; ENDOTHELIUM CELL; ENZYME INHIBITION; ERYTHROCYTE ADHESIVENESS; HUMAN; HUMAN CELL; IN VIVO STUDY; LEUKOCYTE ADHERENCE; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN GLYCOSYLATION; PROTEIN PHOSPHORYLATION; SICKLE CELL ANEMIA; ANIMAL; BIOSYNTHESIS; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; GLYCOSYLATION; LEUKOCYTE; METABOLISM; MOUSE; PATHOLOGY;

ANEMIA, SICKLE CELL; ANIMALS; CELL ADHESION; CELL HYPOXIA; ENDOTHELIAL CELLS; GENE EXPRESSION REGULATION; GLYCOSYLATION; LEUKOCYTES; MICE; P-SELECTIN; THROMBIN; TUNICAMYCIN;

EID: 84903388655     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0099363     Document Type: Article

References (72)

1. Ferrone FA (2004) Polymerization and Sickle Cell Disease: A Molecular View. Microcirculation 11: 115-128.
2. Pauling L, Itano HA, Singer SJ, Wells IC (1949) Sickle Cell Anemia, a. Molecular Disease. Science 110: 543-548.
3. Vichinsky E (2002) New therapies in sickle cell disease. Lancet 360: 629-631.
4. Levasseur DN, Ryan TM, Reilly MP, McCune SL, Asakura T, et al. (2004) A recombinant human hemoglobin with anti-sickling properties greater than fetal hemoglobin. J Biol Chem 279: 27518-27524. (Pubitemid 38812592)
5. Akinsheye I, Alsultan A, Solovieff N, Ngo D, Baldwin CT, et al. (2011) Fetal hemoglobin in sickle cell anemia. Blood 118: 19-27.
6. Miller BA, Salameh M, Ahmed M, Wainscoat J, Antognetti G, et al. (1986) High fetal hemoglobin production in sickle cell anemia in the eastern province of Saudi Arabia is genetically determined. Blood 67: 1404-1410. (Pubitemid 16080612)
7. Yarbro JW, Kennedy BJ, Barnum CP (1965) Hydroxyurea inhibition of DNA synthesis in ascites tumor. Proc Natl Acad Sci USA 53: 1033-1035.
8. Platt OS, Orkin SH, Dover G, Beardsley GP, Miller B, et al. (1984) Hydroxyurea enhances fetal hemoglobin production in sickle cell anemia. J Clin Invest 74: 652-656. (Pubitemid 14054015)
9. Rodgers GP, Dover GJ, Noguchi CT, Schechter AN, Nienhuis AW (1989) Induction of fetal hemoglobin in sickle cell patients by hydroxyurea: the N.I.H. experience. Prog Clin Biol Res 316B: 281-293.
10. van den Tweel XW, van der Lee JH, Heijboer H, Peters M, Fijnvandraat K (2010) Development and validation of a pediatric severity index for sickle cell patients. Am J Hematol 85: 746-751.
11. Ballas SK (2005) Pain management of sickle cell disease. Hematol Oncol Clin North Am 19: 785-802.
12. Setty BN, Stuart MJ (1996) Vascular cell adhesion molecule-1 is involved in mediating hypoxia-induced sickle red blood cell adherence to endothelium: potential role in sickle cell disease. Blood 88: 2311-2320. (Pubitemid 26307936)
13. Matsui NM, Borsig L, Rosen SD, Yaghmai M, Varki A, et al. (2001) P-selectin mediates the adhesion of sickle erythrocytes to the endothelium. Blood 98: 1955-1962.
14. Embury SH, Matsui NM, Ramanujam S, Mayadas TN, Noguchi CT, et al. (2004) The contribution of endothelial cell P-selectin to the microvascular flow of mouse sickle erythrocytes in vivo. Blood 104: 3378-3385. (Pubitemid 39507162)
15. Lee SP, Cunningham ML, Hines PC, Joneckis CC, Orringer EP, et al. (1998) Sickle cell adhesion to laminin: potential role for the alpha5 chain. Blood 92: 2951-2958. (Pubitemid 28469111)
16. Sugihara K, Sugihara T, Mohandas N, Hebbel RP (1992) Thrombospondin mediates adherence of CD36 + sickle reticulocytes to endothelial cells. Blood 80: 2634-2642.
