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Volumn 55, Issue 4, 2014, Pages 839-852

Molecular approach to allergy diagnosis and therapy

Author keywords

Allergen characterization; Allergen specific immunotherapy; Molecule based allergy diagnosis; Recombinant allergens

Indexed keywords

ALLERGEN; BET V 1 ALLERGEN; DER F 1 ALLERGEN; DER F 2 ALLERGEN; GAMMA INTERFERON; GRASS PHL P 1 ALLERGEN; GRASS PHL P 5 ALLERGEN; IMMUNOGLOBULIN E; IMMUNOGLOBULIN G4; INTERLEUKIN 10; MITE DER P 1 ALLERGEN; MITE DER P 2 ALLERGEN; OLIVE OLE E 1 ALLERGEN; PHOSPHOLIPASE A2; POLLEN ANTIGEN; RECOMBINANT ALLERGEN; UNCLASSIFIED DRUG; VACCINE; RECOMBINANT PROTEIN;

EID: 84903194531     PISSN: 05135796     EISSN: None     Source Type: Journal    
DOI: 10.3349/ymj.2014.55.4.839     Document Type: Review
Times cited : (39)

References (85)
  • 1
    • 0035843316 scopus 로고    scopus 로고
    • Allergy and allergic diseases. Second of two parts
    • Kay AB. Allergy and allergic diseases. Second of two parts. N Engl J Med 2001;344:109-13.
    • (2001) N Engl J Med , vol.344 , pp. 109-113
    • Kay, A.B.1
  • 2
    • 0035804276 scopus 로고    scopus 로고
    • Allergy and allergic diseases. First of two parts
    • Kay AB. Allergy and allergic diseases. First of two parts. N Engl J Med 2001;344:30-7.
    • (2001) N Engl J Med , vol.344 , pp. 30-37
    • Kay, A.B.1
  • 3
    • 2342590065 scopus 로고    scopus 로고
    • The global burden of asthma: Executive summary of the GINA Dissemination Committee report
    • Global Initiative for Asthma (GINA) Program
    • Masoli M, Fabian D, Holt S, Beasley R; Global Initiative for Asthma (GINA) Program. The global burden of asthma: executive summary of the GINA Dissemination Committee report. Allergy 2004;59:469-78.
    • (2004) Allergy , vol.59 , pp. 469-478
    • Masoli, M.1    Fabian, D.2    Holt, S.3    Beasley, R.4
  • 6
    • 34047163404 scopus 로고    scopus 로고
    • Mechanisms of allergen-specific immunotherapy
    • Akdis M, Akdis CA. Mechanisms of allergen-specific immunotherapy. J Allergy Clin Immunol 2007;119:780-91.
    • (2007) J Allergy Clin Immunol , vol.119 , pp. 780-791
    • Akdis, M.1    Akdis, C.A.2
  • 7
    • 33749016485 scopus 로고    scopus 로고
    • Immunological mechanisms of allergen-specific immunotherapy
    • Larché M, Akdis CA, Valenta R. Immunological mechanisms of allergen-specific immunotherapy. Nat Rev Immunol 2006;6:761-71.
    • (2006) Nat Rev Immunol , vol.6 , pp. 761-771
    • Larché, M.1    Akdis, C.A.2    Valenta, R.3
  • 9
    • 5144222703 scopus 로고    scopus 로고
    • Vaccination with genetically engineered allergens prevents progression of allergic disease
    • Niederberger V, Horak F, Vrtala S, Spitzauer S, Krauth MT, Valent P, et al. Vaccination with genetically engineered allergens prevents progression of allergic disease. Proc Natl Acad Sci U S A 2004; 101 Suppl 2:14677-82.
    • (2004) Proc Natl Acad Sci U S A , vol.101 , Issue.SUPPL. 2 , pp. 14677-14682
    • Niederberger, V.1    Horak, F.2    Vrtala, S.3    Spitzauer, S.4    Krauth, M.T.5    Valent, P.6
  • 13
    • 0035843316 scopus 로고    scopus 로고
    • Allergy and allergic diseases. Second of two parts
    • Kay AB. Allergy and allergic diseases. Second of two parts. N Engl J Med 2001;344:109-13.
    • (2001) N Engl J Med , vol.344 , pp. 109-113
    • Kay, A.B.1
  • 14
    • 0035804276 scopus 로고    scopus 로고
    • Allergy and allergic diseases. First of two parts
    • Kay AB. Allergy and allergic diseases. First of two parts. N Engl J Med 2001;344:30-7.
    • (2001) N Engl J Med , vol.344 , pp. 30-37
    • Kay, A.B.1
  • 15
    • 2342590065 scopus 로고    scopus 로고
    • The global burden of asthma: Executive summary of the GINA Dissemination Committee report
    • Global Initiative for Asthma (GINA) Program
    • Masoli M, Fabian D, Holt S, Beasley R; Global Initiative for Asthma (GINA) Program. The global burden of asthma: executive summary of the GINA Dissemination Committee report. Allergy 2004;59:469-78.
