β-elemene inhibits proliferation through crosstalk between glia maturation factor β and extracellular signal-regulated kinase 1/2 and impairs drug resistance to temozolomide in glioblastoma cells

Molecular Medicine Reports

Volumn 10, Issue 2, 2014, Pages 1122-1128

  Zhu, Ting Zhun ^a   Li, Xiao Ming ^a   Luo, Li Han ^b   Xu, Ying Hui ^c   Cao, Peng ^a   Liu, Yang ^a   Liang, Guo Biao ^a  

^a GENERAL HOSPITAL OF NORTHERN THEATER COMMAND   (China)

^b Shenyang Entry Exit Inspection and Quarantine Bureau   (China)

^c DALIAN MEDICAL UNIVERSITY   (China)

Author keywords

Extracellular signal regulated kinase 1 2; Glia maturation factor ; Glioblastoma; Temozolomide; elemene

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; BETA ELEMENE; GLIA MATURATION FACTOR; GLIA MATURATION FACTOR BETA; MITOGEN ACTIVATED PROTEIN KINASE 1; PROTEIN BCL 2; SURVIVIN; TEMOZOLOMIDE; UNCLASSIFIED DRUG; 2-(2-AMINO-3-METHOXYPHENYL)-4H-1-BENZOPYRAN-4-ONE; ANTINEOPLASTIC AGENT; BETA-ELEMENE; BIRC5 PROTEIN, HUMAN; DACARBAZINE; FLAVONOID; INHIBITOR OF APOPTOSIS PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE 3; SESQUITERPENE; SMALL INTERFERING RNA;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CELL COUNTING; CELL PROLIFERATION; CELL VIABILITY; GLIA; GLIOBLASTOMA; HUMAN; HUMAN CELL; PROTEIN EXPRESSION; RNA INTERFERENCE; ANALOGS AND DERIVATIVES; ANTAGONISTS AND INHIBITORS; CELL SURVIVAL; CHEMISTRY; CURCUMA; DOWN REGULATION; DRUG EFFECTS; DRUG RESISTANCE; GENETICS; METABOLISM; PATHOLOGY; PHOSPHORYLATION; TOXICITY; TUMOR CELL LINE;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; CELL LINE, TUMOR; CELL PROLIFERATION; CELL SURVIVAL; CURCUMA; DACARBAZINE; DOWN-REGULATION; DRUG RESISTANCE, NEOPLASM; FLAVONOIDS; GLIA MATURATION FACTOR; GLIOBLASTOMA; HUMANS; INHIBITOR OF APOPTOSIS PROTEINS; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-BCL-2; RNA INTERFERENCE; RNA, SMALL INTERFERING; SESQUITERPENES;

EID: 84903310414     PISSN: 17912997     EISSN: 17913004     Source Type: Journal    
DOI: 10.3892/mmr.2014.2273     Document Type: Article

References (35)

