Enantioselective synthesis of protected amines by the catalytic asymmetric addition of hydrazoic acid to ketenes

Angewandte Chemie - International Edition

Volumn 46, Issue 23, 2007, Pages 4367-4369

  Dai, Xing ^a   Nakai, Takashi ^a   Romero, Jan A C ^a   Fu, Gregory C ^a  

^a MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

Amines; Asymmetric catalysis; Homogeneous catalysis; Ketenes; Rearrangement

Indexed keywords

ADDITION REACTIONS; CATALYST ACTIVITY; ENANTIOSELECTIVITY; ORGANIC ACIDS; SYNTHESIS (CHEMICAL);

ASYMMETRIC CATALYSIS; HOMOGENEOUS CATALYSIS; KETENES; MECHANISTIC HYPOTHESIS; REARRANGEMENT;

AMINES;

EID: 34447285728     PISSN: 14337851     EISSN: None     Source Type: Journal    
DOI: 10.1002/anie.200700697     Document Type: Article

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24. 3 by syringe pump over 1-2 h, rather than all at once.
25. 3 does not add to phenyl isopropyl ketene at an appreciable rate in the absence of a catalyst.
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