Targeted inhibition of KCa3.1 attenuates TGF-β-induced reactive astrogliosis through the Smad2/3 signaling pathway

Journal of Neurochemistry

Volumn 130, Issue 1, 2014, Pages 41-49

  Yu, Zhihua ^a,b   Yu, Panpan ^b   Chen, Hongzhuan ^a   Geller, Herbert M ^b  

^a SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^b NATIONAL HEART LUNG AND BLOOD INSTITUTE   (United States)

Author keywords

astrocyte; chondroitin sulfate proteoglycans; culture; GFAP; mouse

Indexed keywords

1 [(2 CHLOROPHENYL)DIPHENYLMETHYL] 1H PYRAZOLE; CALCIUM ION; GLIAL FIBRILLARY ACIDIC PROTEIN; INTERMEDIATE CONDUCTANCE CALCIUM ACTIVATED POTASSIUM CHANNEL; POTASSIUM CHANNEL KCA3.1; PROTEOCHONDROITIN SULFATE; SMAD2 PROTEIN; SMAD3 PROTEIN; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG; URIDINE TRIPHOSPHATE; KCNN4 PROTEIN, MOUSE; PYRAZOLE DERIVATIVE; SMAD2 PROTEIN, MOUSE; SMAD3 PROTEIN, MOUSE;

ANIMAL CELL; ARTICLE; ASTROCYTOSIS; CALCIUM TRANSPORT; CONTROLLED STUDY; GENE INACTIVATION; MOUSE; NONHUMAN; PHARMACOLOGICAL BLOCKING; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; UPREGULATION; ANIMAL; ANTAGONISTS AND INHIBITORS; ASTROCYTE; C57BL MOUSE; CELL CULTURE; DEFICIENCY; DRUG EFFECTS; GENE TARGETING; GENETICS; GLIOSIS; HUMAN; KNOCKOUT MOUSE; METABOLISM; NEWBORN; PHYSIOLOGY; PROCEDURES;

ANIMALS; ANIMALS, NEWBORN; ASTROCYTES; CELLS, CULTURED; GENE TARGETING; GLIOSIS; HUMANS; INTERMEDIATE-CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNELS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; PYRAZOLES; SIGNAL TRANSDUCTION; SMAD2 PROTEIN; SMAD3 PROTEIN; TRANSFORMING GROWTH FACTOR BETA;

EID: 84903178308     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/jnc.12710     Document Type: Article

References (40)