    • (2004) Allergy , vol.59 , pp. 469-478
    • Masoli, M.1    Fabian, D.2    Holt, S.3    Beasley, R.4
  • 18
    • 34047163404 scopus 로고    scopus 로고
    • Mechanisms of allergen-specific immunotherapy
    • Akdis M, Akdis CA. Mechanisms of allergen-specific immunotherapy. J Allergy Clin Immunol 2007;119:780-91.
    • (2007) J Allergy Clin Immunol , vol.119 , pp. 780-791
    • Akdis, M.1    Akdis, C.A.2
  • 19
    • 33749016485 scopus 로고    scopus 로고
    • Immunological mechanisms of allergen-specific immunotherapy
    • Larché M, Akdis CA, Valenta R. Immunological mechanisms of allergen-specific immunotherapy. Nat Rev Immunol 2006;6:761-71.
    • (2006) Nat Rev Immunol , vol.6 , pp. 761-771
    • Larché, M.1    Akdis, C.A.2    Valenta, R.3
  • 21
    • 5144222703 scopus 로고    scopus 로고
    • Vaccination with genetically engineered allergens prevents progression of allergic disease
    • Niederberger V, Horak F, Vrtala S, Spitzauer S, Krauth MT, Valent P, et al. Vaccination with genetically engineered allergens prevents progression of allergic disease. Proc Natl Acad Sci U S A 2004; 101 Suppl 2:14677-82.
    • (2004) Proc Natl Acad Sci U S A , vol.101 , Issue.SUPPL. 2 , pp. 14677-14682
    • Niederberger, V.1    Horak, F.2    Vrtala, S.3    Spitzauer, S.4    Krauth, M.T.5    Valent, P.6
  • 24
    • 84903195179 scopus 로고    scopus 로고
    • Design of protective and therapeutic DNA vaccines to honey bee and Vespula venom by estimation of IgE antibodies to species-specific major allergens Api m1 and Ves v5
    • Weiss R, Hammerl P, Hartl A, Hochreiter R, Leitner WW, Scheiblhofer S, et al. Design of protective and therapeutic DNA vaccines to honey bee and Vespula venom by estimation of IgE antibodies to species-specific major allergens Api m1 and Ves v5. Allergy 2009;64:543-8.
    • (2009) Allergy , vol.64 , pp. 543-548
    • Weiss, R.1    Hammerl, P.2    Hartl, A.3    Hochreiter, R.4    Leitner, W.W.5    Scheiblhofer, S.6
  • 25
    • 0035217040 scopus 로고    scopus 로고
    • Antibody binding to venom carbohydrates is a frequent cause for double positivity to honeybee and yellow jacket venom in patients with stinging-insect allergy
    • Hemmer W, Focke M, Kolarich D, Wilson IB, Altmann F, Wöhrl S, et al. Antibody binding to venom carbohydrates is a frequent cause for double positivity to honeybee and yellow jacket venom in patients with stinging-insect allergy. J Allergy Clin Immunol 2001;108:1045-52.
    • (2001) J Allergy Clin Immunol , vol.108 , pp. 1045-1052
    • Hemmer, W.1    Focke, M.2    Kolarich, D.3    Wilson, I.B.4    Altmann, F.5    Wöhrl, S.6
  • 26
    • 84863828574 scopus 로고    scopus 로고
    • IgE to recombinant allergens Api m 1, Ves v 1, and Ves v 5 distinguish double sensitization from crossreaction in venom allergy
    • Müller U, Schmid-Grendelmeier P, Hausmann O, Helbling A. IgE to recombinant allergens Api m 1, Ves v 1, and Ves v 5 distinguish double sensitization from crossreaction in venom allergy. Allergy 2012;67:1069-73.
    • (2012) Allergy , vol.67 , pp. 1069-1073
    • Müller, U.1    Schmid-Grendelmeier, P.2    Hausmann, O.3    Helbling, A.4
  • 27
    • 79953650370 scopus 로고    scopus 로고
    • Microarrayed recombinant allergens for diagnostic testing
    • Shreffler WG. Microarrayed recombinant allergens for diagnostic testing. J Allergy Clin Immunol 2011;127:843-9.
    • (2011) J Allergy Clin Immunol , vol.127 , pp. 843-849
    • Shreffler, W.G.1
  • 28
    • 23244434086 scopus 로고    scopus 로고
    • Prevalences of positive skin test responses to 10 common allergens in the US population: Results from the third National Health and Nutrition Examination Survey
    • Arbes SJ Jr, Gergen PJ, Elliott L, Zeldin DC. Prevalences of positive skin test responses to 10 common allergens in the US population: results from the third National Health and Nutrition Examination Survey. J Allergy Clin Immunol 2005;116:377-83.
