Upregulation of COX-2 in the lung cancer promotes overexpression of multidrug resistance protein 4 (MRP4) via PGE2-dependent pathway

European Journal of Pharmaceutical Sciences

Volumn 62, Issue , 2014, Pages 189-196

  Maeng, Han Joo ^a   Lee, Wook Joo ^b   Jin, Qing Ri ^c   Chang, Ji Eun ^d   Shim, Won Sik ^b  

^a Inje University   (South Korea)

^b Gachon University   (South Korea)

^c ZHEJIANG A F UNIVERSITY   (China)

^d Seoul National University Bundang Hospital   (South Korea)

Author keywords

Cyclooxygenase 2 (COX 2); Lung cancer; Multidrug resistance associated protein 4 (MRP4)

Indexed keywords

CYCLOOXYGENASE 2; MESSENGER RNA; MULTIDRUG RESISTANCE ASSOCIATED PROTEIN 1; MULTIDRUG RESISTANCE ASSOCIATED PROTEIN 2; MULTIDRUG RESISTANCE ASSOCIATED PROTEIN 3; MULTIDRUG RESISTANCE ASSOCIATED PROTEIN 4; MULTIDRUG RESISTANCE PROTEIN 5; PROSTAGLANDIN E SYNTHASE; PROSTAGLANDIN E2; ABCC4 PROTEIN, HUMAN; ABCC4 PROTEIN, MOUSE; COMPLEMENTARY DNA; MULTIDRUG RESISTANCE PROTEIN; PHORBOL 13 ACETATE 12 MYRISTATE; PTGS2 PROTEIN, HUMAN; PTGS2 PROTEIN, MOUSE; SMALL INTERFERING RNA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DOWN REGULATION; GENE SILENCING; HUMAN; HUMAN CELL; IN VITRO STUDY; LUNG CANCER; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROSTAGLANDIN SYNTHESIS; PROTEIN EXPRESSION; UPREGULATION; ANIMAL; GENETICS; LUNG TUMOR; MALE; METABOLISM; TUMOR CELL LINE;

ANIMALS; CELL LINE, TUMOR; CYCLOOXYGENASE 2; DINOPROSTONE; DNA, COMPLEMENTARY; HUMANS; LUNG NEOPLASMS; MALE; MICE; MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS; RNA, MESSENGER; RNA, SMALL INTERFERING; TETRADECANOYLPHORBOL ACETATE; UP-REGULATION;

EID: 84903267487     PISSN: 09280987     EISSN: 18790720     Source Type: Journal    
DOI: 10.1016/j.ejps.2014.05.023     Document Type: Article

References (46)

