The role of proximal tubular cells in interstitial fibrosis: Understanding TGF-β1

Chang Gung Medical Journal

Volumn 30, Issue 1, 2007, Pages 2-6

  Phillips, Aled ^a  

^a CARDIFF UNIVERSITY   (United Kingdom)

Author keywords

Epithelial cells; Fibrosis; Hyaluronan; Macrophages; TGF 1

Indexed keywords

CD18 ANTIGEN; HYALURONIC ACID; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 1; OSTEOGENIC PROTEIN 1; PLATELET DERIVED GROWTH FACTOR; TRANSFORMING GROWTH FACTOR BETA1;

ARTICLE; CELL STRUCTURE; CELL SURFACE; DIABETIC NEPHROPATHY; DISEASE ASSOCIATION; HUMAN; KIDNEY FIBROSIS; KIDNEY PROXIMAL TUBULE; KIDNEY TUBULE CELL; NON INSULIN DEPENDENT DIABETES MELLITUS; PROTEIN SYNTHESIS;

ANIMALS; FIBROSIS; HUMANS; HYALURONIC ACID; KIDNEY; KIDNEY TUBULES, PROXIMAL; MACROPHAGES; TRANSFORMING GROWTH FACTOR BETA1;

EID: 34247146782     PISSN: 02558270     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (37)