    • (2005) J Allergy Clin Immunol , vol.116 , pp. 377-383
    • Arbes Jr., S.J.1    Gergen, P.J.2    Elliott, L.3    Zeldin, D.C.4
  • 30
  • 31
    • 84903217019 scopus 로고    scopus 로고
    • [Internet]. Italy: Allergome; Available from
    • Allergome [Internet]. Italy: Allergome; 2013. Available from: http://www.allergome.org.
    • (2013) Allergome
  • 32
    • 84903194689 scopus 로고    scopus 로고
    • ImmunoCAP Allergen list [Internet]. Sweden: Termo Fisher Scientific; Available from
    • Termo Fisher Scientific. ImmunoCAP Allergen list [Internet]. Sweden: Termo Fisher Scientific; 2013. Available from: http://www.phadia.com/en/Products/Allergy-testing-products/ImmunoCAP-Allergen-Information/.
    • (2013) Termo Fisher Scientific
  • 34
    • 33745238659 scopus 로고    scopus 로고
    • The performance of a component-based allergen-microarray in clinical practice
    • Wöhrl S, Vigl K, Zehetmayer S, Hiller R, Jarisch R, Prinz M, et al. The performance of a component-based allergen-microarray in clinical practice. Allergy 2006;61:633-9.
    • (2006) Allergy , vol.61 , pp. 633-639
    • Wöhrl, S.1    Vigl, K.2    Zehetmayer, S.3    Hiller, R.4    Jarisch, R.5    Prinz, M.6
  • 35
    • 74049088661 scopus 로고    scopus 로고
    • Sensitization profiles in birch pollen-allergic patients with and without oral allergy syndrome to apple: Lessons from multiplexed component-resolved allergy diagnosis
    • Ebo DG, Bridts CH, Verweij MM, De Knop KJ, Hagendorens MM, De Clerck LS, et al. Sensitization profiles in birch pollen-allergic patients with and without oral allergy syndrome to apple: lessons from multiplexed component-resolved allergy diagnosis. Clin Exp Allergy 2010;40:339-47.
    • (2010) Clin Exp Allergy , vol.40 , pp. 339-347
    • Ebo, D.G.1    Bridts, C.H.2    Verweij, M.M.3    De Knop, K.J.4    Hagendorens, M.M.5    De Clerck, L.S.6
  • 36
    • 77951666161 scopus 로고    scopus 로고
    • Is the detection of IgE to multiple Bet v 1-homologous food allergens by means of allergen microarray clinically useful?
    • Villalta D, Asero R. Is the detection of IgE to multiple Bet v 1-homologous food allergens by means of allergen microarray clinically useful? J Allergy Clin Immunol 2010;125:1158-61.
    • (2010) J Allergy Clin Immunol , vol.125 , pp. 1158-1161
    • Villalta, D.1    Asero, R.2
  • 38
    • 73349118158 scopus 로고    scopus 로고
    • Allergy or tolerance in children sensitized to peanut: Prevalence and differentiation using component-resolved diagnostics
    • Nicolaou N, Poorafshar M, Murray C, Simpson A, Winell H, Kerry G, et al. Allergy or tolerance in children sensitized to peanut: prevalence and differentiation using component-resolved diagnostics. J Allergy Clin Immunol 2010;125:191-7.
    • (2010) J Allergy Clin Immunol , vol.125 , pp. 191-197
    • Nicolaou, N.1    Poorafshar, M.2    Murray, C.3    Simpson, A.4    Winell, H.5    Kerry, G.6
  • 40
    • 84859737960 scopus 로고    scopus 로고
    • How molecular diagnosis can change allergen-specific immunotherapy prescription in a complex pollen area
    • Sastre J, Landivar ME, Ruiz-García M, Andregnette-Rosigno MV, Mahillo I. How molecular diagnosis can change allergen-specific immunotherapy prescription in a complex pollen area. Allergy 2012;67:709-11.
    • (2012) Allergy , vol.67 , pp. 709-711
    • Sastre, J.1    Landivar, M.E.2    Ruiz-García, M.3    Andregnette-Rosigno, M.V.4    Mahillo, I.5
  • 41
    • 0037229842 scopus 로고    scopus 로고
    • Characteristics and immunobiology of grass pollen allergens
    • Andersson K, Lidholm J. Characteristics and immunobiology of grass pollen allergens. Int Arch Allergy Immunol 2003;130:87-107.
    • (2003) Int Arch Allergy Immunol , vol.130 , pp. 87-107
    • Andersson, K.1    Lidholm, J.2
  • 42
    • 84862639928 scopus 로고    scopus 로고
    • Detection of Phl p 1, Phl p 5, Phl p 7 and Phl p 12 specific IgE antibodies in the sera of children and adult patients allergic to Phleum pollen
    • Sekerkova A, Polackova M, Striz I. Detection of Phl p 1, Phl p 5, Phl p 7 and Phl p 12 specific IgE antibodies in the sera of children and adult patients allergic to Phleum pollen. Allergol Int 2012;61: 339-46.