17. Kasschau MR, Barabino GA, Bridges KR, Golan DE (1996) Adhesion of sickle neutrophils and erythrocytes to fibronectin. Blood 87: 771-780. (Pubitemid 26030334)
18. Brittain JE, Mlinar KJ, Anderson CS, Orringer EP, Parise LV (2001) Activation of sickle red blood cell adhesion via integrin-associated protein/CD47-induced signal transduction. J Clin Invest 107: 1555-1562. (Pubitemid 32577083)
19. Chang J, Patton JT, Sarkar A, Ernst B, Magnani JL, et al. (2010) GMI-1070, a novel pan-selectin antagonist, reverses acute vascular occlusions in sickle cell mice. Blood 116: 1779-1786.
20. Turhan A, Weiss LA, Mohandas N, Coller BS, Frenette PS (2002) Primary role for adherent leukocytes in sickle cell vascular occlusion: A new paradigm. Proc Natl Acad Sci USA 99: 3047-3051. (Pubitemid 34240583)
21. Gutsaeva DR, Parkerson JB, Yerigenahally SD, Kurz JC, Schaub RG, et al. (2011) Inhibition of cell adhesion by anti-P-selectin aptamer: a new potential therapeutic agent for sickle cell disease. Blood 117: 727-735.
22. Matsui NM, Varki A, Embury SH (2002) Heparin inhibits the flow adhesion of sickle red blood cells to P-selectin. Blood 100: 3790-3796. (Pubitemid 35303953)
23. Kutlar A, Ataga KI, McMahon L, Howard J, Galacteros F, et al. (2012) A potent oral P-selectin blocking agent improves microcirculatory blood flow and a marker of endothelial cell injury in patients with sickle cell disease. Am J Hematol 87: 536-539.
24. McEver RP, Beckstead JH, Moore KL, Marshall-Carlson L, Bainton DF (1989) GMP-140, a platelet alpha-granule membrane protein, is also synthesized by vascular endothelial cells and is localized in Weibel-Palade bodies. J Clin Invest 84: 92-99. (Pubitemid 19170099)
25. Dwek RA, Butters TD, Platt FM, Zitzmann N (2002) Targeting glycosylation as a therapeutic approach. Nat Rev Drug Discov 1: 65-75. (Pubitemid 37361405)
26. Ryan TM, Ciavatta DJ, Townes TM (1997) Knockout-transgenic mouse model of sickle cell disease. Science 278: 873-876. (Pubitemid 27467926)
27. Ghoshal P, Nganga AJ, Moran-Giuati J, Szafranek A, Johnson TR, et al. (2009) Loss of the SMRT/NCoR2 Corepressor Correlates with JAG2 Overexpression in Multiple Myeloma. Cancer Res 69: 4380-4387
28. van Hoek AN, Wiener MC, Verbavatz JM, Brown D, Lipniunas PH, et al. (1995) Purification and structure-function analysis of native, PNGase F-treated, and endo-beta-galactosidase-treated CHIP28 water channels. Biochemistry 34: 2212-2219.
29. Hebbel RP, Boogaerts MA, Eaton JW, Steinberg MH (1980) Erythrocyte adherence to endothelium in sickle-cell anemia. A possible determinant of disease severity. N Engl J Med 302: 992-995. (Pubitemid 10125408)
30. Johnston GI, Kurosky A, McEver RP (1989) Structural and biosynthetic studies of the granule membrane protein, GMP-140, from human platelets and endothelial cells. J Biol Chem 264: 1816-1823. (Pubitemid 19051029)
31. Tsuchiya S, Kobayashi Y, Goto Y, Okumura H, Nakae S, et al. (1982) Induction of Maturation in Cultured Human Monocytic Leukemia Cells by a Phorbol Diester. Cancer Res 42: 1530-1536. (Pubitemid 12148801)
32. Kurantsin-Mills J, Ofosu FA, Safa TK, Siegel RS, Lessin LS (1992) Plasma factor VII and thrombin-antithrombin III levels indicate increased tissue factor activity in sickle cell patients. Br J Haematol 81: 539-544.
33. Ataga KI, Brittain JE, Desai P, May R, Jones S, et al. (2012) Association of coagulation activation with clinical complications in sickle cell disease. PLoS ONE 7: e29786.
34. Birch KA, Ewenstein BM, Golan DE, Pober JS (1994) Prolonged peak elevations in cytoplasmic free calcium ions, derived from intracellular stores, correlate with the extent of thrombin-stimulated exocytosis in single human umbilical vein endothelial cells. J Cell Physiol 160: 545-554.
35. McEver RP (1994) Selectins. Curr Opin Immunol 6: 75-84.
36. Koutsioulis D, Landry D, Guthrie EP (2008) Novel endo-a-N- acetylgalactosaminidases with broader substrate specificity. Glycobiology 18: 799-805.