1. G. Chan, J.O. Boyle, E.K. Yang, F. Zhang, P.G. Sacks, J.P. Shah, D. Edelstein, R.A. Soslow, A.T. Koki, B.M. Woerer, J.L. Masferrer, and A.J. Dannenberg Cyclooxygenase-2 expression is up-regulated in squamous cell carcinoma of the head and neck Cancer Res. 59 2003 991 994
2. S. Chandrasekharan, N.A. Foley, L. Jania, P. Clark, L.P. Audoly, and B.H. Koller Coupling of COX-1 to mPGES1 for prostaglandin E2 biosynthesis in the murine mammary gland J. Lipid Res. 46 2005 2636 2648 (Pubitemid 43107475)
3. M.-S. Chang, B.-C. Chen, M.-T. Yu, J.-R. Sheu, T.-F. Chen, and C.-H. Lin Phorbol 12-myristate 13-acetate upregulates cyclooxygenase-2 expression in human pulmonary epithelial cells via Ras, Raf-1, ERK, and NF-kappaB, but not p38 MAPK, pathways Cell. Signal. 17 2005 299 310 (Pubitemid 39574691)
4. A.J. Dannenberg, and K. Subbaramaiah Targeting cyclooxygenase-2 in human neoplsia: rationale and promise Cancer Cell 4 2003 431 436 (Pubitemid 38050040)
5. M. Dean, T. Fojo, and S. Bates Tumour stem cells and drug resistance Nat. Rev. Cancer 5 2005 275 284 (Pubitemid 40488633)
6. M.D. Diaz-Munoz, I.C. Osma-Garcia, C. Cacheiro-Llaguno, M. Fresno, and M.A. Iniguez Coordinated up-regulation of cyclooxygenase-2 and microsomal prostaglandin E synthase 1 transcription by nuclear factor kappa B and early growth response-1 in macrophages Cell. Signal. 22 2010 1427 1436
7. E. Fosslien Molecular pathology of cyclooxygenase-2 in neoplasia Ann. Clin. Lab. Sci. 30 2000 3 21 (Pubitemid 30078300)
8. A. Gradilone, F.M. Pulcinelli, L.V. Lotti, S. Martino, T. Mattiello, L. Frati, A.M. Aglianò, and P. Gazzaniga Celecoxib induces MRP-4 in lung cancer cells: therapeutic implications J. Clin. Oncol 25 2007 4318 4320 author reply 20 (Pubitemid 47548578)
9. A. Gradilone, F.M. Pulcinelli, L.V. Lotti, E. Trifirò, S. Martino, O. Gandini, W. Gianni, L. Frati, A.M. Aglianò, and P. Gazzaniga Celecoxib upregulates multidrug resistance proteins in colon cancer: lack of synergy with standard chemotherapy Curr. Cancer Drug Targets 8 2008 414 420
10. A. Greenhough, H.J. Smartt, A.E. Moore, H.R. Roberts, A.C. Williams, C. Paraskeva, and A. Kaidi The COX-2/PGE2 pathway: key roles in the hallmarks of cancer and adaptation to the tumour microenvironment Carcinogenesis 30 2009 377 386
11. K. Gudis, A. Tatsuguchi, K. Wada, S. Futagami, K. Nagata, T. Hiratsuka, Y. Shinji, K. Miyake, T. Tsukui, Y. Fukuda, and C. Sakamoto Microsomal prostaglandin E synthase (mPGES)-1, mPGES-2 and cytosolic PGES expression in human gastritis and gastric ulcer tissue Lab. Invest. 85 2005 225 236 (Pubitemid 40208926)
12. T. Hida, Y. Yatabe, H. Achiwa, H. Muramatsu, K. Kozaki, S. Nakamura, M. Ogawa, T. Mitsudomi, T. Sugiura, and T. Takahashi Increased expression of cyclooxygenase 2 occurs frequently in human lung cancers, specifically in adenocarcinomas Cancer Res. 58 1998 3761 3764 (Pubitemid 28405625)
13. L.L. Ho, J.G. Kench, D.J. Handelsman, G.L. Scheffer, P.D. Stricker, J.G. Grygiel, R.L. Sutherland, S.M. Henshall, J.D. Allen, and L.G. Horvath Androgen regulation of multidrug resistance-associated protein 4 (MRP4/ABCC4) in prostate cancer Prostate 68 2008 1421 1429
14. M. Kool, M. de Haas, G.L. Scheffer, R.J. Scheper, M.J. van Eijk, J.A. Juijn, F. Baas, and P. Borst Analysis of expression of cMOAT (MRP2), MRP3, MRP4, and MRP5, homologues of the multidrug resistance-associated protein gene (MRP1), in human cancer cell lines Cancer Res. 57 1997 3537 3547 (Pubitemid 27355505)
15. M.S. Kwong, E. Bleickardt, and J.R. Murren Camptothecin and taxane regimens for small-cell lung cancer Oncology (Williston Park) 16 2002 33 38