    • (2012) Allergol Int , vol.61 , pp. 339-346
    • Sekerkova, A.1    Polackova, M.2    Striz, I.3
  • 43
    • 77954386055 scopus 로고    scopus 로고
    • House dust mite allergens in asthma and allergy
    • Thomas WR, Hales BJ, Smith WA. House dust mite allergens in asthma and allergy. Trends Mol Med 2010;16:321-8.
    • (2010) Trends Mol Med , vol.16 , pp. 321-328
    • Thomas, W.R.1    Hales, B.J.2    Smith, W.A.3
  • 44
    • 49149107253 scopus 로고    scopus 로고
    • Efficacy of recombinant birch pollen vaccine for the treatment of birch-allergic rhinoconjunctivitis
    • Pauli G, Larsen TH, Rak S, Horak F, Pastorello E, Valenta R, et al. Efficacy of recombinant birch pollen vaccine for the treatment of birch-allergic rhinoconjunctivitis. J Allergy Clin Immunol 2008; 122:951-60.
    • (2008) J Allergy Clin Immunol , vol.122 , pp. 951-960
    • Pauli, G.1    Larsen, T.H.2    Rak, S.3    Horak, F.4    Pastorello, E.5    Valenta, R.6
  • 45
    • 77952232284 scopus 로고    scopus 로고
    • Oralair Birch, a recombinant major birch pollen allergen tablet for sublingual immunotherapy of allergic rhinitis caused by birch pollen
    • Larenas-Linnemann D. Oralair Birch, a recombinant major birch pollen allergen tablet for sublingual immunotherapy of allergic rhinitis caused by birch pollen. Curr Opin Investig Drugs 2010;11: 586-96.
    • (2010) Curr Opin Investig Drugs , vol.11 , pp. 586-596
    • Larenas-Linnemann, D.1
  • 46
    • 84865175753 scopus 로고    scopus 로고
    • Specific subcutaneous immunotherapy with recombinant grass pollen allergens: First randomized dose-ranging safety study
    • Klimek L, Schendzielorz P, Pinol R, Pfaar O. Specific subcutaneous immunotherapy with recombinant grass pollen allergens: first randomized dose-ranging safety study. Clin Exp Allergy 2012;42: 936-45.
    • (2012) Clin Exp Allergy , vol.42 , pp. 936-945
    • Klimek, L.1    Schendzielorz, P.2    Pinol, R.3    Pfaar, O.4
  • 47
    • 0030937231 scopus 로고    scopus 로고
    • Conversion of the major birch pollen allergen, Bet v 1, into two nonanaphylactic T cell epitope-containing fragments: Candidates for a novel form of specific immunotherapy
    • Vrtala S, Hirtenlehner K, Vangelista L, Pastore A, Eichler HG, Sperr WR, et al. Conversion of the major birch pollen allergen, Bet v 1, into two nonanaphylactic T cell epitope-containing fragments: candidates for a novel form of specific immunotherapy. J Clin Invest 1997;99:1673-81.
    • (1997) J Clin Invest , vol.99 , pp. 1673-1681
    • Vrtala, S.1    Hirtenlehner, K.2    Vangelista, L.3    Pastore, A.4    Eichler, H.G.5    Sperr, W.R.6
  • 48
    • 0035462111 scopus 로고    scopus 로고
    • Genetic engineering of a hypoallergenic trimer of the major birch pollen allergen Bet v 1
    • Vrtala S, Hirtenlehner K, Susani M, Akdis M, Kussebi F, Akdis CA, et al. Genetic engineering of a hypoallergenic trimer of the major birch pollen allergen Bet v 1. FASEB J 2001;15:2045-7.
    • (2001) FASEB J , vol.15 , pp. 2045-2047
    • Vrtala, S.1    Hirtenlehner, K.2    Susani, M.3    Akdis, M.4    Kussebi, F.5    Akdis, C.A.6
  • 49
    • 46849121475 scopus 로고    scopus 로고
    • Clinical effects of immunotherapy with genetically modified recombinant birch pollen Bet v 1 derivatives
    • Purohit A, Niederberger V, Kronqvist M, Horak F, Grönneberg R, Suck R, et al. Clinical effects of immunotherapy with genetically modified recombinant birch pollen Bet v 1 derivatives. Clin Exp Allergy 2008;38:1514-25.
    • (2008) Clin Exp Allergy , vol.38 , pp. 1514-1525
    • Purohit, A.1    Niederberger, V.2    Kronqvist, M.3    Horak, F.4    Grönneberg, R.5    Suck, R.6
  • 50
    • 39749123322 scopus 로고    scopus 로고
    • Characterization of a hypoallergenic recombinant Bet v 1 variant as a candidate for allergen-specific immunotherapy
    • Kahlert H, Suck R, Weber B, Nandy A, Wald M, Keller W, et al. Characterization of a hypoallergenic recombinant Bet v 1 variant as a candidate for allergen-specific immunotherapy. Int Arch Allergy Immunol 2008;145:193-206.
