Up-regulation of KCa3.1 promotes human airway smooth muscle cell phenotypic modulation

Pharmacological Research

Volumn 77, Issue , 2013, Pages 30-38

  Yu, Z H ^a   Wang, Y X ^a   Song, Y ^a   Lu, H Z ^a   Hou, L N ^a   Cui, Y Y ^a   Chen, H Z ^a  

^a SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

Author keywords

Human bronchial smooth muscle cells; KCa3.1; Migration; Phenotypic modulation; Proliferation

Indexed keywords

1 [(2 CHLOROPHENYL)DIPHENYLMETHYL] 1H PYRAZOLE; ALPHA SMOOTH MUSCLE ACTIN; CALCIUM ACTIVATED POTASSIUM CHANNEL; CALCIUM ACTIVATED POTASSIUM CHANNEL KCA1.1; CALCIUM ACTIVATED POTASSIUM CHANNEL KCA3.1; CALCIUM ACTIVATED POTASSIUM CHANNEL KCA3.1 BLOCKING AGENT; CALCIUM ION; CYCLIN D1; MYOCARDIN; MYOSIN HEAVY CHAIN; PLATELET DERIVED GROWTH FACTOR; POTASSIUM CHANNEL BLOCKING AGENT; UNCLASSIFIED DRUG; 1,3 BUTADIENE DERIVATIVE; 1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; 2-(4-MORPHOLINYL)-8-PHENYL-4H-1-BENZOPYRAN-4-ONE; ACTIN; CALCIUM; CHROMONE DERIVATIVE; INTERMEDIATE CONDUCTANCE CALCIUM ACTIVATED POTASSIUM CHANNEL; KCNMA1 PROTEIN, HUMAN; KCNN4 PROTEIN, HUMAN; LARGE CONDUCTANCE CALCIUM ACTIVATED POTASSIUM CHANNEL ALPHA SUBUNIT; MORPHOLINE DERIVATIVE; NITRILE; NUCLEAR PROTEIN; PROTEIN KINASE INHIBITOR; PYRAZOLE DERIVATIVE; TRANSACTIVATOR PROTEIN;

ARTICLE; BRONCHUS MUSCLE; CELL ACTIVATION; CELL CULTURE; CELL MEMBRANE DEPOLARIZATION; CELL MIGRATION; CELL PROLIFERATION; CONTROLLED STUDY; DOWN REGULATION; G1 PHASE CELL CYCLE CHECKPOINT; GENE SILENCING; HUMAN; HUMAN CELL; PHENOTYPE; PHENOTYPIC MODULATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATORY MECHANISM; SMOOTH MUSCLE CONTRACTILITY; SMOOTH MUSCLE FIBER; UPREGULATION; ANTAGONISTS AND INHIBITORS; BIOSYNTHESIS; BRONCHUS; CELL CYCLE CHECKPOINT; CELL MOTION; DRUG EFFECTS; GENETICS; METABOLISM; PHYSIOLOGY;

ACTINS; BRONCHI; BUTADIENES; CALCIUM; CELL CYCLE CHECKPOINTS; CELL MOVEMENT; CELL PROLIFERATION; CELLS, CULTURED; CHROMONES; CYCLIN D1; DOWN-REGULATION; GENE SILENCING; HUMANS; INTERMEDIATE-CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNELS; LARGE-CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNEL ALPHA SUBUNITS; MORPHOLINES; MYOCYTES, SMOOTH MUSCLE; MYOSIN HEAVY CHAINS; NITRILES; NUCLEAR PROTEINS; PHENOTYPE; PLATELET-DERIVED GROWTH FACTOR; PROTEIN KINASE INHIBITORS; PYRAZOLES; TRANS-ACTIVATORS; UP-REGULATION;

EID: 84885141103     PISSN: 10436618     EISSN: 10961186     Source Type: Journal    
DOI: 10.1016/j.phrs.2013.09.002     Document Type: Article

References (30)