37. Jacob GS (1995) Glycosylation inhibitors in biology and medicine. Curr Opin Struct Biol 5: 605-611.
38. Saul R, Ghidoni JJ, Molyneux RJ, Elbein AD (1985) Castanospermine inhibits alpha-glucosidase activities and alters glycogen distribution in animals. Proc Natl Acad Sci USA 82: 93-97. (Pubitemid 15168220)
39. Gratton RJ, Gluszynski M, Nygard K, Mazzuca DM, Graham CH, et al. (2004) Reducing agent and tunicamycin-responsive protein (RTP) mRNA expression in the placentae of normal and pre-eclamptic women. Placenta 25: 62-69. (Pubitemid 38100767)
40. Jang WG, Kim EJ, Koh JT (2011) Tunicamycin negatively regulates BMP2-induced osteoblast differentiation through CREBH expression in MC3T3E1 cells. BMB reports 44: 735-740.
41. Liao W, Chan L (2001) Tunicamycin induces ubiquitination and degradation of apolipoprotein B in HepG2 cells. Biochem J 353: 493-501. (Pubitemid 32158317)
42. Sugama Y, Tiruppathi C, offakidevi K, Andersen TT, Fenton JW, et al. (1992) Thrombin-induced expression of endothelial P-selectin and intercellular adhesion molecule-1: a mechanism for stabilizing neutrophil adhesion. J Cell Biol 119: 935-944.
43. Lee DH, Goldberg AL (1998) Proteasome inhibitors: valuable new tools for cell biologists. Trends in Cell Biology 8: 397-403. (Pubitemid 28458705)
44. Heifetz A, Keenan RW, Elbein AD (1979) Mechanism of action of tunicamycin on the UDP-GlcNAc: dolichyl-phosphate GlcNAc-1-phosphate transferase. Biochemistry 18: 2186-2192.
45. Dennis JW, Nabi IR, Demetriou M (2009) Metabolism, Cell Surface Organization, and Disease. Cell 139: 1229-1241.
46. Wellen KE, Thompson CB (2012) A two-way street: reciprocal regulation of metabolism and signalling. Nat Rev Mol Cell Biol 13: 270-276.
47. Weiner DL, Hibberd PL, Betit P, Cooper AB, Botelho CA, et al. (2003) Preliminary assessment of inhaled nitric oxide for acute vaso-occlusive crisis in pediatric patients with sickle cell disease.[erratum appears in JAMA. 2004 Aug 25; 292(8): 925]. JAMA 289: 1136-1142. (Pubitemid 37430328)
48. Closse C, Seigneur M, Renard M, Pruvost A, Dumain P, et al. (1997) Influence of hypoxia and hypoxia-reoxygenation on endothelial P-selectin expression. Thromb Res 85: 159-164. (Pubitemid 27148066)
49. Gutsaeva DR, Montero-Huerta P, Parkerson JB, Yerigenahally SD, Ikuta T, et al. (2014) Molecular mechanisms underlying synergistic adhesion of sickle red blood cells by hypoxia and low nitric oxide bioavailability. Blood 123: 1917-1926.
50. Påhlsson P, Strindhall J, Srinivas U, Lundblad A (1995) Role of N-linked glycosylation in expression of E-selectin on human endothelial cells. Eur J Immunol 25: 2452-2459.
51. Hebbel RP (1997) Adhesive interactions of sickle erythrocytes with endothelium. J Clin Invest 100: 2561-2564.
52. Kaul DK, Tsai HM, Liu XD, Nakada MT, Nagel RL, et al. (2000) Monoclonal antibodies to alpha Vbeta 3 (7E3 and LM609) inhibit sickle red blood cell-endothelium interactions induced by platelet-activating factor. Blood 95: 368-374. (Pubitemid 30041643)
53. Embury SH (2004) The Not-So-Simple Process of Sickle Cell Vasoocclusion. Microcirculation 11: 101-113.
54. Wood KC, Hebbel RP, Granger DN (2004) Endothelial cell P-selectin mediates a proinflammatory and prothrombogenic phenotype in cerebral venules of sickle cell transgenic mice. Am J Physiol Heart Circ Physiol 286: H1608-1614. (Pubitemid 38525445)
55. Gries A, Bode C, Peter K, Herr A, Bohrer H, et al. (1998) Inhaled nitric oxide inhibits human platelet aggregation, P-selectin expression, and fibrinogen binding in vitro and in vivo. Circulation 97: 1481-1487. (Pubitemid 28191304)
56. Nelson RM, Cecconi O, Roberts WG, Aruffo A, Linhardt RJ, et al. (1993) Heparin oligosaccharides bind L- and P-selectin and inhibit acute inflammation. Blood 82: 3253-3258. (Pubitemid 23356692)
57. Trottein F, Schaffer L, Ivanov S, Paget C, Vendeville C, et al. (2009) Glycosyltransferase and sulfotransferase gene expression profiles in human monocytes, dendritic cells and macrophages. Glycoconjugate J 26: 1259-1274.