    • (2008) Int Arch Allergy Immunol , vol.145 , pp. 193-206
    • Kahlert, H.1    Suck, R.2    Weber, B.3    Nandy, A.4    Wald, M.5    Keller, W.6
  • 51
    • 84878090456 scopus 로고    scopus 로고
    • Double-blind, placebo-controlled, dose-ranging study of new recombinant hypoallergenic Bet v 1 in an environmental exposure chamber
    • Meyer W, Narkus A, Salapatek AM, Häfner D. Double-blind, placebo-controlled, dose-ranging study of new recombinant hypoallergenic Bet v 1 in an environmental exposure chamber. Allergy 2013;68:724-31.
    • (2013) Allergy , vol.68 , pp. 724-731
    • Meyer, W.1    Narkus, A.2    Salapatek, A.M.3    Häfner, D.4
  • 53
    • 0031570734 scopus 로고    scopus 로고
    • Identification and mutational analysis of the immunodominant IgE binding epitopes of the major peanut allergen Ara h 2
    • Stanley JS, King N, Burks AW, Huang SK, Sampson H, Cockrell G, et al. Identification and mutational analysis of the immunodominant IgE binding epitopes of the major peanut allergen Ara h 2. Arch Biochem Biophys 1997;342:244-53.
    • (1997) Arch Biochem Biophys , vol.342 , pp. 244-253
    • Stanley, J.S.1    King, N.2    Burks, A.W.3    Huang, S.K.4    Sampson, H.5    Cockrell, G.6
  • 54
    • 8244232505 scopus 로고    scopus 로고
    • Mapping and mutational analysis of the IgE-binding epitopes on Ara h 1, a legume vicilin protein and a major allergen in peanut hypersensitivity
    • Burks AW, Shin D, Cockrell G, Stanley JS, Helm RM, Bannon GA. Mapping and mutational analysis of the IgE-binding epitopes on Ara h 1, a legume vicilin protein and a major allergen in peanut hypersensitivity. Eur J Biochem 1997;245:334-9.
    • (1997) Eur J Biochem , vol.245 , pp. 334-339
    • Burks, A.W.1    Shin, D.2    Cockrell, G.3    Stanley, J.S.4    Helm, R.M.5    Bannon, G.A.6
  • 55
    • 84878108455 scopus 로고    scopus 로고
    • A phase 1 study of heat/phenol-killed, E. coli-encapsulated, recombinant modified peanut proteins Ara h 1, Ara h 2, and Ara h 3 (EMP-123) for the treatment of peanut allergy
    • Wood RA, Sicherer SH, Burks AW, Grishin A, Henning AK, Lindblad R, et al. A phase 1 study of heat/phenol-killed, E. coli-encapsulated, recombinant modified peanut proteins Ara h 1, Ara h 2, and Ara h 3 (EMP-123) for the treatment of peanut allergy. Allergy 2013;68:803-8.
    • (2013) Allergy , vol.68 , pp. 803-808
    • Wood, R.A.1    Sicherer, S.H.2    Burks, A.W.3    Grishin, A.4    Henning, A.K.5    Lindblad, R.6
  • 56
    • 79955478697 scopus 로고    scopus 로고
    • Immunotherapy with peptides
    • Moldaver D, Larché M. Immunotherapy with peptides. Allergy 2011;66:784-91.
    • (2011) Allergy , vol.66 , pp. 784-791
    • Moldaver, D.1    Larché, M.2
  • 57
    • 0037395291 scopus 로고    scopus 로고
    • Allergen-specific T-cell tolerance induction with allergen-derived long synthetic peptides: Results of a phase I trial
    • Fellrath JM, Kettner A, Dufour N, Frigerio C, Schneeberger D, Leimgruber A, et al. Allergen-specific T-cell tolerance induction with allergen-derived long synthetic peptides: results of a phase I trial. J Allergy Clin Immunol 2003;111:854-61.
    • (2003) J Allergy Clin Immunol , vol.111 , pp. 854-861
    • Fellrath, J.M.1    Kettner, A.2    Dufour, N.3    Frigerio, C.4    Schneeberger, D.5    Leimgruber, A.6
  • 59
    • 84875431318 scopus 로고    scopus 로고
    • A nonallergenic birch pollen allergy vaccine consisting of hepatitis PreS-fused Bet v 1 peptides focuses blocking IgG toward IgE epitopes and shifts immune responses to a tolerogenic and Th1 phenotype
    • Marth K, Breyer I, Focke-Tejkl M, Blatt K, Shamji MH, Layhadi J, et al. A nonallergenic birch pollen allergy vaccine consisting of hepatitis PreS-fused Bet v 1 peptides focuses blocking IgG toward IgE epitopes and shifts immune responses to a tolerogenic and Th1 phenotype. J Immunol 2013;190:3068-78.