1. Chen SL, You J and Wang GJ: Supercritical fluid extraction of beta-elemene under lower pressure. Se Pu 19: 179-181, 2001 (In Chinese).
2. Zhang X, Zhang Y and Li Y: β-elemene decreases cell invasion by upregulating E-cadherin expression in MCF-7 human breast cancer cells. Oncol Rep 30: 745-750, 2013.
3. Bao F, Qiu J and Zhang H: Potential role of β-elemene on histone H1 in the H22 ascites hepatoma cell line. Mol Med Rep 6: 185-190, 2012.
4. Wang G, Li X, Huang F, Zhao J, Ding H, Cunningham C, Coad JE, Flynn DC, Reed E and Li QQ: Antitumor effect of beta-elemene in non-small-cell lung cancer cells is mediated via induction of cell cycle arrest and apoptotic cell death. Cell Mol Life Sci 62: 881-893, 2005. (Pubitemid 40655635)
5. Li X, Wang G, Zhao J, Ding H, Cunningham C, Chen F, Flynn DC, Reed E and Li QQ: Antiproliferative effect of beta-elemene in chemoresistant ovarian carcinoma cells is mediated through arrest of the cell cycle at the G2-M phase. Cell Mol Life Sci 62: 894-904, 2005. (Pubitemid 40655636)
6. Zhu T, Zhao Y, Zhang J, Li L, Zou L, Yao Y and Xu Y: β-elemene inhibits proliferation of human glioblastoma cells and causes cell-cycle G0/G1 arrest via mutually compensatory activation of MKK3 and MKK6. Int J Oncol 38: 419-426, 2011.
7. Yao YQ, Ding X, Jia YC, Huang CX, Wang YZ and Xu YH: Anti-tumor effect of beta-elemene in glioblastoma cells depends on p38 MAPK activation. Cancer Lett 264: 127-134, 2008. (Pubitemid 351602131)
8. Zhu T, Xu Y, Dong B, Zhang J, Wei Z, Xu Y and Yao Y: β-elemene inhibits proliferation of human glioblastoma cells through the activation of gliamaturation factor β and induces sensitization to cisplatin. Oncol Rep 26: 405-413, 2011.
9. Yao YQ, Xu YH, Lu J, Zhou HY and Wang YZ: Effect of p38 MAPK on elemene-induced cell cycle arrest in C6 glioblastoma cells. Zhonghua Yi Xue Za Zhi 88: 56-58, 2008 (In Chinese). (Pubitemid 351459712)
10. Zaheer A, Zaheer S, Sahu SK, Knight S, Khosravi H, Mathur SN and Lim R: A novel role of glia maturation factor: induction of granulocyte-macrophage colony-stimulating factor and pro-inflammatory cytokines. J Neurochem 101: 364-376, 2007. (Pubitemid 46525279)
11. Thangavel R, Kempuraj D, Stolmeier D, Anantharam P, Khan M and Zaheer A: Glia maturation factor expression in entorhinal cortex of Alzheimer's disease brain. Neurochem Res 38: 1777-1784, 2013.
12. Lim R, Hicklin DJ, Ryken TC, Han XM, Liu KN, Miller JF and Baggenstoss BA: Suppression of glioma growth in vitro and in vivo by glia maturation factor. Cancer Res 46: 5241-5247, 1986. (Pubitemid 16008296)
13. Paunovic V and Harnett MM: Mitogen-activated protein kinases as therapeutic targets for rheumatoid arthritis. Drugs 73: 101-115, 2013.
14. Lo HW: Targeting Ras-RAF-ERK and its interactive pathways as a novel therapy for malignant gliomas. Curr Cancer Drug Targets 10: 840-848, 2010.
15. Liu HZ, Yu C, Yang Z, He JL, Chen WJ, Yin J, Li WM, Liu HT and Wang YX: Tubeimoside I sensitizes cisplatin in cisplatin-resistant human ovarian cancer cells (A2780/DDP) through down-regulation of ERK and up-regulation of p38 signaling pathways. Mol Med Rep 4: 985-992, 2011.
16. Zhao YS, Zhu TZ, Yao YQ, Liu RY, Wu CM, Wei ZQ, Wang W and Xu YH: β-elemene inhibits Hsp90/Raf-1 molecular complex inducing apoptosis of glioblastoma cells. J Neurooncol 107: 307-314, 2012.
17. Zaheer A and Lim R: In vitro inhibition of MAP kinase (ERK1/ERK2) activity by phosphorylated glia maturation factor (GMF). Biochemistry 35: 6283-6288, 1996. (Pubitemid 26164058)
18. Lim R and Zaheer A: In vitro enhancement of p38 mitogen-activated protein kinase activity by phosphorylated glia maturation factor. J Biol Chem 271: 22953-22956, 1996. (Pubitemid 26314722)
