Asymmetric fluorination of α-branched cyclohexanones enabled by a combination of chiral anion phase-transfer catalysis and enamine catalysis using protected amino acids

Journal of the American Chemical Society

Volumn 136, Issue 14, 2014, Pages 5225-5228

  Yang, Xiaoyu ^a   Phipps, Robert J ^a   Toste, F Dean ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; FLUORINATION; FLUORINE; HALOGENATION; KETONES;

ACTIVATION CYCLES; ASYMMETRIC FLUORINATION; CATALYTIC CYCLES; CYCLOHEXANONES; DUAL CATALYSIS; ENANTIOSELECTIVITES; ORGANOCATALYSTS; PHASE TRANSFER CATALYSIS;

CATALYSIS;

AMINO ACID DERIVATIVE; ANION; BENZYLAMINE; CYCLOHEXANONE DERIVATIVE; DEXTRO PHENYLALANINE; ENAMINE; GLYCINE; GLYCINE METHYL ESTER; KETONE DERIVATIVE; LEUCINE METHYL ESTER; PHENYLALANINE; PHENYLALANINE METHYL ESTER; PHOSPHORIC ACID; AMINE; AMINO ACID; FLUORINATED HYDROCARBON;

ARTICLE; ASYMMETRIC CATALYSIS; CATALYST; CHIRALITY; CONTROLLED STUDY; ENANTIOSELECTIVITY; FLUORINATION; FLUORINE NUCLEAR MAGNETIC RESONANCE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYDROGEN BOND; STEREOCHEMISTRY; CATALYSIS; CHEMICAL STRUCTURE; CHEMISTRY; HALOGENATION; PHASE TRANSITION; SYNTHESIS;

AMINES; AMINO ACIDS; ANIONS; CATALYSIS; CYCLOHEXANONES; HALOGENATION; HYDROCARBONS, FLUORINATED; MOLECULAR STRUCTURE; PHASE TRANSITION;

EID: 84898016896     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja500882x     Document Type: Article

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