    • (2013) J Immunol , vol.190 , pp. 3068-3078
    • Marth, K.1    Breyer, I.2    Focke-Tejkl, M.3    Blatt, K.4    Shamji, M.H.5    Layhadi, J.6
  • 60
    • 79953657092 scopus 로고    scopus 로고
    • Carrier-bound, nonallergenic Ole e 1 peptides for vaccination against olive pollen allergy
    • Twaroch TE, Focke M, Civaj V, Weber M, Balic N, Mari A, et al. Carrier-bound, nonallergenic Ole e 1 peptides for vaccination against olive pollen allergy. J Allergy Clin Immunol 2011;128:178-84.
    • (2011) J Allergy Clin Immunol , vol.128 , pp. 178-184
    • Twaroch, T.E.1    Focke, M.2    Civaj, V.3    Weber, M.4    Balic, N.5    Mari, A.6
  • 61
    • 76349094087 scopus 로고    scopus 로고
    • Developments in allergen-specific immunotherapy: From allergen extracts to allergy vaccines bypassing allergen-specific immunoglobulin E and T cell reactivity
    • Focke M, Swoboda I, Marth K, Valenta R. Developments in allergen-specific immunotherapy: from allergen extracts to allergy vaccines bypassing allergen-specific immunoglobulin E and T cell reactivity. Clin Exp Allergy 2010;40:385-97.
    • (2010) Clin Exp Allergy , vol.40 , pp. 385-397
    • Focke, M.1    Swoboda, I.2    Marth, K.3    Valenta, R.4
  • 62
    • 78650901420 scopus 로고    scopus 로고
    • Development and preliminary clinical evaluation of a peptide immunotherapy vaccine for cat allergy
    • Worm M, Lee HH, Kleine-Tebbe J, Hafner RP, Laidler P, Healey D, et al. Development and preliminary clinical evaluation of a peptide immunotherapy vaccine for cat allergy. J Allergy Clin Immunol 2011;127:89-97.
    • (2011) J Allergy Clin Immunol , vol.127 , pp. 89-97
    • Worm, M.1    Lee, H.H.2    Kleine-Tebbe, J.3    Hafner, R.P.4    Laidler, P.5    Healey, D.6
  • 63
    • 84871713429 scopus 로고    scopus 로고
    • Fel d 1-derived peptide antigen desensitization shows a persistent treatment effect 1 year after the start of dosing: A randomized, placebo-controlled study
    • Patel D, Couroux P, Hickey P, Salapatek AM, Laidler P, Larché M, et al. Fel d 1-derived peptide antigen desensitization shows a persistent treatment effect 1 year after the start of dosing: a randomized, placebo-controlled study. J Allergy Clin Immunol 2013;131: 103-9.
    • (2013) J Allergy Clin Immunol , vol.131 , pp. 103-109
    • Patel, D.1    Couroux, P.2    Hickey, P.3    Salapatek, A.M.4    Laidler, P.5    Larché, M.6
  • 64
    • 0031866059 scopus 로고    scopus 로고
    • Successful immunotherapy with T-cell epitope peptides of bee venom phospholipase A2 induces specific T-cell anergy in patients allergic to bee venom
    • Müller U, Akdis CA, Fricker M, Akdis M, Blesken T, Bettens F, et al. Successful immunotherapy with T-cell epitope peptides of bee venom phospholipase A2 induces specific T-cell anergy in patients allergic to bee venom. J Allergy Clin Immunol 1998;101(6 Pt 1): 747-54.
    • (1998) J Allergy Clin Immunol , vol.101 , Issue.6 PART 1 , pp. 747-754
    • Müller, U.1    Akdis, C.A.2    Fricker, M.3    Akdis, M.4    Blesken, T.5    Bettens, F.6
  • 65
    • 81255170679 scopus 로고    scopus 로고
    • Bet v 1-like pollen allergens of multiple Fagales species can sensitize atopic individuals
    • Hauser M, Asam C, Himly M, Palazzo P, Voltolini S, Montanari C, et al. Bet v 1-like pollen allergens of multiple Fagales species can sensitize atopic individuals. Clin Exp Allergy 2011;41:1804-14.
    • (2011) Clin Exp Allergy , vol.41 , pp. 1804-1814
    • Hauser, M.1    Asam, C.2    Himly, M.3    Palazzo, P.4    Voltolini, S.5    Montanari, C.6
  • 66
    • 0142010606 scopus 로고    scopus 로고
    • Allergen microarray: Comparison of microarray using recombinant allergens with conventional diagnostic methods to detect allergen-specific serum immunoglobulin E
    • Jahn-Schmid B, Harwanegg C, Hiller R, Bohle B, Ebner C, Scheiner O, et al. Allergen microarray: comparison of microarray using recombinant allergens with conventional diagnostic methods to detect allergen-specific serum immunoglobulin E. Clin Exp Allergy 2003;33:1443-9.