16. C.J. Langer The emerging world role of irinotecan in lung cancer Oncology (Williston Park) 15 2001 15 21 (Pubitemid 33738940)
17. M. Leggas, M. Adachi, G.L. Scheffer, D. Sun, P. Wielinga, G. Du, K.E. Mercer, Y. Zhuang, J.C. Panetta, B. Johnston, R.J. Scheper, C.F. Stewart, and J.D. Schuetz MRP4 confers resistance to topotecan and protects the brain from chemotherapy Mol. Cell. Biol. 24 2004 7612 7621 (Pubitemid 39121487)
18. T. Li, J. Lu, and Y. Zong Lentivirus-mediated shRNA interference targeting cyclooxygenase-2 inhibits growth of human non-small cell lung cancer J. Buon. 18 2013 908 914
19. Z.P. Lin, Y.-L. Zhu, D.R. Johnson, K.P. Rice, T. Nottoli, B.C. Hains, J. McGrath, S.G. Waxman, and A.C. Sartorelli Disruption of cAMP and prostaglandin E2 transport by multidrug resistance protein 4 deficiency alters cAMP-mediated signaling and nociceptive response Mol. Pharmacol. 73 2008 243 251 (Pubitemid 350294215)
20. H.-J. Maeng, H. Chapy, S. Zaman, and K.S. Pang Effects of 1a-25-dihyrroxyvitamin D3 on transport and metabolism of adefovir dipivoxil and its metabolites in Caco-2 cells Eur. J. Pharm. Sci. 46 2012 149 166
21. H.-J. Maeng, E.S. Kim, C. Chough, M. Joung, J.W. Lim, C.-K. Shim, and W.-S. Shim Addition of amino acid moieties to lapatinib increases the anti-cancer effect via amino acid transporters Biopharm. Drug Dispos. 35 2014 60 69
22. J.M. Maher, L.M. Aleksunes, M.Z. Dieter, Y. Tanaka, J.M. Peters, J.E. Manautou, and C.D. Klaassen Nrf2- and PPAR alpha-mediated regulation of hepatic Mrp transporters after exposure to perfluorooctanoic acid and perfluorodecanoic acid Toxicol. Sci. 106 2008 319 328
23. S.D. Markowitz Colorectal neoplasia goes with the flow: prostaglandin transport and termination Cancer Prev. Res. (Phila) 1 2008 77 79
24. X.Y. Mu, X.L. Dong, J. Sun, Y.H. Ni, Z. Dong, X.L. Li, E.L. Sun, Z. Yi, and G. Li Simultaneous blockage of epidermal growth factor receptor and cyclooxygenase-2 in a human xenotransplanted lung cancer model Asian Pac. J. Cancer Prev. 15 2014 69 73
25. M.D. Norris, J. Smith, K. Tanabe, P. Tobin, C. Flemming, G.L. Scheffer, P. Wielinga, S.L. Cohn, W.B. London, G.M. Marshall, J.D. Allen, and M. Haber Expression of multidrug transporter MRP4/ABCC4 is a marker of poor prognosis in neuroblastoma and confers resistance to irinotecan in vitro Mol. Cancer Ther. 4 2005 547 553 (Pubitemid 40601835)
26. T. Oguri, T. Isobe, K. Fujitaka, N. Ishikawa, and N. Kohno Association between expression of the MRP3 gene and exposure to platinum drugs in lung cancer Int. J. Cancer 93 2001 584 589 (Pubitemid 32701419)
27. H. Radilova, A. Libra, S. Holasova, M. Safarova, A. Viskova, F. Kunc, and M. Buncek COX-1 is coupled with mPGES-1 and ABCC4 in human cervix cancer cells Mol. Cell. Biochem. 330 2009 131 140
28. G. Reid, P. Wielinga, N. Zelcer, I. van der Heijden, A. Kuil, M. de Haas, J. Wijnholds, and P. Borst The human multidrug resistance protein MRP4 functions as a prostaglandin efflux transporter and is inhibited by nonsteroidal antiinflammatory drugs Proc. Natl. Acad. Sci. U.S.A. 100 2003 9244 9249 (Pubitemid 37033914)
29. B. Renga, M. Migliorati, A. Mencarelli, S. Cipriani, C. D'Amore, E. Distrutti, and S. Fiorucci Farnesoid X receptor suppresses constitutive androstane receptor activity at the multidrug resistance protein-4 promoter Biochim. Biophys. Acta 1809 2011 157 165
30. J. Renkonen, H. Wolff, and T. Paavonen Expression of cyclooxygenase-2 in human tong carcinoma and its precursor lesions Vichows Arch. 440 2002 594 597 (Pubitemid 34809690)
31. F.G. Russel, J.B. Koenderink, and R. Masereeuw Multidrug resistance protein 4 (MRP4/ABCC4): a versatile efflux transporter for drugs and signalling molecules Trends Pharmacol. Sci. 29 2008 200 207
