Increased TRPV1 gene expression in esophageal mucosa of patients with non-erosive and erosive reflux disease

Neurogastroenterology and Motility

Volumn 22, Issue 7, 2010, Pages

  Guarino, Michele Pier Luca ^a   Cheng, L ^b   Ma, J ^b   Harnett, K ^b   Biancani, P ^b   Altomare, A ^a   Panzera, F ^a   Behar, J ^b   Cicala, M ^a  

^a UNIVERSITY CAMPUS BIO MEDICO   (Italy)

^b BROWN UNIVERSITY   (United States)

Author keywords

Esophageal pH; Gastro esophageal reflux disease; Non erosive reflux disease; Vanilloid receptors

Indexed keywords

MESSENGER RNA; VANILLOID RECEPTOR 1;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE ASSOCIATION; ESOPHAGOSCOPY; ESOPHAGUS BIOPSY; ESOPHAGUS MUCOSA; ESOPHAGUS PH; FEMALE; GENE EXPRESSION; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; INFLAMMATORY INFILTRATE; MALE; NEUTROPHIL; NON EROSIVE REFLUX DISEASE; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; REFLUX ESOPHAGITIS; WESTERN BLOTTING;

ADULT; AGED; BLOTTING, WESTERN; ESOPHAGEAL PH MONITORING; ESOPHAGOSCOPY; ESOPHAGUS; FEMALE; GASTRIC ACID; GASTROESOPHAGEAL REFLUX; GENE EXPRESSION; HUMANS; HYDROGEN-ION CONCENTRATION; MALE; MIDDLE AGED; MUCOUS MEMBRANE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; TRPV CATION CHANNELS; YOUNG ADULT;

EID: 77953328654     PISSN: 13501925     EISSN: 13652982     Source Type: Journal    
DOI: 10.1111/j.1365-2982.2010.01514.x     Document Type: Article

References (30)