    • (2003) Clin Exp Allergy , vol.33 , pp. 1443-1449
    • Jahn-Schmid, B.1    Harwanegg, C.2    Hiller, R.3    Bohle, B.4    Ebner, C.5    Scheiner, O.6
  • 68
    • 84865546545 scopus 로고    scopus 로고
    • Component-resolved diagnosis with commercially available D. pteronyssinus Der p 1, Der p 2 and Der p 10: Relevant markers for house dust mite allergy
    • Bronnert M, Mancini J, Birnbaum J, Agabriel C, Liabeuf V, Porri F, et al. Component-resolved diagnosis with commercially available D. pteronyssinus Der p 1, Der p 2 and Der p 10: relevant markers for house dust mite allergy. Clin Exp Allergy 2012;42: 1406-15.
    • (2012) Clin Exp Allergy , vol.42 , pp. 1406-1415
    • Bronnert, M.1    Mancini, J.2    Birnbaum, J.3    Agabriel, C.4    Liabeuf, V.5    Porri, F.6
  • 69
    • 46649085516 scopus 로고    scopus 로고
    • Clinical usefulness of microarray-based IgE detection in children with suspected food allergy
    • Ott H, Baron JM, Heise R, Ocklenburg C, Stanzel S, Merk HF, et al. Clinical usefulness of microarray-based IgE detection in children with suspected food allergy. Allergy 2008;63:1521-8.
    • (2008) Allergy , vol.63 , pp. 1521-1528
    • Ott, H.1    Baron, J.M.2    Heise, R.3    Ocklenburg, C.4    Stanzel, S.5    Merk, H.F.6
  • 70
    • 77956505306 scopus 로고    scopus 로고
    • Performance of a component-based allergen-microarray in the diagnosis of cow's milk and hen's egg allergy
    • D'Urbano LE, Pellegrino K, Artesani MC, Donnanno S, Luciano R, Riccardi C, et al. Performance of a component-based allergen-microarray in the diagnosis of cow's milk and hen's egg allergy. Clin Exp Allergy 2010;40:1561-70.
    • (2010) Clin Exp Allergy , vol.40 , pp. 1561-1570
    • D'Urbano, L.E.1    Pellegrino, K.2    Artesani, M.C.3    Donnanno, S.4    Luciano, R.5    Riccardi, C.6
  • 71
    • 84857367378 scopus 로고    scopus 로고
    • Ovomucoid (Gal d 1) specific IgE detected by microarray system predict tolerability to boiled hen's egg and an increased risk to progress to multiple environmental allergen sensitisation
    • Alessandri C, Zennaro D, Scala E, Ferrara R, Bernardi ML, Santoro M, et al. Ovomucoid (Gal d 1) specific IgE detected by microarray system predict tolerability to boiled hen's egg and an increased risk to progress to multiple environmental allergen sensitisation. Clin Exp Allergy 2012;42:441-50.
    • (2012) Clin Exp Allergy , vol.42 , pp. 441-450
    • Alessandri, C.1    Zennaro, D.2    Scala, E.3    Ferrara, R.4    Bernardi, M.L.5    Santoro, M.6
  • 72
    • 84867508035 scopus 로고    scopus 로고
    • IgE detection to α/β/γ-gliadin and its clinical relevance in wheat-dependent exercise-induced anaphylaxis
    • Hofmann SC, Fischer J, Eriksson C, Bengtsson Gref O, Biedermann T, Jakob T. IgE detection to α/β/γ-gliadin and its clinical relevance in wheat-dependent exercise-induced anaphylaxis. Allergy 2012;67:1457-60.
    • (2012) Allergy , vol.67 , pp. 1457-1460
    • Hofmann, S.C.1    Fischer, J.2    Eriksson, C.3    Bengtsson Gref, O.4    Biedermann, T.5    Jakob, T.6
  • 73
    • 84875651696 scopus 로고    scopus 로고
    • Allergen chip diagnosis for soy-allergic patients: Gly m 4 as a marker for severe food-allergic reactions to soy
    • Berneder M, Bublin M, Hoffmann-Sommergruber K, Hawranek T, Lang R. Allergen chip diagnosis for soy-allergic patients: Gly m 4 as a marker for severe food-allergic reactions to soy. Int Arch Allergy Immunol 2013;161:229-33.
    • (2013) Int Arch Allergy Immunol , vol.161 , pp. 229-233
    • Berneder, M.1    Bublin, M.2    Hoffmann-Sommergruber, K.3    Hawranek, T.4    Lang, R.5
  • 74
    • 85006096862 scopus 로고    scopus 로고
    • Microarray-based component-resolved diagnosis of latex allergy: Isolated IgE-mediated sensitization to latexprofilin Hev b8 may act as confounder
    • Schuler S, Ferrari G, Schmid-Grendelmeier P, Harr T. Microarray-based component-resolved diagnosis of latex allergy: isolated IgE-mediated sensitization to latexprofilin Hev b8 may act as confounder. Clin Transl Allergy 2013;3:11.
