Regulation of expression of ABCB1 and LRP genes by mitogen-activated protein kinase/extracellular signal-regulated kinase pathway and its role in generation of side population cells in canine lymphoma cell lines

Leukemia and Lymphoma

Volumn 54, Issue 6, 2013, Pages 1309-1315

  Tomiyasu, Hirotaka ^a   Watanabe, Manabu ^b   Goto Koshino, Yuko ^a   Fujino, Yasuhito ^a   Ohno, Koichi ^a   Sugano, Sumio ^b   Tsujimoto, Hajime ^a  

^a UNIVERSITY OF TOKYO   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

Author keywords

ABCB1; Dog; LRP; MAPK ERK pathway; Multidrug resistance

Indexed keywords

LUNG RESISTANCE PROTEIN; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MULTIDRUG RESISTANCE PROTEIN 1; SMAD2 PROTEIN; SMAD3 PROTEIN; SMAD4 PROTEIN; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 2;

ABCB1 GENE; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DOG; GENE; GENE EXPRESSION REGULATION; LRP GENE; LYMPHOMA CELL LINE; MICROARRAY ANALYSIS; NONHUMAN; NUCLEOTIDE SEQUENCE; PHENOTYPE; PRIORITY JOURNAL; SIDE POPULATION CELL; UPREGULATION; WESTERN BLOTTING;

ANIMALS; CELL LINE, TUMOR; DOGS; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; G0 PHASE; G1 PHASE; GENE EXPRESSION REGULATION, NEOPLASTIC; LYMPHOMA; MITOGEN-ACTIVATED PROTEIN KINASES; NEOPLASTIC STEM CELLS; P-GLYCOPROTEIN; PROTEIN-SERINE-THREONINE KINASES; RECEPTORS, TRANSFORMING GROWTH FACTOR BETA; SIDE-POPULATION CELLS; SIGNAL TRANSDUCTION; VAULT RIBONUCLEOPROTEIN PARTICLES;

EID: 84877725072     PISSN: 10428194     EISSN: 10292403     Source Type: Journal    
DOI: 10.3109/10428194.2012.751529     Document Type: Article

References (28)