19. Ali K, Lu Y, Das U, Sharma RK, Wiebe S, Meguro K, Sadanand V, Fourney DR, Vitali A, Kelly M, et al: Biomolecular diagnosis of human glioblastoma multiforme using Synchrotron mid-infrared spectromicroscopy. Int J Mol Med 26: 11-16, 2010.
20. Tao L, Zhou L, Zheng L and Yao M: Elemene displays anti-cancer ability on laryngeal cancer cells in vitro and in vivo. Cancer Chemother Pharmacol 58: 24-34, 2006.
21. Li QQ, Wang G, Huang F, Banda M and Reed E: Antineoplastic effect of beta-elemene on prostate cancer cells and other types of solid tumour cells. J Pharm Pharmacol 62: 1018-1127, 2010.
22. Xu YH, Dong B, Luo QZ, Zhou HY, Jia YC, Yang YF and Wang YZ: Influence of elemene on the expression of Bcl-2 family genes in rat C6 glioma cells. Zhonghua Yi Xue Za Zhi 85: 1700-1703, 2005 (In Chinese). (Pubitemid 41166897)
23. Yao YQ, Xu YH, Zhou HY, Cui CZ and Wang YZ: Role of ERK in the inhibitory effects of elemene on the proliferation of rat C6 glioblastoma cells. Tumor 27: 777-779, 2007.
24. Zaheer A, Zaheer S, Thangavel R, Wu Y, Sahu SK and Yang B: Glia maturation factor modulates beta-amyloid-induced glial activation, inflammatory cytokine/chemokine production and neuronal damage. Brain Res 1208: 192-203, 2008.
25. Zaheer A, Zaheer S, Sahu SK, Yang B and Lim R: Reduced severity of experimental autoimmune encephalomyelitis in GMF-deficient mice. Neurochem Res 32: 39-47, 2007. (Pubitemid 46023415)
26. Zaheer S, Wu Y, Bassett J, Yang B and Zaheer A: Glia maturation factor regulation of STAT expression: a novel mechanism in experimental autoimmune encephalomyelitis. Neurochem Res 32: 2123-2131, 2007. (Pubitemid 350059856)
27. Gandhi M, Smith BA, Bovellan M, Paavilainen V, Daugherty-Clarke K, Gelles J, Lappalainen P and Goode BL: GMF is a cofilin homolog that binds Arp2/3 complex to stimulate filament debranching and inhibit actin nucleation. Curr Biol 20: 861-867, 2010.
28. Zaheer A, Knight S, Zaheer A, Ahrens M, Sahu SK and Yang B: Glia maturation factor overexpression in neuroblastoma cells activates glycogen synthase kinase-3beta and caspase-3. Brain Res 1190: 206-214, 2008.
29. Zaheer A and Lim R: Protein kinase A (PKA)- and protein kinase C-phosphorylated glia maturation factor promotes the catalytic activity of PKA. J Biol Chem 272: 5183-5186, 1997. (Pubitemid 27090076)
30. Reardon DA: Treatment of elderly patients with glioblastoma. Lancet Oncol 13: 656-657, 2012.
31. Sengupta S, Marrinan J, Frishman C and Sampath P: Impact of temozolomide on immune response during malignant glioma chemotherapy. Clin Dev Immunol 2012: 831090, 2012.
32. El Azreq MA, Naci D and Aoudjit F: Collagen/β1 integrin signaling up-regulates the ABCC1/MRP-1 transporter in an ERK/MAPK-dependent manner. Mol Biol Cell 23: 3473-3484, 2012.
33. Sato A, Sunayama J, Matsuda K, Seino S, Suzuki K, Watanabe E, Tachibana K, Tomiyama A, Kayama T and Kitanaka C: MEK-ERK signaling dictates DNA-repair gene MGMT expression and temozolomide resistance of stem-like glioblastoma cells via the MDM2-p53 axis. Stem Cells 29: 1942-1951, 2011.
34. Zhang Y, Qu XJ, Liu YP and Hou KZ: PD98059 enhancing the effects of oxaliplatin on human colorectal cancer RKO cells mediated by downregulation of GST-π expression. Chin J Clinicians 5: 6957-6960, 2011.
35. Tomiyasu H, Watanabe M, Goto-Koshino Y, Fujino Y, Ohno K, Sugano S and Tsujimoto H: Regulation of expression of ABCB1 and LRP genes by mitogen-activated protein kinase/extracellular signal-regulated kinase pathway and its role in generation of side population cells in canine lymphoma cell lines. Leuk Lymphoma 54: 1309-1315, 2013.