1. Bignami A., and, Dahl D., (1974) Astrocyte-specific protein and neuroglial differentiation. An immunofluorescence study with antibodies to the glial fibrillary acidic protein. J. Comp. Neurol. 153, 27-38.
2. Bignami A., Eng L. F., Dahl D., and, Uyeda C. T., (1972) Localization of the glial fibrillary acidic protein in astrocytes by immunofluorescence. Brain Res. 43, 429-435.
3. + channel, KCNN4/KCa3.1, improves tissue protection and locomotor recovery after spinal cord injury. J. Neurosci. 31, 16298-16308.
4. v1.3 as novel targets for asthma therapy. Br. J. Pharmacol. 157, 1330-1339.
5. Chen Y. J., Raman G., Bodendiek S., O'Donnell M. E., and, Wulff H., (2011) The KCa3.1 blocker TRAM-34 reduces infarction and neurological deficit in a rat model of ischemia/reperfusion stroke. J. Cereb. Blood Flow Metab. 31, 2363-2374.
6. D'Alessandro G., Catalano M., Sciaccaluga M., et al,. (2013) KCa3.1 channels are involved in the infiltrative behavior of glioblastoma in vivo. Cell Death Dis. 4, e773.
7. Dallerac G., Chever O., and, Rouach N., (2013) How do astrocytes shape synaptic transmission? Insights from electrophysiology Front. Cell. Neurosci. 7, 159.
8. Derynck R., and, Zhang Y. E., (2003) Smad-dependent and Smad-independent pathways in TGF-β family signalling. Nature 425, 577-584. (Pubitemid 37280136)
9. + channel KCa3.1 ameliorates T cell-mediated colitis. Proc. Natl Acad. Sci. USA 107, 1541-1546.
10. 2+ signaling, store refilling and migration of rat microglial cells. PLoS ONE 8, e62345.
11. Fitch M. T., and, Silver J., (1997) Glial cell extracellular matrix: boundaries for axon growth in development and regeneration. Cell Tissue Res. 290, 379-384. (Pubitemid 27470072)
12. Franke H., Verkhratsky A., Burnstock G., and, Illes P., (2012) Pathophysiology of astroglial purinergic signalling. Purinergic Signal. 8, 629-657.
13. Gardos G., (1958) The function of calcium in the potassium permeability of human erythrocytes. Biochim. Biophys. Acta 30, 653-654.
14. Hausmann O. N., (2003) Post-traumatic inflammation following spinal cord injury. Spinal Cord 41, 369-378. (Pubitemid 36819586)
15. Heimer R., Bashey R. I., Kyle J., and, Jimenez S. A., (1995) TGF-β modulates the synthesis of proteoglycans by myocardial fibroblasts in culture. J. Mol. Cell. Cardiol. 27, 2191-2198.
16. Huang C., Shen S., Ma Q., Chen J., Gill A., Pollock C. A., and, Chen X. M., (2013) Blockade of KCa3.1 ameliorates renal fibrosis through the TGF-β1/Smad pathway in diabetic mice. Diabetes 62, 2923-2934.
17. Ito Y., Hikino M., Yajima Y., Mikami T., Sirko S., von Holst A., Faissner A., Fukui S., and, Sugahara K., (2005) Structural characterization of the epitopes of the monoclonal antibodies 473HD, CS-56, and MO-225 specific for chondroitin sulfate D-type using the oligosaccharide library. Glycobiology 15, 593-603. (Pubitemid 41214372)
18. Logan A., Frautschy S. A., Gonzalez A. M., Sporn M. B., and, Baird A., (1992) Enhanced expression of transforming growth factor β1 in the rat brain after a localized cerebral injury. Brain Res. 587, 216-225.
19. Logan A., Berry M., Gonzalez A. M., Frautschy S. A., Sporn M. B., and, Baird A., (1994) Effects of transforming growth factor β1 on scar production in the injured central nervous system of the rat. Eur. J. Neurosci. 6, 355-363. (Pubitemid 24077148)
20. Logan A., Baird A., and, Berry M., (1999) Decorin attenuates gliotic scar formation in the rat cerebral hemisphere. Exp. Neurol. 159, 504-510. (Pubitemid 29485236)
21. + channels and calmodulin. J. Physiol. 554, 255-261. (Pubitemid 38181340)
22. McKeon R. J., Jurynec M. J., and, Buck C. R., (1999) The chondroitin sulfate proteoglycans neurocan and phosphacan are expressed by reactive astrocytes in the chronic CNS glial scar. J. Neurosci. 19, 10778-10788. (Pubitemid 30235724)
23. Moustakas A., and, Heldin C. H., (2005) Non-Smad TGF-β signals. J. Cell Sci. 118, 3573-3584.
24. Petzold G. C., and, Murthy V. N., (2011) Role of astrocytes in neurovascular coupling. Neuron 71, 782-797.
25. Ca3.1 as a Novel Target for Idiopathic Pulmonary Fibrosis. PLoS ONE 8, e85244.
26. Ross S., and, Hill C. S., (2008) How the Smads regulate transcription. Int. J. Biochem. Cell Biol. 40, 383-408. (Pubitemid 351241229)
27. Schneider C. A., Rasband W. S., and, Eliceiri K. W., (2012) NIH Image to ImageJ: 25 years of image analysis. Nat. Methods 9, 671-675.
28. Schonherr E., Jarvelainen H. T., Sandell L. J., and, Wight T. N., (1991) Effects of platelet-derived growth factor and transforming growth factor- β1 on the synthesis of a large versican-like chondroitin sulfate proteoglycan by arterial smooth muscle cells. J. Biol. Chem. 266, 17640-17647. (Pubitemid 21907985)
29. Silver J., and, Miller J. H., (2004) Regeneration beyond the glial scar. Nat. Rev. Neurosci. 5, 146-156. (Pubitemid 38160289)
30. Smith G. M., and, Strunz C., (2005) Growth factor and cytokine regulation of chondroitin sulfate proteoglycans by astrocytes. Glia 52, 209-218. (Pubitemid 43076151)
31. Snow D. M., Lemmon V., Carrino D. A., Caplan A. I., and, Silver J., (1990) Sulfated proteoglycans in astroglial barriers inhibit neurite outgrowth in vitro. Exp. Neurol. 109, 111-130. (Pubitemid 20226710)
32. Sofroniew M. V., (2005) Reactive astrocytes in neural repair and protection. Neuroscientist 11, 400-407. (Pubitemid 41339226)
33. Sofroniew M. V., (2009) Molecular dissection of reactive astrogliosis and glial scar formation. Trends Neurosci. 32, 638-647.
34. Sofroniew M. V., and, Vinters H. V., (2010) Astrocytes: biology and pathology. Acta Neuropathol. 119, 7-35.
35. Susarla B. T., Laing E. D., Yu P., Katagiri Y., Geller H. M., and, Symes A. J., (2011) Smad proteins differentially regulate transforming growth factor-β-mediated induction of chondroitin sulfate proteoglycans. J. Neurochem. 119, 868-878.
36. Toyama K., Wulff H., Chandy K. G., et al,. (2008) The intermediate-conductance calcium-activated potassium channel KCa3.1 contributes to atherogenesis in mice and humans. J. Clin. Invest. 118, 3025-3037.
37. Wang H., Katagiri Y., McCann T. E., et al,. (2008) Chondroitin-4- sulfation negatively regulates axonal guidance and growth. J. Cell Sci. 121, 3083-3091.
38. Weiss A., and, Attisano L., (2013) The TGFbeta superfamily signaling pathway. Wiley Interdiscip. Rev. Dev. Biol. 2, 47-63.
39. Yu Z. H., Wang Y. X., Song Y., Lu H. Z., Hou L. N., Cui Y. Y., and, Chen H. Z., (2013a) Up-regulation of KCa3.1 promotes human airway smooth muscle cell phenotypic modulation. Pharmacol. Res. 77, 30-38.
40. Yu Z. H., Xu J. R., Wang Y. X., Xu G. N., Xu Z. P., Yang K., Wu D. Z., Cui Y. Y., and, Chen H. Z., (2013b) Targeted inhibition of KCa3.1 channel attenuates airway inflammation and remodeling in allergic asthma. Am. J. Respir. Cell Mol. Biol. 48, 685-693.