1. Dent J, Brun J, Fendrick AM et al. An evidence-based appraisal of reflux disease management: the Genval Workshop Report. Gut 1999 44 : S1 16.
2. Mastracci L, Grillo F, Zentilin P et al. Microscopic esophagitis in gastro-esophageal reflux disease: individual lesions, biopsy sampling, and clinical correlations. Virchows Arch 2009 454 : 31 9.
3. Tobey NA, Argote CM, Hosseini SS, Orlando RC. Dilated intercellular spaces and shunt permeability in non erosive acid-damaged esophageal epithelium. Am J Gastroenterol 2004 99 : 13 22.
4. Caviglia R, Ribolsi M, Maggiano N et al. Dilated intercellular spaces of esophageal epithelium in nonerosive reflux disease patients with physiological esophageal acid exposure. Am J Gastroenterol 2005 100 : 543 548.
5. Barlow WJ, Orlando RC. The pathogenesis of heartburn in non erosive reflux disease: a unifying hypothesis. Gastroenterology 2005 128 : 771 778.
6. Bhat YM, Bielefeldt K. Capsaicin receptor (TRPV1) and non-erosive reflux disease. Eur J Gastroenterol Hepatol 2006 18 : 263 270.
7. Knowles CH, Aziz Q. Visceral hypersensitivity in non-erosive reflux disease. Gut 2008 57 : 674 683.
8. Szallasi A, Blumberg PM. Vanilloid (capsaicin) receptors and mechanisms. Pharmacol Rev 1999 51 : 159 212.
9. Banerjee B, Medda BK, Lazarova Z, Bansal N, Shaker R, Sengupta JN. Effect of reflux-induced inflammation on transient receptor potential vanilloid one (TRPV1) expression in primary sensory neurons innervating the esophagus of rats. Neurogastroenterol Motil 2007 19 : 681 691.
10. Kindt S, Vos R, Blondeau K, Tack J. Influence of intra-oesophageal capsaicin instillation on heartburn induction and oesophageal sensitivity in man. Neurogastroenterol Motil 2009 21 : 1032 e82.
11. Olesen AE, Staahl C, Brock C, Arendt-Nielsen L, Drewes AM. Evoked human oesophageal hyperalgesia: a potential tool for analgesic evaluation? Basic Clin Pharmacol Toxicol 2009 105 : 126 136.
12. Führer M, Hammer J. Effect of repeated, long term capsaicin ingestion on intestinal chemo- and mechanosensation in healthy volunteers. Neurogastroenterol Motil 2009 21 : 521 527.
13. Page AJ, Brierley SM, Martin CM et al. Different contributions of ASIC channels 1a, 2, and 3 in gastro-intestinal mechano-sensory function. Gut 2005 54 : 1408 1415.
14. Page AJ, O'Donnell TA, Blackshaw LA. P2X purinoceptor-induced sensitization of ferret vagal mechanoreceptors in esophageal inflammation. J Physiol 2000 523 : 403 411.
15. Veronesi B, Carter JD, Devlin RB, Simon SA, Oortgiesen M. Neuropeptides and capsaicin stimulate the release of inflammatory cytokines in a human bronchial epithelial cell line. Neuropeptides 1999 33 : 447 456. (Pubitemid 30110874)
16. Yiangou Y, Facer P, Dyer NH et al. Vanilloid receptor 1 immunoreactivity in inflamed human bowel. Lancet 2001 357 : 1338 1339.
17. Cheng L, de la Monte S, Ma J et al. HCl-activated neural and epithelial vanilloid receptors (TRPV1) in cat esophageal mucosa. Am J Physiol Gastrointest Liver Physiol 2009 297 : G135 43.
18. Matthews PJ, Aziz Q, Facer P, Davis JB, Thompson DG, Anand P. Increased capsaicin receptor TRPV1 nerve fibres in the inflamed human esophagus. Eur J Gastroenterol Hepatol 2004 16 : 897 902.
19. Dean BB, Gano AJ, Knight K. Effectiveness of proton pump inhibitors in non-erosive reflux disease (NERD). Clin Gastroenterol Hepatol 2004 2 : 656 664.
20. Martinez SD, Malagon IB, Garewal HS, Cui H, Fass R. Non-erosive reflux disease (NERD)-acid reflux and symptom patterns. Aliment Pharmacol Ther 2003 17 : 537 545.
21. Wiklund IK, Junghard O, Grace E et al. Quality of Life in Reflux and Dyspepsia patients. Psychometric documentation of a new disease-specific questionnaire (QOLRAD). Eur J Surg 1998 582 : 56 61.
22. Bradford MM. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 1976 72 : 248 254.
23. Behar J, Sheahan DG, Biancani P, Spiro HM, Storer EH. Medical and surgical management of reflux esophagitis. A 38-month report of a prospective clinical trial. N Engl J Med 1975 293 : 263 268.
24. Quigley EMM, DiBaise JK. Non-erosive reflux disease: the real problem in gastro-esophageal reflux disease. Dig Liver Dis 2001 33 : 523 527.
25. Savarino E, Zentilin P, Tutuian R et al. The role of nonacid reflux in NERD: lessons learned from impedance-pH monitoring in 150 patients off therapy. Am J Gastroenterol 2008 103 : 2685 2693.
26. Prescott SM, Zimmerman GA, Stafforini DM et al. Platelet-activating factor and related lipid mediators. Annu Rev Biochem 2000 69 : 419 445.
27. Paterson WG, Kieffer CA, Feldman MJ, Miller DV, Morris GP. Role of platelet-activating factor in acid-induced esophageal mucosal injury. Dig Dis Sci 2007 52 : 1861 1866.
28. Fujino K, de la Fuente SG, Takami Y, Takahashi T, Mantyh CR. Attenuation of acid-induced oesophagitis in VR-1 deficient mice. Gut 2006 55 : 34 40.
29. Bielefeldt K, Ozaki N, Gebhart GF. Mild gastritis alters voltage-sensitive sodium currents in gastric sensory neurons in rats. Gastroenterology 2002 122 : 752 761. (Pubitemid 34173827)
30. Brady CM, Apostolidis AN, Harper M et al. Parallel changes in bladder suburothelial vanilloid receptor TRPV1 and pan-neuronal marker PGP9.5 immunoreactivity in patients with neurogenic detrusor overactivity after intravesical resiniferatoxin treatment. BJU Int 2004 93 : 770 776.