58. Closse C, Seigneur M, Renard M, Pruvost A, Dumain P, et al. (1996) Influence of hypoxia and hypoxia-reoxygenation on endothelial P-selectin expression. Haemostasis 26 Suppl 4: 177-181. (Pubitemid 26417436)
59. Esko JD (1999) Natural and Synthetic Inhibitors of Glycosylation. In: Ajit Varki RDC, Jeffrey D Esko, Hudson H Freeze, Pamela Stanley, Carolyn R Bertozzi, Gerald W Hart, and Marilynn E Etzler, editor. Essentials of Glycobiology. 2nd ed. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press.
60. Fuhler GM, Drayer AL, Vellenga E (2003) Decreased phosphorylation of protein kinase B and extracellular signal-regulated kinase in neutrophils from patients with myelodysplasia. Blood 101: 1172-1180. (Pubitemid 36139393)
61. Turhan A, Jenab P, Bruhns P, Ravetch JV, Coller BS, et al. (2004) Intravenous immune globulin prevents venular vaso-occlusion in sickle cell mice by inhibiting leukocyte adhesion and the interactions between sickle erythrocytes and adherent leukocytes. Blood 103: 2397-2400. (Pubitemid 38326264)
62. Orbach H, Tishler M, Shoenfeld Y (2004) Intravenous immunoglobulin and the kidney-a two-edged sword. Semin Arthritis Rheum 34: 593-601. (Pubitemid 39643121)
63. Chames P, Van Regenmortel M, Weiss E, Baty D (2009) Therapeutic antibodies: successes, limitations and hopes for the future. Br J Pharmacol 157: 220-233.
64. Whitby K, Pierson TC, Geiss B, Lane K, Engle M, et al. (2005) Castanospermine, a potent inhibitor of dengue virus infection in vitro and in vivo. J Virol 79: 8698-8706. (Pubitemid 40934780)
65. Stegelmeier BL, Molyneux RJ, Asano N, Watson AA, Nash RJ (2008) The comparative pathology of the glycosidase inhibitors swainsonine, castanospermine, and calystegines A3, B2, and C1 in mice. Toxicol Pathol 36: 651-659.
66. Imai C, Saito M, Mochizuki K, Fuchigami M, Goda T, et al. (2014) Cotreatment with the a-glucosidase inhibitor miglitol and DPP-4 inhibitor sitagliptin improves glycemic control and reduces the expressions of CVD risk factors in type 2 diabetic Japanese patients. Metabolism. 63: 746-753.
67. Emoto T, Sawada T, Hashimoto M, Kageyama H, Terashita D, et al. (2012) Effect of 3-month repeated administration of miglitol on vascular endothelial function in patients with diabetes mellitus and coronary artery disease. Am J Cardiol 109: 42-46.
68. Head CA, Swerdlow P, McDade WA, Joshi RM, Ikuta T, et al. (2010) Beneficial effects of nitric oxide breathing in adult patients with sickle cell crisis. Am J Hematol 85: 800-802.
69. Atz AM, Wessel DL (1997) Inhaled nitric oxide in sickle cell disease with acute chest syndrome. Anesthesiology 87: 988-990. (Pubitemid 27456256)
70. Sullivan KJ, Goodwin SR, Evangelist J, Moore RD, Mehta P (1999) Nitric oxide successfully used to treat acute chest syndrome of sickle cell disease in a young adolescent. Crit Care Med 27: 2563-2568.
71. Oppert M, Jorres A, Barckow D, Eckardt KU, Frei U, et al. (2004) Inhaled nitric oxide for ARDS due to sickle cell disease. Swiss Med Wkly 134: 165-167. (Pubitemid 38418936)
72. Rossaint R, Falke KJ, Lopez F, Slama K, Pison U, et al. (1993) Inhaled nitric oxide for the adult respiratory distress syndrome. N Engl J Med 328: 399-405. (Pubitemid 23042288)