Dilated intercellular space diameter as marker of reflux-related mucosal injury in children with chronic cough and gastro-oesophageal reflux disease

Alimentary Pharmacology and Therapeutics

Volumn 39, Issue 7, 2014, Pages 733-742

  Borrelli, O ^a   Mancini, V ^b   Thapar, N ^a   Ribolsi, M ^c   Emerenziani, S ^c   De'Angelis, G ^b   Bizzarri, B ^b   Lindley, K J ^a   Cicala, M ^c  

^a GREAT ORMOND STREET HOSPITAL   (United Kingdom)

^b UNIVERSITY OF PARMA   (Italy)

^c UNIVERSITY CAMPUS BIO MEDICO   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ADOLESCENT; ARTICLE; CHILD; CHRONIC COUGH; CONTROLLED STUDY; CORRELATION ANALYSIS; ESOPHAGEAL MUCOSAL INJURY; ESOPHAGOGASTRODUODENOSCOPY; ESOPHAGUS BIOPSY; ESOPHAGUS INJURY; EXPOSURE; FEMALE; GASTROESOPHAGEAL REFLUX; HUMAN; HUMAN TISSUE; IMPEDANCE; INTERCELLULAR SPACE; INTERCELLULAR SPACE DIAMETER; LONGITUDINAL STUDY; MAJOR CLINICAL STUDY; MALE; PH; PRIORITY JOURNAL; PROSPECTIVE STUDY; TRANSMISSION ELECTRON MICROSCOPY;

ADOLESCENT; BIOLOGICAL MARKERS; BIOPSY; CHILD; CHILD, PRESCHOOL; CHRONIC DISEASE; COUGH; ELECTRIC IMPEDANCE; ESOPHAGOSCOPY; EXTRACELLULAR SPACE; FEMALE; GASTROESOPHAGEAL REFLUX; HUMANS; INTESTINAL MUCOSA; MALE;

EID: 84903368099     PISSN: 02692813     EISSN: 13652036     Source Type: Journal    
DOI: 10.1111/apt.12652     Document Type: Article

References (31)