32. N. Savaraj, C. Wu, M. Wangpaichitr, M.T. Kuo, T. Lampidis, C. Robles, A.J. Furst, and L. Feun Overexpression of mutated MRP4 in cisplatin resistant small cell lung cancer cell line: collateral sensitivity to azidothymidine Int. J. Oncol. 23 2003 173 179
33. G.V. Scagliotti, S. Novello, and G. Selvaggi Multidrug resistance in non-small-cell lung cancer Ann. Oncol. 10 1999 S83 S86
34. M.S. Shaik, A. Chatterjee, and M. Singh Effect of a selective cyclooxygenase-2 inhibitor, nimesulide, on the growth of lung tumors and their expression of cyclooxygenase-2 and peroxisome proliferator-activated receptor-gamma Clin. Cancer Res. 10 2004 1521 1529 (Pubitemid 38365248)
35. R.A. Soslow, A.J. Dannenberg, D. Rush, B.M. Woerner, K.N. Khan, J. Masferrer, and A.T. Koki COX-2 is expressed in human pulmonary, colonic, and mammary tumors Cancer 89 2000 2637 2645 (Pubitemid 32011609)
36. H.H. Tai, M. Tong, and Y. Ding 15-hydroxyprostaglandin dehydrogenase (15-PGDH) and lung cancer Prostaglandins Other Lipid Mediat. 83 2007 203 208 (Pubitemid 46661259)
37. Q. Tian, J. Zhang, T.M. Tan, E. Chan, W. Duan, S.Y. Chan, U.A. Boelsterli, P.C. Ho, H. Yang, J.S. Bian, M. Huang, Y.Z. Zhu, W. Xiong, X. Li, and S. Zhou Human multidrug resistance associated protein 4 confers resistance to camptothecins Pharm. Res. 22 2005 1837 1853 (Pubitemid 41504337)
38. M. Tong, Y. Ding, and H.H. Tai Reciprocal regulation of cyclooxygenase-2 and 15-hydroxyprostaglandin dehydrogenase expression in A549 human lung adenocarcinoma cells Carcinogenesis 27 2006 2170 2179 (Pubitemid 44644805)
39. B.L. Urquhart, R.G. Tirona, and R.B. Kim Nuclear receptors and the regulation of drug-metabolizing enzymes and drug transporters: implications for interindividual variability in response to drugs J. Clin. Pharmacol. 47 2007 566 578 (Pubitemid 46632158)
40. R.A. van Aubel, P.H. Smeets, J.G. Peters, R.J. Bindels, and F.G. Russel The MRP4/ABCC4 gene encodes a novel apical organic anion transporter in human kidney proximal tubules: putative efflux pump for urinary cAMP and cGMP J. Am. Soc. Nephrol. 13 2002 595 603 (Pubitemid 34183923)
41. H. Wolff, K. Saukkonen, S. Anttila, A. Karjalainen, H. Vainio, and A. Ristimaki Expression of cyclooxygenase-2 in human lung carcinoma Cancer Res. 58 1998 4997 5001 (Pubitemid 28521147)
42. S. Xu, J. Weerachayaphorn, S.Y. Cai, C.J. Soroka, and J.L. Boyer Aryl hydrocarbon receptor and NF-E2-related factor 2 are key regulators of human MRP4 expression Am. J. Physiol. Gastrointest. Liver Physiol. 299 2010 G126 G135
43. R. Yang, W.-S. Shim, F.D. Cui, G. Cheng, X. Han, Q.R. Jin, D.-D. Kim, S.-J. Chung, and C.-K. Shim Enhanced electrostatic interaction between chotosan-modified PLGA nanoparticle and tumor Int. J. Pharm. 371 2009 142 147
44. L.C. Young, B.G. Campling, S.P. Cole, R.G. Deeley, and J.H. Gerlach Multidrug resistance proteins MRP3, MRP1, and MRP2 in lung cancer: correlation of protein levels with drug response and messenger RNA levels Clin. Cancer Res. 7 2001 1798 1804 (Pubitemid 32708651)
45. L.C. Young, B.G. Campling, T. Voskoglou-Nomikos, S.P. Cole, R.G. Deeley, and J.H. Gerlach Expression of multidrug resistance protein-related genes in lung cancer: correlation with drug response Clin. Cancer Res. 5 1999 673 680 (Pubitemid 29131979)
46. X.O. Zhu, Z. Yang, C.M. Guo, X.T. Ni, J.N. Li, Y.C. Ge, L. Myatt, and K. Sun Paradoxical stimulation of cyclooxygenase-2 expression by glucocorticoids via a cyclic AMP response element in human amnion fibroblasts Mol. Endocrinol. 23 2009 1839 1849