    • (2013) Clin Transl Allergy , vol.3 , pp. 11
    • Schuler, S.1    Ferrari, G.2    Schmid-Grendelmeier, P.3    Harr, T.4
  • 75
    • 77953633697 scopus 로고    scopus 로고
    • Microarrays of recombinant Hevea brasiliensis proteins: A novel tool for the component-resolved diagnosis of natural rubber latex allergy
    • Ott H, Schröder C, Raulf-Heimsoth M, Mahler V, Ocklenburg C, Merk HF, et al. Microarrays of recombinant Hevea brasiliensis proteins: a novel tool for the component-resolved diagnosis of natural rubber latex allergy. J Investig Allergol Clin Immunol 2010;20:129-38.
    • (2010) J Investig Allergol Clin Immunol , vol.20 , pp. 129-138
    • Ott, H.1    Schröder, C.2    Raulf-Heimsoth, M.3    Mahler, V.4    Ocklenburg, C.5    Merk, H.F.6
  • 76
    • 75749097934 scopus 로고    scopus 로고
    • Safety and tolerability of recombinant Bet v 1 (rBet v 1) tablets in sublingual immunotherapy (SLIT) [abstract]
    • Winther L, Poulsen LK, Robin B, Melac M, Malling HJ. Safety and tolerability of recombinant Bet v 1 (rBet v 1) tablets in sublingual immunotherapy (SLIT) [abstract]. J Allergy Clin Immunol 2009;123(Suppl):S215.
    • (2009) J Allergy Clin Immunol , vol.123 , Issue.SUPPL.
    • Winther, L.1    Poulsen, L.K.2    Robin, B.3    Melac, M.4    Malling, H.J.5
  • 77
    • 23244437462 scopus 로고    scopus 로고
    • Allergen-specific nasal IgG antibodies induced by vaccination with genetically modified allergens are associated with reduced nasal allergen sensitivity
    • Reisinger J, Horak F, Pauli G, van Hage M, Cromwell O, König F, et al. Allergen-specific nasal IgG antibodies induced by vaccination with genetically modified allergens are associated with reduced nasal allergen sensitivity. J Allergy Clin Immunol 2005;116: 347-54.
    • (2005) J Allergy Clin Immunol , vol.116 , pp. 347-354
    • Reisinger, J.1    Horak, F.2    Pauli, G.3    van Hage, M.4    Cromwell, O.5    König, F.6
  • 78
    • 34047152536 scopus 로고    scopus 로고
    • Vaccination with genetically modified birch pollen allergens: Immune and clinical effects on oral allergy syndrome
    • Niederberger V, Reisinger J, Valent P, Krauth MT, Pauli G, van Hage M, et al. Vaccination with genetically modified birch pollen allergens: immune and clinical effects on oral allergy syndrome. J Allergy Clin Immunol 2007;119:1013-6.
    • (2007) J Allergy Clin Immunol , vol.119 , pp. 1013-1016
    • Niederberger, V.1    Reisinger, J.2    Valent, P.3    Krauth, M.T.4    Pauli, G.5    van Hage, M.6
  • 79
    • 77955380658 scopus 로고    scopus 로고
    • Inhibition of CD23-dependent facilitated allergen binding to B cells following vaccination with genetically modified hypoallergenic Bet v 1 molecules
    • Pree I, Shamji MH, Kimber I, Valenta R, Durham SR, Niederberger V. Inhibition of CD23-dependent facilitated allergen binding to B cells following vaccination with genetically modified hypoallergenic Bet v 1 molecules. Clin Exp Allergy 2010;40:1346-52.
    • (2010) Clin Exp Allergy , vol.40 , pp. 1346-1352
    • Pree, I.1    Shamji, M.H.2    Kimber, I.3    Valenta, R.4    Durham, S.R.5    Niederberger, V.6
  • 80
    • 0013687727 scopus 로고    scopus 로고
    • Comparison of genetically engineered hypoallergenic rBet v 1 derivatives with rBet v 1 wild-type by skin prick and intradermal testing: Results obtained in a French population
    • Pauli G, Purohit A, Oster JP, De Blay F, Vrtala S, Niederberger V, et al. Comparison of genetically engineered hypoallergenic rBet v 1 derivatives with rBet v 1 wild-type by skin prick and intradermal testing: results obtained in a French population. Clin Exp Allergy 2000;30:1076-84.
    • (2000) Clin Exp Allergy , vol.30 , pp. 1076-1084
    • Pauli, G.1    Purohit, A.2    Oster, J.P.3    De Blay, F.4    Vrtala, S.5    Niederberger, V.6
  • 84
    • 24744438448 scopus 로고    scopus 로고
    • The effect of Fel d 1-derived T-cell peptides on upper and lower airway outcome measurements in cat-allergic subjects
    • Alexander C, Tarzi M, Larché M, Kay AB. The effect of Fel d 1-derived T-cell peptides on upper and lower airway outcome measurements in cat-allergic subjects. Allergy 2005;60:1269-74.
    • (2005) Allergy , vol.60 , pp. 1269-1274
    • Alexander, C.1    Tarzi, M.2    Larché, M.3    Kay, A.B.4


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