1. Gimenez-Bonafe P, Tortosa A, Perez-Tomas R . Overcoming drug resistance by enhancing apoptosis of tumor cells . Curr Cancer Drug Targets 2009; 9: 320- 340.
2. Harris AL, Hochhauser D . Mechanisms of multidrug resistance in cancer treatment . Acta Oncol 1992; 31: 205- 213.
3. Baguley BC . Multiple drug resistance mechanisms in cancer . Mol Biotechnol 2010; 46 : 308 - 316.
4. Moserle L, Ghisi M, Amadori A, et al . Side population and cancer stem cells: Therapeutic implications . Cancer Lett 2010; 288: 1- 9.
5. Lee CG, Das B, Lin TL, et al . A rare fraction of drug-resistant follicular lymphoma cancer stem cells interacts with follicular dendritic cells to maintain tumourigenic potential. Br J Haematol 2012; 158: 79- 90.
6. Vega F, Davuluri Y, Cho-Vega JH, et al . Side population of a murine mantle cell lymphoma model contains tumour-initiating cells responsible for lymphoma maintenance and dissemination . J Cell Mol Med 2010; 14 : 1532 - 1545.
7. Hadnagy A, Gaboury L, Beaulieu R, Balicki D . SP analysis may be used to identify cancer stem cell populations . Exp Cell Res 2006; 312 : 3701 - 3710.
8. Wu C, Alman BA . Side population cells in human cancers . Cancer Lett 2008; 268: 1- 9.
9. Z hang N, L i R, T ao K S, et a l. C haracterization of a stem-like population in hepatocellular carcinoma MHCC97 cells . Oncol Rep 2010; 23 : 827 - 831.
10. MacEwen EG . Spontaneous tumors in dogs and cats: Models for the study of cancer biology and treatment . Cancer Metastasis Rev 1990; 9 : 125 - 136.
11. Vail DM, MacEwen EG . Spontaneously occurring tumors of companion animals as models for human cancer . Cancer Invest 2000; 18 : 781 - 792.
12. Nemoto Y, Maruo T, Sato T, et al . Identifi cation of cancer stem cells derived from a canine lung adenocarcinoma cell line . Vet Pathol 2011; 48 : 1029 - 1034.
13. Ferletta M, Grawe J, Hellmen E . Canine mammary tumors contain cancer stem-like cells and form spheroids with an embryonic stem cell signature . Int J Dev Biol 2011; 55: 791- 799.
14. Y amazaki J, B aba K, G oto-Koshino Y, et a l. Q uantitative assessment of minimal residual disease (MRD) in canine lymphoma by using realtime polymerase chain reaction . Vet Immunol Immunopathol 2008; 126 : 321 - 331.
15. Hiraoka H, Minami K, Kaneko N, et al . Aberrations of the FHIT gene and Fhit protein in canine lymphoma cell lines . J Vet Med Sci 2009; 71 : 769 - 777.
16. Arends B, Vankelecom H, Vander Borght S, et al . The dog liver contains a " side population " of cells with hepatic progenitor-like characteristics . Stem Cells Dev 2009; 18 : 343 - 350.
17. Modok S, Mellor HR, Callaghan R . Modulation of multidrug resistance effl ux pump activity to overcome chemoresistance in cancer. Curr Opin Pharmacol 2006; 6: 350- 354.
18. Gromicho M, Dinis J, Magalhaes M, et al . Development of imatinib and dasatinib resistance: Dynamics of expression of drug transporters ABCB1, ABCC1, ABCG2, MVP, and SLC22A1 . Leuk Lymphoma 2011; 52 : 1980 - 1990.
19. Tomiyasu H, Goto-Koshino Y, Takahashi M, et al . Quantitative analysis of mRNA for 10 diff erent drug resistance factors in dogs with lymphoma . J Vet Med Sci 2010; 72: 1165- 1172.
20. Y ang J M, V assil A D, H ait W N. A ctivation of phospholipase C induces the expression of the multidrug resistance (MDR1) gene through the Raf-MAPK pathway. Mol Pharmacol 2001; 60: 674- 680.
21. Z hang Z, K noepp S M, K u H, et a l. Differential expression of FAK and Pyk2 in metastatic and non-metastatic EL4 lymphoma cell lines. Clin Exp Metastasis 2011; 28 : 551 - 565.
22. Kabashima A, Higuchi H, Takaishi H, et al . Side population of pancreatic cancer cells predominates in TGF-beta-mediated epithelial to mesenchymal transition and invasion . Int J Cancer 2009; 124 : 2771 - 2779.
23. Yin L, Castagnino P, Assoian RK . ABCG2 expression and side population abundance regulated by a transforming growth factor beta-directed epithelial-mesenchymal transition . Cancer Res 2008; 68 : 800 - 807.
24. Hu XF, Slater A, Kantharidis P, et al . Altered multidrug resistance phenotype caused by anthracycline analogues and cytosine arabinoside in myeloid leukemia . Blood 1999; 93 : 4086 - 4095.
25. Goldie JH, Coldman AJ . The genetic origin of drug resistance in neoplasms: Implications for systemic therapy . Cancer Res 1984; 44 : 3643 - 3653.
26. V alera E T, S crideli C A, Q ueiroz R G, et a l. M ultiple drug resistance protein (MDR-1), multidrug resistance-related protein (MRP) and lung resistance protein (LRP) gene expression in childhood acute lymphoblastic leukemia . Sao Paulo Med J 2004; 122: 166- 171.
27. Ho MM, Ng AV, Lam S, et al . Side population in human lung cancer cell lines and tumors is enriched with stem-like cancer cells. Cancer Res 2007; 67: 4827- 4833.
28. S hen H, X u W, L uo W, et a l. U pregulation of mdr1 gene is related to activation of the MAPK/ERK signal transduction pathway and YB-1 nuclear translocation in B-cell lymphoma . Exp Hematol 2011; 39 : 558 - 569.