Enantioselective nucleophile-catalyzed synthesis of tertiary alkyl fluorides via the α-Fluorination of ketenes: Synthetic and mechanistic studies

Journal of the American Chemical Society

Volumn 136, Issue 25, 2014, Pages 8899-8902

  Lee, Sarah Yunmi ^a,b   Neufeind, Stefan ^b   Fu, Gregory C ^a,b  

^a California Institute of Technology   (United States)

^b MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ENANTIOSELECTIVITY; FLUORINE; MECHANICS; NUCLEOPHILES;

ALKYL FLUORIDES; ASYMMETRIC COUPLING; ASYMMETRIC SYNTHESIS; ELEMENTARY STEPS; ENANTIOSELECTIVE; ENOLATES; MECHANISTIC STUDIES; REACTION PATHWAYS;

FLUORINE COMPOUNDS;

BENZENESULFONAMIDE DERIVATIVE; ESTER DERIVATIVE; FLUORIDE; FLUORINE; KETENE DERIVATIVE; NUCLEOPHILE; TERTIARY ALKYL GROUP; 2,3,4,5,6-PENTAFLUOROPHENOL; ETHYLENE DERIVATIVE; FLUORINATED HYDROCARBON; FLUOROBENZENE; KETENE; KETONE; N-FLUORODIBENZENESULFONIMIDE; PHENOL DERIVATIVE; SULFONAMIDE;

ACYLATION; ARTICLE; ASYMMETRIC SYNTHESIS; CATALYSIS; CATALYST; CHEMICAL STRUCTURE; ENANTIOSELECTIVITY; FLUORINATION; REACTION ANALYSIS; CHEMISTRY; HALOGENATION; STEREOISOMERISM; SYNTHESIS;

CATALYSIS; ETHYLENES; FLUOROBENZENES; HALOGENATION; HYDROCARBONS, FLUORINATED; KETONES; MOLECULAR STRUCTURE; PHENOLS; STEREOISOMERISM; SULFONAMIDES;

EID: 84903287319     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja5044209     Document Type: Article

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