1. Sherman PM, Hassall E, Fagundes-Neto U, et al,. A global, evidence-based consensus on the definition of gastroesophageal reflux disease in the paediatric population. Am J Gastroenterol 2009; 104: 1278-95.
2. El-Serag HB, Gilger M, Kuebeler M, et al,. Extraoesophageal associations of gastroesophageal reflux disease in children without neurologic defects. Gastroenterology 2001; 121: 1294-9.
3. Tolia V, Vandenplas Y,. Systematic review: the extra-oesophageal reflux symptoms of gastrooesophageal reflux disease in children. Aliment Pharmacol Ther 2009; 29: 258-72.
4. Irwin RS,. Chronic cough due to gastroesophageal reflux disease: AACP evidence-based clinical practice guidelines. Chest 2006; 19: 80S-94S.
5. Khoshoo V, Edell D, Mohnot S, et al,. Associated factors in children with chronic cough. Chest 2009; 136: 811-5.
6. Borrelli O, Marabotto C, Mancini V, et al,. Role of gastro-esophageal reflux in children with unexplained chronic cough. J Pediatr Gastroenterol Nutr 2011; 53: 287-92.
7. van Malenstein H, Farré R, Sifrim D,. Oesophageal dilated intercellular spaces (DIS) and nonerosive reflux disease. Am J Gastroenterol 2008; 103: 1021-8.
8. Mancini V, Ribolsi M, Gentile M, et al,. Oesophageal mucosal intercellular space diameter and reflux pattern in childhood erosive and non-erosive reflux disease. Dig Liver Dis 2012; 44: 981-7.
9. Farré R, Blondeau K, Clement D, et al,. Evaluation of oesophageal mucosa integrity by the intraluminal impedance technique. Gut 2011; 60: 885-92.
10. Chang AB, Glomb WB,. Guidelines for evaluating chronic cough in paediatrics: AACP evidence-based clinical practice guidelines. Chest 2006; 19: 260S-83S.
11. Lundell L, Dent J, Bennett J, et al,. Endoscopic assessment of esophagitis: clinical and functional correlates and further validation of Los Angeles classification. Gut 1999; 45: 172-80.
12. Tobey NA, Carson JL, Alkiek RA, et al,. Dilated intercellular spaces: a morphological feature of acid reflux-damaged human esophageal epithelium. Gastroenterology 1996; 111: 1200-5.
13. Caviglia R, Ribolsi M, Maggiano N, et al,. Dilated intercellular spaces of esophageal epithelium in nonerosive reflux disease patients with physiological esophageal acid exposure. Am J Gastroenterol 2005; 100: 543-8.
14. Caviglia R, Ribolsi M, Gentile M, et al,. Dilated intercellular spaces and acid reflux at the distal and proximal esophagus in patients with non-erosive gastro-oesophageal reflux disease. Aliment Pharmacol Ther 2007; 25: 629-36.
15. Borrelli O, Battaglia M, Galos F, et al,. Non-Acid gastro-oesophageal reflux in children with suspected pulmonary aspiration. Dig Liv Dis 2010; 42: 115-21.
16. Sifrim D, Castell D, Dent J, et al,. Gastro-oesophageal reflux monitoring: review and consensus report on detection and definitions of acid, non-Acid, and gas reflux. Gut 2004; 53: 1024-31.
17. Borrelli O, Salvatore S, Mancini V, et al,. Relationship between baseline impedance levels and oesophageal mucosal integrity in children with erosive and non-erosive reflux disease. Neurogastroenterol Motil 2012; 24: 828-e394.
18. Bredenoord AJ, Wuesten BL, Smouth AJ,. Symptom association analysis in ambulatory gastrooesophageal reflux monitoring. Gut 2005; 54: 1810-7.
19. Omari TI, Schwarzer A, vanWijk MP, et al,. Optimization of the reflux-symptom association statistics for use in infants being investigated by 24-hour pH impedance. J Pediatr Gastroenterol Nutr 2011; 52: 408-13.
20. Marchant JM, Newcombe PA, Juniper EF, et al,. What is the burden of chronic cough for families? Chest 2008; 134: 303-9.
21. Guarino MP, Cheng L, Ma J, et al,. Increased TRPV1 gene expression in oesophageal mucosa of patients with non-erosive and erosive reflux disease. Neurogastroenterol Motil 2010; 22: 746-51.
22. Kandulski A, Jechorek D, Caro C, et al,. Histomorphological differentiation of non-erosive reflux disease and functional heartburn in patients with PPI-refractory heartburn. Aliment Pharmacol Ther 2013; 38: 643-51.
23. Kessing BF, Bredenoord AJ, Weijenborg PW, et al,. Esophageal acid exposure decreases intraluminal baseline impedance levels. Am J Gastroenterol 2011; 106: 2093-7.
24. Loots CM, Wijnakker R, van Wijk MP, et al,. Oesophageal impedance baselines in infants before and after placebo and proton pump inhibitor therapy. Neurogastroenterol Motil 2012; 24: 758-62.
25. Woodland P, Al-Zinaty M, Yazaki E, et al,. In vivo evaluation of acid-induced changes in oesophageal mucosa integrity and sensitivity in non-erosive reflux disease. Gut 2013; 62: 1256-61.
26. Javorkova N, Varechova S, Pecova R, et al,. Acidification of the esophagus acutely increases the cough sensitivity in patients with gastro-oesophageal reflux and chronic cough. Neurogastroenterol Motil 2008; 20: 119-24.
27. Smith JA, Decalmer S, Kelsall A, et al,. Acoustic cough-reflux associations in chronic cough: potential triggers and mechanisms. Gastroenterology 2010; 139: 754-62.
28. Winter HS, Madara JL, Stafford RJ, et al,. Intraepithelial eosinophils: a new diagnostic criterion for reflux esophagitis. Gastroenterology 1982; 83: 818-23.
29. Schäppi M, Mougenot J, Belli DC,. Upper gastrointestinal endoscopy. In Kleinman et al. editors Walker's Pediatric Gastrointestinal Disease. 5th ed. Hamilton, ON, Canada: BC Decker Inc, 2008; 1265-83.
30. Mastracci L, Spaggiari P, Grillo F, et al. Microscopic esophagitis in gastro-esophageal reflux disease: individual lesions, biopsy sampling, and clinical correlations. Virchows Arch 2009; 454: 31-9.
31. Fiocca R, Mastracci L, Riddell R, et al. Development of consensus guidelines for the histologic recognition of microscopic esophagitis in patients with gastroesophageal reflux disease: the Esohisto project. Hum Pathol 2010; 41: 223-31.