1. A.J. Halayko, T. Tran, S.Y. Ji, A. Yamasaki, and R. Gosens Airway smooth muscle phenotype and function: interactions with current asthma therapies Curr Drug Targets 7 2006 525 540 (Pubitemid 43744820)
2. A.J. Halayko, H. Salari, X. Ma, and N.L. Stephens Markers of airway smooth muscle cell phenotype Am J Physiol 270 1996 L1040 L1051
3. X. Ma, Y. Wang, and N.L. Stephens Serum deprivation induces a unique hypercontractile phenotype of cultured smooth muscle cells Am J Physiol 274 1998 C1206 C1214
4. J.H. Lee, P.R. Johnson, M. Roth, N.H. Hunt, and J.L. Black ERK activation and mitogenesis in human airway smooth muscle cells Am J Physiol-Lung Cell Mol Physiol 280 2001 L1019 L1029
5. S.J. Kim, S.Y. Kim, C.H. Kwon, and Y.K. Kim Differential effect of FGF and PDGF on cell proliferation and migration in osteoblastic cells Growth Factors 25 2007 77 86 (Pubitemid 47487574)
6. G. Damera, K.M. Druey, P.R. Cooper, V.P. Krymskaya, R.J. Soberman, and Y. Amrani An RGS4-mediated phenotypic switch of bronchial smooth muscle cells promotes fixed airway obstruction in asthma PLoS ONE 7 2012 e28504
7. M. Ebina, T. Takahashi, T. Chiba, and M. Motomiya Cellular hypertrophy and hyperplasia of airway smooth muscles underlying bronchial asthma. A 3-D morphometric study Am Rev Respir Dis 148 1993 720 726 (Pubitemid 23263786)
8. J. Bousquet, P.K. Jeffery, W.W. Busse, M. Johnson, and A.M. Vignola Asthma. From bronchoconstriction to airways inflammation and remodeling Am J Respir Crit Care Med 161 2000 1720 1745 (Pubitemid 30329053)
9. M.N. Oliver, B. Fabry, A. Marinkovic, S.M. Mijailovich, J.P. Butler, and J.J. Fredberg Airway hyperresponsiveness, remodeling, and smooth muscle mass: right answer, wrong reason Am J Respir Mol Biol 37 2007 264 272 (Pubitemid 350067606)
10. + channels regulate human airway smooth muscle proliferation Am J Respir Mol Biol 37 2007 525 531 (Pubitemid 350058183)
11. + channels are required for human fibrocyte migration J Allergy Clin Immunol 128 2011 1303 1309
12. P. Bradding, and H. Wulff The K1 channels K(Ca)3.1 and K(v)1.3 as novel targets for asthma therapy Br J Pharmacol 157 2009 1330 1339
13. S.J. Hirst, J.G. Martin, J.V. Bonacci, V. Chan, E.D. Fixman, and Q.A. Hamid Proliferative aspects of airway smooth muscle J Allergy Clin Immunol 114 2004 S2 S17
14. W.T. Gerthoffer Migration of airway smooth muscle cells Proc Am Thorac Soc 5 2008 97 105
15. V.A. Snetkov, S.J. Hirst, C.H. Twort, and J.P. Ward Potassium currents in human freshly isolated bronchial smooth muscle cells Br J Pharmacol 115 1995 1117 1125
16. Z.H. Yu, J.R. Xu, Y.X. Wang, G.N. Xu, Z.P. Xu, and K. Yang Targeted inhibition of KCa3.1 channel attenuates airway inflammation and remodeling in allergic asthma Am J Respir Mol Biol 48 2013 685 693
17. L. Di, S. Srivastava, O. Zhdanova, Y. Ding, Z. Li, and H. Wulff Inhibition of the K1 channel KCa3.1 ameliorates T cell-mediated colitis Proc Natl Acad Sci U S A 107 2010 1541 1546
18. K. Toyama, H. Wulff, K.G. Chandy, P. Azam, G. Raman, and T. Saito The intermediate-conductance calcium-activated potassium channel KCa3.1 contributes to atherogenesis in mice and humans J Clin Invest 118 2008 3025 3037
19. D.H. Yu, Q. Lu, J. Xie, C. Fang, and H.Z. Chen Peptide-conjugated biodegradable nanoparticles as a carrier to target paclitaxel to tumor neovasculature Biomaterials 31 2010 2278 2292
20. X.L. Deng, C.P. Lau, K. Lai, K.F. Cheung, G.K. Lau, and G.R. Li Cell cycle-dependent expression of potassium channels and cell proliferation in rat mesenchymal stem cells from bone marrow Cell Prolif 40 2007 656 670 (Pubitemid 47416548)
21. + channel is expressed in C2C12 myoblasts and is downregulated during myogenesis Am J Physiol-Cell Physiol 289 2005 C89 C96
22. I. Grgic, E. Kiss, B.P. Kaistha, C. Busch, M. Kloss, and J. Sautter Renal fibrosis is attenuated by targeted disruption of KCa3.1 potassium channels Proc Natl Acad Sci U S A 106 2009 14518 14523
23. V.A. Snetkov, S.J. Hirst, and J.P. Ward Ion channels in freshly isolated and cultured human bronchial smooth muscle cells Exp Physiol 81 1996 791 804 (Pubitemid 26332080)
24. G.K. Owens, M.S. Kumar, and B.R. Wamhoff Molecular regulation of vascular smooth muscle cell differentiation in development and disease Physiol Rev 84 2004 767 801 (Pubitemid 38823766)
25. S.Q. Kuang, C.S. Kwartler, K.L. Byanova, J. Pham, L. Gong, and S.K. Prakash Rare, nonsynonymous variant in the smooth muscle-specific isoform of myosin heavy chain, MYH11, R247C, alters force generation in the aorta and phenotype of smooth muscle cells Circ Res 110 2012 1411 1422
26. C.P. Regan, P.J. Adam, C.S. Madsen, and G.K. Owens Molecular mechanisms of decreased smooth muscle differentiation marker expression after vascular injury J Clin Invest 106 2000 1139 1147
27. R. Hutcheson, R. Terry, J. Chaplin, E. Smith, A. Musiyenko, and J.C. Russell MicroRNA-145 restores contractile vascular smooth muscle phenotype and coronary collateral growth in the metabolic syndrome Arteriosc Thromb Vasc Biol 33 2013 727 736
28. R. Nagai, T. Suzuki, K. Aizawa, S. Miyamoto, T. Amaki, and K. Kawai-Kowase Phenotypic modulation of vascular smooth muscle cells: dissection of transcriptional regulatory mechanisms N Y Acad Sci 947 2001 56 66
29. M. Ramakrishnan, N.L. Musa, J. Li, P.T. Liu, R.G. Pestell, and M.B. Hershenson Catalytic activation of extracellular signal regulated kinases induces cyclin D1 expression in primary tracheal myocytes Am J Respir Mol Biol 18 1998 736 740 (Pubitemid 128358419)
30. K. Page, J. Li, Y. Wang, S. Kartha, R.G. Pestell, and M.B. Hershenson Regulation of cyclin D(1) expression and DNA synthesis by phosphatidylinositol 3-kinase in airway smooth muscle cells Am J Respir Mol Biol 23 2000 436 443