1. Eddy AA. Molecular insights into renal interstitial fibrosis. J Am Soc Nephrol 1996;7:2495-508.
2. Remuzzi G, Ruggeneti P, Benignin A. Understanding the nature of renal disease progression. Kidney Int 1997;51:2-15.
3. Bader R, Bader H, Grund KE, Mackensen-Haen S, Christ H, Bohle A. Structure and function of the kidney in diabetic glomerulosclerosis: Correlations between morphological and functional parameters. Pathol Res Pract 1980;167:204-16.
4. Bohle A, Mackensen-Haen S, Gise H. Significance of tubulointerstitial changes in the renal cortex for the excretory function and concentration ability of the kidney: A morphometric contribution. Am J Nephrol 1987;6:421-33.
5. Wehrmann M, Bohle A, Bogenschutz O, Eissele R, Freislederer A, Ohlschlegel C, Schumm G, Batz C, Gartner HV. Long-term prognosis of chronic idiopathic membranous glomerulonephritis. Clin Nephrol 1989;31:67-76.
6. Wehrmann M, Bohle A, Held H, Schumm G, Kendziorra H, Pressler H. Long-term prognosis of focal sclerosing glomerulonephritis. An analysis of 250 cases with particular regard to tubointerstitial changes. Clin Nephrol 1990;33:115-22.
7. Bogenschutz O, Bohle A, Batz C, Wehrmann M, Pressler H, Kendziorra H, Gartner HV. IgA Nephritis: On the Importance of Morphological and Clinical Parametes in the Long-term Prognosis of 239 Patients. Am J Nephrol 1990;10:137-47.
8. Mackensen-Haen S, Bohle A, Christensen J, Wehrmann M, Kendziorra H, Kokot F. The consequences for renal function of widening of the interstitium and changes in the tubular epithelium of the renal cortex and outer medulla in various renal diseases. Clin Nephrol 1992;37:70-7.
9. Phillips AO, Steadman R, Topley N, Williams JD. Elevated D-glucose concentrations modulate TGF-β1 synthesis by human cultured renal proximal tubular cells: the permissive role of platelet derived growth factor. Am J Pathol 1995;147:362-74.
10. Phillips AO, Topley N, Steadman R, Morrisey K, Williams J. Induction of TGF-β1 synthesis in D-glucose primed human proximal tubular cells: differential stimulation by the macrophage derived pro-inflammatory cytokines IL-1β and TNFα. Kidney Int 1996;50:1546-54.
11. Fraser DJ, Wakefield L, Phillips AO. Independent Regulation of Transforming Growth Factor-{beta}1 Transcription and Translation by Glucose and Platelet-Derived Growth Factor. Am J Pathol 2002;161:1039-49.
12. Fraser DJ, Brunskill NJ, Phillips AO. Long-term exposure of proximal tubular epithelial cells to glucose induces TGF-β1 synthesis via an autocrine PDGF loop. Am J Pathol 2003;163:65-74.
13. Morrisey K, Evans RA, Wakefield L, Phillips AO. Translational regulation of renal proximal tubular epithelial cell transforming growth factorβ1 generation by insulin. Am J Pathol 2001;159:1905-15.
14. Yang J, Liu Y. Dissection of key events in tubular epithelial to myofibroblast transition and its implications in renal interstitial fibrosis. Am J Pathol 2001;159:1465-75.
15. Zeisberg M, Hanai J, Sugimoto H, Mammoto T, Charytan D, Strutz F, Kalluri R. BMP-7 counteracts TGF-beta1-induced epithelial-to-mesenchymal transition and reverses chronic renal injury. Nat Med 2003;9:964-8.
16. Derynck R, Jarrett JA, Chen EY, Eaton DH, Bell JR, Assoian RK, Roberts AB, Sporn MB, Goeddel DV. Human transforming growth factor-beta complementary DNA sequence and expression in normal and transformed cells. Nature 1985;316:701-5.
17. Sonenberg M. mRNA translation: Influence of the 5′ and 3′ untranslated regions. Curr Opin Genet Dev 1994;4:310-5.
18. Kim SJ, Park K, Koellers D, Kim KY, Wakefield LM. Post-transcriptional regulation of the human transforming growth factor beta1 gene. J Biol Chem 1992;267:13702-7.
19. Fraser DJ, Van Roeyen C, Muhlenberg P, Mertens PR, Phillips AO. YB-1 controls translation of TGF-β1 in proximal tubular cells: Implications for the pathogenesis of diabetic nephropathy. J Am Soc Nephrol 2003;14:46A.
20. Young BA, Johnson RJ, Alpers CE, Eng CE, Gordon K, Floege J, Couser W. Cellular events in the evolution of experimental diabetic nephropathy. Kidney Int 1995;47:935-44.
21. Sassy-Pringent C, Heudes D, Mandet C, Belair MF, Michel O, Perdereau B, Bariety J, Bruneval P. Early glomerular macrophage recruitment in streptozotocin induced diabetic rats. Diabetes 2000;49:466-75.
22. Phillips AO, Baboolal K, Riley SG, Gröne HJ, Janssen U, Steadman R, Williams JD, Floege J. Association of prolonged hyperglycaemia with glomerular hypertrophy and renal basement membrane thickening in the Goto Kakizaki model of NIDDM. Am J Kidney Dis 2001;37:400-10.
23. Janssen U, Riley SG, Vassiliadou A, Floege J, Phillips AO. Hypertension superimposed on type II diabetes in GK rats induces progressive nephropathy. Kidney Int 2003;63:2162-70.
24. Furuta T, Saito T, Ootaka T, Soma J, Obara K, Keishi A, Yohinaga K. The role of macrophages in diabetic glomerulosclerosis, Am J Kidney Dis 1993;21:480-5.
25. Cuff CA, Kothapalli D, Azonobi I, Chun S, Zhang Y, Belkin R, Yeh C, Secreto A, Assonian RK, Rader DJ, Pure E. The adhesion receptor CD44 promotes atherosclerosis by mediating inflammatory cell recruitment and vascular cell activation. J Clin Invest 2001;108:1031-40.
26. Sampson PM, Rochester CL, Freundlich B, Elias JA. Cytokine regulation of human lung fibroblast hyaluronan production. J Clin Invest 1992;90:1492-503.
27. Hua Q, Knudson CB, Knudson W. Internalisation of hyaluronan by chondrocytes occurs via receptor-mediated endocytosis. J Cell Sci 1993;106:365-75.
28. Beck-Schimmer B, Oertli B, Pasch T, Wüthrich RP. Hyaluronan induces monocyte chemoattractant protein-1 expression in renal tubular epithelial cells. J Am Soc Nephrol 1998;9:2283-90.
29. Oertli B, Beck-Schimmer B, Fan X, Wuthrich RP. Mechanisms of hyaluronan-induced up-regulation of ICAM-1 and VCAM-1 expression by murine kidney tubular epithelial cells: Hyaluronan triggers cell adhesion molecule expression through a mechanism involving activation of nuclear factor -kB activating protein-1. J Immunol 1998;161:3431-7.
30. Ito T, Williams JD, Fraser DJ, Phillips AO. Hyaluronan attenuates TGF-β1 mediated signalling in renal proximal tubular epithelial cells. Am J Pathol 2004;164:1979-88.
31. Ito T, Williams JD, Fraser DJ, Phillips AO. Hyaluronan regulates TGF-β1 receptor compartmentalisation. J Biol Chem 2004;279:25326-32.
32. Evanko SP, Angello JC, Wight TN. Formation of hyaluronan- and versican-rich pericellular matrix is required for proliferation and migration of vascular smooth muscle cells. Arterioscler Thromb Vasc Biol 1999;19:1004-13.
33. Cohen M, Klein E, Geiger B, Addadi L. Organization and adhesive properties of the hyaluronan pericellular coat of chondrocytes and epithelial cells. Biophys J 2003;85: 1996-2005.
34. Knudson W, Aguiar DJ, Hua Q, Knudson CB. CD-44 anchored hyaluronan-rich pericellular matrices: An ultrastructural and biochemical analysis. Exp Cell Res 1996;228:216-28.
35. Selbi WD, De La Motte CA, Hascall VC, Phillips AO. BMP-7 modulates HA mediated proximal tubular cell-monocyte interaction. J Am Soc Nephrol 2004;15:1199-211.
36. Zhang XL, Selbi WD, De La Motte CA, Hascall VC, Phillips AO. Renal proximal tubular epithelial cells Transforming Growth Factor s1 generation and monocyte binding. Am J Pathol 2004;165:763-73.
37. Jones SG, Jones S, Phillips AO. Regulation of renal proximal tubular epithelial cell hyaluronan generation: Implications for diabetic nephropathy. Kidney Int 2001;59:1739-49.